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State-of-the-Art Review: Assessing the Safety Profiles of New Anticoagulants for Major Orthopedic Surgery ThromboprophylaxisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The definitions of bleeding events that clinical trials of thromboprophylaxis use in their assessment of new anticoagulants strongly influences each drug’s perceived safety profile and may underestimate bleeding risks. Clinical studies of new anticoagulants urgently need standardization of bleeding definitions to allow intertrial comparability and to ensure consistent reporting of clinically relevant outcomes.
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Hull, R. D., Yusen, R. D., Bergqvist, D. Tags: Article Source Type: journals

Interpretation of Benefit-Risk of Enoxaparin as Comparator in the RECORD Program: Rivaroxaban Oral Tablets (10 milligrams) for Use in Prophylaxis in Deep Vein Thrombosis and Pulmonary Embolism in Patients Undergoing Hip or Knee Replacement SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Regulation of Coagulation in Major Orthopedic surgery reducing the Risk of DVT and PE (RECORD) clinical program of rivaroxaban consists of 4 phase III clinical trials comparing rivaroxaban with enoxaparin for the prevention of venous thromboembolism (VTE) in patients undergoing either total hip or total knee replacement surgery. Despite the comprehensive and extensive nature of this program, it had some logistic issues that included the dosing of the enoxaparin which was not only inconsistent with the recommendations but the dosages used were not optimal. The duration of treatment while consistent with rivaroxaban did ...
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Van Thiel, D., Kalodiki, E., Wahi, R., Litinas, E., Haque, W., Rao, G. Tags: Article Source Type: journals

Isolation and Characterization of Contaminants in Recalled Unfractionated Heparin and Low-Molecular-Weight HeparinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recently, a contaminant was found in some clinically used unfractionated heparin (UFH) preparations. Administration of this UFH was associated with an increased risk of developing a wide range of adverse effects including death. To further investigate the chemical profile of the contaminant, contaminated batches of UFH were treated by exhaustive nitrous acid depolymerization followed by methanol precipitation to remove heparin oligosaccharides. Because contaminated heparins may have been used as starting material in the production of low-molecular-weight heparins (LMWHs), a similar procedure was carried out using an experi...
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Viskov, C., Bouley, E., Hubert, P., Martinez, C., Herman, F., Jeske, W., Hoppensteadt, D., Walenga, J. M., Fareed, J. Tags: Article Source Type: journals

Are Prothrombotic Variants of Platelet Glycoprotein Receptor Polymorphisms Involved in the Pathogenesis of Thrombotic Microangiopathies?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thrombotic microangiopathies are life-threatening disorders characterized by vascular microthromboses, schistocytic hemolytic anemia, and thrombocytopenia. Although recent research has partially explained the pathogenesis of these rare entities, the determinants contributing to the onset and modulating the severity of thrombotic microangiopathies are largely unknown. The present study assessed the putative role of prothrombotic platelet receptor polymorphisms in thrombotic microangiopathies that have been found to be associated with premature onset of myocardial infarction in predisposed individuals. Thirty-four consecutiv...
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Sucker, C., Schmitz, M., Hetzel, G. R., Grabensee, B., Maruhn-Debowski, B., Ostojic, L., Scharf, R. E., Zotz, R. B. Tags: Article Source Type: journals

Assessing the Coagulation Factor Levels, Inherited Thrombophilia, and ABO Blood Group on the Risk for Venous Thrombosis Among BraziliansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Increased coagulation factor levels have been demonstrated to be a risk factor for venous thromboembolism in patients of Caucasian origin. Coagulation factors, hereditary thrombophilia, and ABO blood group were evaluated for venous thrombosis risk in a heterogeneous Brazilian population consisting of 122 women and 53 men, with a median age of 36 years (range 13-63), matched to a control group by age, sex, and ethnicity. Increased levels of factor VIII (odds ratio [OR], 3.1; 95% confidence interval [CI], 1.6-6.0), von Willebrand factor (OR, 2.8; 95% CI, 1.4-5.4), non-O blood group (OR, 2.1; 95% CI, 1.3-3.4), and thrombophil...
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Teixeira Mello, T. B., Machado, T. F. G., Montavao, S. A. L., Ozello, M. C., Annichino-Bizzacchi, J. M. Tags: Article Source Type: journals

Prevalence of Thrombophilic Mutations and ACE I/D Polymorphism in Turkish Ischemic Stroke PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to evaluate the prevalence of factor V Leiden (FVL), prothrombin G20210A, methylenetetrahydrofolate reductase (MTHFR) C677T gene mutations, and angiotensin-converting enzyme (ACE) I/D polymorphism in ischemic stroke (IS) patients. A total of 162 Turkish IS patients were included and analyzed according to stroke subtype by the TOAST classification. Their genotype data were compared with those of the control group, representing the healthy population, using the 2 test. The frequency of FVL heterozygocity was 12.3% in this series—higher than that in the normal population (9.8%; statistically in...
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Celiker, G., Can, U., Verdi, H., Yazici, A. C., Ozbek, N., Atac, F. B. Tags: Article Source Type: journals

