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Value of eight-amino-acid matches in predicting the allergenicity status of proteins: an empirical bioinformatic investigationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of biotechnological techniques to introduce novel proteins into food crops (transgenic or GM crops) has motivated investigation into the properties of proteins that favor their potential to elicit allergic reactions. As part of the allergenicity assessment, bioinformatic approaches are used to compare the amino-acid sequence of candidate proteins with sequences in a database of known allergens to predict potential cross reactivity between novel food proteins and proteins to which people have become sensitized. Two criteria commonly used for these queries are searches over 80-amino-acid stretches for >35% identity, ...
Source: Clinical and Molecular Allergy - October 29, 2009 Category: Allergy & Immunology Authors: Rod HermanPing SongArvind ThirumalaiswamySekhar Source Type: journals

Characterization of Regulatory T cells in Urban NewbornsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: U.S. urban newborns have Treg cells that express Foxp3, albeit with an immature phenotype and function as compared to the mothers. Longitudinal follow-up is needed to delineate Treg cell maturation and subsequent risk for atopic diseases in this urban birth cohort. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - July 7, 2009 Category: Allergy & Immunology Authors: Ngoc LyBegona Ruiz-PerezRachel McLoughlinCynthia VisnessPaul WallaceWilliam CruikshankAuthur TzianabosGeorge O'ConnorDiane GoldJames Gern Source Type: journals

Genetics of asthma: a molecular biologist perspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Asthma belongs to the category of classical allergic diseases which generally arise due to IgE mediated hypersensitivity to environmental triggers. Since its prevalence is very high in developed or urbanized societies it is also referred to as "disease of civilizations". Due to its increased prevalence among related individuals, it was understood quite long back that it is a genetic disorder. Well designed epidemiological studies reinforced these views.The advent of modern biological technology saw further refinements in our understanding of genetics of asthma and led to the realization that asthma is not a disorder with s...
Source: Clinical and Molecular Allergy - May 6, 2009 Category: Allergy & Immunology Authors: Amrendra Kumar and Balaram Ghosh Source Type: journals

An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This particular AbM extract may both prevent allergy development and be used as a therapeutical substance against established allergy. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - May 5, 2009 Category: Allergy & Immunology Authors: Linda K Ellertsen and Geir Hetland Source Type: journals

T regulatory cells: an overview and intervention techniques to modulate allergy outcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dysregulated immune response results in inflammatory symptoms in the respiratory mucosa leading to asthma and allergy in susceptible individuals. The T helper type 2 (Th2) subsets are primarily involved in this disease process. Nevertheless, there is growing evidence in support of T cells with regulatory potential that operates in non-allergic individuals. These regulatory T cells occur naturally are called natural T regulatory cells (nTregs) and express the transcription factor Foxp3. They are selected in the thymus and move to the periphery. The CD4 Th cells in the periphery can be induced to become regulatory T cells an...
Source: Clinical and Molecular Allergy - March 12, 2009 Category: Allergy & Immunology Authors: Subhadra Nandakumar, Christopher W. T. Miller and Uday Kumaraguru Source Type: journals

Food hypersensitivity by inhalationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Though not widely recognized, food hypersensitivity by inhalation can cause major morbidity in affected individuals. The exposure is usually more obvious and often substantial in occupational environments but frequently occurs in non-occupational settings, such as homes, schools, restaurants, grocery stores, and commercial flights. The exposure can be trivial, as in mere smelling or being in the vicinity of the food. The clinical manifestations can vary from a benign respiratory or cutaneous reaction to a systemic one that can be life-threatening. In addition to strict avoidance, such highly-sensitive subjects should carry...
Source: Clinical and Molecular Allergy - February 20, 2009 Category: Allergy & Immunology Authors: Daniel A Ramirez and Sami L Bahna Source Type: journals

Mapping IgE-binding epitopes of Cyn d 1, a major allergen from Bermuda Grass Pollen (BGP)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study describes the localization of the human IgE-binding regions of the major group 1 pollen allergen Cyn d 1 from Bermuda grass. Methods: A cDNA library was constructed from Bermuda grass pollen (BGP) using a Lambda gt11 expression vector. The gene encoding the Cyn d 1 allergen was isolated by screening the library with a mouse monoclonal antibody raised against grass group 1 allergen. In order to characterize the IgE epitopes on Cyn d 1, seven overlapping fragments and three deletion mutants were cloned and over-expressed in E. coli. The recombinant fragments and deletion mutants were evaluated for their comparativ...
Source: Clinical and Molecular Allergy - February 2, 2009 Category: Allergy & Immunology Authors: Ruby Tiwari, Prem L Bhalla and Mohan B Singh Source Type: journals

