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Immunohistochemical study of the phenotypic change of the mesenchymal cells during portal tract maturation in normal and fibrous (ductal plate malformation) fetal liverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: As in adult liver, there is a phenotypic heterogeneity of the mesenchymal cells during fetal liver development. During portal tract maturation, myofibroblastic cells disappear in normal development but persist in fibrosis following ductal plate malformation.
Source: Comparative Hepatology - July 14, 2009 Category: Gastroenterology Authors: Julien VilleneuveFanny Pelluard-NehmeChantal CombeDominique CarlesChristine ChaponnierJean RipocheCharles BalabaudPaulette Bioulac-SageSebastien Lepreux Source Type: journals

Early effect of a single intravenous injection of ethanol on hepatic sinusoidal endothelial fenestrae in rabbitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: It has been postulated that ethanol affects hepatic sinusoidal and perisinusoidal cells. In the current experimental study, we investigated the early effect of a single intravenous dose of ethanol on the diameter of liver sinusoidal endothelial fenestrae in New Zealand White rabbits. The diameter of fenestrae in these rabbits is similar to the diameter found in humans with healthy livers. The effect of ethanol on the size of fenestrae was studied using transmission electron microscopy, because plastic embedding provides true measures for the diameter of fenestrae. Results: After intravenous administration of a ...
Source: Comparative Hepatology - July 13, 2009 Category: Gastroenterology Authors: Frank JacobsEddie WisseBart De Geest Source Type: journals

Comparison of different methods to obtain and store liver biopsies for molecular and histological researchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: At least two biopsies (RNAlater and formalin) are needed. Since human and canine liver diseases are highly comparable, it is conceivable that the protocols described here can be easily translated into the human biomedical field.
Source: Comparative Hepatology - July 8, 2009 Category: Gastroenterology Authors: Gaby HoffmannJooske IjzerBas BrinkhofBaukje SchotanusTed van den InghLouis PenningJan Rothuizen Source Type: journals

Bile constituents in hibernating golden-mantled ground squirrels (Spermophilus lateralis)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The data indicate that despite extended anorexia, differences in metabolic fuel privation, and bouts of reduced body temperatures, hibernators normally do not experience broad changes in hepatobiliary function.
Source: Comparative Hepatology - May 26, 2009 Category: Gastroenterology Authors: Julie BakerFrank van Breukelen Source Type: journals

Low affinity glucocorticoid binding site ligands as potential anti-fibrogenicsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: LAGS ligands inhibit HSC trans-differentiation and proliferation in vitro but show little efficacy in inhibiting liver fibrosis, in vivo. The reason(s) for this disparity is/are likely associated with an altered myofibroblast phenotype, in vitro, with expression of rPGMRC1 in vitro but not in vivo. These data emphasize the limitations of in vitro-derived myofibroblasts for predicting their activity in vivo, in studies of fibrogenesis. The data also demonstrate that the anti-fibrogenic effects of PCN in vivo are likely mediated entirely via the PXR.
Source: Comparative Hepatology - May 11, 2009 Category: Gastroenterology Authors: Carylyn J Marek, Karen Wallace, Elaine Durward, Matthew Koruth, Val Leel, Lucy J Leiper and Matthew C Wright Source Type: journals

Phospholipase C beta 4 in mouse hepatocytes: Rhythmic expression and cellular distributionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results indicate that PLCbeta4 gene and protein expression is regulated by a circadian clock in the mouse liver and is not dependent on the external photoperiod. A light-independent daily translocation of PLCbeta4 implies that it may play a key role in nuclear signaling in hepatocytes and serve as a daily temporal cue for physiological processes in the liver.
Source: Comparative Hepatology - October 28, 2008 Category: Gastroenterology Authors: Brittany M Klein, Jane B Andrews, Barbra A Bannan, Ashley E Nazario-Toole, Travis C Jenkins, Kimberly D Christensen, Sorinel A Oprisan and Elizabeth L Meyer-Bernstein Source Type: journals

Non invasive in vivo investigation of hepatobiliary structure and function in STII medaka (Oryzias latipes): Methodology and applicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: A novel transparent stock of medaka (Oryzias latipes; STII), recessive for all pigments found in chromatophores, permits transcutaneous imaging of internal organs and tissues in living individuals. Findings presented describe the development of methodologies for non invasive in vivo investigation in STII medaka, and the successful application of these methodologies to in vivo study of hepatobiliary structure, function, and xenobiotic response, in both 2 and 3 dimensions. Results: Using brightfield, and widefield and confocal fluorescence microscopy, coupled with the in vivo application of fluorescent probes, st...
Source: Comparative Hepatology - October 6, 2008 Category: Gastroenterology Authors: Ron C Hardman, Seth W Kullman and David E Hinton Source Type: journals