Prevalence of Platelet Dysfunction and Abnormal Coagulation: Results of a Population-Based StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The prevalence of impairments in the hemostatic process is unknown in acutely ill people. Data on hemostasis (PFA 100®) and the coagulation cascade of 1015 people are presented here, establishing a cohort of unselected emergency patients in a population-based approach. A high prevalence of reduced platelet function (38%) was found, which was more frequent than expected. In contrast, there was a lower prevalence (20%) of abnormal plasmatic coagulation, which was almost always explained by medication, whereas medication could not predict abnormal platelet function. Moreover, a history of disproportionate bleeding did not...
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Marxsen, J. H., Forchheim, S., Zuske-Matthaus, A., Wagner, T. Tags: Article Source Type: journals

Heparin-Induced Thrombocytopenia: An Estimate of the Average Cost in the Hospital Setting in FranceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Heparin-induced thrombocytopenia is a severe drug adverse effect with possible dramatic consequences. The risk is 0.1% to 5%. The costs of heparin-induced thrombocytopenia in France were estimated using the Programme Médicalisé des Systèmes d’Information (PMSI) national discharge database. Hospitalizations with heparin-induced thrombocytopenia were identified using diagnostic codes. Costs were assessed from the perspective of the French Sickness Fund or hospitals. Heparin-induced thrombocytopenia could be the reason of admission or could occur during the stay and lead to a different tariff or to ...
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Elalamy, I., Le Gal, G., Nachit-Ouinekh, F., Lafuma, A., Emery, C., Le-Fur, C., Chapuis, F. Tags: Article Source Type: journals

Association of Angiotensin-Converting Enzyme Gene 2350G>A Polymorphism With Myocardial Infarction in a Chinese PopulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Angiotensin-converting enzyme (ACE) gene 2350G>A polymorphism has the most significant effect on plasma ACE concentrations. But the association between this polymorphism and myocardial infarction (MI) is presently unknown. We carried out a case-control study in the Chinese Han population. ACE2350G>A genotypes of 231 patients with MI and 288 healthy controls were detected by PCR-RFLP. Differences in frequencies of ACE genotypes and alleles and their associations with clinical features were assessed. The distribution of the ACE2350G>A genotypes (GG, GA, and AA) was 20.78%, 51.08%, and 28.14% in the MI group and 31.6...
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Min Pan, , Jiang, M.-H., Wei, M.-F., Liu, Z.-H., Jiang, W.-P., Geng, H.-H., Cui, Z.-C., Zhang, D.-L., Zhu, J.-H. Tags: Article Source Type: journals

The Effect of Plasminogen Activator Inhibitor-1 -675 4G/5G Polymorphism on Familial Mediterranean Fever (FMF) DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Familial Mediterranean fever (FMF) is an autosomal recessive disease that is the most common of a rare group of disorders collectively termed familial hereditary periodic fever syndromes, also known as autoinflammatory syndromes. FMF is predominantly affecting people of Mediterranean descent and clinically characterized by intermittent attacks of fever with peritonitis and abdominal pain, pleuritis, arthritis, or erysipelas-like rashes. Amyloidosis due to chronic inflammation progressing to renal failure is one of the most serious potential complications of this disease.Patients with inflammatory diseases, such as systemic...
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Ozel Demiralp, D., Ekim, M., Akar, N. Tags: Article Source Type: journals

Patterns of Acquired Bleeding Disorders in a Tertiary Care HospitalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bleeding disorders constitute a large proportion of referrals to hematology departments. Worldwide, acquired causes of bleeding are commoner than inherited ones. To identify the spectrum of these disorders, we evaluated all referrals for bleeding encountered in this tertiary care centre over a one-year period. Of the total 1342 cases, 1040 (77.5%) had underlying exclusively acquired causes, whereas inherited causes constituted 302 cases (22.5%). Amongst acquired causes, disseminated intravascular coagulation was seen in 297 (28.6%), hepatic coagulopathy in 218 (20.9%), neurosurgical causes (intracranial bleeds) in 154 (14....
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Asthana, B., Sharma, P., Ranjan, R., Jain, P., Aravindan, A., Chandra Mishra, P., Saxena, R. Tags: Article Source Type: journals

Is There Any Effect of Tumor Burden on Hemostatic Parameters in Cancer Patients? A Case--Control Study of Hemostatic Abnormalities and Anticardiolipin Antibodies in Solid TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hemostatic complications are one of the leading causes of mortality in cancer patients. In the present study, we assessed the hemostatic parameters and anticardiolipin antibodies in patients with solid tumors (n = 104) and healthy controls (n = 25) and also find out whether the abnormalities in these hemostatic parameters vary related to tumor burden. Prothrombin time, activated partial thromboplastine time, D-dimer, and fibrinogen as hemostatic parameters were determined by photo-optometric clot detection system, and serum anticardiolipin levels were measured by enzyme-linked immunosorbent assay. The plasma levels of fibr...
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Turna, H., Ozguroglu, M., Bolayirli, M., Orhanoglu, T., Balci, H. Tags: Article Source Type: journals