Novel concepts in virally induced asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Viruses are the predominant infectious cause of asthma exacerbations in the developed world. In addition, recent evidence strongly suggests that viral infections may also have a causal role in the development of childhood asthma. In this article, we will briefly describe the general perception of how the link between infections and asthma has changed over the last century, and then focus on very recent developments that have provided new insights into the contribution of viruses to asthma pathogenesis. Highlighted areas include the contribution of severe early life viral infections to asthma inception, genetic determinants...
Source: Clinical and Molecular Allergy - January 20, 2009 Category: Allergy & Immunology Authors: Matthew M Huckabee and R. Stokes Peebles Source Type: journals

Should digestion assays be used to estimate persistence of potential allergens in tests for safety of novel food proteins?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Food allergies affect an estimated 3 to 4% of adults and up to 8% of children in developed western countries. Results from in vitro simulated gastric digestion studies with purified proteins are routinely used to assess the allergenic potential of novel food proteins. The digestion of purified proteins in simulated gastric fluid typically progresses in an exponential fashion allowing persistence to be quantified using pseudo-first-order rate constants or half lives. However, the persistence of purified proteins in simulated gastric fluid is a poor predictor of the allergenic status of food proteins, potentially due to food...
Source: Clinical and Molecular Allergy - January 15, 2009 Category: Allergy & Immunology Authors: Santiago Schnell and Rod A Herman Source Type: journals

Anaphylaxis to husband's seminal plasma and treatment by local desensitizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of IgE-mediated anaphylaxis to seminal plasma that was diagnosed by skin prick tests and successfully treated by local desensitization. 32-year-old woman suffering from angioedema and hypotension after exposure to semen was treated with epinephrine upon admission. Skin prick tests and immunoblotting for IgE binding components showed that she was sensitized to her husband's seminal plasma. Local desensitization, which persisted for six months, was achieved by intravaginal administration of serial dilutions of her husband's seminal plasma. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - December 5, 2008 Category: Allergy & Immunology Authors: Jaechun Lee, Sohyung Kim, Miok Kim, Young-Bae Chung, Jung-Sik Huh, Chul Min Park, Keun Hwa Lee and Jeong Hong Kim Source Type: journals

Differential response of human basophil activation markers: a multi-parameter flow cytometry approachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Use of polychromatic flow cytometry allowed efficient basophil electronic purification and identification of different behaviors of the major activation markers. The simultaneous use of two markers of activation and careful choice of activator are essential steps for reliable assessment of human basophil functions. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - October 16, 2008 Category: Allergy & Immunology Authors: Salvatore Chirumbolo, Antonio Vella, Riccardo Ortolani, Marzia De Gironcoli, Pietro Solero, Giuseppe Tridente and Paolo Bellavite Source Type: journals

Diversity of the gut microbiota and eczema in early lifeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings suggest that reduced microbial diversity is associated with the development of eczema in early life. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - September 22, 2008 Category: Allergy & Immunology Authors: Erick Forno, Andrew B Onderdonk, John McCracken, Augusto A Litonjua, Daniel Laskey, Mary L Delaney, Andrea M DuBois, Diane R Gold, Louise M Ryan, Scott T Weiss and Juan C Celedon Source Type: journals

CpG Immunotherapy in Chenopodium album sensitized mice: the comparison of IFN-gamma, IL-10 and IgE responses in intranasal and subcutaneous administrationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: According to the results of this experiment we concluded that immunotherapy via the I.N co-administration of CpG/Ch.a in comparison with S.C route is more effective to stimulate the mucosal and regulatory responses in Ch.a induced asthma. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - September 17, 2008 Category: Allergy & Immunology Authors: Tahereh Mousavi, Nader Tajik, Maziar Moradi and Masoomeh FALLAH Radjabzadeh Source Type: journals

Three dimensional structure directs T-cell epitope dominance associated with allergyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: During the initiation of allergy, the N- and/or C-terminal ends of proteolytic processing intermediates were preferentially loaded into antigen presenting proteins for the priming of CD4+ T cells. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - September 15, 2008 Category: Allergy & Immunology Authors: Scott J Melton and Samuel J Landry Source Type: journals

