Clinical and Experimental AllergyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Does gastric acid suppression increase the risk of drug allergies?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - November 21, 2009 Category: Allergy & Immunology Authors: C. Pickard, A. P. Sampson Source Type: journals

Application of multiplexed immunoglobulin E determination on a chip in component-resolved diagnostics in allergyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - November 12, 2009 Category: Allergy & Immunology Authors: E. F. Knol, A. C. Knulst Source Type: journals

Interferon-γ and pulmonary macrophages contribute to the mechanisms underlying prolonged airway hyperresponsivenessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Airway hyperresponsiveness (AHR) in asthmatics includes a variable component that persists following an allergen challenge. This may be dissociated from inflammatory cell recruitment, implying a role for resident pulmonary cells in regulating the response. Using improved methods of assessing AHR in a mouse model of allergic airway disease, to investigate the basis of the development of prolonged AHR. BALB/c mice were systemically sensitized and then challenged with aerosolized ovalbumin (OVA). Airway and tissue responsiveness were measured at baseline and at 1 day, and 1, 2 and 3 weeks after the last OVA challenge. Inflamm...
Source: Clinical and Experimental Allergy - November 10, 2009 Category: Allergy & Immunology Authors: M. Yang, R. K. Kumar, P. S. Foster Source Type: journals

Asthma tests in the assessment of military conscriptsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Respiratory diseases such as asthma may affect individuals' fitness for military service. In order to assess fitness for military service in subjects with asthma symptoms at conscription, objective and reliable tests are needed. To prospectively determine the diagnostic value of the mannitol and methacholine bronchial provocation test (BPT) as well as exhaled nitric oxide in assessing physician-diagnosed asthma in a group of Swiss Armed Forces conscripts. Questionnaire, spirometry, BPT with methacholine and mannitol, exhaled nitric oxide (FeNO) and skin prick testing were conducted in 18[ndash]20-year-old male conscripts. ...
Source: Clinical and Experimental Allergy - November 6, 2009 Category: Allergy & Immunology Authors: D. Miedinger, N. Mosimann, R. Meier, C. Karli, P. Florek, F. Frey, K. Scherer, C. Surber, B. Villiger, F. Michel, J. D. Leuppi Source Type: journals

Molecular variability of group 1 and 5 grass pollen allergens between Pooideae species: implications for immunotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Differences between major allergens from distinct grass species remain to be investigated, both in terms of structure and antigenicity. Group 1 and 5 allergens purified from five common Pooideae species were analysed by mass spectrometry (MS). Major histocompatibility complex (MHC) class II-restricted T cell epitopes were identified using predictive algorithms and human leucocyte antigen (HLA)-binding assays. CD4+ T cell reactivity and IgE binding were assessed based on the induction of CD154 expression in peripheral blood mononuclear cells and using competitive ELISA assays, respectively. MS analysis of group 5 pollen all...
Source: Clinical and Experimental Allergy - November 5, 2009 Category: Allergy & Immunology Authors: H. Chabre, B. Gouyon, A. Huet, V. Boran Bodo, E. Nony, M. Hrabina, F. Fenaille, A. Lautrette, M. Bonvalet, B. Maillère, V. Bordas-Le Floch, L. Van Overtvelt, K. Jain, E. Ezan, T. Batard, P. Moingeon Source Type: journals

The minimal clinically important difference in allergic rhinitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
When presented with results from clinical measurements or research findings, clinicians must first make an interpretation of their importance, not only in statistical terms, but also the 'clinical importance' given the size of the change observed. To do this, they require an understanding of the relationship between their outcome measures, and the patient's perception of change. The minimal clinically important difference (MCID) illustrates this relationship by calculating the smallest change in a given outcome that is meaningful to a patient. There are few reports of calculated MCIDs in the Rhinology literature. To calcul...
Source: Clinical and Experimental Allergy - November 5, 2009 Category: Allergy & Immunology Authors: M. L. Barnes, S. Vaidyanathan, P. A. Williamson, B. J. Lipworth Source Type: journals

Prostaglandin E2 and cysteinyl leukotriene concentrations in sputum: association with asthma severity and eosinophilic inflammationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inflammation of the airways in asthma is associated with the production of cysteinyl leukotrienes (cysLT), prostaglandin (PG)E2, 8-isoprostane, nitric oxide and other mediators. However, the relationship between asthma severity or eosinophilic inflammation and the concentrations of mediators in sputum is unclear. To assess sputum PGE2, cysLT, 8-isoprostane and nitrate concentrations, as well as urinary leukotriene (LT)E4 and 9[alpha],11[beta]-prostaglandin (PG)F2 concentrations, in patients with differing severities of asthma and eosinophilic or non-eosinophilic airway inflammation. Inflammatory cells in sputum were assess...
Source: Clinical and Experimental Allergy - November 5, 2009 Category: Allergy & Immunology Authors: S. Aggarwal, Y. P. Moodley, P. J. Thompson, N. L. Misso Source Type: journals