PIA1/A2 Polymorphism of the Platelet Glycoprotein Receptor IIb/IIIIa and Its Correlation to Cerebrovascular Diseases: An AppraisalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Platelet glycoprotein (GP) IIb/IIIa is a membrane receptor for fibrinogen and von Willebrand factor. There is considerable controversy regarding the clinical role of the GP IIb/IIIa PIA1/A2 as a risk factor of cerebrovascular diseases. Here, the author performs a summative analysis on the recent previous reports on the GP IIb/IIIa PIA1/A2 and its correlation to cerebrovascular diseases. The metanalysis was performed to assess the correlation between the pattern of GP IIb/IIIa PIA1/A2 polymorphism and cerebrovascular diseases. From available 4 case-control studies, 553 patients and 1059 controls are evaluated. From overall ...
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Wiwanitkit, V. Tags: Article Source Type: journals

Successful Use of Danaparoid in Two Pregnant Women With Heart Valve Prosthesis and Heparin-Induced Thrombocytopenia Type II (HIT)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study reports on a 26-year-old woman with tricuspidal valve prosthesis and a 37-year-old woman with a St. Jude Medical mitral valve prosthesis who were anticoagulated with danaparoid during pregnancy because of HIT. Anti-Xa levels were between 0.6 and 1.2 IU/mL during pregnancy with target levels of 1.0 IU/mL. Cesarean section was performed at anti-Xa levels of 0.3 and 0.7 IU/mL. One woman developed a placental hematoma at the 32nd week of gestation, which did not increase over the following week. Both patients delivered healthy boys. Heparin-induced thrombocytopenia in pregnant women with prosthetic heart valve can b...
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Gerhardt, A., Scharf, R. E., Zotz, R. B. Tags: Article Source Type: journals

Pericardial Hemorrhage Due to Acetylsalicylic Acid in a Patient With Essential ThrombocythemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Essential thrombocythemia is a clonal myeloproliferative disorder that causes thrombocytosis. Essential thrombocythemia is characterized by increased incidence of thrombosis with arterial event more than venous events and hemorrhagic complications. Acetylsalicylic acid enhances both minor and major bleedings. The authors describe pericardial hemorrhage, which is related to the use of low-dose acetylsalicylic acid in a patient with essential thrombocythemia. The patient was successfully managed with clopidogrel therapy during the 16 months follow-up without recurrent thrombotic or hemorrhagic events.
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Kayrak, M., Acar, K., Yazici, M., Kaya, C., Selim Ayhan, S., Gok, H. Tags: Article Source Type: journals

Myocardial Infarction in a 28-Year-Old Thalassemia Intermedia PatientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 28-year-old Lebanese thalassemia intermedia (TI) patient with homozygous IVS1-110 mutation sustained atypical chest pain of 1 day’s duration. The EKG reading revealed ST segment elevation in the chest leads V1 to V5. Coronary angiography showed 2 plaques in the left anterior descending coronary artery. He underwent subsequent angioplasty with stenting of the left anterior descending coronary artery. An extensive thrombophilia profile was negative. He was started on medication, and his medical condition improved and chest pain ceased. This is the first case report of myocardial infarction in a TI patient among thala...
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: El Rassi, F. A., Ismaeel, H. A., Koussa, S. C., Taher, A. T. Tags: Article Source Type: journals

Potential Role of Thrombelastography in the Monitoring of Acquired Factor VIII Inhibitor Hemophilia A: Report on a 78-year-old Woman With Life-threatening BleedingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 78-year-old woman was admitted to our hospital because of syncope associated with hematomas in both legs. Acquired hemophilia A (AHA) with a low antifactor VIII antibodies activity was diagnosed. Whole blood (WB) thrombelastographic profile depicted a hypocoagulable state. During hospitalization, the patient experienced life-threatening bleedings in the neck and in the right thigh. FVIII concentrates and rFVIIa was safe and effective in controlling acute hemorrhagic symptoms. Immunosuppressive therapy was used successfully to eradicate the inhibitor. At discharge, FVIII inhibitor was absent and thrombelastogram showed a ...
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Spiezia, L., Meneghetti, L., Dalla Valle, F., Tognin, G., Radu, C., Saggiorato, G., Fadin, M., Zanon, E., Simioni, P. Tags: Article Source Type: journals

Factor V Leiden in Mexican Pediatric Patients With ThrombosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Parra-Ortega, I., Sanchez-Huerta, J. L., Lopez-Martinez, B. Tags: Article Source Type: journals

Response to Factor V Leiden in MexicoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Majluf-Cruz, A. Tags: Article Source Type: journals

Book Review: TRALI: Mechanisms, Management, and Prevention. Stephen Kleinman and Mark A. Popovsky, Editors. AABB Press, Bethesda, MD. 2008. pp 196. ISBN 978-1-56395-267-8 soft cover, price $196.50Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Wehrmacher, W. H., Messmore, H. L. Tags: Article Source Type: journals

