Clinical and Experimental Metastasis This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Predictive value of 18  F-FDG PET/CT versus bone marrow biopsy and aspiration in pediatric neuroblastoma
Conclusion18  F-FDG-PET/CT is a valuable method for evaluating BMM in NB. The routine practice of performing a BMBA without discrimination may need to be reassessed. Negative result from 18 F-FDG-PET/CT could potentially spare children with invasive bone marrow biopsies. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - April 13, 2024 Category: Cancer & Oncology Source Type: research

Microarray-based detection and expression analysis of drug resistance in an animal model of peritoneal metastasis from colon cancer
AbstractChemotherapy drugs efficiently eradicate rapidly dividing differentiated cells by inducing cell death, but poorly target slowly dividing cells, including cancer stem cells and dormant cancer cells, in the later course of treatment. Prolonged exposure to chemotherapy results in a decrease in the proportion of apoptotic cells in the tumour mass. To investigate and characterize the molecular basis of this phenomenon, microarray-based expression analysis was performed to compare tHcred2-DEVD-EGFP-caspase 3-sensor transfected C-26 tumour cells that were harvested after engraftment into mice treated with or without 5-FU....
Source: Clinical and Experimental Metastasis - April 12, 2024 Category: Cancer & Oncology Source Type: research

Stress-induced phosphoprotein 1: how does this co-chaperone influence the metastasis steps?
AbstractIn several cancer types, metastasis is associated with poor prognosis, survival, and quality of life, representing a life risk more significant than the primary tumor itself. Metastasis is a multi-step process that spreads tumor cells from primary sites to surrounding or distant organs, originating secondary tumors. The interconnected steps that drive metastasis depend of several capabilities that enable cells to detach from the primary tumor, acquire motility and migrate through the basal membrane; invade and spread through the vascular system, and finally settle and originate a new tumor. Recently, stress-induced...
Source: Clinical and Experimental Metastasis - April 6, 2024 Category: Cancer & Oncology Source Type: research

Lung-derived soluble factors support stemness/plasticity and metastatic behaviour of breast cancer cells via the FGF2-DACH1 axis
In this study, we hypothesized that soluble lung-derived factors secreted in the presence of a primary TNBC tumor can influence stemness/plasticity of breast cancer cells. Using an ex vivo pulmonary metastasis assay (PuMA), we obse rved that the lung microenvironment supports colonization and growth of ALDHhiCD44+ TNBC cells, potentially via interactions with lung-derived FGF2. Exposure of TNBC cells to lung-conditioned media (LCM) generated from mice bearing TNBC primary tumors (tbLCM) significantly enhanced the proportion of ALDHhiCD44+ cells compared to control or LCM from tumor-na ïve mice (tnLCM). Further analysis us...
Source: Clinical and Experimental Metastasis - April 6, 2024 Category: Cancer & Oncology Source Type: research

Nomogram to predict central lymph node metastasis in papillary thyroid carcinoma
AbstractCentral lymph node metastasis (CLNM) of papillary thyroid carcinoma (PTC) is common. In our study, we built a nomogram to predict CLNM. We retrospectively analyzed 1,392 PTC patients. This group of patients was divided into a training cohort (including 1,009 patients) and a validation cohort (including 383 patients). Analyses of the correlation between inflammatory indicators, ultrasonic characteristics, pathological characteristics and CLNM were conducted. In the training cohort and validation cohort, the metastatic rates of CLNM were 60.16% and 64.23%, respectively. Univariate and multivariate logistic regression...
Source: Clinical and Experimental Metastasis - April 3, 2024 Category: Cancer & Oncology Source Type: research

Transcriptomic characterization of the histopathological growth patterns in breast cancer liver metastases
AbstractMetastatic breast cancer (mBC) remains incurable and liver metastases (LM) are observed in approximately 50% of all patients with mBC. In some cases, surgical resection of breast cancer liver metastases (BCLM) is associated with prolonged survival. However, there are currently no validated marker to identify these patients. The interactions between the metastatic cancer cells and the liver microenvironment result in two main histopathological growth patterns (HGP): replacement (r-HGP), characterized by a direct contact between the cancer cells and the hepatocytes, and desmoplastic (d-HGP), in which a fibrous rim su...
Source: Clinical and Experimental Metastasis - March 29, 2024 Category: Cancer & Oncology Source Type: research

How much do we know about the metastatic process?
AbstractCancer cells can leave their primary sites and travel through the circulation to distant sites, where they lodge as disseminated cancer cells (DCCs), even during the early and asymptomatic stages of tumor progression. In experimental models and clinical samples, DCCs can be detected in a non-proliferative state, defined as cellular dormancy. This state can persist for extended periods until DCCs reawaken, usually in response to niche-derived reactivation signals. Therefore, their clinical detection in sites like lymph nodes and bone marrow is linked to poor survival. Current cancer therapy designs are based on the ...
Source: Clinical and Experimental Metastasis - March 23, 2024 Category: Cancer & Oncology Source Type: research

