Clinics in Dermatology
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The sudden arrival of Marfan syndrome: the Rust family's experience
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After the wedding we made our first home in a little flat located in a new area, finding a new church and new friends, just like many other young couples that we knew. We were so excited at the birth of our first son in 1968, although noticing that he seemed to be very long – totally filling the crib – and that he had very long slim arms, legs, fingers and toes – and absolutely huge feet! As I breastfed him I remember not quite knowing how to hold him as he seemed to be so big and I, at that time, was very petite! His eyes were beautiful, very bright, and we were absolutely thrilled with the new addition to our fami...
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Diane Rust Tags: Contemporary Dermatology Source Type: journals
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Physicians, and more particularly dermatologists, have always had a bent for discovering the strange and uncommon. Witness the century-old book by Gould and Pyle, Anomalies and Curiosities of Medicine, where the unusual to the macabre are presented, ranging from Duhring's bearded woman to various Siamese twins. More recently, Bondeson gathered additional curiosities in his volume, A Cabinet of Medical Curiosities, such as the two-headed boy of Bengal and the infamous Mary Toft who claimed to have given birth to rabbits. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Lawrence Charles Parish Tags: Contemporary Dermatology Source Type: journals
Chemotherapy and biologic therapies for melanoma: do they work?
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Abstract: The incidence of melanoma is increasing, and the therapeutic options for unresectable disease are limited, resulting in an increase in the death rate. Melanoma is usually resistant to standard chemotherapy, and the response rate for any single agent or combination of agents is 15% to 25%. High-dose interleukin-2 results in prolonged responses in a minority of patients, and biochemotherapy (combinations of chemotherapy, interferon, and interleukin-2) is associated with an improved response rate, but no clear effect on overall survival. A number of promising new agents have entered clinical trials in recent years, ...
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Lucia B. Jilaveanu, Saadia A. Aziz, Harriet M. Kluger Source Type: journals
Obstacles to and opportunities for more effective peptide-based therapeutic immunization in human melanoma
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Abstract: Melanoma cells can play a number of tricks to evade the host immune response. They can make themselves invisible to cells of the immune system poised to attack them, elaborate molecules that are frankly immunosuppressive, and can create a microenvironment that is hostile to cells of the immune system. Efforts are underway to institute measures that would make tumor cells more susceptible to immune attack, but these efforts have not been all that successful so far. This contribution reviews the history and the rationale of cancer vaccines, the major obstacles to peptide-based immunization, and a discussion on how ...
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Swagatam Ray, Arvind Chhabra, Shikhar Mehrotra, Nitya G. Chakraborty, Antoni Ribas, James Economou, Bijay Mukherji Source Type: journals
Mohs micrographic surgery for the treatment of malignant melanoma
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Abstract: Mohs micrographic surgery (MMS) is very successful in the treatment of nonmelanoma skin cancer. Examining 100% of the margin using MMS improves cure rates. This method has obvious appeal in treating melanoma. Evaluating the lateral margins of melanomas using frozen tissue sections is complicated. Some studies have shown that basic frozen sections can be accurate in margin evaluation, but others have shown that they are unreliable. The use of immunostains on frozen sections is one method that may make the analysis of frozen sections more accurate. Other modifications, including the use of rush paraffin sections in...
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: James Whalen, Douglas Leone Source Type: journals
Sentinel lymph node biopsy from the vantage point of an oncologic surgeon
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Abstract: Sentinel lymph node biopsy has greatly influenced the surgical management of clinically localized primary melanoma. Lymphatic mapping and sentinel lymph node biopsy have been used for the selective management of the draining regional lymph node basin of primary cutaneous melanoma. Oncologic surgeons have adopted this procedure to selectively identify occult nodal status in melanoma patients who are at a higher risk of regional metastasis. The current standard of treatment of tumor-positive sentinel lymph node metastasis is immediate completion lymphadenectomy, but considerable debate surrounds the utility of this...