Bronchial hyperresponsiveness: a rather irritable subjectEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - November 5, 2009 Category: Allergy & Immunology Authors: D. Spina Source Type: journals

Subcutaneous allergen immunotherapy restores human dendritic cell innate immune functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We recently reported that human blood dendritic cells from allergic subjects have impaired IFN-[alpha] production following toll-like receptor 9 (TLR9)-dependent innate immune stimulation. It is not known how subcutaneous allergen immunotherapy (SCIT) affects dendritic cell immune responses. The aim of this study is to determine how SCIT affects human dendritic cell function. Peripheral blood mononuclear cell (PBMC) and plasmacytoid dendritic cells (pDCs) were isolated from the blood of seven dust mite allergic subjects at baseline and upon reaching a standard SCIT maintenance dose that included dust mite and other aeroall...
Source: Clinical and Experimental Allergy - November 4, 2009 Category: Allergy & Immunology Authors: J. R. Tversky, A. P. Bieneman, K. L. Chichester, R. G. Hamilton, J. T. Schroeder Source Type: journals

The role of iodine in hypersensitivity reactions to radio contrast mediaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hypersensitivity reactions to iodinated radio contrast media (RCM) are either immediate-type (IT) or delayed reactions (DT). In IT, the pathomechanism is unclear. In DT, delayed positive patch (PT) and intradermal tests (IDT) and RCM-specific T cells suggest a T cell-mediated mechanism. In both, the role of iodine has not been clarified; however, patients are often labelled as 'iodine allergic'. Occasionally, positive skin tests to iodine-containing drugs are observed. We investigated the presence of hypersensitivity to iodine in patients with a history of hypersensitivity reactions to RCM. Nineteen patients with a history...
Source: Clinical and Experimental Allergy - November 3, 2009 Category: Allergy & Immunology Authors: K. Scherer, T. Harr, S. Bach, A. J. Bircher Source Type: journals

The role of paracetamol in the pathogenesis of asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Paracetamol use represents a putative risk factor for the development of asthma. There is convincing epidemiological evidence that the risk of asthma may be increased with exposure to paracetamol in the intrauterine environment, infancy, later childhood and adult life. A dose-dependent association has also been observed in these different age groups in different populations world-wide. An association has also been shown between paracetamol use in both rhinoconjunctivitis and eczema. There is biological plausibility with paracetamol use leading to decreased glutathione levels resulting in increased oxidant-induced inflammat...
Source: Clinical and Experimental Allergy - November 3, 2009 Category: Allergy & Immunology Authors: H. Farquhar, A. Stewart, E. Mitchell, J. Crane, S. Eyers, M. Weatherall, R. Beasley Source Type: journals

IL-33: a tissue derived cytokine pathway involved in allergic inflammation and asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Besides classic T cell-derived T-helper type 2 (Th2) cytokines such as IL-4, IL-5 and IL-13, tissue-produced cytokines such as thymic stromal lymphopoietin, IL-25 and IL-33 are now recognized as important contributors to allergic inflammation. IL-33 is produced by various tissue dwelling cells and broadly enhances allergic inflammation through its effects on hematopoietic cell types. The environmental or endogenous triggers that provoke IL-33 cellular release may be associated with infection, inflammation or tissue damage. This review summarizes the wide range of documented IL-33 activities on human cellular mediators of i...
Source: Clinical and Experimental Allergy - November 3, 2009 Category: Allergy & Immunology Authors: D. E. Smith Source Type: journals

Component-resolved diagnosis from latex allergy by microarrayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A positive specific IgE (sIgE) result for latex does not always mirror the clinical situation and is frequently found in individuals without overt latex allergy. We sought to investigate the potential of component-resolved diagnosis (CRD) of latex allergy by microarray and to assess whether the technique allows discriminating genuine allergy from asymptomatic sensitization. Twenty-six healthy controls without a history of latex allergy with a negative latex sIgE and skin test, 22 latex-allergic patients with a compelling history of latex allergy with a positive latex sIgE and prick test and 20 latex-sensitized individuals ...
Source: Clinical and Experimental Allergy - November 3, 2009 Category: Allergy & Immunology Authors: D. G. Ebo, M. M. Hagendorens, K. J. De Knop, M. M. Verweij, C. H. Bridts, L. S. De Clerck, W. J. Stevens Source Type: journals

