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IndexEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinics in Perinatology)
Source: Clinics in Perinatology - August 31, 2009 Category: Perinatology & Neonatology Source Type: journals

Fetal Neurological Assessment Using Noninvasive MagnetoencephalographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SQUID Array for Reproductive Assessment is a unique magnetoencephalography device designed for the noninvasive recording of fetal brain activity. In this article, we provide a general overview of the technology and its potential application to fetal medicine. A large number of studies that have been conducted and published describing this device since it was brought into operation are referenced throughout the article. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - August 31, 2009 Category: Perinatology & Neonatology Authors: Curtis L. Lowery, Rathinaswamy B. Govindan, Hubert Preissl, Pam Murphy, Hari Eswaran Source Type: journals

The Current State and Future of Fetal ImagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fetal magnetic resonance imaging (MRI) may add important diagnostic information to prenatal sonography and has the power to confirm or change decisions at critical points in clinical care. Recent studies have shown MRI to be a critical clinical adjunct in the evaluation of the developing central nervous system (CNS), especially at early gestational ages, and MRI has been used in three significant ways: (1) for the quantification of brain growth and structural abnormalities using biometry, (2) for the qualitative evaluation of CNS microstructure, and (3) for the qualitative assessment of dynamic fetal movements in utero. (S...
Source: Clinics in Perinatology - August 31, 2009 Category: Perinatology & Neonatology Authors: Romy Chung, Gregor Kasprian, Peter C. Brugger, Daniela Prayer Source Type: journals

Probing the Fetal Cardiac Signal for Antecedents of Brain InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Obstetric care providers and researchers have long relied on analysis of the fetal heart rate tracing for insight into the fetal neurologic status. Although a normal fetal heart rate tracing does provide reassurance of intact neurologic function, an abnormal pattern is a very poor predictor of newborn brain injury. Indeed, if the clinical end point of interest is cerebral palsy, a non-reassuring fetal heart rate tracing has a 99% false positive rate. More recent analyses of fetal heart rate variability and fetal ECG waveforms, however, hold promise for improved diagnostic accuracy. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - August 31, 2009 Category: Perinatology & Neonatology Authors: Adam J. Wolfberg, Errol R. Norwitz Source Type: journals

The Fetal Heart Rate Response to Hypoxia: Insights from Animal ModelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article examines recent studies that have systematically dissected features of fetal heart rate responses to labor that may help identify developing fetal compromise, such as the slope of the deceleration, overshoot, and variability. Although repeated deep decelerations are never necessarily benign, fetuses with normal placental reserve can fully compensate even for frequent deep but brief decelerations for surprisingly prolonged intervals before developing profound acidosis and hypotension. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - August 31, 2009 Category: Perinatology & Neonatology Authors: Laura Bennet, Alistair Jan Gunn Source Type: journals

Fetal Infections and Brain DevelopmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Current microbial diagnostics enable rapid and specific identification of the agents causing intrauterine and perinatal infections, and CT and MRI allow precise characterization of the central nervous system effects of these pathogens. Although infections with Toxoplasma gondii, Toxoplasma pallidum, Toxoplasma cruzi, and cytomegalovirus cannot currently be prevented by immunization, postnatal therapy of infected neonates can substantially improve outcome. Therapy with acyclovir should be initiated whenever perinatal herpes simplex virus encephalitis is suspected. Despite these strategies, intrauterine and perinatal infecti...
Source: Clinics in Perinatology - August 31, 2009 Category: Perinatology & Neonatology Authors: James F. Bale Source Type: journals

Primary Disorders of Metabolism and Disturbed Fetal Brain DevelopmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article explores the association of malformations of cerebral development reported in association with inborn errors of metabolism, and speculates on potential mechanisms by which such malformations arise. The detection of cerebral malformations prenatally should lead to a search for both genetic etiologies and inborn errors of metabolism in the fetus. Improving the changes of an early diagnosis provides for timely therapeutic interventions and it is hoped a brighter future for affected children and their families. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - August 31, 2009 Category: Perinatology & Neonatology Authors: Asuri N. Prasad, Gustavo Malinger, Tally Lerman-Sagie Source Type: journals