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Lori L. Wilson Source Type: journals
What sentinel node biopsy in patients with melanoma (or patients whose doctors worry that they could have melanoma) might and might not do
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Abstract: The sentinel lymph node biopsy has taught us important lessons about the behavior of melanoma and, perhaps, of melanocytic nevi. It is of proven prognostic importance in patients whose diagnosis of melanoma is clear-cut. Sentinel lymph node biopsy is an imperfect prognostic tool, however, and although the morbidity of the procedure is low, completion lymphadenectomy has a high morbidity rate and unproven benefit. In the setting of a borderline lesion, small nodal deposits must be interpreted with caution. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Philip E. LeBoit Source Type: journals
Unusual variants of malignant melanoma
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Abstract: Melanoma is as diverse in its presentation as it can be in its behavior. This contribution will review the clinical and histologic features of some of the more unusual variants of malignant melanoma that clinicians and pathologists are likely to encounter. There will be a disproportionate focus on the histopathology and prognosis because the clinical presentation of these lesions is in most cases, elusive, and in some cases, frankly deceptive. The discussion will include desmoplastic melanoma, nevoid melanoma, spitzoid melanoma, angiotropic melanoma, and malignant blue nevus. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Raymond L. Barnhill, Kapil Gupta Source Type: journals
Melanoma of the feet: misdiagnosed and misunderstood
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Abstract: Acral lentiginous melanoma of the foot is a relatively rare but often very aggressive variant of melanoma. More commonly identified in patients with darker skin, diagnosis of the lesions is often delayed because the area is not routinely examined by patients or primary care physicians. In addition, these lesions often mimic other entities, including vascular lesions and infections. Greater awareness of this entity and performing appropriate biopsies will result in more timely diagnoses and improved survival. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Douglas Albreski, Steven Brett Sloan Source Type: journals
Spitzoid melanoma
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Abstract: Because spitzoid melanoma shares many histopathologic features with Spitz nevus, it is one of the most difficult lesions to diagnose in dermatopathology. Uncertainty exists in the medical literature about how to diagnose melanocytic proliferations including Spitz nevus and spitzoid melanoma. A misdiagnosis of a melanoma as Spitz nevus is one of the most frequent causes of malpractice lawsuits in surgical pathology and dermatopathology. This contribution provides a review of the clinical presentation, histopathology, ancillary studies, treatment, and the differential diagnosis of spitzoid melanoma. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Hideko Kamino Source Type: journals
Melanoma in the elderly patient: relevance of the aging immune system
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Abstract: The rapidly expanding segment of the aging population with its rising incidence of cutaneous melanoma will present major challenges in therapeutic management. Immune strategies will be important in designing effective treatment of melanoma because it is a highly immunogenic tumor. Aging, however, is associated with dysregulation of the immune system and is likely to affect the success of melanoma treatment in the elderly population. This population represents an ideal in vivo model to study the effects of the aging immune system on the natural history of melanoma in the elderly. We review the epidemiology, histop...
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Upendra P. Hegde, Nitya Chakraborty, Philip Kerr, Jane M. Grant-Kels Source Type: journals
Childhood melanoma
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Abstract: Pediatric melanoma is rare but increasing in incidence. Because early diagnosis and treatment improves prognosis, clinicians need to include it as a possible diagnosis when evaluating a pigmented lesion in a pediatric patient. Some risk factors for melanoma include xeroderma pigmentosum, giant congenital melanocytic nevi, dysplastic nevus syndrome, atypical nevi, many acquired melanocytic nevi, family history of melanoma, and immunosuppression. Definitive treatment is with surgical excision. Adjuvant therapies such as chemotherapy, immunotherapy, and radiation therapy can be used in advanced cases. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Melinda Jen, Michael Murphy, Jane M. Grant-Kels Source Type: journals
Melanoma: part II
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Those of us who read journals like the Wall Street Journal are aware that the public craves medical information. Despite this fact and the fact that athletes (Troy Aikman, Dallas Cowboy quarterback), musicians (Danny Federici, drummer for Bruce Springsteen's band, and Bob Marley, both of whom died of melanoma), news reporters (Sam Donaldson), actors (Ewan MacGregor), and politicians and their families (Maureen Reagan and John McCain) have gone public about their melanomas, much of the population are still visiting tanning parlors, sunbathing and burning on the beaches, and not getting regular cutaneous examinations. (Sourc...