Book ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Authors: Wehrmacher, W. H Tags: Article Source Type: journals

Clinical and Applied Thrombosis/Hemostasis: Instructions for AuthorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Clinical and Applied Thrombosis/Hemostasis - September 1, 2009 Category: Hematology Tags: Article Source Type: journals

In Vivo Hemostatic Effect of the Medicinal Plant Extract Ankaferd Blood Stopper in Rats Pretreated With WarfarinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: ABS has in vivo hemostatic actions that may provide a therapeutic potential for the management of patients with deficient primary hemostasis in clinical medicine.
Source: Clinical and Applied Thrombosis/Hemostasis - May 21, 2009 Category: Hematology Authors: Cipil, H. S., Kosar, A., Kaya, A., Uz, B., Haznedaroglu, I. C., Goker, H., Ozdemir, O., Koroglu, M., Kirazli, S., Firat, H. C. Tags: Article Source Type: journals

Lessons From Ximelagatran: Issues for Future Studies Evaluating New Oral Direct Thrombin Inhibitors for Venous Thromboembolism Prophylaxis in Orthopedic SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study suggested that the risk-benefit profile of ximelagatran—and probably other similar agents— depends on the type of surgery, the initial timing of administration, and probably the dose. These issues should be explicitly explored in future trials evaluating new direct thrombin inhibitors.
Source: Clinical and Applied Thrombosis/Hemostasis - May 21, 2009 Category: Hematology Authors: Lazo-Langner, A., Rodger, M. A., Wells, P. S. Tags: Article Source Type: journals

Coagulation and Fibrinolysis are in Balance After Moderate Exercise in Middle-aged ParticipantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, 24 young (25 + 1 years) and 24 middle-aged healthy nonsmokers (48 + 1 years) underwent an individualized exercise test with 80% of individual anaerobic threshold (young individuals: 127 + 6 W; middle-aged individuals: 128 + 5 W; values are expressed as mean + standard error of mean) for 60 minutes. The blood samples were collected before and after the exercise. The age-related higher (P ≤ .05) levels could be detected in factors II, VII, VIII, IX, XI, XII, prothrombin fragment 1+2, in tissue plasminogen activator antigen and activity, as well as in plasminogen. The relative exercise-induced increases in t...
Source: Clinical and Applied Thrombosis/Hemostasis - May 21, 2009 Category: Hematology Authors: Menzel, K., Hilberg, T. Tags: Article Source Type: journals

The Effectiveness of Measuring for Fragmented Red Cells Using an Automated Hematology Analyzer in Patients With Thrombotic MicroangiopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thrombotic microangiopathy (TMA) or thrombotic thrombocytopenic purpura (TTP) is a life-threatening syndrome characterized by increased number of fragmented red cells (FRCs) and thrombocytopenia. FRCs can be measured using the recently developed automated hematology analyzer XE-2100. The normal range for FRCs is 0% to 0.205%, as determined by the automated hematology analyzer XE-2100. The FRC count is significantly elevated in patients with TMA associated with liver transplantation, bone marrow transplantation, or TTP. In patients with TMA after liver transplantation, the FRC count is significantly higher than in those wit...
Source: Clinical and Applied Thrombosis/Hemostasis - May 15, 2009 Category: Hematology Authors: Abe, Y., Wada, H., Yamada, E., Noda, M., Ikejiri, M., Nishioka, J., Kobayashi, T., Matsumoto, T., Masuya, M., Isaji, S., Usui, M., Uemoto, S., Katayama, N., Nobori, T. Tags: Article Source Type: journals

Need for Inferior Vena Cava Filters in Cancer Patients: A Surrogate Marker for Poor OutcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. The need for the insertion of an IVC filter projected markedly reduced survival. Patients requiring an IVC filter rather than AC as initial therapy face a 2-fold increase in risk of death. Whether or not this therapeutic procedure has a positive impact on outcome in cancer patients is uncertain. Complications resulting from thrombosis were also analyzed in this cohort. A prospective randomized trial at our institution is addressing this issue.
Source: Clinical and Applied Thrombosis/Hemostasis - May 15, 2009 Category: Hematology Authors: Barginear, M. F., Lesser, M., Akerman, M. L., Strakhan, M., Shapira, I., Bradley, T., Budman, D. R. Tags: Article Source Type: journals

Evolution of Prenatal Diagnostic Techniques From Phenotypic Diagnosis to Gene Arrays: Its Likely Impact on Prenatal Diagnosis of HemophiliaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prenatal diagnostic techniques in hemophilia have evolved through the early sex-determination techniques of offering a nonspecific diagnosis in case of a male fetus through the various mutation screening techniques to the more recent gene array techniques. Each of these techniques has specific advantages and disadvantages. The sampling techniques have evolved simultaneously to suit the requirements of each technique and also the different gestation periods. The DNA-based testing methods provide a range of aberrations detected with different levels of genomic resolution. The more recent gene array analysis is poised to have...
Source: Clinical and Applied Thrombosis/Hemostasis - May 15, 2009 Category: Hematology Authors: Ghosh, K., Shetty, S., Tulsiani, M. Tags: Article Source Type: journals