A new parameter using serum lactate dehydrogenase and alanine aminotransferase level is useful for predicting the prognosis of patients at an early stage of acute liver injury: a retrospective studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: ALT-LDH index was useful to predict the prognosis of the patients with acute liver injury and should be helpful to begin preparation for LT soon after admission.
Source: Comparative Hepatology - August 14, 2008 Category: Gastroenterology Authors: Kazuhiro Kotoh, Munechika Enjoji, Masaki Kato, Motoyuki Kohjima, Makoto Nakamuta and Ryoichi Takayanagi Source Type: journals

Relation between lipogranuloma formation and fibrosis, and the origin of brown pigments in lipogranuloma of the canine liverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Lipogranulomas are not a contributing factor in hepatic fibrosis, but might be a potential indicator of the accumulation of iron and lipid inside the liver.
Source: Comparative Hepatology - May 12, 2008 Category: Gastroenterology Authors: Kaori Isobe, Hiroyuki Nakayama and Koji Uetsuka Source Type: journals

The influence of oxygen tension on the structure and function of isolated liver sinusoidal endothelial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Viability, structure and many of the essential functional characteristics of isolated LSECs are clearly better preserved when the cultures are maintained under more physiologic oxygen levels. Endogenous production of hydrogen peroxide is to a large extent responsible for the toxic effects observed in high oxygen environments.
Source: Comparative Hepatology - May 5, 2008 Category: Gastroenterology Authors: Inigo Martinez, Geir I Nedredal, Cristina I Oie, Alessandra Warren, Oddmund Johansen, David G LeCouteur and Bard Smedsrod Source Type: journals

Sustained virological and biochemical responses to lamivudine and adefovir dipivoxil combination in a chronic hepatitis B infection despite mutations conferring resistance to both drugsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This case illustrates that rtM204V/I, rtA181V, and rtN236T resistance mutations can coexist in a patient but do not preclude the recycling of lamivudine and adefovir in combination therapy, when no other therapeutic choices are available.
Source: Comparative Hepatology - March 12, 2008 Category: Gastroenterology Authors: Sylvie Larrat, Marie-Noelle Hilleret, Raphaele Germi, Julien Lupo, Sandrine Nicod, Jean-Pierre Zarski, Jean-Marie Seigneurin and Patrice Morand Source Type: journals

Over-expression of glutamine synthase in focal nodular hyperplasia (part 1): Early stages in the formation support the hypothesis of a focal hyper-arterialisation with venous (portal and hepatic) and biliary damageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The findings confirm that in FNH there is a portal tract injury leading to local portal vein injury. This leads to a cascade of events, including arterial venous shunts, ductular reaction, and scar formation.
Source: Comparative Hepatology - February 29, 2008 Category: Gastroenterology Authors: Paulette Bioulac-Sage, Herve Laumonier, Gaelle Cubel, Jean Saric and Charles Balabaud Source Type: journals

Plasma redox status is impaired in the portacaval shunted rat - the risk of the reduced antioxidant abilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings suggest that in rats with a portacaval shunt a systemic reduction of oxidant scavenging ability, correlated with hyperammonemia, is principally produced. It could be hypothesized, therefore, that the reduced antioxidant defences would mediate a systemic inflammation.
Source: Comparative Hepatology - February 5, 2008 Category: Gastroenterology Authors: Maria-Angeles Aller, Maria-Inmaculada Garcia-Fernandez, Fernando Sanchez-Patan, Luis Santin, Jose Rioja, Raquel Anchuelo, Jaime Arias and Jorge-Luis Arias Source Type: journals

Establishment of an early liver fibrosis model by the hydrodynamics-based transfer of TGF-beta1 geneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results show that TGF-beta1 in pPK9a-transferred mice liver with ZnSO4 feeding can achieve a high expression level with significant fibrosis. However, since TGF-beta1 induction is transient in our model, the fibrotic level does not reach a large scale (panlobular fibrosis) as seen in the CCl4-treated liver. Our model hence represents a dynamic and reversible liver fibrosis and could be a useful tool for studying early molecular mechanism of fibrogenesis or screening of antifibrotic drugs for clinical use.
Source: Comparative Hepatology - October 19, 2007 Category: Gastroenterology Authors: Kun-Lin Yang, Kuo-Chen Hung, Wen-Teng Chang and Eric IC Li Source Type: journals