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Jane M. Grant-Kels Source Type: journals
Contents
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(Source: Clinics in Dermatology)
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Source Type: journals
Editorial Board
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(Source: Clinics in Dermatology)
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Source Type: journals
Ethics of selling skin care
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In the July/August 2009 issue of Clinics in Dermatology (volume 27, issue 4, pages 355-8), the name of the senior author should have read: Mari Paz Castanedo-Tardan, MD. The editors regret any confusion this may have caused. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Authors: Mari Paz Castanedo-Tardan, Leslie Baumann Tags: Contemporary Dermatology Source Type: journals
Charles Hilton Fagge (1838-1883): an early skin physician in London
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Charles Hilton Fagge () was born on June 30, 1838, at Hythe in Kent, England, to a family with a medical tradition. His maternal uncle, John Hilton (1804-1878), was an anatomist and surgeon, President of the Royal College of Surgeons, and surgeon extraordinary to Queen Victoria. His father, Charles Fagge, and his grandfather were also physicians. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Authors: Andrzej Grzybowski, Tags: Contemporary Dermatology Source Type: journals
A physician's meanderings on tattooing, body piercing, and suspension practices
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Mrs. Jones was jaundiced and her abdomen was distended. On the left side of her chest, there was a 7/8th inch high blue-black blurry tattoo, O+ (). What was the story behind this tattoo, 53 years old, and placed when the patient was 7 years old? She told me the symbol represented her blood type. She had stood in line together with her class mates. First, her blood was taken with a small prick, and then the tattoo gun pierced her side with pain! Children around her were crying, and some were hiding. The cause was worthy, so her parents had not refused. Her diagnosis was cryptogenic cirrhosis, but what if she really had hepa...
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Authors: Anne Laumann Tags: Contemporary Dermatology Source Type: journals
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Starting out in dermatology as a resident (S.P.), delving into the field and learning about dermatologic diseases can be a daunting task. Although there are numerous texts to study, General Dermatology provides an excellent foundation upon which to build (). The book is divided into 25 chapters. Each topic is presented in a clear and organized fashion, starting with clinical presentation, pathogenesis, and diagnosis, and ending with laboratory testing and treatment. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Authors: Shaily Patel, Maria M. Tsoukas Tags: Contemporary Dermatology Source Type: journals
Cosmeceuticals and patents: the physician and dentist brands
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Abstract: In response to consumer and patient demands for the newest, clinically proven technologies, physicians are increasingly developing and patenting their own products. Patented technologies come in many forms from new bioengineered molecules, to new uses of old compounds, to multiple ingredient complexes that work synergistically. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Authors: Louis C. Paul Source Type: journals
Cosmeceuticals and natural products: wound healing
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Abstract: Despite several technologic and strategic advances in the field, wound care has returned to the roots of medicine and embraced some of the remedies used millennia ago. Some of the many potentially beneficial natural products include the β-glucans, honey, aloe, cocoa, and oak bark extracts. There has recently been a surge of interest for their possible roles in wound healing. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Authors: Stephen C. Davis, Robert Perez Source Type: journals
Clinical and cosmeceutical uses of hydroxyacids
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Abstract: The hydroxyacids are represented by the α-hydroxyacids, β-hydroxyacids, polyhydroxy acids, and bionic acids. Together, these ingredients form a class of compounds with unparalleled benefits to the skin and unprecedented usage in the cosmeceutical market in cosmetic and therapeutic formulations alike. The most commonly used hydroxyacid is glycolic acid, an α-hydroxyacid that has been used extensively in cosmetic antiaging formulations, moisturizers, and peels, and in treatment products to improve hyperpigmentation and acne. The newer polyhydroxy and bionic acids offer the benefits of α-hydroxyacids without irr...