Fetal Effects of Psychoactive DrugsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article describes the effects of three drugs with similar molecular targets that involve monoaminergic transmitter systems: cocaine, methamphetamine, and selective serotonin re-uptake inhibitors (SSRIs) used to treat maternal depression during pregnancy. We propose a possible common epigenetic mechanism for their potential effects on the developing child. We suggest that exposure to these substances acts as a stressor that affects fetal programming, disrupts fetal placental monoamine transporter expression and alters neuroendocrine and neurotransmitter system development. We also discuss neurobehavioral techniques tha...
Source: Clinics in Perinatology - August 31, 2009 Category: Perinatology & Neonatology Authors: Amy L. Salisbury, Kathryn L. Ponder, James F. Padbury, Barry M. Lester Source Type: journals

Fetal Hypoxia Insults and Patterns of Brain Injury: Insights from Animal ModelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The outcome of perinatal hypoxiaischemia is highly variable, with only a very broad relationship to the ‘severity’ of oxygen debt as shown by peripheral base deficit and the risk of damage. The present article examines the pathophysiology of asphyxial injury. We dissect the multiple factors that modify the risk of injury, including the depth (‘severity’), duration, and repetition of the insult, the maturity, and condition of the fetus, pre-existing hypoxia, and exposure to pyrexia and infection/inflammation. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - August 31, 2009 Category: Perinatology & Neonatology Authors: Alistair Jan Gunn, Laura Bennet Source Type: journals

Disorders of the Fetal Circulation and the Fetal BrainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Even in the presence of normal placental function, cerebral oxygen-substrate supply may be disrupted by disturbances in the fetal circulation caused by anomalous cardiac development. The impact of these cardiac lesions is likely dictated primarily by the volume and oxygen-substrate composition of transverse aortic arch perfusion. Advances in fetal echocardiography, fetal Doppler ultrasound, and advanced fetal magnetic resonance imaging techniques capable of quantitative structural and functional measurements are providing major insights into the in vivo effects of these cardiac lesions on brain growth and development. The ...
Source: Clinics in Perinatology - August 31, 2009 Category: Perinatology & Neonatology Authors: Catherine Limperopoulos Source Type: journals

Disorders of Placental Circulation and the Fetal BrainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Disorders of the placental circulation, including the release of deleterious mediators to the fetus, are important risk factors for central nervous system complications. These disorders result in discrete patterns of placental injury detectable by a thorough placental pathologic examination. Consideration of the location, severity, multiplicity, and timing of these lesions is critical to a full understanding of their significance. Less than 10% of placentas from term infants that later develop cerebral palsy lack any evidence of placental abnormalities potentially related to adverse outcome. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - August 31, 2009 Category: Perinatology & Neonatology Authors: Raymond W. Redline Source Type: journals

Cerebral Blood Flow and Metabolism in the Developing FetusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The inaccessibility of the human fetal brain to studies of perfusion and metabolism has impeded progress in the understanding of the normal and abnormal systems of oxygen substrate supply and demand. Consequently, current understanding is based on studies in fetal animals or in the premature infant (ex utero fetus), neither of which is ideal. Despite promising developments in fetal magnetic resonance imaging (MRI) and Doppler ultrasound, major advances in fetal neurodiagnostics will be required before rational and truly informed brainoriented care of the fetus becomes feasible. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - August 31, 2009 Category: Perinatology & Neonatology Authors: Adré J. du Plessis Source Type: journals

Development of the Human Cerebellum and Its DisordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The cerebellum arises from two anatomically and molecularly different proliferative compartments: the cerebellar ventricular zone and the rhombic lip. The protracted development makes the cerebellum vulnerable to a broad spectrum of developmental disorders, of which the more frequent (the Dandy-Walker and related malformations and the pontocerebellar hypoplasias) are discussed in this article. Several genes for congenital malformations of the human cerebellum have recently been identified, including genes causing Joubert syndrome, the Dandy-Walker malformation, and pontocerebellar hypoplasias. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - August 31, 2009 Category: Perinatology & Neonatology Authors: Hans J. ten Donkelaar, Martin Lammens Source Type: journals