Surfactant protein D inhibits mite-induced alveolar macrophage and dendritic cell activations through TLR signalling and DC-SIGN expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was performed to characterize the immunomodulatory effects of SP-D on mite allergen (Dermatophagoides pteronyssinus, Der p)-induced inflammatory signalling in AMs and DCs. Murine AM, alveolar macrophage cell line derived from BALB/c mice (MH-S cells), and human monocyte-derived dendritic cells (MDDC) were used as model systems. The production of nitric oxide (NO) and TNF-[alpha], expression of surface Toll-like receptors (TLRs), and expression of the C-type lectin receptor known as dendritic cell (DC)-specific ICAM-grabbing non-integrin (DC-SIGN) were measured as a function of pretreatment with SP-D and subseque...
Source: Clinical and Experimental Allergy - November 2, 2009 Category: Allergy & Immunology Authors: C-F Liu, M. Rivere, H-J Huang, G. Puzo, J-Y Wang Source Type: journals

Pollen-derived low-molecular weight factors inhibit 6-sulfo LacNAc+ dendritic cells' capacity to induce T-helper type 1 responsesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aims at analysing the impact of pollen-associated lipid mediators on cytokine secretion and maturation of 6-sulfo LacNAc+ dendritic cells (slanDCs), the most abundant native dendritic cell (DC) in human peripheral blood, and further dissecting the biologically active substance(s) within aqueous pollen extracts. Aqueous birch pollen extracts dose-dependently inhibited the lipopolysaccharide (LPS)-induced IL-12 p70 production, while the levels of IL-6 remained unaffected. PPE1 inhibited secretion of both IL-12 p70 and IL-6. Aqueous pollen extracts, but not PPE1 or F1-phytoprostanes significantly reduced the LPS-in...
Source: Clinical and Experimental Allergy - November 2, 2009 Category: Allergy & Immunology Authors: S. Gilles, D. Jacoby, C. Blume, M. J. Mueller, T. Jakob, H. Behrendt, K. Schaekel, C. Traidl-Hoffmann Source Type: journals

Mannitol challenge for assessment of airway responsiveness, airway inflammation and inflammatory phenotype in asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to evaluate mannitol as a tool for assessing airway responsiveness and airway inflammation in asthma, compared with hypertonic saline. Fifty-five subjects with stable asthma completed a hypertonic (4.5%) saline challenge and a mannitol challenge at two separate visits, performed 48[ndash]72 h apart, in random order. Induced sputum was obtained from 49 (89%) subjects during the saline challenge and 42 (76%) subjects during the mannitol challenge (P>0.05). There was a significant correlation between the greatest percentage fall in forced expiratory volume in 1 s (FEV1) (r=0.6, P (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - October 30, 2009 Category: Allergy & Immunology Authors: L. G. Wood, H. Powell, P. G. Gibson Source Type: journals

Interleukin-13: prospects for new treatmentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
IL-13 is a T-helper type 2 cytokine. Animal models have implicated IL-13 as a critical cytokine in the development of asthma and chronic obstructive pulmonary disease (COPD). In vitro IL-13 exerts important effects on both structural and inflammatory cells within the airway and has the capacity to drive the clinical features of airways disease. In asthma, this view is strongly supported by associations with IL-13 genetic polymorphisms and increased mRNA and protein expression in blood, sputum and bronchial submucosa. In particular, IL-13 up-regulation is associated with severe disease. Current evidence in COPD is conflicti...
Source: Clinical and Experimental Allergy - October 30, 2009 Category: Allergy & Immunology Authors: C. E. Brightling, S. Saha, F. Hollins Source Type: journals

Association between asthma control and bronchial hyperresponsiveness and airways inflammation: a cross-sectional study in daily practiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The primary end-point in the management of asthma is to obtain optimal control. The aim of this study was to assess the relationships between the markers of airway inflammation (sputum eosinophilia and exhaled nitric oxide), bronchial hyperresponsiveness (BHR) and asthma control. One hundred and thirty-four patients were recruited from our asthma clinic between January 2004 and September 2005 [mean age: 42 years, mean forced expiratory volume in 1 s (FEV1): 86% predicted]. Eighty-six of them were treated by inhaled corticosteroids, 99 were atopic and 23 were current smokers. They all underwent detailed investigations inclu...
Source: Clinical and Experimental Allergy - October 7, 2009 Category: Allergy & Immunology Authors: V. Quaedvlieg, J. Sele, M. Henket, R. Louis Source Type: journals