The TT Genotype of the C677T Polymorphism in the Methylentetrahydrofolate Reductase as a Risk Factor in Thrombotic Microangiopathies: Results From a Pilot StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we assessed the potential role of the TT genotype of the gene of the methylenetetrahydrofolate reductase for the manifestation of thrombotic microangiopathies, enrolling 40 affected patients (mean age [± standard deviation] 35 ± 11 years). As a result, the methylenetetrahydrofolate reductase 677TT genotype was more prevalent in patients with thrombotic microangiopathies compared with controls (adjusted odds ratio = 2.58, 95% confidence interval = 1.2-5.7, P = .018), particularly in those suffering from the hemolytic uremic syndrome. A hemolytic more severe clinical course of thrombotic microang...
Source: Clinical and Applied Thrombosis/Hemostasis - May 15, 2009 Category: Hematology Authors: Sucker, C., Kurschat, C., Farokhzad, F., Hetzel, G. R., Grabensee, B., Maruhn-Debowski, B., Loncar, R., Scharf, R. E., Zotz, R. B. Tags: Article Source Type: journals

Global Risk Profile Verification in Patients with Venous Thromboembolism (GRIP VTE) in 5 Gulf CountriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: VTE remains a common problem in medical and surgical patients in the Arabian Gulf states. Recognition of the common risk factors is of extreme importance to implement the appropriate prophylactic strategy according to the published guidelines.
Source: Clinical and Applied Thrombosis/Hemostasis - May 15, 2009 Category: Hematology Authors: Al Sayegh, F., Almahmeed, W., Al Humood, S., Marashi, M., Bahr, A., Al Mahdi, H., Bakir, S., Al Farhan, M. Tags: Article Source Type: journals

Monitoring of Functional Plasminogen in the Blood of Patients on FibrinolyticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There are no reliable data on functional plasminogen in the blood of patients receiving fibrinolytic treatment. Here, artifactual in vitro changes of functional plasminogen were prevented by arginine stabilization blood samples of myocardial infarction patients: 12 received 36.4 mg reteplase in bolus, and 1 patient received 100 mg tissue plasminogen activator in continuous infusion. Arginine (1.5 M, 1.3 mL, pH 8.7) was used to stabilize 2.6 mL ethylenediaminetetraacetic acid-blood. The arginine-stabilized plasma was analyzed with a functional oxidative assay for plasminogen. Functional plasminogen decreased within 2 minute...
Source: Clinical and Applied Thrombosis/Hemostasis - May 15, 2009 Category: Hematology Authors: Stief, T. W., Richter, A., Maisch, B., Renz, H. Tags: Article Source Type: journals

Seasonal Variation in the Occurrence of Venous Thromboembolism: Data From the MASTER RegistryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Many studies showed that the occurrence of cardiovascular and cerebrovascular events exhibits a seasonal variation. As for venous thromboembolism (VTE), not univocal results are available, and studies are mainly retrospective. We aimed to confirm the existence of a seasonal pattern in the occurrence of VTE on a large prospective population. The analysis considered consecutive cases of VTE enrolled into the MASTER Registry in 25 Italian hospitals, between January 2002 and November 2004. The total population consisted of 2119 subjects (1056 men, mean age 59 ± 18 years). The total sample was divided into subgroups by g...
Source: Clinical and Applied Thrombosis/Hemostasis - May 15, 2009 Category: Hematology Authors: Manfredini, R., Imberti, D., Gallerani, M., Verso, M., Pistelli, R., Ageno, W., Agnelli, G. Tags: Article Source Type: journals

Methodological Issues in Genetic Association Studies of Inherited Thrombophilia: Original Report of Recent PracticeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aims of this article are to evaluate the methodological quality of genetic association studies on the inherited thrombophilia published during 2003 to 2005, to identify the most common mistakes made by authors of those studies, and to examine if overall quality of the article correlates with the quality of the journal. Articles were evaluated by 2 independent reviewers using the checklist of 16 items. A total of 58 eligible studies were identified. Average total score was 7.59 ± 1.96. Total article score did not correlate with the journal impact factor (r = 0.3971; 95% confidence interval [CI], 0.1547-0.5944, P ...
Source: Clinical and Applied Thrombosis/Hemostasis - May 15, 2009 Category: Hematology Authors: Simundic, A.-M., Nikolac, N., Topic, E. Tags: Article Source Type: journals