The Hoover's sign of pulmonary disease: molecular basis and clinical relevanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a clinical and molecular review of the Hoover's sign and explain how it could be utilized in the bedside and emergent management of airway disease. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - September 5, 2008 Category: Allergy & Immunology Authors: Chambless R Johnston, Narayanaswamy Krishnaswamy and Guha Krishnaswamy Source Type: journals

Polymorphisms in IL12A and cockroach allergy in children with asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: IL12A has been implicated in T-cell development and may thus influence the development of atopy and allergic diseases. Methods: We tested for association between four linkage disequilibrium (LD)-tagging SNPs (rs2243123, rs2243151, rs668998, and rs17826053) in IL12A and asthma and allergy-related (serum total and allergen-specific IgE, and skin test reactivity [STR] to two common allergens) phenotypes in two samples: 417 Costa Rican children with asthma and their parents, and 470 families of 503 white children in the Childhood Asthma Management Program (CAMP). The analysis was conducted using the family-based a...
Source: Clinical and Molecular Allergy - July 31, 2008 Category: Allergy & Immunology Authors: Michael Pistiner, Gary M. Hunninghake, Manuel E. Soto-Quiros, Lydiana Avila, Amy Murphy, Jessica Lasky-Su, Brooke Schuemann, Barbara J. Klanderman, Benjamin A. Raby and Juan C. Celedon Source Type: journals

X-linked agammaglobulinemia diagnosed late in life: case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Common variable immune deficiency (CVID), one of the most common primary immunodeficiency diseases presents in adults, whereas X-linked agammaglobulinemia (XLA), an inherited humoral immunodeficiency, is usually diagnosed early in life after maternal Igs have waned. However, there have been several reports in the world literature in which individuals have either had a delay in onset of symptoms or have been misdiagnosed with CVID and then later found to have mutations in Bruton's tyrosine kinase (BTK) yielding a reclassification as adult-onset variants of XLA. The typical finding of absent B cells should sugges...
Source: Clinical and Molecular Allergy - June 2, 2008 Category: Allergy & Immunology Authors: Justin R Sigmon, Ehab Kasasbeh and Guha Krishnaswamy Source Type: journals

Severe asthma and the omalizumab optionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Atopic diseases and asthma are increasing at a remarkable rate on a global scale. It is now well recognized that asthma is a chronic inflammatory disease of the airways. The inflammatory process in many patients is driven by an immunoglobulin E (IgE)-dependent process. Mast cell activation and release of mediators, in response to allergen and IgE, result in a cascade response, culminating in B lymphocyte, T lymphocyte, eosinophil, fibroblast, smooth muscle cell, and endothelial activation. This complex cellular interaction, release of cytokines, chemokines and growth factors and inflammatory remodeling of the airways leads...
Source: Clinical and Molecular Allergy - May 20, 2008 Category: Allergy & Immunology Authors: Christopher W T Miller, Narayanaswamy Krishnaswamy, Chambless Johnston and Guha Krishnaswamy Source Type: journals

Incense smoke: clinical, structural and molecular effects on airway diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In Asian countries where the Buddhism and Taoism are mainstream religions, incense burning is a daily practice. A typical composition of stick incense consists of 21% (by weight) of herbal and wood powder, 35% of fragrance material, 11% of adhesive powder, and 33% of bamboo stick. Incense smoke (fumes) contains particulate matter (PM), gas products and other organic compounds. On average, incense burning produces particulates greater than 45 mg/g burned (as compared to 10 mg/g burned for cigarettes). The gas products from burning incense include CO, CO2, NO2, SO2, and others. Incense burning also produces volatile organic ...
Source: Clinical and Molecular Allergy - April 25, 2008 Category: Allergy & Immunology Authors: Ta-Chang Lin, Guha Krishnaswamy and David S Chi Source Type: journals

New treatments addressing the pathophysiology of hereditary angioedemaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hereditary angioedema is a serious medical condition caused by a deficiency of C1-inhibitor. The condition is the result of a defect in the gene controlling the synthesis of C1-inhibitor, which regulates the activity of a number of plasma cascade systems. Although the prevalence of hereditary angioedema is low - between 1:10,000 to 1:50,000 - the condition can result in considerable pain, debilitation, reduced quality of life, and even death in those afflicted. Hereditary angioedema presents clinically as cutaneous swelling of the extremities, face, genitals, and trunk, or painful swelling of the gastrointestinal mucosa. A...
Source: Clinical and Molecular Allergy - April 14, 2008 Category: Allergy & Immunology Authors: Alvin E. Davis Source Type: journals