Major HGF-mediated regenerative pathways are similarly affected in human and canine cirrhosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In canine hepatitis and cirrhosis the major regenerative downstream pathways were activated. Signaling pathways are similarly activated in human cirrhotic liver samples, irrespective of the differences in etiology in the human samples (alcohol abuse and HCV-infection). Therefore, canine hepatitis and cirrhosis could be an important clinical model to evaluate novel interventions prior to human clinical trials.
Source: Comparative Hepatology - July 31, 2007 Category: Gastroenterology Authors: Bart Spee, Brigitte Arends, Ted SGAM van den Ingh, Tania Roskams, Jan Rothuizen and Louis C Penning Source Type: journals

Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic optionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite intensive studies, the clinical opportunities for patients with fibrosing liver diseases have not improved. This will be changed by increasing knowledge of new pathogenetic mechanisms, which complement the "canonical principle" of fibrogenesis. The latter is based on the activation of hepatic stellate cells and their transdifferentiation to myofibroblasts induced by hepatocellular injury and consecutive inflammatory mediators such as TGF-beta. Stellate cells express a broad spectrum of matrix components. New mechanisms indicate that the heterogeneous pool of (myo-)fibroblasts can be supplemented by epithelial-mesen...
Source: Comparative Hepatology - July 30, 2007 Category: Gastroenterology Authors: Olav A Gressner, Ralf Weiskirchen and Axel M Gressner Source Type: journals

Regeneration in pig livers by compensatory hyperplasia induces high levels of telomerase activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data demonstrate telomerase activation in liver regeneration by compensatory hyperplasia in a large animal model with telomere biology comparable to humans. Telomerase activation may constitute a mechanism to protect proliferating liver cells against telomere shortening and oxidative stress.
Source: Comparative Hepatology - July 2, 2007 Category: Gastroenterology Authors: Henning Wege, Anett Mueller, Lars Mueller, Susan Petri, Joerg Petersen and Christian Hillert Source Type: journals

Glucocorticoids activate TGF-beta induced PAI-1 and CTGF expression in rat hepatocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The data provide evidence that beside the TGF-beta-Smad 3 pathway CTGF and PAI-1 expression is additionally dependent on Erk activity in hepatocytes giving new insights into regulation of the profibrogenic proteins.
Source: Comparative Hepatology - May 2, 2007 Category: Gastroenterology Authors: Lucia Wickert, Nicolas Chatain, Karin Kruschinsky and Axel M Gressner Source Type: journals

CIDE-A is expressed in liver of old mice and in type 2 diabetic mouse liver exhibiting steatosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The corresponding increase in CIDE-A expression with hyperinsulinemia and liver steatosis suggests a novel pathway for lipid accumulation in the liver.
Source: Comparative Hepatology - May 1, 2007 Category: Gastroenterology Authors: Bruce Kelder, Keith Boyce, Andres Kriete, Darlene E Berryman, Ryan Clark, Sheila Nagatomi, Edward O List, Mark Braughler and John J Kopchick Source Type: journals

TGF-β dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The data provide evidence that TGF-β induces NADPH oxidase activity which causes radical production upon the transdifferentiation of activated HSCs to M-HTs. Myofibroblastoid cells are equipped with high levels of superoxide dismutase activity as well as glutathione to counterbalance NADPH oxidase dependent oxidative stress and to avoid cellular damage.
Source: Comparative Hepatology - February 20, 2007 Category: Gastroenterology Authors: Verena Proell, Irene Carmona-Cuenca, Miguel M Murillo, Heidemarie Huber, Isabel Fabregat and Wolfgang Mikulits Source Type: journals

Sensitivity to endothelin-1 is decreased in isolated livers of endothelial constitutive nitric oxide synthase knockout miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Livers of ecNOS knockout mice have a decreased sensitivity to endothelin at physiologic concentrations; this is associated with a decreased expression of ETA receptors, but not with other factors, such as iNOS, ETB receptors, adrenomedullin or heme-oxygenase. Further studies targeting adaptive changes in ETA receptor distribution and/or intracellular signaling downstream of the receptor are indicated.
Source: Comparative Hepatology - December 5, 2006 Category: Gastroenterology Authors: Andrea De Gottardi, Erwin Biecker, Abraham Koshy, Dieter Bohler, Sidney Shaw, Hans Saegesser and Jurg Reichen Source Type: journals

