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Use of Fertility Drugs and Risk of Uterine Cancer: Results From a Large Danish Population-based Cohort StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Some epidemiologic studies have indicated that uterine cancer risk may be increased after use of fertility drugs. To further assess this association, the authors used data from a large cohort of 54,362 women diagnosed with infertility who were referred to Danish fertility clinics between 1965 and 1998. In a case-cohort study, rate ratios and 95% confidence intervals were used to assess the effects of 4 groups of fertility drugs on overall risk of uterine cancer after adjustment for potentially confounding factors. Through mid-2006, 83 uterine cancers were identified. Ever use of any fertility drug was not associated with u...
Source: American Journal of Epidemiology - November 18, 2009 Category: Epidemiology Authors: Jensen, A., Sharif, H., Kjaer, S. K. Tags: RESEARCH-ARTICLE Source Type: journals

Use of Fertility Drugs and Risk of Uterine Cancer: Results From a Large Danish Population-based Cohort Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Some epidemiologic studies have indicated that uterine cancer risk may be increased after use of fertility drugs. To further assess this association, the authors used data from a large cohort of 54,362 women diagnosed with infertility who were referred to Danish fertility clinics between 1965 and 1998. In a case-cohort study, rate ratios and 95% confidence intervals were used to assess the effects of 4 groups of fertility drugs on overall risk of uterine cancer after adjustment for potentially confounding factors. Through mid-2006, 83 uterine cancers were identified. Ever use of any fertility drug was not associated wi...
Source: Am J Epidemiol - November 1, 2009 Category: Epidemiology Authors: Jensen A, Sharif H, Kjaer SK Tags: Am J Epidemiol Source Type: journals

Treatment of clomiphene citrate-related ovarian cysts in a prospective randomized study. A single center experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Any treatment might be appropriate for patients with a CC-related ovarian cyst. However, there is no evidence to administer OC for treating CC-related ovarian cysts. Expectant management may also achieve similar success rates. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - October 22, 2009 Category: OBGYN Authors: Sunduz Ozlem Altinkaya, Betul Bayir Talas, Tayfun Gungor, Cavidan Gulerman Tags: Clinical Investigations Source Type: journals

Using Clomid After Tubal Reversal SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Some women fail to become pregnant after tubal reversal surgery because they do not ovulate regularly. The cause may be that their pituitary glands don't produce enough follicle stimulating hormone (FSH) and luteinizing hormone (LH) at the right time during the cycle. For these women, the medication most doctors prescribe is clomiphene citrate (Clomid). Chapel Hill Tubal Reversal Center patients and message board members discuss the use of Clomid after tubal reversal surgery and inquire whether others have experienced changes in their cycle while using Clomid. (Source: Tubal Ligation Reversal News)
Source: Tubal Ligation Reversal News - October 21, 2009 Category: Reproduction Medicine Source Type: organizations

Comparison of mild stimulation and conventional stimulation in ART outcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Clomiphene + delayed low dose gonadotropin + flexible GnRH − antagonist stimulation is an acceptable alternative protocol for IVF in patients with regularly menstruation. Content Type Journal ArticleCategory Reproductive MedicineDOI 10.1007/s00404-009-1252-4Authors Mohammad Ali Karimzadeh, Shahid Sadoughi University of Medical Science Department of Obstetrics and Gynecology, Research and Clinical Center for Infertility Bouali Ave, Safaieh 8916877391 Yazd IranShahnaz Ahmadi, Shahid Sadoughi University of Medical Science Department of Obstetrics and Gynecology, ...
Source: Archives of Gynecology and Obstetrics - October 15, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

The value of measuring anti-Mullerian hormone in women with anovulatory polycystic ovary syndrome undergoing laparoscopic ovarian diathermyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Pretreatment circulating AMH level seems to be a good predictor of the ovarian response to LOD. (Source: Human Reproduction)
Source: Human Reproduction - October 15, 2009 Category: Reproduction Medicine Authors: Amer, S.A., Li, T.C., Ledger, W.L. Tags: Infertility Source Type: journals