Usefulness of manufactured tomato extracts in the diagnosis of tomato sensitization: comparison with the prick-prick methodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the study was to assess the potential diagnostic of freeze-dried extracts of Canary Islands tomatoes, comparing the wheal sizes induced by prick test with the prick-prick method. Methods: Two groups of patients were analyzed: Group I: 26 individuals reporting clinical symptoms induced by tomato contact or ingestion. Group II: 71 control individuals with no symptoms induced by tomato: 12 of them were previously skin prick test positive to a tomato extract, 39 were atopic and 20 were non-atopic. All individuals underwent prick-prick with fresh ripe peel Canary tomatoes and skin prick tested with freeze-dried...
Source: Clinical and Molecular Allergy - January 9, 2008 Category: Allergy & Immunology Authors: Angel Ferrer, Angel J Huertas, Carlos H Larramendi, Jose L Garcia-Abujeta, Joan Bartra, Jose R Lavin, Carmen Andreu, Juan A Pagan, Maria A Lopez-Matas, Enrique Fernandez-Caldas and Jeronimo Carnes Source Type: journals

Baicalein inhibits IL-1beta- and TNF-alpha-induced inflammatory cytokine production from human mast cells via regulation of the NF-kapaB pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results showed that BAI inhibited the production of inflammatory cytokines through inhibition of NF-kapaB activation and IkapaBalpha phosphorylation and degradation in human mast cells. This inhibitory effect of BAI on the expression of inflammatory cytokines suggests its usefulness in the development of novel anti-inflammatory therapies. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - November 26, 2007 Category: Allergy & Immunology Authors: Chia-Jung Hsieh, Kenton Hall, Tuanzhu Ha, Chuanfu Li, Guha Krishnaswamy and David S. Chi Source Type: journals

Systemic and local eosinophil inflammation during the birch pollen season in allergic patients with predominant rhinitis or asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our study indicates that patients with allergic asthma and allergic rhinitis have the same degree of eosinophil inflammation. Despite this, only the asthmatic group experienced an impairment in lung function during the pollen season. This indicated that factors other than the eosinophil inflammation determine whether or not allergic patients develop asthma. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - October 29, 2007 Category: Allergy & Immunology Authors: Mary Kampe, Gunnemar Stahlenheim, Christer Janson, Ingrid Stolt and Marie Carlson Source Type: journals

Looking ahead at the potential benefits of biotechnology-derived allergen therapeuticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
While biotechnology-derived allergen therapeutics show promise in improving the safety of immunotherapy, they may prove to have additional benefits in comparison to conventional allergenic extracts that deserve commentary. These issues range from product stability and compatibility to medical practice issues, which will be the focus of this article. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - July 4, 2007 Category: Allergy & Immunology Authors: Jason Behrmann Source Type: journals

Assessment of allergen cross-reactivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The prediction of allergen cross-reactivity is currently largely based on linear sequence data, but will soon include 3D information on homology among surface exposed residues. To evaluate procedures for these predictions, we need ways to quantitatively assess actual cross-reactivity between two allergens. Three parameters are mentioned: 1) the fraction of the epitopes that is cross-reactive; 2) the fraction of IgE that is cross-reactive; 3) the relative affinity of the interaction between IgE and the two allergens. This editorial briefly compares direct binding protocols with the often more appropriate reciprocal inhibiti...
Source: Clinical and Molecular Allergy - February 9, 2007 Category: Allergy & Immunology Authors: Rob C Aalberse Source Type: journals

Immune response modulation by curcumin in a latex allergy modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that curcumin has potential therapeutic value for controlling allergic responses resulting from exposure to allergens. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - January 25, 2007 Category: Allergy & Immunology Authors: Viswanath P Kurup, Christy S Barrios, Raghavan Raju, Bryon D Johnson, Michael B Levy and Jordan N Fink Source Type: journals