Lactic acid bacteria differ in their ability to induce functional regulatory T cells in humansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Trials with probiotic lactic acid bacteria have yielded different results, which may be due to the strains used. Lactobacilli and bifidobacteria are known to be potent modulators of the immune system. The capacity of these bacteria used as probiotics to influence both T helper type 1 (Th1)- and Th2-mediated diseases has been shown before. However, the ability of strains to induce forkhead box P3 (FOXP3+) expressing regulatory T cells has not yet been investigated. Test the inherent differences between strains in their capacity to induce functional regulatory T cells in human peripheral blood mononuclear cells (PBMC). Human...
Source: Clinical and Experimental Allergy - October 6, 2009 Category: Allergy & Immunology Authors: S. de Roock, M. van Elk, M. E. A. van Dijk, H. M. Timmerman, G. T. Rijkers, B. J. Prakken, M. O. Hoekstra, I. M. de Kleer Source Type: journals

The effect of oral steroids with and without vitamin D3 on early efficacy of immunotherapy in asthmatic childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The possibility of additional strategies to enhance the effectiveness of specific immunotherapy (SIT) is highly attractive. The aim of our study was to assess the influence of oral corticosteroids and oral corticosteroids combined with vitamin D3 on the early clinical and immunological effects of SIT. It was a randomized, double-blind, placebo-controlled trial conducted in 54 asthmatic children allergic to house dust mites. Intervention was based on receiving a single dose of oral steroid, with or without vitamin D3, or placebo only on the day of the build-up phase of SIT. After 12 months of SIT, the median daily inhaled c...
Source: Clinical and Experimental Allergy - October 6, 2009 Category: Allergy & Immunology Authors: P. Majak, B. Rychlik, I. Stelmach Source Type: journals

Suppression of gastric acid increases the risk of developing Immunoglobulin E-mediated drug hypersensitivity: human diclofenac sensitization and a murine sensitization modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hypersensitivity reactions towards non-steroidal anti-inflammatory drugs (NSAID) are common, although true allergies are detectable only in a subgroup of patients. The current study was prompted by a case observation, where a patient experienced generalized urticaria following his second course of diclofenac and proton pump inhibitor medication, and was found to have diclofenac-specific IgE. During recent years, our group has been investigating the importance of gastric digestion in the development of food allergies, demonstrating anti-acid medication as a risk factor for sensitization against food proteins. Here, we aimed...
Source: Clinical and Experimental Allergy - October 6, 2009 Category: Allergy & Immunology Authors: A. B. Riemer, S. Gruber, I. Pali-Schöll, T. Kinaciyan, E. Untersmayr, E. Jensen-Jarolim Source Type: journals

Establishing the sequential progression of multiple allergic diagnoses in a UK birth cohort using the General Practice Research DatabaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is considerable international interest in understanding the sequential progression of multiple allergic conditions (also sometimes known as 'the allergic march'). To study the sequential progression of multiple allergic conditions in a national birth cohort throughout childhood. We constructed a birth cohort of 43 477 children born in 1990 and registered in UK general practices within a year of birth, using the national General Practice Research Database. Of these, 24 112 with complete follow-up until the age of 18 years were studied in order to understand disease progression and to estimate the absolute and relative...
Source: Clinical and Experimental Allergy - October 6, 2009 Category: Allergy & Immunology Authors: Y. S. Punekar, A. Sheikh Source Type: journals

Volatile organic compounds in exhaled breath as a diagnostic tool for asthma in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The correct diagnosis of asthma in young children is often hard to achieve, resulting in undertreatment of asthmatic children and overtreatment in transient wheezers. To develop a new diagnostic tool that better discriminates between asthma and transient wheezing and that leads to a more accurate diagnosis and hence less undertreatment and overtreatment. A first stage in the development of such a tool is the ability to discriminate between asthmatic children and healthy controls. The integrative analysis of large numbers of volatile organic compounds (VOC) in exhaled breath has the potential to discriminate between various...
Source: Clinical and Experimental Allergy - September 27, 2009 Category: Allergy & Immunology Authors: J. W. Dallinga, C. M. H. H. T. Robroeks, J. J. B. N. van Berkel, E. J. C. Moonen, R. W. L. Godschalk, Q. Jöbsis, E. Dompeling, E. F. M. Wouters, F. J. van Schooten Source Type: journals

Effects of allergen and trigger factor avoidance advice in primary care on asthma control: a randomized-controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Allergy contributes significantly to asthma exacerbation, yet avoidance of triggers, in particular allergens, is rarely addressed in detail in regular asthma review in primary care. To determine whether structured, individually tailored allergen and trigger avoidance advice, given as part of a primary care asthma review, improves lung function and asthma control. In a randomized-controlled trial 214 adults with asthma in six general practices were either offered usual care during a primary care asthma review or usual care with additional allergen and trigger identification (by skin prick testing and structured allergy asse...
Source: Clinical and Experimental Allergy - September 27, 2009 Category: Allergy & Immunology Authors: C. Bobb, T. Ritz, G. Rowlands, C. Griffiths Source Type: journals