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Authors: Barbara A. Green, Ruey J. Yu, Eugene J. Van Scott Source Type: journals
Cosmeceuticals and peptides
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Abstract: In nature, the majority of chemical reactions, biological responses, and regulatory processes are modulated in some part by specific amino acid sequences. The transfer of these interactive sequences and the biological activities they induce to short, stable, and readily synthesized peptides has created a diverse new field of modulating molecules applicable to dermatology and skin care industries. Areas such as inflammation, pigmentation, cell proliferation and migration, angiogenesis, innate immunity, and extracellular matrix synthesis have yielded peptide candidates for application to this area. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Authors: Lijuan Zhang, Timothy J. Falla Source Type: journals
Cosmeceuticals and silibinin
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Abstract: Cosmeceuticals are used for nourishing and improving the appearance of the skin and are also documented as effective agents for treating various dermatologic conditions. Cosmeceutical preparations from herbal origin are most popular among consumers because these agents are mostly nontoxic and possess strong antioxidant activity. Because oxidative stress is one of the major mechanisms for skin aging and dermatologic conditions, phytochemicals with proven antioxidant activity, such as silibinin, could be useful for treating many dermatologic conditions as well as skin aging. Silibinin is a flavonolignan compound fr...
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Authors: Rana P. Singh, Rajesh Agarwal Source Type: journals
Cosmeceuticals and polyphenols
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Abstract: Phenolic compounds found in plants are believed to be effective in prevention of oxidative stress related diseases. An interest in antioxidants and natural foods continues to grow along with a commercial interest in plant-derived phenolic products. Flavonoids represent a family of plant compounds high in phenolic related antioxidant activity. They are poorly absorbed in the body. Many published studies show the antioxidant activity of the flavonoid, but fail to consider the activity of the metabolite which is actually bioavailable to the body. The paper concludes that there remains a need to develop adequate phys...
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Authors: Howard Epstein Source Type: journals
Cosmeceuticals vitamins
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Abstract: The term cosmeceutical was created over 25 years ago to define products with active substances that cannot be considered cosmetics or drugs. Cosmeceuticals are increasingly popular, with sales representing one of the largest growing segments of the skin care market. These products are found in many forms, including vitamins, peptides, growth factors, and botanical extracts. Cosmeceuticals that contain topically applied vitamins have an increasing role in skin care. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Authors: Mônica Manela-Azulay, Ediléia Bagatin Source Type: journals
Cosmeceuticals and active ingredients
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Abstract: Cosmetic ingredients previously considered “inert” have potential to provide a biologic effect to skin. In a cosmeceutical formulation, the boundary between an “active” and “inert” ingredient may be obscured. For this reason, the cosmeceutical distributor must find a nonambiguous method to demonstrate the efficacy of a new ingredient. For a product to be successful in the marketplace, the benefits of the product must clearly be communicated to the consumer, and the consumer must be satisfied with product performance. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Authors: Karl Lintner, Claire Mas-Chamberlin, Philippe Mondon, Olivier Peschard, Louis Lamy Source Type: journals
Cosmeceutical vehicles
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Abstract: Consumers will pay a premium for high-performance skin and hair care products. The demand exists, and in return for the high cost, consumers expect the product to perform as claimed and to meet aesthetic standards beyond many products found in the mass market. To be successful in this highly competitive market, products must function as claimed or consumers will not repurchase. Effective contemporary high-end products must be properly formulated in nonirritating vehicles that consumers will perceive as elegant. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Authors: Howard Epstein Source Type: journals
Cosmeceuticals: myths and misconceptions
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Abstract: Cosmeceuticals, or physiologically active cosmetics, are subject to many misconceptions. Most consumers mistakenly believe that cosmeceuticals are regulated and tested as drugs. They also believe that the ingredients and final products have been tested for safety and that the claims made in advertisements are valid. Although cosmeceuticals and pharmaceutical ingredients have never been closer together, their regulatory environments are vastly different due to the distinct Congressional mandates given the Food and Drug Administration. Physicians are in a good position to help patients and potential cosmeceutical u...