Mode of delivery and cord blood cytokines: a birth cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Cesarean section is associated with increased levels of IL-13 and IFN-gamma, perhaps because of lack of labor and/or reduced exposure to specific microbes (e.g., gram-positive anaerobes) at birth. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - September 26, 2006 Category: Allergy & Immunology Authors: Ngoc P Ly, Begona Ruiz-Perez, Andrew B Onderdonk, Arthur O Tzianabos, Augusto A Litonjua, Catherine Liang, Daniel Laskey, Mary L Delaney, Andrea M DuBois, Hara Levy, Diane R Gold, Louise M Ryan, Scott T Weiss and Juan C Celedon Source Type: journals

Molecular and immunological characterization of allergens from the entomopathogenic fungus Beauveria bassianaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Four putative Beauveria bassiana allergens were identified. Recombinant proteins corresponding to two of the four, Bb-Eno1 and Bb-Ald were bound by sera IgEs derived from patients with fungal allergies. These data confirm the potential allergenicity of B. bassiana by identification of specific human IgE reactive epitopes. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - September 22, 2006 Category: Allergy & Immunology Authors: Greg S Westwood, Shih-Wen Huang and Nemat O Keyhani Source Type: journals

Specific antibodies to recombinant allergens of Aspergillus fumigatusin cystic fibrosis patients with ABPAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: When results of several allergens such as Asp f 1, f 2, f 3, f 4, and f 6 in their binding to IgA, IgG, and IgE antibodies were analyzed, a more strong discrimination of CF patients with ABPA was possible from the other groups studied. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - July 21, 2006 Category: Allergy & Immunology Authors: Viswanath P Kurup, Alan P Knutsen, Richard B Moss and Naveen K Bansal Source Type: journals

Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Comprehensive characterization of genetic variation in extended cytokine candidate gene regions is now needed. Large study networks must follow to investigate the association of risk patterns defined by genetic predisposing and environmental risk factors with specific atopic phenotypes. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - June 7, 2006 Category: Allergy & Immunology Authors: Medea Imboden, Alexandra Nieters, Andreas J Bircher, Martin Brutsche, Nikolaus Becker, Matthias Wjst, Ursula Ackermann-Liebrich, Wolfgang Berger, Nicole M Probst-Hensch and The SAPALDIA Team Source Type: journals

Intestinal strongyloidiasis and hyperinfection syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In spite of recent advances with experiments on animal models, strongyloidiasis, an infection caused by the nematode parasite Strongyloides stercoralis, has still been an elusive disease. Though endemic in some developing countries, strongyloidiasis still poses a threat to the developed world. Due to the peculiar but characteristic features of autoinfection, hyperinfection syndrome involving only pulmonary and gastrointestinal systems, and disseminated infection with involvement of other organs, strongyloidiasis needs special attention by the physician, especially one serving patients in areas endemic for strongyloidiasis....
Source: Clinical and Molecular Allergy - May 30, 2006 Category: Allergy & Immunology Authors: Raja S Vadlamudi, David S Chi and Guha Krishnaswamy Source Type: journals

A possible link between sinusitis and lower airway hypersensitivity: the role of Staphylococcal enterotoxin BEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present results indicate that a possible link exists between CRS and lower airway hypersensitivity. Sinusitis derived SEB may play a role in sustaining Th2 responses in the low airway hypersensitivity related to sinusitis. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - May 7, 2006 Category: Allergy & Immunology Authors: Tao Liu, Bin-Quan Wang and Ping-Chang Yang Source Type: journals

CCR3, CCR5, CCR8 and CXCR3 expression in memory T helper cells from allergic rhinitis patients, asymptomatically sensitized and healthy individualsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We conclude that even though allergen and antigen induced increased chemokine receptor expression, no differences in profiles were identified in memory Th cells from patient groups with different atopic status. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - April 19, 2006 Category: Allergy & Immunology Authors: Mille Holse, Kristian Assing and Lars K. Poulsen Source Type: journals

House dust mite major allergens Der p 1 and Der p 5 activate human airway-derived epithelial cells by protease-dependent and protease-independent mechanismsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to assess whether HDM components of Dermatophagoides pteronissinus with protease activity (Der p 1) and unknown enzymatic activity (Der p 2, Der p 5) induce biological responses in a human airway-derived epithelial cell line (A549), and if so, to elucidate the underlying mechanism(s) of action. A549 cells were incubated with HDM extract, Der p 1, recombinant Der p 2 and recombinant Der p 5. Cell desquamation was assessed by microscopy. The proinflammatory cytokines, IL-6 and IL-8, were measured by ELISA. Intracellular Ca2+ levels were assessed in A549 cells and in mouse fibroblasts expressin...
Source: Clinical and Molecular Allergy - March 28, 2006 Category: Allergy & Immunology Authors: Henk F. Kauffman, Michael Tamm, J. Andre B. Timmerman and Peter Borger Source Type: journals