The Molecular and Genetic Mechanisms of Neocortex DevelopmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews key recent findings in the field of human cortical development. This development is divided into three major time-dependent phases: neural proliferation of inhibitory and excitatory neurons in spatially distinct regions, migration through multiple cellular boundaries, and maturation through morphologic changes that result in the elaboration of dendrites and axons and that establish the multitude of cellular contacts that underlie neuronal processing. Many of the neurocognitive disorders treated in the clinic can trace their origin to a disorder in one or more of these key steps. Along with this update,...
Source: Clinics in Perinatology - August 31, 2009 Category: Perinatology & Neonatology Authors: Alejandro L. Diaz, Joseph G. Gleeson Source Type: journals

PrefaceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
That events in the fetal period may be critical determinants of lifelong neuropsychological function is not a new concept. However, the vast extent and diversity of fetal experiences and the broad spectrum of their postnatal impact are rapidly achieving greater recognition. Two apparently parallel avenues begin at this time to intersect in an enticing way. First, the accelerating field of neurogenetics is vitalizing our understanding of the highly programmed process of brain development and, in cases of brain dysgenesis, its derailment. Second, investigations of internal and external environmental influences are greatly ex...
Source: Clinics in Perinatology - August 31, 2009 Category: Perinatology & Neonatology Authors: Adré J. du Plessis Source Type: journals

Forthcoming IssuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinics in Perinatology)
Source: Clinics in Perinatology - August 31, 2009 Category: Perinatology & Neonatology Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinics in Perinatology)
Source: Clinics in Perinatology - August 31, 2009 Category: Perinatology & Neonatology Source Type: journals

IndexEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Tags: Research/Future Directions Source Type: journals

Fetal Tissue EngineeringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article offers an outlook on a relatively new dimension in fetal cell-based therapies, namely the engineering of tissues in the laboratory, along with its prospective applications. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Authors: Christopher G.B. Turner, Dario O. Fauza Tags: Research/Future Directions Source Type: journals

Prenatal Stem Cell Transplantation and Gene TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
At the present time, the most likely and eminent application of stem cell therapy to the fetus is in utero hematopoietic stem cell transplantation (IUHCT), and this stem cell type will be discussed as a paradigm for all prenatal stem cell therapy. The authors feel that the most likely initial application of IUHCT will use adult HSC derived from bone marrow (BM) or peripheral blood (PB), and will focus this article on this specific approach. The article also reviews the experimental data that support the capacity of IUHCT to induce donor-specific tolerance. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Authors: Matthew T. Santore, Jessica L. Roybal, Alan W. Flake Tags: Research/Future Directions Source Type: journals

Cardiac Anomalies in the FetusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article focuses on the current status of in utero catheter interventions for CHD with particular interest in therapy for defects characterized by progressive stenosis or atresia of the semilunar valves, the aortic and pulmonary, with development of subsequent ventricular hypoplasia. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Authors: Christopher G.B. Turner, Wayne Tworetzky, Louise E. Wilkins-Haug, Russell W. Jennings Tags: Specific Diseases Source Type: journals

Fetal Surgery for MyelomeningoceleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fetal intervention for myelomeningocele (MMC) may improve hydrocephalus and hindbrain herniation associated with the Arnold-Chiari II malformation and may reduce the need for ventriculoperitoneal shunting. As of now, there is little evidence that prenatal repair of MMC improves neurologic function. MMC is the first nonlethal disease under consideration and study for fetal surgery. As a result, potential improvements in outcome must be balanced with maternal safety and well-being, in addition to that of the unborn patient. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Authors: Shinjiro Hirose, Diana L. Farmer Tags: Specific Diseases Source Type: journals

Complicated Monochorionic Twin Pregnancies: Updates in Fetal Diagnosis and TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Monochorionic (MC) twin pregnancies may develop significant complications, and twin-to-twin transfusion syndrome (TTTS) has become among the best known to obstetricians and patients alike. A significant percentage of patients referred for suspected TTTS have a different underlying pathologic condition, however, and differentiating the subcategories of MC pathophysiologic conditions may change treatment course and outcome. The key to understanding complicated MC pregnancies lies in the placental angioarchitecture and intertwin vascular communications between the fetuses. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Authors: Larry Rand, Hanmin Lee Tags: Specific Diseases Source Type: journals