Buy clomid onlineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Nature Network London - Upcoming Events - October 12, 2009 Category: Science Source Type: events

Tamoxifen use during OI improves endometrial thicknessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Switching to tamoxifen in ovulation induction cycles started with clomiphene citrate improves endometrial thickness in women with an adequate follicular recruitment and endometrial thickness under 7 mm, show US study results. (Source: MedWire News - Ob/Gyn)
Source: MedWire News - Ob/Gyn - September 28, 2009 Category: OBGYN Source Type: news

Polycystic ovarian syndrome: diagnosis and management of related infertilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Polycystic ovarian syndrome (PCOS) is the most common cause of anovulatory infertility accounting for about 75% of cases. It is defined as a syndrome of ovarian dysfunction associated with hyperandrogenism and polycystic ovary morphology. The diagnosis of PCOS is based on the presence of at least two of three criteria including: (1) olig-/anovulation; (2) hyperandrogenaemia (clinical and/or biochemical); and (3) polycystic ovaries on ultrasound scan. Several treatment options are available for women with anovulatory infertility related to PCOS including weight reduction, clomiphene citrate (CC), gonadotropins, la...
Source: Obstetrics, Gynaecology and Reproductive Medicine - September 22, 2009 Category: OBGYN Authors: Saad A.K. Amer Tags: Reviews Source Type: journals

CLOMIPHENE CITRATEtablet [Par Pharmaceutical Inc]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Sep 22, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - September 22, 2009 Category: Drugs & Pharmacology Source Type: organizations

Clomiphene citrate and testosterone gel replacement therapy for male hypogonadism: efficacy and ...Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rush University Medical Center-Department of Urology, Chicago, IL, USA. (Source: UroToday)
Source: UroToday - September 14, 2009 Category: Urology & Nephrology Tags: Browse Categories - Androgen Deficiency Source Type: info

Comparison of metformin treatment and laparoscopic ovarian diathermy in patients with polycystic ovary syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Objective: To compare hormone levels and clinical outcomes in patients with polycystic ovary syndrome (PCOS) after metformin therapy or laparoscopic ovarian diathermy (LOD) at 6 months follow-up.Methods: A randomized trial was conducted in 126 patients with PCOS who had a history of infertility for at least 1 year and resistance to clomiphene citrate (CC). Patients (n=63) received metformin treatment or underwent LOD (n=63).Results: Levels of follicle-stimulating hormone did not change in either group after the intervention (P>0.05). Serum levels of testosterone (P (Source: International Journal of Gynaecology and Obstetrics)
Source: International Journal of Gynaecology and Obstetrics - September 4, 2009 Category: OBGYN Authors: Mansoor Ashrafinia, Reihaneh Hosseini, Ashraf Moini, Bita Eslami, Zahra Asgari Tags: Clinical articles Source Type: journals

Ultrasound-Guided Transvaginal Ovarian Needle Drilling (UTND) for Treatment of Polycystic Ovary Syndrome: A Randomized Controlled TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews a novel ovarian drilling technique for the ovaries in women with polycystic ovary syndrome (PCOS). The authors, in Mansoura, Egypt, randomized 163 women with PCOS refractory to clomiphene citrate treatment (defined as 100mg/d and/or ovulatory response but an endometrial lining (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - August 31, 2009 Category: OBGYN Authors: Gary N. Frishman Tags: Capsule Summaries Source Type: journals

Luteal-phase clomiphene citrate in PCOSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: I read with interest the article by Badawy et al. on luteal phase clomiphene citrate (CC) treatment . There were two points on which I would like to request clarification. (Source: Fertility and Sterility)
Source: Fertility and Sterility - August 23, 2009 Category: Reproduction Medicine Authors: Dhiraj Gada Tags: Letters to the editor Source Type: journals

