Clinical Reviews in Bone and Mineral Metabolism This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

An Overview of Osteoporosis and Possible Treatment Approaches
AbstractOsteoporosis  is most prevalent in postmenopausal women and is a widespread condition that impacts millions of individuals worldwide. A decrease in bone mineral density and elevated susceptibility to fractures as a result of bone architecture deterioration are the primary attributes of osteoporosis. Due to the challenging nature of treating osteoporosis as a chronic condition, further research into innovative and efficacious therapeutic and animal models that aim to test these drug approaches is necessary. Numerous preclinical and clinical studies have focused on identifying the most efficacious therapeu tic appr...
Source: Clinical Reviews in Bone and Mineral Metabolism - April 4, 2024 Category: Internal Medicine Source Type: research

Natural Products and Traditional Herbal Medicines as Managerial Therapies to Combat Rheumatoid Arthritis
This study attempts to provide a complete overview of synthetic medications and natural items used to treat RA. It specifically investigates the pathophysiological mechanisms that underpin RA and the efficacy and safety profiles of synthetic pharmaceuticals. Synthetic medications, such as disease-modifying antirheumatic drugs (DMARDs), and biologics remain important treatments for RA, albeit with hazards. So to explore safer and more effective therapy for the treatment of RA, a need to exploit the possible therapeutic benefits of natural items such as antioxidants, plant secondary metabolites, and traditional herbal remedi...
Source: Clinical Reviews in Bone and Mineral Metabolism - March 8, 2024 Category: Internal Medicine Source Type: research

An Integrated Approach to Clinical and Translational Metabolism Research
(Source: Clinical Reviews in Bone and Mineral Metabolism)
Source: Clinical Reviews in Bone and Mineral Metabolism - December 20, 2023 Category: Internal Medicine Source Type: research

Type 2 Diabetes and Bone Disease
AbstractDiabetes and osteoporosis are age-related conditions contributing to the burgeoning burden of health care as life expectancy increases. Over the past 30  years, evidence has emerged indicating that these two conditions are related. Diabetes is well recognized to affect bone health, contributing to decreased bone formation, increased bone marrow adiposity, and heightened risk of fracture. Age-related inflammation and oxidative stress promote the dev elopment of osteoporosis primarily by reducing bone formation, and they are augmented in diabetes. There is an association between reduced bone remodeling and increased...
Source: Clinical Reviews in Bone and Mineral Metabolism - April 29, 2023 Category: Internal Medicine Source Type: research

Pregnancy-Associated Osteoporosis: A Literature Review
AbstractPregnancy-associated osteoporosis (PAO) is a rare pathology affecting women in pregnancy or the postpartum period. During normal pregnancy and lactation, there are substantial physiological changes in the woman ’s skeletal structure as well as calcium homeostasis to meet demands of the developing fetus. While these adaptations and generally of no clinical consequence for the mother, and subsequently resolve postpartum, a small number of women will develop osteoporosis and suffer from non-traumatic fragil ity fractures. Due to the rarity of PAO, systematic study to date has been limited. Etiology is poorly underst...
Source: Clinical Reviews in Bone and Mineral Metabolism - March 4, 2023 Category: Internal Medicine Source Type: research

The Macrophage ’s Role on Bone Remodeling and Osteogenesis: a Systematic Review
AbstractMacrophages are one of the most abundant immune cells in the human body. They have several roles and functions in the body; however, their role in bone osteogenesis and remodulation has yet to be accurately determined. Thus, this systematic review aimed to determine and explain the macrophages ’ role associated with remodeling and osteogenesis. Electronic search was conducted through MEDLINE (PubMed) and Web of Science (WoS), with the following focused question “What is the real macrophages’ role in the bone remodeling and osteogenesis and what would be the conditions to trigger the behavior?” After initial...
Source: Clinical Reviews in Bone and Mineral Metabolism - February 20, 2023 Category: Internal Medicine Source Type: research

A Review on the Recent Trend in Osteoporosis Highly Cited Papers
AbstractThe goal of this study was to compile the list of highly cited papers in osteoporosis across Web of Science Clarivate Analytics to identify current trends in osteoporosis research. We searched the Web of Science on 18 February 2021 with a search strategy including osteoporosis and all its related keywords. Search results were limited to the highly cited papers published in the last 5  years (2016–2020). Our search strategy on the Web of Science database retrieved 94 highly cited papers, related to osteoporosis. Out of 94 included papers, the biggest portion was secondary studies (44.7%) followed by animals/precl...
Source: Clinical Reviews in Bone and Mineral Metabolism - December 26, 2022 Category: Internal Medicine Source Type: research

Limb Preference and Limb Bone Mineral Density: an Overview of Empirical Findings
This study presents an overview of empirical findings from a systematic search of the published literature on the association between limb preference and limb bone mineral density (BMD) asymmetries. References for this review were generated by a comprehensive literature search of reliable, third-party, online, and offline published sources on the topic of the effects of upper and lower limb lateralization on limb BMD asymmetry. The data collected from all published sources portrayed a picture of considerable variation in the measurements of bilateral BMD asymmetry, since the cause of asymmetric development was not always o...
Source: Clinical Reviews in Bone and Mineral Metabolism - December 17, 2022 Category: Internal Medicine Source Type: research

