Clinical and Developmental Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

IL-22, a vital cytokine in autoimmune diseases
Clin Exp Immunol. 2024 Apr 23:uxae035. doi: 10.1093/cei/uxae035. Online ahead of print.ABSTRACTInterleukin-22 (IL-22) is a vital cytokine that is dysregulated in various autoimmune conditions including rheumatoid arthritis (RA), multiple sclerosis (MS), and Alzheimer's disease (AD). As the starting point for the activation of numerous signaling pathways, IL-22 plays an important role in the initiation and development of autoimmune diseases. Specifically, imbalances in IL-22 signaling can interfere with other signaling pathways, causing cross regulation of target genes which ultimately leads to the development of immune dis...
Source: Clinical and Developmental Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Jiajin Li Zhen Wu Yuxin Wu Xin Yu Hu Jun Yang Dacheng Zhu Mingyue Wu Xin Li Lutterodt Bentum-Ennin Wanglai Hu Source Type: research

Genomic Testing Identifies Monogenic Causes in Patients with Very Early-Onset Inflammatory Bowel Disease: A Multi-center Survey in an Iranian Cohort
Clin Exp Immunol. 2024 Apr 23:uxae037. doi: 10.1093/cei/uxae037. Online ahead of print.ABSTRACTPatients with very early-onset inflammatory bowel disease (VEO-IBD) may present because of underlying monogenic inborn errors of immunity (IEI). Strong differences have been observed in the causes of monogenic IBD among ethnic populations. This multi-center study was carried out on 16 Iranian patients with VEO-IBD. We reviewed clinical and basic immunologic evaluation including flow cytometry and immunoglobulin levels. All patients underwent clinical whole exome sequencing (WES). Sixteen patients (8 females and 8 males) with a me...
Source: Clinical and Developmental Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Golnaz Eslamian Mahnaz Jamee Tooba Momen Pejman Rohani Sarehossadat Ebrahimi Mehrnaz Mesdaghi Soodeh Ghadimi Mahboubeh Mansouri Seyed Alireza Mahdaviani Mahnaz Sadeghi-Shabestari Morteza Fallahpour Bibi Shahin Shamsian Narges Eslami Samin Sharafian Naghi Source Type: research

NK-like CD8 T Cell: One Potential Evolutionary Continuum between Adaptive Memory and Innate Immunity
Clin Exp Immunol. 2024 Apr 23:uxae038. doi: 10.1093/cei/uxae038. Online ahead of print.ABSTRACTCD8 T cells are crucial adaptive immune cells with cytotoxicity to fight against pathogens or abnormal self-cells via major histocompatibility complex class I-dependent priming pathways. The composition of the memory CD8 T cell pool is influenced by various factors. Physiological aging, chronic viral infection, and autoimmune diseases promote the accumulation of CD8 T cells with highly differentiated memory phenotypes. Accumulating studies have shown that some of these memory CD8 T cells also exhibit innate-like cytotoxicity and ...
Source: Clinical and Developmental Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Qiulei Wang Shaodan Chen Zhenhong Guo Sheng Xia Minghui Zhang Source Type: research

Targeting T-bet expressing B cells for therapeutic interventions in autoimmunity
Clin Exp Immunol. 2024 Apr 22:uxae036. doi: 10.1093/cei/uxae036. Online ahead of print.ABSTRACTApart from serving as a Th1 lineage commitment regulator, transcription factor T-bet is also expressed in other immune cell types and thus orchestrates their functions. In case of B cells, more specifically, T-bet is responsible for their isotype switching to specific IgG sub-classes (IgG2a/c in mice and IgG1/3 in humans). In various autoimmune disorders, such as systemic lupus erythematosus and/or rheumatoid arthritis, subsets of T-bet expressing B cells, known as age-associated B cells (CD19+CD11c+CD21-T-bet+) and/or double-neg...
Source: Clinical and Developmental Immunology - April 22, 2024 Category: Allergy & Immunology Authors: Athanasios Sachinidis Malamatenia Lamprinou Theodoros Dimitroulas Alexandros Garyfallos Source Type: research

Obesity Differs from Diabetes Mellitus in Antibody and T Cell Responses Post COVID-19 Recovery
This study aims to investigate the humoral and cellular immune responses to SARS-CoV-2 in adult COVID-19 survivors with obesity and DM in Bangladesh. In this cross-sectional study, SARS-CoV-2-specific antibody and T cell responses were investigated in 63 healthy and 75 PCR-confirmed COVID-19 recovered individuals in Bangladesh, during the pre-vaccination first wave of the COVID-19 pandemic in 2020. In COVID-19 survivors, SARS-CoV-2 infection induced robust antibody and T cell responses, which correlated with disease severity. After adjusting for age, sex, DM status, disease severity, and time since onset of symptoms, obesi...
Source: Clinical and Developmental Immunology - April 20, 2024 Category: Allergy & Immunology Authors: Mohammad Ali Stephanie Longet Isabel Neale Patpong Rongkard Forhad Uddin Hassan Chowdhury Jennifer Hill Anthony Brown Stephen Laidlaw Tom Tipton Ashraful Hoque Nazia Hassan Carl-Philipp Hackstein Sandra Adele Hossain Delowar Akther Priyanka Abraham Shreba Source Type: research