Reply of the Authors: Luteal-phase clomiphene citrate in PCOSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I would like to thank Dr. Dhiraj Gada for his comments. We have always started medroxyprogesterone acetate (MPA) on day 16 of the cycle—that is, after menstruation, whether this menstruation occurred naturally or was triggered by medication. We measure the serum human chorionic gonadotropin (hCG) level on the last day of MPA administration to rule out pregnancy before starting the clomiphene citrate (CC) protocol. (Source: Fertility and Sterility)
Source: Fertility and Sterility - August 23, 2009 Category: Reproduction Medicine Authors: Ahmed Badawy Tags: Letters to the editor Source Type: journals

Clomiphene Citrate and Testosterone Gel Replacement Therapy for Male Hypogonadism: Efficacy and Treatment CostEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. CC represents a treatment option for men with hypogonadism, demonstrating biochemical and clinical efficacy with few side effects and lower cost as compared with TGRT. Taylor F, and Levine L. Clomiphene citrate and testosterone gel replacement therapy for male hypogonadism: Efficacy and treatment cost. J Sex Med **;**:**[ndash]**. (Source: The Journal of Sexual Medicine)
Source: The Journal of Sexual Medicine - August 16, 2009 Category: Sexual Medicine Authors: Frederick Taylor, Laurence Levine Source Type: journals

Combination Clomiphene Citrate And Antioxidant Therapy For Idiopathic Male Infertility: A Randomized Controlled TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
UroToday.com - Empirical medical treatment for idiopathic male factor infertility is a controversial issue. Several medications are used empirically for the treatment of idiopathic male factor infertility, including follicle stimulating hormone (FSH), antiestrogen, L-carnitine, and antioxidants. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 3, 2009 Category: Consumer Health News Tags: Fertility Source Type: news

A simple and rapid ESI-LC-MS/MS method for simultaneous screening of doping agents in urine samplesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion:</b> The method developed based on controlled pH extraction method and HPLC-mass spectrometry analysis allowed better identification and confirmation of glucocorticosteroids and a few other drugs in different categories. The validated method has been used successfully for testing of 1000 In-competition samples. The method helped in detection of chemically and pharmacologically different banned drugs in urine in a single short run at a minimum required performance limit set by WADA. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - July 30, 2009 Category: Drugs & Pharmacology Authors: I Madhusudhana Reddy, Alka Beotra, S Jain, S Ahi Source Type: journals

Beyond the Abstract - Combination clomiphene citrate and antioxidant therapy for idiopathic ...Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BERKELEY, CA (UroToday.com) - Empirical medical treatment for idiopathic male... (Source: UroToday)
Source: UroToday - July 21, 2009 Category: Urology & Nephrology Tags: Browse Categories - Beyond the Abstract Source Type: info

Successful Fertility Treatment for Klinefelter's SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Microdissection testicular sperm extraction is an effective sperm retrieval technique in men with Klinefelter's syndrome. Men with hypogonadism who respond to medical therapy may have a better chance of sperm retrieval. (Source: The Journal of Urology)
Source: The Journal of Urology - July 20, 2009 Category: Urology & Nephrology Authors: Ranjith Ramasamy, Joseph A. Ricci, Gianpiero D. Palermo, Lucinda Veeck Gosden, Zev Rosenwaks, Peter N. Schlegel Tags: Sexual Function/Infertility Source Type: journals

Cumulative delivery rates in different age groups after artificial insemination with donor spermEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Our study corroborates the impact of age on donor insemination outcome. Nevertheless, even in some older age subgroups, acceptable expected cumulative delivery rates were observed. Despite this, the main reason for discontinuing treatment, however, was the anticipated low success rate. Women, up until 42 years of age, could be encouraged to continue treatment. (Source: Human Reproduction)
Source: Human Reproduction - July 13, 2009 Category: Reproduction Medicine Authors: De Brucker, M., Haentjens, P., Evenepoel, J., Devroey, P., Collins, J., Tournaye, H. Tags: Infertility Source Type: journals