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Authors: Amy E. Newburger Source Type: journals
Common cosmeceuticals
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Abstract: In the cosmetic arena, many materials are used commercially and claim to provide skin effects (eg, antiaging effects) when used topically. Considering there are so many such materials and many skin appearance effects are encompassed, this short contribution must, by necessity, be selective in terms of the number of materials discussed and the depth with which any particular material is overviewed. This presentation, therefore, focuses on only 10 types of cosmeceutical agents: five vitamins (A, B3, C, E, panthenol), peptides, hydroxyl acids, sugar amines, ceramides, and metals. In particular, this contribution con...
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Authors: Donald L. Bissett Source Type: journals
Cosmeceuticals: undefined, unclassified, and unregulated
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Abstract: The cosmeceutical category is an undefined, unclassified, and unregulated area of dermatology that is yet in its infancy. Traditional cosmeceuticals involve the topical application of biologically active ingredients that affect the skin barrier and overall skin health. The ability of these ingredients to enhance skin functioning depends on how they are formulated into products that can maintain the integrity of the active ingredient, deliver it in a biologically active form to the skin, reach the target site in sufficient quantity to exert an effect, and properly release from the carrier vehicle. In the United St...
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Authors: Zoe Diana Draelos Source Type: journals
Cosmeceuticals versus pharmaceuticals
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Abstract: Four major categories of interest in the cosmeceutical market are nonbleaching agents, antioxidants, peptides, and growth factors. The trend toward introducing natural products considered to be safe is influenced by media hype and consumer interest. This is driving the cosmeceutical market to develop safer products that are naturally derived. Some of these naturally derived products have proven to be helpful, whereas more evidence is needed for other products before physicians can consider recommending their use. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Authors: Mohamed Amer, Mina Maged Source Type: journals
Four decades of cosmeceuticals
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More than 4 decades have passed since the term “cosmeceutical” was introduced. The term continues to be ambiguous today, as it was then. It is generally accepted that a cosmeceutical is a material that will not harm the individual and may indeed be beneficial. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Authors: Howard Epstein Source Type: journals
Contents
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(Source: Clinics in Dermatology)
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Source Type: journals
Editorial Board
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(Source: Clinics in Dermatology)
Source: Clinics in Dermatology - August 20, 2009 Category: Dermatology Source Type: journals
Dermatology at the movies
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Skin diseases frequently are portrayed in cinema, perhaps second only to movies, including psychological and psychiatric subject matter. Plots involving issues of the mind and skin may be attractive to film makers due to the seeming ease of depiction in film. Viewers cannot, of course, directly see the thoughts of film characters, but character speech, behavior, and interactions with other characters allow the audience to vicariously experience portrayals of psychological and psychiatric conditions. Psychologists and psychiatrists have analyzed films with behavioral content that contain topics about which they are expert, ...