Protective effect of the DNA vaccine encoding the major house dust mite allergens on allergic inflammation in the murine model of house dust mite allergyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Vaccination with DNA encoding the major house dust mite allergens provides a promising approach for treating allergic responses to whole house dust mite allergens. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - February 20, 2006 Category: Allergy & Immunology Authors: Nacksung Kim, Soon Seog Kwon, Jaechun Lee, Sohyung Kim and Tai June Yoo Source Type: journals

Impact of IL8 and IL8-Receptor alpha polymorphisms on the genetics of bronchial asthma and severe RSV infectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We conclude from our data that IL8 might play a role in the genetic predisposition to asthma and that these effects are different or even opposite to the effects on severe RSV diseases. Furthermore, IL8RA is unlikely to play a major role in the genetics of either disease. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - February 17, 2006 Category: Allergy & Immunology Authors: Beena Puthothu, Marcus Krueger, Jessica Heinze, Johannes Forster and Andrea Heinzmann Source Type: journals

IL-4 alpha chain receptor (IL-4Rα) polymorphisms in allergic bronchopulmonary sspergillosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The presence of IL-4Rα SNPs, principally ile75val, appears to be a genetic risk for the development of ABPA. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - February 17, 2006 Category: Allergy & Immunology Authors: Alan P Knutsen, Barbara Kariuki, Judy D Consolino and Manoj R Warrier Source Type: journals

Aluminum sulfate significantly reduces the skin test response to common allergens in sensitized patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Aluminum sulfate was found to reduce the in vivo allergic reaction cascade induced by skin testing with common allergens. The exact mechanism is not clear but appears to involve the alteration of IgE-binding epitopes on the allergen. Our results indicate that it may be possible to diminish the allergenicity of an environment by application of the active agent aluminum sulfate, thus producing environmental control without complete removal of the allergen. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - February 14, 2006 Category: Allergy & Immunology Authors: C Steven Smith, Scott A Smith, Thomas J Grier and David E Justus Source Type: journals

Insulin allergy and resistance successfully treated by desensitisation with Aspart insulinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 25-year-old, with type I Diabetes Mellitus with a previous diagnosis of Protamine Allergy but not to human Insulin, started to notice anaphylactic reactions inmmediatly after bolus with Insulin. Skin prick and intradermal test were positive to all insulins. Skin tests to other potential allergens resulted negative. Examination after bolus of Human Insulin revealed urticaria. Daily insulin requirement were around 2-2,4 U/Kg/day. Slow desensitisation with Aspart insulin, the insulin with lowest size of skin test, was performed using subcutaneous insulin pump. Six months after the end of desensitisation his daily insulin re...
Source: Clinical and Molecular Allergy - December 23, 2005 Category: Allergy & Immunology Authors: Victor Matheu, Eva Perez, Marta Hernández, Elisa Díaz, Ricardo Darias, Abel González, Jose C García, Inmaculada Sánchez, Laura Feliciano, Agueda Caballero and Fernando de la Torre Source Type: journals

Interleukin-4 (IL4) and Interleukin-4 receptor (IL4RA) polymorphisms in asthma: a case control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results show a trend of association between the genetic combination of the T allele of -33C>TIL4 and the A allele of 576Q>RIL4RA with asthma. This genetic variant was more frequently observed in patients with persistent asthma. As long as this study was performed in a small population, further studies in other populations are needed to confirm these results. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - November 29, 2005 Category: Allergy & Immunology Authors: María Isidoro-García, Ignacio Dávila, Elena Laffond, Esther Moreno, Félix Lorente and Rogelio González-Sarmiento Source Type: journals

Severe allergic reactions to guinea pigEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Severe IgE-mediated reactions can occur following non-occupational guinea pig exposure. Physicians should be aware of this possibility. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - October 27, 2005 Category: Allergy & Immunology Authors: Michael C Zacharisen, Michael B Levy, Jeffrey L Shaw and Viswanath P Kurup Source Type: journals