Clomiphene citrate resistance in relation to follicle-stimulating hormone receptor Ser680Ser-polymorphism in polycystic ovary syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Chance of resistance to CC is almost double in women with PCOS harbouring the Ser/Ser genotype. (Source: Human Reproduction)
Source: Human Reproduction - July 13, 2009 Category: Reproduction Medicine Authors: Overbeek, A., Kuijper, E.A.M., Hendriks, M.L., Blankenstein, M.A., Ketel, I.J.G., Twisk, J.W.R., Hompes, P.G.A., Homburg, R., Lambalk, C.B. Tags: Reproductive genetics Source Type: journals

Aromatase Inhibitors for Ovulation and Pregnancy in Polycystic Ovary Syndrome (July/August).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Further trials comparing aromatase inhibitors with clomiphene citrate are necessary before aromatase inhibitors can be recommended routinely for ovulation induction in women with PCOS and infertility. However, aromatase inhibitors may be considered in a subset of this population, specifically women who are clomiphene citrate resistant or those who, after discussion of risks and benefits, are not candidates for clomiphene citrate, gonadotropins, or GnRH analogs. PMID: 19584394 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - July 6, 2009 Category: Drugs & Pharmacology Authors: Eckmann KR, Kockler DR Tags: Ann Pharmacother Source Type: journals

Question Directed To Dr. Gary Berger at Chapel Hill Tubal Reversal CenterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tubal Reversal Message Board member 'jodib' directs her questions to Dr. Gary Berger who performed her tubal ligation reversal in 2006. Since then, she has had 2 tubal reversal babies but is concerned that she has not yet conceived her third pregnancy after having her tubes untied. All the staff of Chapel Hill Tubal Reversal Center - doctors, nurses, anesthesia, administrator, surgical techs, and medical secretaries - respond to questions and concerns daily on the message board. Dr. Berger posts, "I doubt that having taken Clomid would interfere with your ovulation cycles now since you have such regular periods. If necessa...
Source: Tubal Ligation Reversal News - July 6, 2009 Category: Reproduction Medicine Source Type: organizations

CLOMIPHENE CITRATEtablet [Sanofi-Aventis U.S. LLC]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Jun 30, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - June 30, 2009 Category: Drugs & Pharmacology Source Type: organizations

CLOMID (Clomiphene Citrate) Tablet [Sanofi-Aventis U.S. LLC]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Jun 30, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - June 30, 2009 Category: Drugs & Pharmacology Source Type: organizations

Short-term metformin treatment for clomiphene citrate–resistant women with polycystic ovary syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The short-course pretreatment with metformin decreased hyperandrogenism and insulin resistance and improved cervical sores, ovulation rate, and pregnancy rate among women with CC-resistant PCOS. (Source: International Journal of Gynaecology and Obstetrics)
Source: International Journal of Gynaecology and Obstetrics - June 23, 2009 Category: OBGYN Authors: Talieh Kazerooni, Fariborz Ghaffarpasand, Yasaman Kazerooni, Marjaneh Kazerooni, Sasan Setoodeh Tags: Clinical articles Source Type: journals

Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Parasite infection can lead to alterations in the permeability of host plasma membranes. Presented here is the first demonstration that this phenomenon occurs in Plasmodium-infected liver cells. Using the whole-cell patch-clamp technique, volume-regulated anion channel (VRAC) activity was characterized in Huh-7 cells (a human hepatoma cell line) before and after infection with Plasmodium berghei. Consistent with the presence of VRACs, hypotonic bath solution induced large ion currents in Huh-7 cells that rectified outwardly, reversed close to the equilibrium potential for Cl- and were inhibited by tamoxifen, clomiphene, me...
Source: Cellular Microbiology - June 2, 2009 Category: Microbiology Authors: Miguel Prudêncio, Elvira T. Derbyshire, Catarina A. Marques, Sanjeev Krishna, Maria M. Mota, Henry M. Staines Source Type: journals

Unexplained infertility and inherited thrombophiliaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, unexplained infertility may represent another indication to perform genetic thrombophilia screening. (Source: Fertility and Sterility)
Source: Fertility and Sterility - May 24, 2009 Category: Reproduction Medicine Authors: S. Bianca, B. Barrano, N. Cutuli, L. Indaco, A. Cataliotti, G. Milana, C. Barone, G. Ettore Tags: Letters to the editor Source Type: journals