Factor VIII Gene Haplotypes and Linkage Disequilibrium for the Indirect Genetic Analysis of Hemophilia A in IndiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Genomic consequences of factor VIII gene haplotypes for the indirect genetic analysis of haemophilia A has not been done in India hitherto. Consequently, BclI/intron18, HindIII/intron 19, and XbaI/intron 22 restriction sites were investigated in 159 individuals from 42 families with hemophilia A. The frequencies of haplotype II, IV, VI, that is, BclI (+)-HindIII (–)- XbaI (+), BclI (+)HindIII (+)-XbaI (–), and BclI (–)-HindIII (–)-XbaI (+) were 0.312, 0.198, and 0.164 respectively. The high heterogeneity of haplotype II highlighted its potential for indirect genetic diagnosis of factor VIII. Analysi...
Source: Clinical and Applied Thrombosis/Hemostasis - May 15, 2009 Category: Hematology Authors: Singh, M., Singh, P. Tags: Article Source Type: journals

Thrombophilia in Human Immunodeficiency Virus--Infected Patients with Osteonecrosis: Is There a Real Connection? The First Case-Control StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several reports have described an increased incidence of osteonecrosis in human immunodeficiency virus—infected patients (HIV+), but the cause has not been established. The association between thrombophilia and osteonecrosis in HIV+ was studied. A case-control study in HIV+, 19 cases and 38 controls, was designed. Magnetic resonance imaging was made in both groups to confirm or exclude hip osteonecrosis. The extensive tests of thrombophilia were measured, and the clinical data were recorded, nadir of CD4+ cell count and well-known risk factors for osteonecrosis. Thrombophilia has been frequently found both in patient...
Source: Clinical and Applied Thrombosis/Hemostasis - May 15, 2009 Category: Hematology Authors: de Larranaga, G., Bottaro, E., Martinuzzo, M., Figueroa, R., Iglesias Varela, M. L., Peres Wingeyer, S., Forastiero, R., Adamczuk, Y., Corti, M., Puga, L., Benetucci, J. Tags: Article Source Type: journals

High Incidence of Factor V Leiden and Prothrombin G20210A in Healthy Southern ItaliansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Factor V Leiden (FVL) and G20210 prothrombin (FII G20210A) mutations are risk factors for thromboembolism. In Europe, FVL is more prevalent in the north (7%) than in the south (3%), whereas FII G20210A is more common in the south (3% to 7%) than in the north (2% to 5%). In Italy, the prevalence is 2% to 3% for both. The aim of this study was to assess if these polymorphisms could be more frequent in the south than in the rest of Italy. In 105 blood donors in southern Italy, the prevalence of FVL and FIIG20210A was 9.5% and 5.7%, respectively. These prevalence data are higher when compared with published data. The results o...
Source: Clinical and Applied Thrombosis/Hemostasis - May 15, 2009 Category: Hematology Authors: Sottilotta, G., Mammi, C., Furlo, G., Oriana, V., Latella, C., Trapani Lombardo, V. Tags: Article Source Type: journals

The G1691A Mutation of the Factor V Gene (Factor V Leiden) and the G20210A Mutation of the Prothrombin Gene as Risk Factors in Thrombotic MicroangiopathiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Factor V Leiden (FVL) mutation and prothrombin G20210A mutation are common hereditary risk factors for venous thrombosis. In the current study, 40 patients (mean age ± standard deviation, 35 ± 11 years) and 764 healthy control subjects (mean age ± standard deviation, 37 ± 14 years) were enrolled to assess the potential role of these mutations in the manifestation of thrombotic microangiopathies. Compared with controls, neither the heterozygous FVL mutation (7.5% vs 8.5%; P = 1) nor the heterozygous prothrombin mutation (2.5% vs 2.8%; P = 1) was more prevalent in the patients. The findings do not...
Source: Clinical and Applied Thrombosis/Hemostasis - May 15, 2009 Category: Hematology Authors: Sucker, C., Kurschat, C., Hetzel, G. R., Grabensee, B., Maruhn-Debowski, B., Loncar, R., Ostojic, L., Scharf, R. E., Zotz, R. B. Tags: Article Source Type: journals

Structural and Functional Characterization of Low-molecular-weight Heparins: Impact on the Development of Guidelines for Generic ProductsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Low-molecular-weight heparins (LMWHs) are poly-pharmacologic drugs used to treat thrombotic and cardiovascular disorders. Recently, several generic versions of branded LMWHs have been introduced. Although generic versions of LMWHs exhibit similar profiles, marked differences in their biological and pharmacologic properties have been demonstrated. Several studies have demonstrated differences in terms of anti-Xa activity and tissue factor pathway inhibitor release. The current data emphasize the need to consider multiple functional parameters when defining bioequivalence of biologic drugs and also underscore the importance ...
Source: Clinical and Applied Thrombosis/Hemostasis - April 7, 2009 Category: Hematology Authors: Adiguzel, C., Jeske, W. P., Hoppensteadt, D., Walenga, J. M., Bansal, V., Fareed, J. Tags: Original Articles Source Type: journals