Forty years on: a brief history of clinical and experimental metastasis
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - March 23, 2024 Category: Cancer & Oncology Source Type: research

TGF β signalling pathway impacts brain metastases profiles in locally advanced colorectal cancer
ConclusionOur results suggest the TGF β pathway as a crucial player in the development of brain metastases in primary CRC. In some types of colorectal cancer, downregulation of the TGFβ pathway might hinder primary colorectal cancer to metastasize to the nervous system. While the paradoxical functioning of the TGFβ pathway is still n ot fully understood, these shed light on yet another clinical implication of this complex pathway. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - March 18, 2024 Category: Cancer & Oncology Source Type: research

The movement of mitochondria in breast cancer: internal motility and intercellular transfer of mitochondria
AbstractAs a major energy source for cells, mitochondria are involved in cell growth and proliferation, as well as migration, cell fate decisions, and many other aspects of cellular function. Once thought to be irreparably defective, mitochondrial function in cancer cells has found renewed interest, from suggested potential clinical biomarkers to mitochondria-targeting therapies. Here, we will focus on the effect of mitochondria movement on breast cancer progression. Mitochondria move both within the cell, such as to localize to areas of high energetic need, and between cells, where cells within the stroma have been shown ...
Source: Clinical and Experimental Metastasis - March 15, 2024 Category: Cancer & Oncology Source Type: research

Current pharmacologic treatment of brain metastasis in non-small cell lung cancer
AbstractLung cancer is a type of cancer that can metastasize to the lungs, brain, bones, liver, adrenal glands, and other organs; however, the occurrence of brain metastases is the most common event. Symptoms of brain metastasis include motor dysfunction, mental dysfunction, seizures, headaches, nausea, and vomiting, and significantly reduce the quality of life of cancer patients. Brain metastases are a poor prognostic factor, and controlling them is extremely important for prolonging prognosis and improving the quality of life. Currently, local surgery and radiotherapy are recommended for their treatment. However, recentl...
Source: Clinical and Experimental Metastasis - March 11, 2024 Category: Cancer & Oncology Source Type: research

From pre-clinical to translational brain metastasis research: current challenges and emerging opportunities
AbstractBrain metastasis, characterized by poor clinical outcomes, is a devastating disease. Despite significant mechanistic and therapeutic advances in recent years, pivotal improvements in clinical interventions have remained elusive. The heterogeneous nature of the primary tumor of origin, complications in drug delivery across the blood –brain barrier, and the distinct microenvironment collectively pose formidable clinical challenges in developing new treatments for patients with brain metastasis. Although current preclinical models have deepened our basic understanding of the disease, much of the existing research on...
Source: Clinical and Experimental Metastasis - March 2, 2024 Category: Cancer & Oncology Source Type: research

Differentiation of benign and metastatic lymph nodes in soft tissue sarcoma
This study shows significant associations between LNM and imaging features as well as laboratory parameters of STS patients. The largest SAD, SUVmax in FDG-PET-CT scan, the presence of central necrosis, and high serum LDH level are the most important param eters to distinguish benign from metastatic LNs. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - February 29, 2024 Category: Cancer & Oncology Source Type: research

Prediction of transformation in the histopathological growth pattern of colorectal liver metastases after chemotherapy using CT-based radiomics
This study included 181 patients with 298 CRLMs who underwent preoperative contrast-enhanced CT followed by partial hepatectomy between January 2007 and July 2022 at two institutions. HGPs were categorized as pure desmoplastic HGP (pdHGP) or non-pdHGP. The samples were allocated to training, internal validation, and external validation cohorts comprising 153, 65, and 29 CRLMs, respectively. Radiomics analysis was performed on pre-enhanced, arterial phase, portal venous phase (PVP), and fused images. The model was used to predict prechemotherapy HGPs in 112 CRLMs, and HGP transformation was analysed by comparing these findi...
Source: Clinical and Experimental Metastasis - February 28, 2024 Category: Cancer & Oncology Source Type: research

Poor patient outcome correlates with active engulfment of cytokeratin positive CTCs within cancer-associated monocyte population in lung cancer
AbstractHigh rates of mortality in non-small cell lung cancer lung cancer is due to inherent and acquired resistance to systemic therapies and subsequent metastatic burden. Metastasis is supported by suppression of the immune system at secondary organs and within the circulation. Modulation of the immune system is now being exploited as a therapeutic target with immune checkpoint inhibitors. The tracking of therapeutic efficacy in a real-time can be achieved with liquid biopsy, and evaluation of circulating tumour cells and the associated immune cells. A stable liquid biopsy biomarker for non-small cell lung cancer lung ca...
Source: Clinical and Experimental Metastasis - February 28, 2024 Category: Cancer & Oncology Source Type: research