Ovarian reserve screening in infertility: Practical applications and theoretical directions for researchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, these tests are discussed and compared; we also present practical strategies to organise screening as presently used at our institutions. Experimental challenges to the long-held tenet of irreversible ovarian ageing are also introduced and explored. While pregnancy rates after IVF are influenced by multiple (non-ovarian) factors including in vitro laboratory conditions, semen parameters, psychological stress and technique of embryo transfer, predicting response to gonadotropin treatment nevertheless remains an important aim in the evaluation of the couple struggling with infertility. (Source: European Journ...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - May 24, 2009 Category: OBGYN Authors: Eric Scott Sills, Michael M. Alper, Anthony P.H. Walsh Tags: Reviews Source Type: journals

Clomid Use After Having Fallopian Tubes UntiedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Some women fail to become pregnant after tubal reversal surgery because they do not ovulate regularly. Their pituitary gland may not produce enough follicle stimulating hormone (FSH) or luteinizing hormone (LH) at the right time during the cycle. If a woman is menstruating, even irregularly, clomiphene (Clomid) is usually effective. Gail, a member of the message board at Chapel Hill Tubal Reversal Center posts, "I took my first cycle of Clomid in April. I had 3 eggs mature, 2 on the right side and 1 on the left. My right tube is blocked. I got a positive pregnancy test that month and I am currently 7 weeks pregnant." (Sour...
Source: Tubal Ligation Reversal News - May 24, 2009 Category: Reproduction Medicine Source Type: organizations

A simple and rapid ESI-LC-MS/MS method for simultaneous screening of doping agents in urine samplesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion:</b> The method developed based on controlled pH extraction method and HPLC-mass spectrometry analysis allowed better identification and confirmation of glucocorticosteroids and a few other drugs in different categories. The validated method has been used successfully for testing of 1000 In-competition samples. The method helped in detection of chemically and pharmacologically different banned drugs in urine in a single short run at a minimum required performance limit set by WADA. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - May 19, 2009 Category: Drugs & Pharmacology Authors: Reddy I Madhusudhana, Beotra Alka, Jain S, Ahi S Source Type: journals

Increasing doses of clomiphene improve ovulation rate in PCOS.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gradually increasing doses of clomiphene, then U/S, reduce time to ovulation, may improve ovulation rate in PCOS women. (Source: Modern Medicine)
Source: Modern Medicine - May 15, 2009 Category: Journals (General) Source Type: info

Ser/Ser FSHR genotype linked to poor CC response in women with PCOSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women with polycystic ovary syndrome are almost twice as likely to be resistant to clomiphene citrate during ovulation induction if they harbor the Ser/Ser genotype of the follicle-stimulating hormone receptor 680-polymorphism, according to Dutch study results. (Source: MedWire News - Ob/Gyn)
Source: MedWire News - Ob/Gyn - May 11, 2009 Category: OBGYN Source Type: news

Combination Clomiphene Citrate and Antioxidant Therapy for Idiopathic Male Infertility: A ...Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Department of Andrology, Faculty of Medicine, Cairo University, Cairo, Egypt. (Source: UroToday)
Source: UroToday - May 7, 2009 Category: Urology & Nephrology Tags: Browse Categories - Male Infertility & Reproduction Source Type: info

Evaluating the equivalence of clomiphene citrate with and without metformin in ovulation induction in PCOS patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Although identical ovulation rates were observed in both arms equivalence could not be concluded with respect to the specified criteria. Content Type Journal ArticleCategory ASSISTED REPRODUCTIONDOI 10.1007/s10815-009-9304-zAuthors TI Siebert, Stellenbosch University and Tygerberg Academic Hospital Reproductive Biology Unit, Department of Obstetrics and Gynaecology PO Box 19063 Tygerberg 7505 South AfricaTF Kruger, Stellenbosch University and Tygerberg Academic Hospital Reproductive Biology Unit, Department of Obstetrics and Gynaecology PO Box 19063 Tygerberg 7505 South AfricaCarl Lombard, M...
Source: Journal of Assisted Reproduction and Genetics - April 25, 2009 Category: Reproduction Medicine Tags: Journal of Assisted Reproduction and Genetics Source Type: journals