Increased Prevalence of Antiheparin Platelet Factor 4 Antibodies in Patients May Be Due to Contaminated HeparinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
During the period of November 2007 to January 2008, an increased prevalence of adverse reactions to heparin was noted. These adverse events have been attributed to the presence of purposeful contaminant, oversulfated chondroitin sulfate (OSCS) from April 2007 to May 2008. An analysis of dialysis patients' plasma obtained in 2006 and 2007 consistently had a low (5%) prevalence of AHPF4 antibodies. Blood samples from 78 patients on maintenance hemodialysis, who were potentially exposed to OSCS-contaminated heparin, were analyzed for the presence of all AHPF4 antibodies using a commercially available ELISA kit from GTI. Altho...
Source: Clinical and Applied Thrombosis/Hemostasis - April 7, 2009 Category: Hematology Authors: Adiguzel, C., Bansal, V., Litinas, E., Cunanan, J., Iqbal, O., Nelson, K., Kannan, M., Hoppensteadt, D., Fareed, J. Tags: Original Articles Source Type: journals

Glanzmann's Thrombasthenia: An OverviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glanzmann's thrombasthenia (GT) is an autosomal recessive inherited bleeding disorder due to a defect in platelet function. The hallmark of this disease is severely reduced/absent platelet aggregation in response to multiple physiological agonists. Bleeding signs in GT include epistaxis, bruising, gingival hemorrhage, gastrointestinal hemorrhage, hematuria, menorrhagia, and hemarthrosis. Homozygous or compound heterozygous mutations in the genes of GPIIb and GPIIIa lead to GT. A patient with GT, with no possible causative mutations in GPIIb and GPIIIa genes, may harbor defects in a regulatory element affecting the transcri...
Source: Clinical and Applied Thrombosis/Hemostasis - April 7, 2009 Category: Hematology Authors: Kannan, M., Saxena, R. Tags: Original Articles Source Type: journals

Correlation Between Maternal Plasma Thrombomodulin and Infant Birth Weight in Hypertensive Disorders of PregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Elevated plasma thrombomodulin levels in hypertensive disorders of pregnancy were well correlated with related infant birth weights of these pathologies. Plasma thrombomodulin levels might point out placental vascular endothelial damage reflecting on infant birth weights.
Source: Clinical and Applied Thrombosis/Hemostasis - April 7, 2009 Category: Hematology Authors: Varol, F. G., Ozgen, L., Sayin, N. C., Demir, M. Tags: Original Articles Source Type: journals

Gastrointestinal Complications After 3 Months of Dual Antiplatelet Therapy for Drug-eluting Stents as Assessed by Wireless Capsule EndoscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Little is known about the frequency of symptomatic and asymptomatic gastrointestinal complications of dual antiplatelet therapy. We recruited 30 patients between 18 and 80 years who were started on aspirin and clopidogrel following percutaneous coronary intervention with drug-eluting stents. We hypothesized that the 3 months of dual antiplatelet therapy would be associated with frequent upper gastrointestinal endoscopic abnormalities. Patients were followed with weekly phone calls to inquire about the new gastrointestinal symptoms and after a minimum of 80 days, their upper gastrointestinal mucosa was visualized with PillC...
Source: Clinical and Applied Thrombosis/Hemostasis - April 7, 2009 Category: Hematology Authors: Seddighzadeh, A., Wolf, A. T., Parasuraman, S., Shetty, R., Vallurupalli, N., Reddy, S., Goldhaber, S. Z. Tags: Original Articles Source Type: journals

Cangrelor Attenuates Coated-Platelet FormationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
P2Y12 inhibitors were introduced clinically as effective inhibitors of adenosine-5'-diphosphate (ADP) mediated platelet activation and aggregation. This class of pharmacological agents has enjoyed considerable success. Cangrelor is a recently developed P2Y12 inhibitor that has the advantage of being an active drug not requiring metabolic conversion, although it is not orally available. Coated-platelets are a subclass of activated platelets generated on dual agonist activation with collagen plus thrombin; the primary hallmark of coated-platelets is their ability to support prothrombinase activity. Interestingly, we recently...
Source: Clinical and Applied Thrombosis/Hemostasis - April 7, 2009 Category: Hematology Authors: Norgard, N. B., Hann, C. L., Dale, G. L. Tags: Original Articles Source Type: journals

The Homozygous Leu Variant of the Factor XIII Val34Leu Polymorphism as a Risk Factor for the Manifestation of Thrombotic MicroangiopathiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The 34 Leu (100T) variant of the factor XIII Val34Leu (G100T-) polymorphism slows down fibrinolysis and has been proposed as a thrombotic risk factor. In this pilot study, we enrolled 40 patients (mean age ± SD = 38 ± 11 years) and 728 controls to assess the role of this genetic variant for the manifestation of thrombotic microangiopathies. From the genotype prevalences, an increased manifestation risk for carriers of the TT genotype (homozygous Leu variant) of the factor XIII Val34Leu (G100T-) polymorphism was calculated (odds ratio [OR] = 2.44; 95% confidence interval [CI] = 0.8-7.6; P = .11). This associat...
Source: Clinical and Applied Thrombosis/Hemostasis - April 7, 2009 Category: Hematology Authors: Sucker, C., Farokhzad, F., Kurschat, C., Grabensee, B., Scharf, R. E., Zotz, R. B., Maruhn-Debowski, B., Hetzel, G. R. Tags: Original Articles Source Type: journals