Twin-to-Twin Transfusion Syndrome: A Comprehensive UpdateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article presents an overview of what is known about the pathophysiology and the diagnosis of TTTS, the role of echocardiography in TTTS, treatment options available for TTTS, complications of treatment for TTTS, and short- and long-term outcomes of TTTS. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Authors: Mounira Habli, Foong Yen Lim, Timothy Crombleholme Tags: Specific Diseases Source Type: journals

Fetal Lower Urinary Tract ObstructionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors present an overview of the prenatal diagnosis, evaluation, contemporary intervention, and antenatal management of lower urinary tract obstruction. They review early experimental models that confirmed the relation between urinary tract obstruction and renal fibrocystic dysplasia and that early in utero relief of the obstruction could prevent irreversible renal injury. Subsequent studies of the electrolyte and protein concentrations in fetal urine from human cases established prognostic threshold values and helped to develop an algorithm to select candidates for antenatal therapy. Although shunting has improved s...
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Authors: Serena Wu, Mark Paul Johnson Tags: Specific Diseases Source Type: journals

Management of Fetal Lung LesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prenatal diagnosis provides insight into the in utero evolution of fetal thoracic lesions such as congenital cystic adenomatoid malformation (CCAM), bronchopulmonary sequestration (BPS), congenital lobar emphysema, and mediastinal teratoma. Serial sonographic study of fetuses with thoracic lesions has helped define the natural history of these lesions, determine the pathophysiologic features that affect clinical outcome, and formulate management based on prognosis. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Authors: N. Scott Adzick Tags: Specific Diseases Source Type: journals

Tracheal Occlusion for Fetal Congenital Diaphragmatic Hernia: The US ExperienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the experimental basis of fetal therapy for CDH and the US clinical experience with tracheal occlusion. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Authors: Eric Jelin, Hanmin Lee Tags: Specific Diseases Source Type: journals

Changing Perspectives on the Perinatal Management of Isolated Congenital Diaphragmatic Hernia in EuropeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Congenital diaphragmatic hernia (CDH) should be diagnosed in the prenatal period and prompt referral to a tertiary referral center for imaging, genetic testing, and multidisciplinary counseling. Individual prediction of prognosis is based on the absence of additional anomalies, lung size, and liver herniation. In severe cases, a prenatal endotracheal balloon procedure is currently being offered at specialized centers. Fetal intervention is now also offered to milder cases within a trial, hypothesizing that this may reduce the occurrence of bronchopulmonary dysplasia in survivors. Postnatal management has been standardized ...
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Authors: Jan A. Deprest, Eduardo Gratacos, Kypros Nicolaides, Elise Done, Tim Van Mieghem, Leonardo Gucciardo, Filip Claus, Anne Debeer, Karel Allegaert, Irwin Reiss, Dick Tibboel Tags: Specific Diseases Source Type: journals

The Role of Fetal Echocardiography in Fetal Intervention: A Symbiotic RelationshipEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this review, the authors explore the role of noninvasive and invasive fetal interventions in fetal cardiovascular disease guided by observations at fetal echocardiography. They first review fetal cardiac lesions that may be ameliorated by fetal intervention and then review noncardiac fetal pathologic findings for which fetal echocardiography can provide important insight into the pathophysiology and aid in patient selection for and timing of intervention and postintervention surveillance. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Authors: Priya Sekar, Lisa K. Hornberger Tags: Imaging Source Type: journals

MRI of the Fetal Central Nervous System and BodyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
MRI is being increasingly used to assess for fetal abnormalities. Although significant progress in the field of fetal MRI has occurred during the past 20 years, continued technical advances will likely contribute to significant growth of the field. Moreover, with continued hardware and software improvements, additional MRI sequences will likely become available. Prenatal MRI complements ultrasound because of larger field-of-view, superior soft tissue contrast, easier and more precise volumetric measurement, and greater accuracy in the demonstration of intracranial and spinal abnormalities. While ultrasound remains the pri...
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Authors: Orit A. Glenn, Fergus V. Coakley Tags: Imaging Source Type: journals

The Use of Ultrasound in Fetal SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Obstetric ultrasound (US) is an integral part of fetal surgery for open and minimally invasive techniques. With advances in US imaging, the ability to refine diagnosis, predict prognosis, and contribute to fetal treatment continues to grow. Current research in fetal diagnosis and treatment includes identifying the most reliable sonographic features for determining prognosis before and after surgery. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Authors: Linda M. Hopkins, Vickie A. Feldstein Tags: Imaging Source Type: journals

