Clinical and Translational Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

PI3K inhibitor treatment ameliorates the glucocorticoid insensitivity of PBMCs in severe asthma
Glucocorticoid (GC) insensitivity is an important feature of severe and fatal asthma. Oxidative stress can induce phosphoinositide-3-kinase (PI3K) activation, contributing to the development of GC insensitivit... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 28, 2020 Category: Internal Medicine Authors: Jing Bi, Zhihui Min, Honglei Yuan, Zhilong Jiang, Ruolin Mao, Tao Zhu, Chunfang Liu, Yuzhen Zeng, Juan Song, Chunling Du and Zhihong Chen Tags: Research Source Type: research

A trans-ethnic two-stage polygenetic scoring analysis detects genetic correlation between osteoporosis and schizophrenia
To explore the genetic correlation between schizophrenia (SCZ) and osteoporosis (OP). (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 27, 2020 Category: Internal Medicine Authors: Li Liu, Yan Wen, Yujie Ning, Ping Li, Bolun Cheng, Shiqiang Cheng, Lu Zhang, Mei Ma, Xin Qi, Chujun Liang, Tielin Yang, Xiangding Chen, Lijun Tan, Hui Shen, Qing Tian, Hong-Wen Deng & hellip; Tags: Research Source Type: research

2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies
An ongoing outbreak of 2019-nCoV pneumonia was first identified in Wuhan, Hubei province, China at the end of 2019. With the spread of the new coronavirus accelerating, person-to-person transmission in family ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 20, 2020 Category: Internal Medicine Authors: Jun She, Jinjun Jiang, Ling Ye, Lijuan Hu, Chunxue Bai and Yuanlin Song Tags: Review Source Type: research

Bone mineral density is negatively correlated with ulcerative colitis: a systematic review and meta-analysis
Newer epidemiological studies suggest that the incidence of ulcerative colitis might be increasing rapidly. Furthermore, osteoporosis in ulcerative colitis patients has gained great attention, but the epidemio... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 18, 2020 Category: Internal Medicine Authors: Tianyu Zhou, Jiaqi Pan, Bin Lai, Li Cen, Wenxi Jiang, Chaohui Yu and Zhe Shen Tags: Review Source Type: research

Computational determination of human PPARG gene: SNPs and prediction of their effect on protein functions of diabetic patients
The Peroxisome proliferator-activated receptor gamma gene (PPARG), encodes a member of the peroxisome-activated receptor subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) wh... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 17, 2020 Category: Internal Medicine Authors: Howeida Abdullah Mustafa, Afraa Mohamed Suliman Albkrye, Buthiena Mohamed AbdAlla, Mona AbdelRahman Mohammed Khair, Nidal Abdelwahid and Hind Abdelaziz Elnasri Tags: Research Source Type: research

EGFR T790M relative mutation purity predicts osimertinib treatment efficacy in non-small cell lung cancer patients
Despite the impressive anti-tumor activity of osimertinib in epidermal growth factor receptor (EGFR) T790M-positive non-small cell lung cancer (NSCLC) patients, 30 –40% of patients still show limited response. ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 17, 2020 Category: Internal Medicine Authors: Qiufan Zheng, Shaodong Hong, Yan Huang, Hongyun Zhao, Yunpeng Yang, Xue Hou, Yuanyuan Zhao, Yuxiang Ma, Ting Zhou, Yaxiong Zhang, Wenfeng Fang and Li Zhang Tags: Research Source Type: research

The novel llama-human chimeric antibody has potent effect in lowering LDL-c levels in hPCSK9 transgenic rats
The advent of proprotein convertase subtilisin/kexin type 9 (PCSK9) –inhibiting drugs have provided an effective, but extremely expensive treatment for the management of low density lipoprotein (LDL). Our aim w... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 13, 2020 Category: Internal Medicine Authors: Xinyang Li, Meiniang Wang, Xinhua Zhang, Chuxin Liu, Haitao Xiang, Mi Huang, Yingying Ma, Xiaoyan Gao, Lin Jiang, Xiaopan Liu, Bo Li, Yong Hou, Xiuqing Zhang, Shuang Yang and Naibo Yang Tags: Research Source Type: research