Coagulation Activation by LipopolysaccharidesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lipopolysaccharides at approximate plasma reactivities >3 ng/mL or β-glucans at >0.5-1 Âµg/mL are toxic for human blood; lipopolysaccharide interacts with membrane components of susceptible cells (eg, monocytes) activating phospholipase A2 that destroys the cell membrane. Cell fragments (microparticles or DNA) possess polynegative niches that activate intrinsic hemostasis. Pathologic disseminated intravascular coagulation arises. Blood vessels are obstructed by disseminated thrombi, and vital organ areas become ischemic. Multiorgan failure threatens life of the patient. Diagnosis and therapy of pathologic diss...
Source: Clinical and Applied Thrombosis/Hemostasis - April 7, 2009 Category: Hematology Authors: Stief, T. W. Tags: Original Articles Source Type: journals

Intrahospital Correlation of the International Normalized RatioEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. These results are clearly inadequate for clinical use because such a variation would most probably induce the clinician to make a change in warfarin dose. Standardization of instruments, reagents, and controls is warranted to decrease this variation.
Source: Clinical and Applied Thrombosis/Hemostasis - April 7, 2009 Category: Hematology Authors: Lazo-Langner, A., Villa-Marquez, R., Hernandez-Hernandez, D., Rojas-Maya, S., Piedras, J. Tags: Original Articles Source Type: journals

Use of Recombinant Activated Factor VII to Arrest Uncontrolled Bleeding: A Case SeriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A retrospective analysis is described to assess the effects of using recombinant activated factor VII to control bleeding in a series of patients who had failed to respond to conventional hemostatic measures. In all, 18 patients (aged 16-65 years) with a range of conditions resulting in bleeding refractory to conventional methods of control were treated with recombinant activated factor VII (60-120 Âµg/kg; 1-4 doses). The effects of recombinant activated factor VII on bleeding were noted together with the patients' transfusion requirements and hematological parameters. Administration of recombinant activated factor VII s...
Source: Clinical and Applied Thrombosis/Hemostasis - April 7, 2009 Category: Hematology Authors: Alsayegh, F., Fakeir, A., Alhumood, S., Abdumalek, K., Matar, H., Samaul, I., Nampoory, N., Kabalawi, H., Mousa, S. A. Tags: Original Articles Source Type: journals

A Functional Ser413/Ser413 PAI-2 Polymorphism Is Associated With Susceptibility and Damage Index Score in Systemic Lupus ErythematosusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Systemic lupus erythematosus in some cases is characterized for development of thrombotic events with a significantly increased risk of mortality. The frequencies and clinical associations of Ser413/Cys413 PAI-2 polymorphism in 40 systemic lupus erythematosus, 50 rheumatoid arthritis patients, and 100 healthy subjects were investigated. The Ser413/Ser413 genotype frequency was 53% (lupus), 36% (rheumatoid arthritis), and 35% (healthy subjects). The Ser413 allele was associated with systemic lupus erythematosus (P = .04, odds ratio = 1.76, 95% confidence interval = 1.01-3.06). In all, 4 patient carriers of Ser413/Ser413 gen...
Source: Clinical and Applied Thrombosis/Hemostasis - April 7, 2009 Category: Hematology Authors: Palafox-Sanchez, C. A., Vazquez-Del Mercado, M., Orozco-Barocio, G., Garcia-De la Torre, I., Torres-Carrillo, N., Torres-Carrillo, N. M., Illades-Aguiar, B., Munoz-Valle, J. F. Tags: Original Articles Source Type: journals

Unexpected Pulseless Disease Associated With Recurrent Venous ThromboembolismsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Venous thromboembolic disease is a well-documented complication of Klinefelter's syndrome, even if mechanisms underlying this prothrombotic state have not been conclusively established. On the contrary, arterial thrombosis is far less frequent, and a case of a patient with Klinefelter's syndrome presenting with simultaneous venous thrombtoembolic disease and a complete thrombosis of the left subclavian artery is presented. Elevated levels of type 1 plasminogen activator inhibitor, in the absence of other usual thrombophilic abnormalities, raise the question of the role played by this inhibitor of the fibrinolysis in the ar...
Source: Clinical and Applied Thrombosis/Hemostasis - April 7, 2009 Category: Hematology Authors: Morelle, J., Tintillier, M., Martinot, J.-B., Moortgat, S., Hermans, C. Tags: Case Report Source Type: journals

The Inefficacy of Enoxaparin Prophylaxis in a Patient With Congenital Antithrombin DeficiencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Clinical and Applied Thrombosis/Hemostasis - April 7, 2009 Category: Hematology Authors: Tomkowski, W. Z., Dybowska, M., Kuca, P., Gralec, R., Burakowski, J. Tags: Letters to the Editor Source Type: journals

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