Clinical effects of sulphite additivesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sulphites are widely used as preservative and antioxidant additives in the food and pharmaceutical industries. Topical, oral or parenteral exposure to sulphites has been reported to induce a range of adverse clinical effects in sensitive individuals, ranging from dermatitis, urticaria, flushing, hypotension, abdominal pain and diarrhoea to life-threatening anaphylactic and asthmatic reactions. Exposure to the sulphites arises mainly from the consumption of foods and drinks that contain these additives; however, exposure may also occur through the use of pharmaceutical products, as well as in occupational settings. While co...
Source: Clinical and Experimental Allergy - September 22, 2009 Category: Allergy & Immunology Authors: H. Vally, N. L. A. Misso, V. Madan Source Type: journals

Reduced helminth burden increases allergen skin sensitization but not clinical allergy: a randomized, double-blind, placebo-controlled trial in VietnamEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Observational evidence suggests that infection with helminths protects against allergic disease and allergen skin sensitization. It is postulated that such effects are mediated by helminth-induced cytokine responses, in particular IL-10. We tested this hypothesis in a rural area of central Vietnam where hookworm infection is endemic. One thousand five hundred and sixty-six schoolchildren aged 6[ndash]17 were randomly allocated to receive either anti-helminthic therapy or a placebo at 0, 3, 6, and 9 months. We compared changes in the prevalence of exercise-induced bronchoconstriction, allergen skin sensitization, flexural e...
Source: Clinical and Experimental Allergy - September 14, 2009 Category: Allergy & Immunology Authors: C. Flohr, L. N. Tuyen, R. J. Quinnell, S. Lewis, T. T. Minh, J. Campbell, C. Simmons, G. Telford, A. Brown, T. T. Hien, J. Farrar, H. Williams, D. I. Pritchard, J. Britton Source Type: journals

Severe asthma: a consequence of over exuberant repair?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - September 14, 2009 Category: Allergy & Immunology Authors: C. E. Brightling, D. Desai, S. Siddiqui Source Type: journals

Airway smooth muscle chemokine receptor expression and function in asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chemokine receptors play an important role in cell migration and wound repair. In asthma, CCR3 and 7 are expressed by airway smooth muscle (ASM) and CCR7 has been implicated in the development of ASM hyperplasia. The expression profile of other chemokine receptors by ASM and their function needs to be further explored. We sought to investigate ASM chemokine receptor expression and function in asthma. ASM cells were derived from 17 subjects with asthma and 36 non-asthmatic controls. ASM chemokine receptor expression was assessed by flow cytometry and immunofluorescence. The function of chemokine receptors expressed by more ...
Source: Clinical and Experimental Allergy - September 7, 2009 Category: Allergy & Immunology Authors: R. Saunders, A. Sutcliffe, D. Kaur, S. Siddiqui, F. Hollins, A. Wardlaw, P. Bradding, C. Brightling Source Type: journals

Diagnostic testing in suspected fluoroquinolone hypersensitivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Because of their broad antibacterial activity in the gram-negative and gram-positive spectrum, high oral bioavailability, and good tissue penetration, fluoroquinolone antibiotics are widely used. Besides direct drug-related side-effects, fluoroquinolones may cause hypersensitivity reactions. The aim of this retrospective analysis was to present the results of diagnostic testing in cases of clinically suspected fluoroquinolone-induced immediate or delayed hypersensitivity. We studied 101 patients with a history of immediate or delayed hypersensitivity symptoms in temporal relation to treatment with a fluoroquinolone antibio...
Source: Clinical and Experimental Allergy - September 3, 2009 Category: Allergy & Immunology Authors: C. S. Seitz, E. B. Bröcker, A. Trautmann Source Type: journals

Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responsesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Among sensitized infants, those with high, as compared with low levels, of salivary secretory IgA (SIgA) are less likely to develop allergic symptoms. Also, early colonization with certain gut microbiota, e.g. Lactobacilli and Bifidobacterium species, might be associated with less allergy development. Although animal and in vitro studies emphasize the role of the commensal gut microbiota in the development of the immune system, the influence of the gut microbiota on immune development in infants is unclear. To assess whether early colonization with certain gut microbiota species associates with mucosal and systemic immune ...
Source: Clinical and Experimental Allergy - September 2, 2009 Category: Allergy & Immunology Authors: Y. M. Sjögren, S. Tomicic, A. Lundberg, M. F. Böttcher, B. Björkstén, E. Sverremark-Ekström, M. C. Jenmalm Source Type: journals