Source: Clinics in Dermatology - June 25, 2009 Category: Dermatology Authors: Conner Chan, Richard F. Wagner Tags: Contemporary Dermatology Source Type: journals
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It has been said that if you would be remembered, do something worth remembering. I have had the privilege of reviewing a new reference work about those who have made great contributions in dermatology and are very much worth remembering. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - June 25, 2009 Category: Dermatology Authors: Charles J. Hammer Tags: Contemporary Dermatology Source Type: journals
“I swear!” Physician oaths and their current relevance
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Abstract: Most graduating medical students will take some sort of oath that is to inspire them to take their proper place in the comradeship of physicians and remind them of their obligations to their patients, society, and their profession. The nature of these oaths has changed over the years as society itself has changed. What may be considered moral, ethical, or legal at one time can appear quaint or outrageous in another time and place. Several classic and newer oaths can be compared and contrasted in what they are tasking the newly minted physician to do. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - June 25, 2009 Category: Dermatology Authors: Jeffrey J. Meffert Source Type: journals
Ethics education for dermatology residents
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Abstract: The Accreditation Council for Graduate Medical Education and the Royal College of Physicians and Surgeons of Canada both require the teaching and demonstration of general competencies, which include professionalism and ethics as a condition of training program accreditation and specialty certification, respectively. Residents in dermatology and other specialties perceive their training in ethics is inadequate in numerous areas. Residents and specialists in dermatology encounter numerous ethical and professional issues throughout their workday. A dermatoethics curriculum was developed at The Warren Alpert Medical ...
Source: Clinics in Dermatology - June 25, 2009 Category: Dermatology Authors: Lionel Bercovitch, Thomas P. Long Source Type: journals
The ethics of national health insurance: a personal essay
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Abstract: As the number of uninsured and underinsured American citizens increases, there is new interest in developing some sort of national health plan to ensure what many consider a basic right in industrialized countries. The debate is no longer merely between the “socialized medicine” advocates and those who believe the government should stay completely out of health care delivery. Now between those who agree that some sort of national health plan is necessary, there is conflict between the “incrementalists” and the “revolutionists,” who have differing ideas on how to best expand health care access to those...
Source: Clinics in Dermatology - June 25, 2009 Category: Dermatology Authors: Steven Fenichel Source Type: journals
Volunteering for humanitarian projects
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Abstract: Many professional societies, along with official government missions and nongovernmental organizations, currently work to provide health care and medical education in developing countries and other underserved areas. Before interested physicians volunteer, they must make sure that they are emotionally, physically, and logistically prepared to provide useful assistance. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - June 25, 2009 Category: Dermatology Authors: James J. Nordlund Source Type: journals
Medical experiments on humans and the development of guidelines governing them: the central role of dermatology
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Abstract: The advancement of medical science has come, at times, at the expense of patient comfort and dignity. Over the years, guidelines for human experimentation have become more defined and regulated, often after events in which researchers egregiously abused or neglected their subjects. From this specialty's very beginning, dermatologists have also been guilty of crossing these lines of professional behavior and ethics. Questionable studies sponsored and performed by some of dermatology's most esteemed names continued even into the late 20th century. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - June 25, 2009 Category: Dermatology Authors: Wolfgang Weyers Source Type: journals
Clinical research regulation: challenges to the institutional review board system
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Abstract: The system in place to ensure the ethical conduct of human subject research in accordance with federal regulations has drawn great criticism from all sides, to include clinical investigators, administrators, research subjects, and legislators. The administrative requirements associated with clinical trials has changed dramatically in the last several decades, as has the complexity of the science being regulated. The institutional review board (IRB) system, however, appears to be struggling to keep pace, and has even been labeled a “system in jeopardy” by a national committee of experts. This contribution outl...
Source: Clinics in Dermatology - June 25, 2009 Category: Dermatology Authors: Timothy M. Straight Source Type: journals
Ethical coding
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Abstract: It is ethical, legal, and proper for a dermatologist to maximize income through proper coding of patient encounters and procedures. The overzealous physician can misinterpret reimbursement requirements or receive bad advice from other physicians and cross the line from aggressive coding to coding fraud. Several of the more common problem areas are discussed. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - June 25, 2009 Category: Dermatology Authors: Barry I. Resnik Source Type: journals
Cyberdermatoethics II: a case-based approach to teledermatology ethics
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Abstract: Teledermatology is the use of telecommunication for medical diagnosis and patient care in dermatology. The visual nature of diagnosis in dermatology makes it particularly well suited to the practice of telemedicine. The differences between the two basic types of teledermatology, real-time and store-and-forward, are reviewed. Case scenarios are used to examine some of the ethical and clinical issues that can occur, such as the nature of the doctor-patient relationship, follow-up of incidental diagnoses, limitations of telemedicine, privacy issues, and licensing. Guidelines for the use of telemedicine in dermatolog...