The Maternal Side of Maternal–Fetal SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The term fetal surgery is used widely for fetal intervention during pregnancy; maternal–fetal surgery may be more appropriate, because all these invasive procedures also affect the mother. Although there is no direct benefit to the mother from these procedures, the risk to her is for a purely altruistic purpose. It is therefore important to understand the potential complications of maternal–fetal surgery, so the physician can provide accurate counseling to the patient. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Authors: Danny Wu, Robert H. Ball Tags: Overview Source Type: journals

Ethics of Fetal SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article provides a comprehensive approach to the ethics of clinical investigation of fetal surgery. Investigators should address the initiation and assessment of clinical trials to determine whether they establish a standard of care and use an appropriate informed consent process to recruit and enroll subjects, consider whether selection criteria should include the abortion preferences of the pregnant woman, and consider whether physicians have an obligation to offer referral to such investigation. This approach is comprehensive because it takes account of the physician's obligations to the fetal patient, the pregnant...
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Authors: Frank A. Chervenak, Laurence B. McCullough Tags: Overview Source Type: journals

A History of Fetal SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article offers a concise overview of the history of fetal surgery, from its tumultuous early days to its current status as an important means for the early treatment of potentially devastating congenital anomalies. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Authors: Tim Jancelewicz, Michael R. Harrison Tags: Overview Source Type: journals

Drugs of Choice for Sedation and Analgesia in the Neonatal ICUEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article discusses the indications for and advantages and disadvantages of the commonly used analgesic drugs. Guidance and references for drugs and dosing for specific neonatal procedures are provided. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Authors: R. Whit Hall, Rolla M. Shbarou Source Type: journals

ErratumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A drug dosage error appeared in the March 2009 issue of Clinics in Perinatology, Volume 36, No. 1, in the article “Drugs of Choice for Sedation and Analgesia in the Neonatal ICU” by R. Whit Hall and Rolla M. Shbarou. In Table 1, the dose for Remifentanil was listed as 1 mg/kg. The correct dosage should be 1 mcg/kg. As a matter of policy, this article has been removed from the March 2009 issue on record. A corrected version of the article is republished in its entirety in the June 2009 issue. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Source Type: journals

PrefaceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fetal surgery is a multidisciplinary field that relies on the participation and expertise of perinatologists, radiologists, neonatologists, pediatric/fetal surgeons, pediatric cardiologists, social workers, and a variety of other clinicians and support staff. Coordinating input from many different specialists is critical in overcoming the particular challenges of diagnosing and treating maternal–fetal patients. This issue of Clinics in Perinatology devoted to fetal surgery covers the history of the field, maternal considerations, diagnostic considerations, and ethical concerns, as well as specific diseases that may be am...
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Authors: Hanmin Lee Source Type: journals

Forthcoming issuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 31, 2009 Category: Perinatology & Neonatology Source Type: journals

IndexEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinics in Perinatology)
Source: Clinics in Perinatology - March 1, 2009 Category: Perinatology & Neonatology Source Type: journals

The Role of Genomics in the Neonatal ICUEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article provides the reader with an overview of the issues in technology and study design relating to genome-wide association studies and summarizes the current state of association studies in neonatal ICU populations with a brief review of the relevant literature. Future recommendations for genomic association studies in neonatal ICU populations are also provided. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - March 1, 2009 Category: Perinatology & Neonatology Authors: Karen Maresso, Ulrich Broeckel Source Type: journals

Postnatal Corticosteroids for Bronchopulmonary DysplasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Corticosteroids are used to improve lung function in infants who are progressing toward bronchopulmonary dysplasia. Corticosteroids facilitate extubation, but there is conflicting information about adverse effects on the developing brain. An approach to minimizing risk is to use low-dose, short-duration treatments in the highest risk ventilator-dependent patients. Questions remain about which corticosteroid is the safest and how to dose that corticosteroid. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - March 1, 2009 Category: Perinatology & Neonatology Authors: Alan H. Jobe Source Type: journals

Optimizing Growth in the Preterm InfantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article examines several of these issues, including the controversies regarding optimal postnatal growth velocity, early aggressive nutritional support, and the transition to enteral nutrition in preterm infants. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - March 1, 2009 Category: Perinatology & Neonatology Authors: Michael R. Uhing, Utpala (Shonu) G. Das Source Type: journals