Treatment Reduces Ovulation Time in Ovarian SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Treatment consisting of gradually increasing doses of clomiphene followed by ultrasound is effective in reducing the time to ovulation and often improves the ovulation rate in women with polycystic ovarian syndrome (PCOS) who do not respond to lower doses of the drug, according to a study in the May issue of the American Journal of Obstetrics & Gynecology. (Source: Modern Medicine)
Source: Modern Medicine - April 23, 2009 Category: Journals (General) Source Type: info

Discussion: ‘Novel clomiphene protocol in polycystic ovarian syndrome’ by Hurst et alEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the roundtable that follows, clinicians discuss a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research. Article discussed:Hurst BS, Hickman JM, Matthews ML, Usadi RS, Marshburn PB. Novel clomiphene “stair-step” protocol reduces time to ovulation in women with polycystic ovarian syndrome. Am J Obstet Gynecol 2009;200:510.e1-510.e4. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - April 20, 2009 Category: OBGYN Authors: G. Wright Bates, Stacy Shomento, Katherine McKnight, Hope M. McLean Tags: Journal Club Roundtable Source Type: journals

Novel clomiphene protocol in polycystic ovarian syndrome: Hurst et alEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The article below summarizes a roundtable discussion of a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research. Article discussed:Hurst BS, Hickman JM, Matthews ML, Usadi RS, Marshburn PB. Novel clomiphene “stair-step” protocol reduces time to ovulation in women with polycystic ovarian syndrome. Am J Obstet Gynecol 2009;200:510.e1-510.e4.The full discussion appears at www.AJOG.org, pages e1-e3. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - April 20, 2009 Category: OBGYN Authors: G. Wright Bates, Stacy Shomento, Katherine McKnight, Hope M. McLean Tags: Journal Club Source Type: journals

Novel clomiphene “stair-step” protocol reduces time to ovulation in women with polycystic ovarian syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: It is not necessary to induce menses before increasing clomiphene doses in nonresponsive PCOS patients. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - April 20, 2009 Category: OBGYN Authors: Bradley S. Hurst, Jennifer M. Hickman, Michelle L. Matthews, Rebecca S. Usadi, Paul B. Marshburn Tags: Reproductive Endocrinology and Infertility Source Type: journals

Clomiphene citrate–induced severe hypertriglyceridemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion(s): Clomiphene citrate should be used cautiously in women having risk factors for dyslipidemia, and, even in the presence of a normal lipid profile, lipid levels should be closely monitored when CC treatment is instituted. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 19, 2009 Category: Reproduction Medicine Authors: Hamiyet Yılmaz Yaşar, Özden Ertuğrul Tags: Case report summaries Source Type: journals

Drug treatments for polycystic ovary syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Polycystic ovary syndrome is a condition present in approximately 5 to 10 percent of women of childbearing age. Diagnosis can be difficult because the signs and symptoms can be subtle and varied. These may include hirsutism, infertility, menstrual irregularities, and biochemical abnormalities, most notably insulin resistance. Treatment should target specific manifestations and individualized patient goals. When choosing a treatment regimen, physicians must take into account comorbidities and the patient's desire for pregnancy. Lifestyle modifications should be used in addition to medical treatments for optimal results....
Source: American Family Physician - April 14, 2009 Category: Primary Care Authors: Radosh L Tags: Am Fam Physician Source Type: journals

Comparative effects of risedronate, atorvastatin, estrogen and SERMs on bone mass and strength in ovariectomized ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: While risedronate sodium prevented the decrease in bone mineral density in ovariectomized rats, atorvastatin maintained mechanical characteristics of bone and also prevented the decrease in bone mineral density as risedronate sodium. (Source: Maturitas)
Source: Maturitas - April 12, 2009 Category: Primary Care Authors: Yıldız Uyar, Yesim Baytur, Umit Inceboz, Bilge Cetinkaya Demir, Gul Gumuser, Kemal Ozbilgin Tags: Research articles Source Type: journals

