Cosmetic Skin Lightening: Contextualizing Biomedical and Ethical Issues
The skin lightening (SL) industry has a global reach and is projected to continue to grow over the coming decade. While SL treatments may be safely prescribed for treatment of some dermatologic conditions, many over-the-counter SL products contain ingredients that can cause harm to the skin and other organ systems. Given a lack of transparent information to patients and the historical colorist foundation that contextualizes a component of the cosmetic SL industry, dermatologists need to navigate biomedical and ethical concerns when explaining SL products to patients. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - April 12, 2024 Category: Dermatology Authors: James Bradley M. Parente, Genevieve S. Silva, Jeromy W. Gotschall, Alana L. Ferreira, Jane M. Grant-Kels Tags: Comment and Controversy Source Type: research

Cover 2 - Editorial Board with barcode
(Source: Clinics in Dermatology)
Source: Clinics in Dermatology - March 1, 2024 Category: Dermatology Source Type: research

Table of Contents
(Source: Clinics in Dermatology)
Source: Clinics in Dermatology - March 1, 2024 Category: Dermatology Source Type: research

Shared Contributions and Collaboration between Persian and Jewish Dermatologists
Clinics in Dermatology has published on the contributions of Jewish and Persian dermatologists. Herein, we recount the collaborations between both cultures. Historically, the Jewish and Persian people share a rich history marked by cultural exchanges, coexistence, and mutual respect. Despite recent events, religious diversity and tolerance were a prominent part of ancient Persian history. The Persian-Jewish connection can be traced back to when King Cyrus the Great's decree granted the Jews the right to return to their homeland and rebuild the Temple in Jerusalem after the Babylonian exile (597-538 BCE). (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - February 22, 2024 Category: Dermatology Authors: Mohamad Goldust, Marina Landau, Jane M. Grant-Kels Source Type: research

Ethics of AI in Dermatology
The integration of artificial intelligence (AI) in dermatology holds promise for enhancing clinical accuracy, enabling earlier detection of skin malignancies, suggesting potential management of skin lesions and eruptions, and promoting improved continuity of care. However, AI implementation in dermatology raises several ethical concerns. This review explores the current benefits and challenges associated with AI integration, underscoring ethical considerations related to autonomy, informed consent, and privacy. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - February 22, 2024 Category: Dermatology Authors: Maggie Chen, Albert E. Zhou, Neelesh Jain, Christian Gronbeck, Hao Feng, Jane M. Grant-Kels Source Type: research

Balancing Ethical Principles in Dermatology: Disclosing Clinical Trial Underrepresentation During Informed Consent
I was recently approached by a medical student on an elective who asked me if speaking about the lack of clinical trial representation for patients from minoritized groups during informed consent is ethically appropriate or necessary. The specific scenario was a transgender man starting isotretinoin therapy. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - February 22, 2024 Category: Dermatology Authors: Alana Ferreira, Jeromy W. Gotschall, Jane M. Grant-Kels Source Type: research

Is it ethical to lie by omission for a patient?
In the age of increasing transparency dermatologists may encounter requests from patients to alter or withhold key medical information from their electronic medical records. As per the Health Insurance Portability and Accountability Act patients have the right to view their medical record and request amendments, however, the physician is the final decision maker on what information should be included in the chart. It is integral that medically necessary information is included in the chart in accordance with the principle of beneficence and non-maleficence. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - February 22, 2024 Category: Dermatology Authors: Krishan Parashar, Jane M. Grant-Kels, Abraham M. Korman Source Type: research

The global burden of HIV
remains a formidable challenge, affecting millions. Despite significant progress in understanding, treatment and prevention the virus, HIV/AIDS continues to exert a substantial impact on personal and public health, particularly in sub-Saharan Africa, where the prevalence is highest. The virus not only poses a direct threat to the well-being of individuals but also contributes to social and economic disparities. Approximately 38 million people worldwide are living with HIV, with millions unaware of their status. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - February 20, 2024 Category: Dermatology Authors: Dr Sashini Payagala, Anton Pozniak Source Type: research

Eponyms That Honor Jewish Dermatologists: A Celebration and a Remembrance Part Three: Jewish Physicians Who Practiced During the Holocaust and in its Aftermath
Part III of this contribution continues to celebrate the many contributions that Jewish physicians have made to advance the specialty of dermatology, as reflected by eponyms that honor their names. Part I covered the years before 1933, a highly productive period of creativity by Jewish dermatologists especially in Germany and Austria. The lives of 17 Jewish physicians and their eponyms were presented in Part I.Part II focused on the years from 1933 to 1945, when the Nazis rose to power in Europe and how their anti-Semitic genocidal policies impacted leading Jewish dermatologists caught within the Third Reich. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - February 8, 2024 Category: Dermatology Authors: By Leonard J. Hoenig, Dan Lipsker, Lawrence Charles Parish Tags: Reflections on Dermatology: Past, Present and Future Source Type: research