Controversies in the Treatment of Gastroesophageal Reflux Disease in Preterm InfantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gastroesophageal reflux (GER) is common in preterm infants and usually is a physiologic phenomenon with little clinical consequence. GER resulting in clinical signs and symptoms is considered pathologic gastroesophageal reflux disease (GERD). Correlation of clinical signs and symptoms with GER has been poor in most studies. The efficacy of GERD therapy has not been studied systematically in preterm infants. Furthermore, GERD therapy, particularly with prokinetic agents and surgery, carries potential risks that must be considered before initiation of therapy. Alternative diagnoses, pretreatment diagnostic testing, and desir...
Source: Clinics in Perinatology - March 1, 2009 Category: Perinatology & Neonatology Authors: Neelesh A. Tipnis, Sajani M Tipnis Source Type: journals

Screening for Maternal Depression in the Neonatal ICUEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Postpartum depression is common in women with infants in the neonatal ICU. Maternal depression can affect infant health and development adversely. A screening program for depression in the neonatal ICU could identify women who have depressive symptoms and facilitate their referral for follow-up services. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - March 1, 2009 Category: Perinatology & Neonatology Authors: Kyle O. Mounts Source Type: journals

Evaluation and Management of Stroke in the NeonateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ischemic perinatal stroke (IPS) occurs in 1 of 2300 to 5000 live births. It is an under-recognized cause of significant long-term disabilities, including hemiplegic cerebral palsy, epilepsy, cognitive delays, and behavioral impairments. The pathophysiology is complex and multifactorial, involving maternal, fetal, placental, and neonatal factors. Knowledge and interventions are emerging to facilitate early diagnosis and treatment of IPS. Early treatment may translate into improved long-term neurodevelopmental outcomes. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - March 1, 2009 Category: Perinatology & Neonatology Authors: Alan R. Barnette, Terrie E. Inder Source Type: journals

Anemia in the Preterm Infant: Erythropoietin Versus Erythrocyte Transfusion—It's not that SimpleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since the late 1980s recombinant human erythropoietin (r-EPO) has been studied as an alternative to packed red blood cell (RBC) transfusion for the treatment of anemia of prematurity in very low birth weight infants. Initial trials and reports focused on r-EPO's ability to prevent or treat anemia of prematurity with the goal of eliminating RBC transfusion but achieved limited success. New concerns about the safety of r-EPO administration have emerged. Past cost–benefit analyses of r-EPO administration versus transfusion for the treatment of anemia of prematurity have been nearly balanced. Autologous transfusion, blood-sp...
Source: Clinics in Perinatology - March 1, 2009 Category: Perinatology & Neonatology Authors: Isabelle Von Kohorn, Richard A. Ehrenkranz Source Type: journals

Short Bowel Syndrome: How Short is Too Short?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article discusses the prognostic factors that predict weaning from parenteral nutrition in SBS. The article also delineates an approach to enteral feeding in SBS. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - March 1, 2009 Category: Perinatology & Neonatology Authors: Praveen S. Goday Source Type: journals

Indications for Home Apnea Monitoring (or Not)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article focuses on issues that affect decision making regarding the use of home monitors in these two groups of infants and reviews existing data to guide a decision to discontinue monitoring at hospital discharge or to prescribe monitoring in the home. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - March 1, 2009 Category: Perinatology & Neonatology Authors: Jean M. Silvestri Source Type: journals

Evaluation and Treatment of Hypotension in the Preterm InfantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A large proportion of very preterm infants receive treatment for hypotension. The definition of hypotension is unclear, and, currently, there is no evidence that treating it improves outcomes or, indeed, which treatment to choose among the available alternatives. Assessment of circulatory adequacy of the preterm infant requires a careful clinical assessment and may also require ancillary investigations. The most commonly used interventions, fluid boluses and dopamine, are problematic: fluid boluses are statistically associated with worse clinical outcomes and may not even increase blood pressure, whereas dopamine increases...
Source: Clinics in Perinatology - March 1, 2009 Category: Perinatology & Neonatology Authors: E.M. Dempsey, K.J. Barrington Source Type: journals