Disrupting B and T cell Collaboration in Autoimmune Disease: T cell engagers versus CAR T cell therapy?
Clin Exp Immunol. 2024 Apr 20:uxae031. doi: 10.1093/cei/uxae031. Online ahead of print.ABSTRACTB and T cells collaborate to drive autoimmune disease (AID). Historically, B and T cell (B-T cell) co-interaction was targeted through different pathways such as alemtuzumab, abatacept, and dapirolizumab with variable impact on B cell depletion (BCD), whereas the majority of patients with AID including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and organ transplantation benefit from targeted BCD with anti-CD20 monoclonal antibodies such as rituximab, ocrelizumab or ofatumumab. Refractory AID is a signi...
Source: Clinical and Developmental Immunology - April 20, 2024 Category: Allergy & Immunology Authors: Kavina Shah Maria Leandro Mark Cragg Florian Kollert Franz Schuler Christian Klein Venkat Reddy Source Type: research

Dysregulated Lipid Metabolism Networks Modulate T-cell Function in People with Relapsing Remitting Multiple Sclerosis
Clin Exp Immunol. 2024 Apr 16:uxae032. doi: 10.1093/cei/uxae032. Online ahead of print.ABSTRACTAltered cholesterol, oxysterol, sphingolipid, and fatty acid concentrations are reported in blood, cerebrospinal fluid, and brain tissue of people with relapsing remitting multiple sclerosis (RRMS) and are linked to disease progression and treatment responses. CD4+ T cells are pathogenic in RRMS, and defective T cell function could be mediated in part by liver X receptors (LXRs) - nuclear receptors that regulate lipid homeostasis and immunity. RNA-sequencing and pathway analysis identified that genes within the 'lipid metabolism'...
Source: Clinical and Developmental Immunology - April 16, 2024 Category: Allergy & Immunology Authors: Lucia Martin-Gutierrez Kirsty E Waddington Annalisa Maggio Leda Coelewij Alexandra Oppong Nina Yang Marsilio Adriani Petra Nytrova Rachel Farrell In és Pineda-Torra Elizabeth C Jury Source Type: research

Immune cell composition and inflammatory profile of human peri-implantitis and periodontitis lesions
Clin Exp Immunol. 2024 Apr 15:uxae033. doi: 10.1093/cei/uxae033. Online ahead of print.ABSTRACTPeri-implantitis and periodontitis are common oral inflammatory diseases, which seem to exhibit critical differences in some of their molecular features. Thus, we assessed the immune cell composition of peri-implantitis and periodontitis lesions and the corresponding inflammatory profile in soft tissues and crevicular fluid. Peri-implantitis, periodontitis and control patients were recruited (n=62), and soft tissue biopsies were collected during surgery. Crevicular fluid around implant or tooth was collected. The proportions of m...
Source: Clinical and Developmental Immunology - April 15, 2024 Category: Allergy & Immunology Authors: Sebastian Malmqvist Reuben Clark Gunnar Johannsen Annsofi Johannsen Elisabeth A Bostr öm Ronaldo Lira-Junior Source Type: research

Allergens induce upregulated IL-18 and IL-18R α expression in blood Th2 and Th17 cells of patients with allergic asthma
Clin Exp Immunol. 2024 Apr 8:uxae022. doi: 10.1093/cei/uxae022. Online ahead of print.ABSTRACTAllergic asthma (AA) is closely associated with the polarization of T helper (Th)2 and Th17 cells. Interleukin (IL)-18 acts as an inducer of Th2 and Th17 cell responses. However, expressions of IL-18 and IL-18 receptor alpha (IL-18Rα) in blood Th2 and Th17 cells of patients with AA remain unclear. We therefore investigated their expressions in Th2 and Th17 cells using flow cytometric analysis, qPCR and murine AA model. We observed increased proportions of Th2, Th17, IL-18+, IL-18+ Th2 and IL-18+ Th17 cells in blood CD4+ T cells o...
Source: Clinical and Developmental Immunology - April 8, 2024 Category: Allergy & Immunology Authors: Junling Wang Mengmeng Zhan Yaping Zhai Siqin Wang Fangqiu Gu Zhuo Zhao Zhaolong Zhang Yifei Li Xin Dong Yijie Zhang Bingyu Qin Source Type: research