Recovery of persistent hypogonadism by clomiphene in males with prolactinomas under dopamine agonist treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Clomiphene restores normal testosterone levels and improves sperm motility in most patients with prolactinomas and persistent hypogonadism under DA therapy. Recovery of gonadal function by clomiphene independent of prolactin levels. PMID: 19359408 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 8, 2009 Category: Endocrinology Authors: Ribeiro R, Abucham J Tags: Eur J Endocrinol Source Type: journals

Intrauterine inseminationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS IUI treatment requires ovarian stimulation to achieve modest results, but the high multiple pregnancy rates mean that it is no more than a poor substitute for IVF treatment. More trials are needed on IUI treatment with mild stimulation and on the order of IUI and other treatments. (Source: Human Reproduction Update)
Source: Human Reproduction Update - April 8, 2009 Category: OBGYN Authors: The ESHRE Capri Workshop Group Tags: Reviews Source Type: journals

Evaluation of the relationship between plasma concentrations of en- and zuclomiphene and induction of ovulation in anovulatory women being treated with clomiphene citrateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The concentrations of En and Zu in plasma, on their own or in combination with other covariates (e.g., weight, body mass index, free androgen index), are not a predictor of the ovulation response to CC or of the dose requirement. Further studies are needed to explore the role of additional covariates, including the presence of active metabolites, and the balance of the effects of En and Zu. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2009 Category: Reproduction Medicine Authors: Cyrus Ghobadi, Saad Amer, Hany Lashen, Martin S. Lennard, William L. Ledger, Amin Rostami-Hodjegan Tags: Ovulation induction Source Type: journals

Comparison of daily and alternate day recombinant follicle-stimulating hormone stimulation protocols for intrauterine inseminationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion(s): Daily recombinant FSH stimulation for IUI seems to be associated with a higher clinical pregnancy rate than alternate-day FSH stimulation. Prospective randomized trials would be needed to determine whether this is indeed the case. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2009 Category: Reproduction Medicine Authors: Nadia Kabli, Camille Sylvestre, Togas Tulandi, William Buckett Tags: Ovulation induction Source Type: journals

Ovarian epithelial neoplasia after hormonal infertility treatment: long-term follow-up of a historical cohort in SwedenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion(s): Our findings of increased risk of ovarian cancer after gonadotropins and of borderline tumors after clomiphene treatment need to be interpreted with caution. However, concern is raised, and further research on the long-term safety particularly of modern hormonal infertility treatment in IVF programs is warranted. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2009 Category: Reproduction Medicine Authors: Karin Sanner, Peter Conner, Kjell Bergfeldt, Paul Dickman, Karin Sundfeldt, Torbjörn Bergh, Kerstin Hagenfeldt, Per Olof Janson, Staffan Nilsson, Ingemar Persson Tags: Ovulation induction Source Type: journals

Determination of antiovarian antibodies after laparoscopic ovarian electrocauterization in patients with polycystic ovary syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion(s): The ovarian trauma consequent to laparoscopic ovarian electrocauterization in patients with resistant PCOS does not result in a significant production of AOA. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2009 Category: Reproduction Medicine Authors: Saeed Alborzi, Fahimeh Tavazoo, Alamtaj Samsami Dehaghani, Abbas Ghaderi, Soroosh Alborzi, Mehrnoosh Alborzi Tags: Polycystic ovary syndrome Source Type: journals

Ultrasound-guided transvaginal ovarian needle drilling (UTND) for treatment of polycystic ovary syndrome: a randomized controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion(s): UTND can be adopted as an outpatient office procedure. The ease of scheduling, reduced costs, and rapid recovery suggest it as a first-line treatment for PCOS cases resistant to clomiphene citrate. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2009 Category: Reproduction Medicine Authors: Ahmed Badawy, Moustafa Khiary, Ahmed Ragab, Moustafa Hassan, Lotfi Sherief Tags: Polycystic ovary syndrome Source Type: journals