Looking at Mountains: Role of Sustained Hypoxia in Regulating Bone Mineral Homeostasis in Relation to Wnt Pathway and Estrogen
AbstractDeteriorated bone microarchitecture is a major health concern affecting millions worldwide, amounting to high mortality along with psychological, social, and economic burden. Hypoxia has been known to affect bone mineral metabolism in various in vitro and in vivo experiments in an inconclusive manner and only a few studies are available on natives or travelers of high altitude, pointing towards the deterioration of bone health. HIF proteins, fundamental to hypoxia signaling have also been shown to affect bone remodeling by mediating osteoblastogenesis and osteoclastogenesis but the underlying mechanism of this proc...
Source: Clinical Reviews in Bone and Mineral Metabolism - November 22, 2022 Category: Internal Medicine Source Type: research

Correction to: Periodontitis and Rheumatoid Arthritis: The Common Thread
AbstractThe two immunoinflammatory disorders, rheumatoid arthritis (RA) and Periodontitis (PD) are characterized by synovitis, joint damage, and alveolar bone degradation, are triggered by certain inflammatory mediators and leukocyte invasion, respectively. Rheumatoid arthritis is an infectious disorder which attacks changed self-epitopes and thus affects 1% of the human population, whereas 11% of the worldwide population aged is afflicted by extreme periodontal diseases in which commensal microbes upon the tooth surface is substituted by dysbiosis of the bacterial community that facilitate chronic inflammatory periodontal...
Source: Clinical Reviews in Bone and Mineral Metabolism - December 14, 2021 Category: Internal Medicine Source Type: research

The Distraction Osteogenesis Callus: a Review of the Literature
AbstractThe distraction osteogenesis has been an integrated treatment approach in significant bone deficiencies resulting from debridement or high-energy trauma. Nevertheless, it usually demands a prolonged treatment period attributed to the more profound distraction osteogenesis callus physiology. This distraction callus is a tissue not naturally present in mammals and results after surgical intervention. Despite sharing quite similar molecular and biomechanical mechanisms to the fracture-healing callus, it recruits unique physiological pathways. This review presents the deep physiology of the distraction osteogenesis cal...
Source: Clinical Reviews in Bone and Mineral Metabolism - December 1, 2021 Category: Internal Medicine Source Type: research

Understanding the Role of Metalloproteinases and Their Inhibitors in Periodontology
AbstractPeriodontitis is a complex and inflammatory disorder characterized by elevated level of tissue-degrading enzymes leading to the destruction of periodontal tissue and ultimately causes loss of the tooth. Apart from standard therapeutic measures used to control periodontal infection and inflammation, matrix metalloproteinase (MMP) control plays an important role in improving outcomes of periodontal therapy. In chronic periodontitis, levels of endogenous tissue inhibitor are not sufficient to inhibit the elevated MMPs, leading to increased pathogenesis of the periodontal disease. Literature evidence revealed adjunctiv...
Source: Clinical Reviews in Bone and Mineral Metabolism - December 1, 2021 Category: Internal Medicine Source Type: research

Effect of Oxidative Stress on Bone Remodeling in Periprosthetic Osteolysis
AbstractThe success of implant performance and arthroplasty is based on several factors, including oxidative stress-induced osteolysis. Oxidative stress is a key factor of the inflammatory response. Implant biomaterials can release wear particles which may elicit adverse reactions in patients, such as local inflammatory response leading to tissue damage, which eventually results in loosening of the implant. Wear debris undergo phagocytosis by macrophages, inducing a low-grade chronic inflammation and reactive oxygen species (ROS) production. In addition, ROS can also be directly produced by prosthetic biomaterial oxidation...
Source: Clinical Reviews in Bone and Mineral Metabolism - August 3, 2021 Category: Internal Medicine Source Type: research

Making Sense of the Highly Variable Effects of Alcohol on Bone
AbstractAlcohol consumption is often reported to influence bone health in a dose-dependent manner where moderate alcohol intake is deemed beneficial and heavy drinking detrimental. However, this relationship may not be valid for individual alcohol consumers, as small quantities of alcohol can have detrimental skeletal effects and not all studies report clinically relevant bone loss with long-duration alcohol abuse. These discrepant findings suggest that factors beyond quantity of alcohol consumed contribute to the observed skeletal response. We propose that the interplay between intrinsic factors  (e.g., age, sex, skeleta...
Source: Clinical Reviews in Bone and Mineral Metabolism - July 31, 2021 Category: Internal Medicine Source Type: research

Insights into the Perspective Correlation Between Vitamin D and Regulation of Hormones: Thyroid and Parathyroid Hormones
AbstractVitamin D is a vital contributor to the regulation of calcium and phosphorus homeostasis to preserve healthy bones and teeth. This was previously assumed as the only role of vitamin D, but the amount of recent studies gives it popularity as panacea for cases beyond bone mineralization especially after reporting vitamin D receptors in many human cells. This led to a growing evidence that vitamin D could have a greater effect on human health. Accordingly, several functions of vitamin D have been agreed, and in several disorders, its deficiency is crucially suggested. Current reports have also demonstrated a striking ...
Source: Clinical Reviews in Bone and Mineral Metabolism - July 24, 2021 Category: Internal Medicine Source Type: research