Allergic sensitization is enhanced in early life through toll-like receptor 7 activationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prospective cohort studies suggest that children hospitalized in early life with severe infections are significantly more likely to develop recurrent wheezing and asthma. Using an inhalational mouse model of allergic airways inflammation, we sought to determine the effect of viral and bacterial-associated molecular patterns on the magnitude of the allergic inflammatory response and whether this effect was age dependent. BALB/c mice were sensitized by intranasal administration of endotoxinlow ovalbumin (OVA) in the absence or presence of viral single-stranded (ss)RNA, lipoteichoic acid or flagellin as neonates (within the f...
Source: Clinical and Experimental Allergy - September 2, 2009 Category: Allergy & Immunology Authors: S. Phipps, N. Hansbro, C. E. Lam, S. Y. Foo, K. I. Matthaei, P. S. Foster Source Type: journals

Allelic variants of CD40 and CD40L genes interact to promote antibiotic-induced cutaneous allergic reactionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we evaluated associations between variations in the genes involved in danger signal pathways and antibiotic-induced cutaneous allergic reactions (AICARs). Two hundred cases with urticaria, angio-oedema, maculopapular rash, and erythema multiforme caused by antibiotics were extracted from the database of the Adverse Drug Reaction Research Group in Korea. All cases were confirmed by an allergy specialist. Causative antibiotics included penicillin, cephalosporin, quinolone, and others (approximately 40 different types). Ten single nucleotide polymorphisms (SNPs) in seven genes ([minus]318C>T, +49A>G, and +6230G...
Source: Clinical and Experimental Allergy - September 2, 2009 Category: Allergy & Immunology Authors: Sae-H Kim, J-E Lee, Sang-H Kim, Y-K Jee, Y-K Kim, H-S Park, K-U Min, H-W Park Source Type: journals

Sensitization profiles in birch pollen-allergic patients with and without oral allergy syndrome to apple: lessons from multiplexed component-resolved allergy diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Component-resolved diagnosis (CRD) using microarray technology has recently been introduced into the field of clinical allergology. To further validate the use of CRD by microarray technology in allergy diagnosis. Thiry-seven patients allergic to birch pollen were included. The discriminative value of apple-specific IgE (sIgE), recombinant Mal d 1 (rMal d 1) sIgE, apple skin prick test and rMal d 1 on the microarray was assessed between patients with a birch-related oral allergy syndrome to apple (OAS+, n=20) and healthy control individuals (HC, n=8) without a history of inhalant allergies or apple-induced OAS. An addition...
Source: Clinical and Experimental Allergy - August 26, 2009 Category: Allergy & Immunology Authors: D. G. Ebo, C. H. Bridts, M. M. Verweij, K. J. De Knop, M. M. Hagendorens, L. S. De Clerck, W. J. Stevens Source Type: journals

Comparison of wheat and rye flour solutions for skin prick testing: a multi-centre study (Stad 1)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Skin prick testing (SPT) is the basic method for diagnosing IgE-mediated allergies. However, skin reactivity is related to the quality of allergen extracts, which are often poorly defined for occupational allergens. To compare wheat and rye flour SPT solutions from different producers. Standardized SPTs were performed in seven allergy centres with wheat and rye flour solutions from four producers in 125 symptomatic bakers. Optimal cut-off levels for weal sizes were assessed with the Youden Index. Comparisons between SPT results of different solutions were made with flour-specific IgE (sIgE) as the gold standard. Sensitivit...
Source: Clinical and Experimental Allergy - August 25, 2009 Category: Allergy & Immunology Authors: V. van Kampen, R. Merget, S. Rabstein, I. Sander, T. Bruening, H. C. Broding, C. Keller, H. Muesken, A. Overlack, G. Schultze-Werninghaus, J. Walusiak, M. Raulf-Heimsoth Source Type: journals

Mapping of the lingual immune system reveals the presence of both regulatory and effector CD4+ T cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sublingual immunotherapy (SLIT) is safe and reduces both symptoms and medication requirements in patients with type I respiratory allergies. Nonetheless, immune mechanisms underlying SLIT need to be further documented. A detailed characterization of the lingual immune system was undertaken in mice, to investigate the presence of tolerogenic and pro-inflammatory mechanisms. Immune cells were characterized in lingual tissues from BALB/c mice using immunohistology and flow cytometry. Resident CD4+ T cells were sorted and toll-like receptor (TLR) expression profiles as well as functional characterization were assessed by RT-PC...
Source: Clinical and Experimental Allergy - August 20, 2009 Category: Allergy & Immunology Authors: L. Mascarell, V. Lombardi, A. Zimmer, A. Louise, S. Tourdot, L. Van Overtvelt, P. Moingeon Source Type: journals

