Clinical and Experimental Pharmacology and Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Metformin ameliorates endometrial thickness in a rat model of thin endometrium
In conclusion, the study demonstrated that metformin ameliorates endometrial thickness in a rat model of thin endometrium by increasing endometrial proliferation and angiogenesis, without restoration of embryo implantation.PMID:38621769 | DOI:10.1111/1440-1681.13862 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 15, 2024 Category: Drugs & Pharmacology Authors: M Imran Aditya Khandvilkar Siddhanath Metkari Geetanjali Sachdeva Uddhav Chaudhari Source Type: research

Colorectal cancer cells with stably expressed SIRT3 demonstrate proliferating retardation by Wnt/ β-catenin cascade inactivation
In conclusion, our findings suggest that the inhibition of CRC cell proliferation by SIRT3 is closely associated with the inactivation of the Wnt/β-catenin signalling pathway.PMID:38621772 | DOI:10.1111/1440-1681.13856 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 15, 2024 Category: Drugs & Pharmacology Authors: Tianyu Li Leqi Fan Yijiang Jia Chen Xu Wei Guo Yuji Wang Ye Li Source Type: research

NPAS2, transcriptionally activated by ARRB1, promotes the malignant behaviours of lung adenocarcinoma cells and regulates the reprogramming of glucose metabolism
In conclusion, our study suggests that ARRB1 could transcriptionally activate NPAS2, facilitating malignant activities and glycolysis, and ultimately promoting the progression of LUAD, proving a novel therapeutic strategy for the treatment of LUAD.PMID:38584327 | DOI:10.1111/1440-1681.13860 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 8, 2024 Category: Drugs & Pharmacology Authors: Shenglan Wang Chunhong Huang Yanbin Zheng Xinjie Wu Yutong Zhong Source Type: research

Overexpression of HSP27 accelerates stress-induced gastric ulcer healing via the CXCL12/CXCR4 axis
Clin Exp Pharmacol Physiol. 2024 May;51(5):e13857. doi: 10.1111/1440-1681.13857.ABSTRACTChronic stress often triggers gastrointestinal complications, including gastric injury and ulcers. Understanding the role of heat shock protein 27 (HSP27) in stress-induced gastric ulcers could unveil novel therapeutic targets. Here, we established a stress-induced gastric ulcer rat model using water immersion restraint stress and administered adenovirus-packaged HSP27 overexpression vector. Gastric ulcer severity was scored, and mucosal changes were assessed. Gastric epithelial and endothelial cells were treated with lipopolysaccharide...
Source: Clinical and Experimental Pharmacology and Physiology - April 3, 2024 Category: Drugs & Pharmacology Authors: Qiaoyan Lu Hua Tang Source Type: research