Interventional and device treatment of the periocular area
Growth in the research, innovation, and development of laser and energy-based technologies over the past few decades have led to dramatic increases in treatment options for dermatologic and cosmetic concerns of the periorbital area. We highlight recent treatment options using laser and energy-based devices for the clearance of periocular pigmented lesions, including solar lentigines and Nevus of Ota; vascular lesions, including port wine birthmarks, infantile hemangiomas, superficial telangiectasias, and reticular veins; laser ablation of benign tumors, such as xanthelasma; cosmetic rejuvenation; treatment of infraorbital ...
Source: Clinics in Dermatology - February 7, 2024 Category: Dermatology Authors: Shirin Bajaj, David Orbuch, Jordan V Wang, Brian S Biesman, Roy G Geronemus Source Type: research

Merkel Cell Carcinoma and the Eye
Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine tumor with a poor five year survival rate. Yearly cases have risen nearly 350% since the early 1980 ’s, and these are predicted to increase as the overall U.S. population ages. MCC of the eyelid is uncommon and can be misdiagnosed as other benign inflammatory and neoplastic eyelid disorders. While MCC of the head and neck is often more aggressive than other sites, eyelid MCC shows a lower diseas e specific mortality rate. A biopsy is essential for accurate diagnosis, including an immunohistochemical panel of CK20 and TTF-1, although other markers may be neces...
Source: Clinics in Dermatology - February 5, 2024 Category: Dermatology Authors: Rodolfo Valentini, Jane M. Grant-Kels, Madina Falcone, Campbell L. Stewart Source Type: research

Update on Skin and Eye Diseases: Part III
Ophthalmologists and dermatologists collaborate frequently for diseases that impact the skin and eyes and for lesions located peri-ocularly —close collaboration between our two specialties results in better patient outcomes. In Part III and the last of our series published in Clinics in Dermatology on this topic [1, 2], we will predominantly deal with other neoplastic diseases not yet covered, as well as surgery and laser around the e ye. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - January 30, 2024 Category: Dermatology Authors: Andrzej Grzybowski, Jane M. Grant-Kels Tags: Commentary Source Type: research

Ocular and Orbital Tumors in Childhood
Pediatric tumors of the eye and orbit can be benign or malignant as well as congenital or acquired and are usually distinctively different than those seen in adults.1 Although most of these neoplasms are benign (e.g. dermoid cyst, chalazion or molluscum), their location near and within a vital organ can result in serious dermatologic and ophthalmologic sequelae. Lesions discussed include vascular lesions, retinoblastomas (the most common primary pediatric intraocular malignancy), rhabdomyosarcoma (the most common primary pediatric orbital malignancy), Langerhans cell histiocytosis, and metastatic lesions to the orbit (neur...
Source: Clinics in Dermatology - January 30, 2024 Category: Dermatology Authors: Kathryn Bentivegna, Nicholas J. Saba, Roman Shinder, Jane M. Grant-Kels Source Type: research

Malignancies with a tendency to metastasize to the eyelid or ocular structures
Metastatic tumors to the eye and eyelid are generally seen in patients with disseminated metastases in the setting of advanced disease. Occasionally, they can present as the first sign of occult malignancy. The choroid is the most common site of intraocular metastases secondary to its dense vascular supply. Similar to the eye, metastatic tumors to the eyelid can present with variety of clinical findings and are most often seen in patients with known history of cancer. The most common skin malignancy that can spread to ocular structures is cutaneous melanoma, whereas the most common non-cutaneous malignancy is breast cancer...
Source: Clinics in Dermatology - January 29, 2024 Category: Dermatology Authors: Elnara Muradova, Ashley M. Hine, Madina Falcone, Jane M. Grant Kels, Gillian Weston Source Type: research

Evaluation and management of benign tumors of the eye and eyelid
Benign tumors of the eye and eyelid are common in children and adults, and rarely undergo malignant transformation. Their workup and management have evolved over the years with increasing advancements in surgical and laser therapies. This contribution focuses on describing the following benign eye and eyelid tumors and their diagnostic and treatment approaches: Congenital and acquired melanocytic nevi; Nevus of Ota (Hori nevus); Conjunctival papilloma; Seborrheic keratosis; Epidermoid cyst; Dermoid cyst; Milium; Xanthelasma; Hemangioma (cherry angioma and pyogenic granuloma); Neurofibroma; Neurilemmoma (schwannoma); and Fi...
Source: Clinics in Dermatology - January 26, 2024 Category: Dermatology Authors: Regina Brown, Sara Fard, Paula Feng, Philip E. Kerr Source Type: research