Circulating basophil count as a prognostic marker of tumor aggressiveness and survival outcomes in colorectal cancer
Accumulating evidence demonstrated immune/inflammation-related implications of basophils in affecting tissue microenvironment that surrounded a tumor, and this study aimed to elucidate the clinical value of se... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 10, 2020 Category: Internal Medicine Authors: Qi Liu, Dakui Luo, Sanjun Cai, Qingguo Li and Xinxiang Li Tags: Research Source Type: research

Embryos derived from donor or patient oocytes are not different for in vitro fertilization outcomes when PGT allows euploid embryo selection: a retrospective study
At our facilities, patients that received embryos using donor oocyte during in vitro fertilization (IVF), usually have had at least one failed attempt to produce at least one euploid embryo with their own oocy... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 7, 2020 Category: Internal Medicine Authors: Elizabeth Schaeffer, Leonardo M. Porchia, Adina Neumann, Almena Luna, Tania Rojas and Esther L ópez-Bayghen Tags: Research Source Type: research

The clinical potential of gene editing as a tool to engineer cell-based therapeutics
The clinical application of ex vivo gene edited cell therapies first began a decade ago with zinc finger nuclease editing of autologous CD4+ T-cells. Editing aimed to disrupt expression of the human immunodeficie... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 7, 2020 Category: Internal Medicine Authors: Candice Ashmore-Harris and Gilbert O. Fruhwirth Tags: Review Source Type: research

Prediction of hepatic metastasis and relapse in colorectal cancers based on concordance analyses with liver fibrosis scores
Liver fibrosis, resulted from several liver diseases, are increasing up to 25% in population in global. It remains undetermined how much impact liver fibrosis have on the development of hepatic metastasis and ... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 5, 2020 Category: Internal Medicine Authors: Xiang Hu, Audrey Marietta, Wei-Xing Dai, Ya-Qi Li, Xiao-ji Ma, Long Zhang, San-Jun Cai and Jun-Jie Peng Tags: Research Source Type: research

Unveiling ncRNA regulatory axes in atherosclerosis progression
Completion of the human genome sequencing project highlighted the richness of the cellular RNA world, and opened the door to the discovery of a plethora of short and long non-coding RNAs (the dark transcriptom... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - February 3, 2020 Category: Internal Medicine Authors: Estanislao Navarro, Adrian Mall én, Josep M. Cruzado, Joan Torras and Miguel Hueso Tags: Review Source Type: research

PI3K inhibitors in thrombosis and cardiovascular disease
Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate important intracellular signalling and vesicle trafficking events via the generation of 3-phosphoinositides. Comprising eight core isoforms ac... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 31, 2020 Category: Internal Medicine Authors: Tom N. Durrant and Ingeborg Hers Tags: Review Source Type: research

Personalized CT-based radiomics nomogram preoperative predicting Ki-67 expression in gastrointestinal stromal tumors: a multicenter development and validation cohort
To develop and validate radiomic prediction models using contrast-enhanced computed tomography (CE-CT) to preoperatively predict Ki-67 expression in gastrointestinal stromal tumors (GISTs). (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 31, 2020 Category: Internal Medicine Authors: Qing-Wei Zhang, Yun-Jie Gao, Ran-Ying Zhang, Xiao-Xuan Zhou, Shuang-Li Chen, Yan Zhang, Qiang Liu, Jian-Rong Xu and Zhi-Zheng Ge Tags: Research Source Type: research

Dilemmas about instructions for administering drugs and indications for their use: is there negative effect of pharmaceutical industry?
Instructions for administering some drugs and indications for their use raise certain dilemmas and controversies questioning the appropriateness of the treatment in this way. In this article, some controversie... (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - January 30, 2020 Category: Internal Medicine Authors: Enver Zerem Tags: Perspective Source Type: research