Basophil responsiveness in patients with insect sting allergies and negative venom-specific immunoglobulin E and skin prick test resultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Current guidelines do not adequately address the question of how best to manage patients with a convincing history of insect allergy, but negative venom-specific IgE and skin test results. Forty-seven patients out of a total of 1219 (4%), with a positive history of sting allergy, were recruited over a period of 4.5 years. All recruited patients had a convincing history of a severe or a life-threatening anaphylactic reaction of Mueller grade II[ndash]IV (median grade III) after Hymenoptera sting, but negative venom-specific IgE and skin prick test results. Diagnostic work-up was prospectively followed by the CD63 basophil a...
Source: Clinical and Experimental Allergy - August 18, 2009 Category: Allergy & Immunology Authors: P. Korosec, R. Erzen, M. Silar, N. Bajrovic, P. Kopac, M. Kosnik Source Type: journals

Allergen-specific antibody and cytokine responses, mast cell reactivity and intestinal permeability upon oral challenge of sensitized and tolerized miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Food allergy has reached an epidemic level in westernized countries and although central mechanisms have been described, the variability associated with genetic diversity underscores the still unresolved complexity of these disorders. To develop models of food allergy and oral tolerance, both strictly induced by the intestinal route, and to compare antigen-specific responses. BALB/c mice were mucosally sensitized to ovalbumin (OVA) in the presence of the mucosal adjuvant cholera toxin, or tolerized by intra-gastric administrations of OVA alone. Antibody titres and cytokines were determined by ELISA, and allergic status was...
Source: Clinical and Experimental Allergy - August 17, 2009 Category: Allergy & Immunology Authors: C. Perrier, A.-C. Thierry, A. Mercenier, B. Corthésy Source Type: journals

Digested Ara h 1 has sensitizing capacity in Brown Norway ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Food allergies are a public health issue of growing concern, with peanuts in particular being associated with severe reactions. The peanut allergen, Ara h 1, belongs to the cupin plant food allergen family, which, unlike other structural families, appears to be broken down rapidly following gastrointestinal digestion. Using Ara h 1 as a model allergen, the ability of digested protein to sensitize has been investigated. Ara h 1 was purified from whole roasted peanuts. Intact Ara h 1 was digested in an in vitro model, simulating the human gastrointestinal digestion process. Digestion products were analysed for peptide sizes ...
Source: Clinical and Experimental Allergy - August 17, 2009 Category: Allergy & Immunology Authors: K. L. Bøgh, S. Kroghsbo, L. Dahl, N. M. Rigby, V. Barkholt, E. N. C. Mills, C. B. Madsen Source Type: journals

Fluvastatin and lovastatin inhibit granulocyte macrophage–colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eosinophil accumulation in the lung is an important feature of airway inflammation in asthma. There is therefore much interest in developing novel therapies to prevent this process. Accumulating evidence suggests that statins have anti-inflammatory properties, including inhibition of leucocyte accumulation. We therefore assessed the ability of five statins to inhibit human eosinophil adhesion to recombinant human inter-cellular adhesion molecule (rhICAM)-1 under physiologically relevant flow conditions. Purified eosinophils were pre-treated with a panel of statins before elucidation of the adhesion profiles of resting and ...
Source: Clinical and Experimental Allergy - August 17, 2009 Category: Allergy & Immunology Authors: A. J. Robinson, D. Kashanin, F. O'Dowd, K. Fitzgerald, V. Williams, G. M. Walsh Source Type: journals

Comparison of skin prick tests with specific serum immunoglobulin E in the diagnosis of fungal sensitization in patients with severe asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is consistent with previous reports that fungal sensitization is common in patients with severe asthma. At present, it remains necessary to undertake both SPT and specific serum IgE testing to identify all cases of fungal sensitization. This may be important in the identification of patients with ABPA and SAFS who may benefit from antifungal therapy. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - August 17, 2009 Category: Allergy & Immunology Authors: B. R. O'Driscoll, G. Powell, F. Chew, R. M. Niven, J. F. Miles, A. Vyas, D. W. Denning Source Type: journals

Localization of pathology in asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - August 11, 2009 Category: Allergy & Immunology Authors: A. L. James Source Type: journals

Swine flu vaccination in patients with egg allergyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - July 29, 2009 Category: Allergy & Immunology Authors: S. Nasser, N. Brathwaite Source Type: journals

Angiotensin converting enzyme inhibitor induced angio-oedema: a review of the pathophysiology and risk factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Angio-oedema (AE) is a known adverse effect of angiotensin converting enzyme inhibitor (ACE-I) therapy. Over the past several decades, evidence of failure to diagnose this important and potentially fatal reaction is commonly found in the literature. Because this reaction is often seen first in the primary care setting, a review was undertaken to analyse and document the keys to both diagnostic criteria as well as to investigate potential risk factors for ACE-I AE occurrence. A general review of published literature was conducted through Medline, EMBASE, and the Cochrane Database, targeting ACE-I-related AE pathomechanism, ...
Source: Clinical and Experimental Allergy - July 28, 2009 Category: Allergy & Immunology Authors: T. Hoover, M. Lippmann, E. Grouzmann, F. Marceau, P. Herscu Source Type: journals