Source: Clinics in Dermatology - June 25, 2009 Category: Dermatology Authors: Nicole Grenier, Lionel Bercovitch, Thomas P. Long Source Type: journals
Cyberdermatoethics I: ethical, legal, technologic, and clinical aspects of patient-physician e-mail
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Abstract: As Internet access has become ubiquitous, electronic mail (e-mail) is becoming more widely used as a means of communication between patient and dermatologist. Dealing with the ethical, legal, and clinical consequences has lagged behind the technology. Privacy of e-mail cannot exist without security, and as a foundation for understanding e-mail security, the elements of e-mail technology are reviewed. One of the greatest risks of e-mail is compromise of privacy. Although self-documenting and convenient, e-mail lacks the emotional cues of face-to-face encounters, is asynchronous and not always read in timely fashio...
Source: Clinics in Dermatology - June 25, 2009 Category: Dermatology Authors: John Luo, Christopher Logan, Thomas P. Long, Lionel Bercovitch Source Type: journals
Ethics of selling skin care
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Abstract: One of the most controversial topics surrounding the practice of dermatology is in-office dispensing of nonprescription skin care products by dermatologists. The controversy is not new, with legitimate arguments debated for and against it. The ongoing debate will continue, emotionally charged and with sharply demarcated battle lines, but without the promise of ever reaching a consensus. Regardless of one's position, the objective is to develop strategies to improve the practice of dermatology and the welfare of patients. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - June 25, 2009 Category: Dermatology Authors: Mari Paz Castanedo-Tardan, Leslie Baumann Source Type: journals
Sentinel lymph node biopsy and completion lymph node dissection for malignant melanoma are not standard of care
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Abstract: Malignant melanoma is a cutaneous malignancy characterized by high metastatic potential and an unpredictable course. Enormous amounts of research have been done into surgical and adjunctive therapies for melanoma. Given the regularity with which sentinel lymph node biopsy and completion lymph node dissection are performed at private and academic hospitals, it would seem that evidence supporting these procedures is not controversial. A growing body of studies, however, points to sentinel lymph node biopsy and completion lymph node dissection as ineffective treatment for malignant melanoma and necessitates a discus...
Source: Clinics in Dermatology - June 25, 2009 Category: Dermatology Authors: Brett M. Coldiron, Scott Dinehart, Howard W. Rogers Source Type: journals
No more pens: what the 2009 Pharmaceutical Research and Manufacturer's Association code changes really mean
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Abstract: In 2002, new guidelines for interactions with the pharmaceutical industry and physicians were published as an official code of conduct. Adherence to the guidelines was voluntary, and there were no provisions for discipline to companies who did not subscribe to the code or who subscribed but did not comply. Many of the code standards are routinely violated, sometimes egregiously, with many violations on easy display at national professional meetings. In response to further problems and complaints, tougher code standards—now famous for the specific ban on logo pens and coffee cups—were adopted in 2009. Subscrip...
Source: Clinics in Dermatology - June 25, 2009 Category: Dermatology Authors: Jeffrey J. Meffert Source Type: journals
The ethics of consulting with pharmaceutical companies
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Abstract: Acting as a speaker or consultant to the pharmaceutical industry, while adding to a physician's recognition and income, serves a vital role in graduate and postgraduate medical education. Such activities work, especially when one becomes involved with several different companies or organizations, can expose the speaker and researcher to a number of potential ethical conflicts. These include publication and prescribing bias. These also lead to the real or apparent conflict of interest when the consultant receives unearned, unjustified, or excessive compensation and gifts. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - June 25, 2009 Category: Dermatology Authors: Andrew Miner, Alan Menter Source Type: journals