Is intrinsic asthma synonymous with infection?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rackemann described the 'intrinsic asthma' population over 50 years ago as a unique subgroup that was characterized by onset of progressive loss of lung function beginning later in life, possibly after a respiratory infection. It has also been associated with a female predominance, aspirin-sensitive bronchospasm, and nasal polyposis. While the aetiology is not understood, we propose that persistent respiratory infections play a central role in the development of intrinsic asthma. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - July 22, 2009 Category: Allergy & Immunology Authors: P. E. Dahlberg, W. W. Busse Source Type: journals

Further confirmation of the relevance of cockroach and dust mite sensitization to inner-city asthma morbidityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - July 22, 2009 Category: Allergy & Immunology Authors: M. S. Perzanowski, T. A. E. Platts-Mills Source Type: journals

To be or not to be: CD25 expression by regulatory CD4+ T cells in the prevention of allergic inflammationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - July 22, 2009 Category: Allergy & Immunology Authors: P. A. Stumbles Source Type: journals

Associations between decay-accelerating factor polymorphisms and allergic respiratory diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Allergic diseases such as asthma and allergic rhinitis are major causes of morbidity in developed countries. The pathology underlying allergic respiratory diseases is considered to be IgE-mediated type I allergy characterized by mucosal inflammation that occurs in response to allergen exposure. They are common diseases involving a complex inheritance. Complement systems are known to play an important role in allergic diseases. Decay-accelerating factor (DAF) is important for the regulation of the complement system and is a good candidate for determining the susceptibility to allergic diseases. The present study aimed to in...
Source: Clinical and Experimental Allergy - July 21, 2009 Category: Allergy & Immunology Authors: T. Kawai, S. Takeshita, Y. Imoto, Y. Matsumoto, M. Sakashita, D. Suzuki, M. Shibasaki, M. Tamari, T. Hirota, T. Arinami, S. Fujieda, E. Noguchi Source Type: journals

Inflammatory biomarkers in airways of patients with severe asthma compared with non-severe asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
About 5[ndash]10% of patients with asthma suffer from poorly-controlled disease despite corticosteroid (CS) therapy. We determined whether there were any differences in inflammatory biomarkers between severe and non-severe asthma patients. Nineteen severe and 20 non-severe asthma patients were recruited and underwent collection of induced sputum, bronchoalveolar lavage (BAL) fluid and bronchial biopsies. Biopsy results showed no differences in eosinophils (major basic protein positive), neutrophils, macrophages, T cells and mast cells in the bronchial submucosa. However, subbasement membrane (SBM) thickness and smooth musc...
Source: Clinical and Experimental Allergy - July 19, 2009 Category: Allergy & Immunology Authors: P. Macedo, M. Hew, A. Torrego, S. Jouneau, T. Oates, A. Durham, K. F. Chung Source Type: journals

Seasonal changes in suppressive capacity of CD4+ CD25+ T cells from patients with hayfever are allergen-specific and may result in part from expansion of effector T cells among the CD25+ populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined possible explanations for this effect of seasonal pollen exposure on suppression of allergen responses. CD4+ CD25[minus] and CD4+ CD25+ T cells were isolated from blood obtained from 44 volunteers with allergic rhinoconjunctivitis during and out of the UK grass pollen season. Co-cultures were performed with grass pollen extract and house dust mite (HDM) to examine allergen specificity. The frequency of IL-5 and IL-10 producing cells was determined by ELISPOT and the expression of T cell activation markers and the CD25+ regulatory T cell-associated transcription factor Foxp3 were examined. Lactic acid stripping ...
Source: Clinical and Experimental Allergy - July 19, 2009 Category: Allergy & Immunology Authors: A. E. Anderson, K. J. Mackerness, M. Aizen, V. A. Carr, D. Nguyen, F. Du Pre, S. R. Durham, D. S. Robinson Source Type: journals

The definition and diagnosis of AsthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The diagnosis of asthma depends on what we mean by the word. Its definition continues to be controversial because there is no single genetic or environmental cause. Addressed from a descriptive point of view, the disease components include airway inflammation, symptoms, variable airflow limitation and chronic airflow limitation. The essentialist definition conveys the message that asthma is a separate disease entity, fails to identify a primary defining characteristic which separates it from other diseases and is long winded. These disadvantages are overcome by the nominalist definition of asthma in which the word 'asthma'...
Source: Clinical and Experimental Allergy - July 19, 2009 Category: Allergy & Immunology Authors: F. E. Hargreave, P. Nair Source Type: journals