Feeding and fasting controls liver expression of a regulator of G protein signaling (Rgs16) in periportal hepatocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Rgs16 is one of a subset of genes that is circadian regulated both in SCN and liver. Rgs16 mRNA expression in liver responds rapidly to changes in feeding schedule, coincident with key transcription factors controlling the circadian clock. Rgs16 expression can be used as a marker to identify and investigate novel G-protein mediated metabolic and circadian pathways, in specific zones within the liver.
Source: Comparative Hepatology - November 23, 2006 Category: Gastroenterology Authors: Jie Huang, Victor Pashkov, Deborah M Kurrasch, Kan Yu, Stephen J Gold and Thomas M Wilkie Source Type: journals

Morphological characterisation of portal myofibroblasts and hepatic stellate cells in the normal dog liverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In the normal formalin-fixed and paraffin embedded canine liver hepatic portal MF and HSC can be identified by alpha-SMA, HHF35 and to a lesser extent desmin immunostaining. These antibodies can thus be used in further studies on hepatic fibrosis. Synaptophysin, GFAP and NCAM do not seem suitable for marking of canine HSC. The positivity of HSC for alpha-SMA and HHF35 in the normal canine liver may eventually reflect a more active regulation of hepatic sinusoidal flow by these HSC compared to other species.
Source: Comparative Hepatology - November 16, 2006 Category: Gastroenterology Authors: Jooske IJzer, Tania Roskams, Ronald F Molenbeek, Ton Ultee, Louis C Penning, Jan Rothuizen and Ted SGAM van den Ingh Source Type: journals

The hepatic transcriptome in human liver diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The transcriptome is the mRNA transcript pool in a cell, organ or tissue with the liver transcriptome being amongst the most complex of any organ. Functional genomics methodologies are now being widely utilized to study transcriptomes including the hepatic transcriptome. This review outlines commonly used methods of transcriptome analysis, especially gene array analysis, focusing on publications utilizing these methods to understand human liver disease. Additionally, we have outlined the relationship between transcript and protein expressions as well as summarizing what is know about the variability of the transcriptome in...
Source: Comparative Hepatology - November 7, 2006 Category: Gastroenterology Authors: Nicholas A Shackel, Devanshi Seth, Paul S Haber, Mark D Gorrell and Geoff W McCaughan Source Type: journals

Endothelin-1 enhances fibrogenic gene expression, but does not promote DNA synthesis or apoptosis in hepatic stellate cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We show that ET-1 stimulates fibrogenic gene expression for 1st passage HSC and it inhibits HSC proliferation for 4th passage HSC. These data indicate the profibrogenic and antifibrogenic action of ET-1 for HSC are involved in the process of liver fibrosis.
Source: Comparative Hepatology - October 24, 2006 Category: Gastroenterology Authors: Masahiko Koda, Michael Bauer, Anja Krebs, Eckhart G Hahn, Detlef Schuppan and Yoshikazu Murawaki Source Type: journals

Distribution of hepatitis C virus genotypes in patients infected by different sources and its correlation with clinical and virological parameters: a preliminary studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Genotypes 3a and 1a in Iran are less prevalent in IVDU than in Europe and USA, but there is a high similarity between the pattern of genotype in IVDU in both Europe and United States, and Iran. However, in this case it can not be due to people migration among countries since history of travel abroad existed only in 6 cases (13.3%).
Source: Comparative Hepatology - October 2, 2006 Category: Gastroenterology Authors: Ali Kabir, Seyed-Moayed Alavian and Hussein Keyvani Source Type: journals

Expression of AFP and Rev-Erb A / Rev-Erb B and N-CoR in fetal rat liver, liver injury and liver regenerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Expression of fetal AFP could be demonstrated during liver development and during proliferation of the so-called oval cells. Changes of expression of orphan nuclear receptors, however, did not correlate with AFP expression. Other regulatory pathways were possibly involved in controlling AFP expression, in vivo.
Source: Comparative Hepatology - July 5, 2006 Category: Gastroenterology Authors: Volker Meier, Kyrylo Tron, Danko Batusic, Abderrahim Elmaouhoub and Giuliano Ramadori Source Type: journals

Expression of AFP and Rev-Erb A/Rev-Erb B and N-CoR in fetal rat liver, liver injury and liver regenerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Expression of fetal AFP could be demonstrated during liver development and during proliferation of the so-called oval cells. Changes of expression of orphan nuclear receptors, however, did not correlate with AFP expression. Other regulatory pathways were possibly involved in controlling AFP expression, in vivo.
Source: Comparative Hepatology - July 5, 2006 Category: Gastroenterology Authors: Volker Meier, Kyrylo Tron, Danko Batusic, Abderrahim Elmaouhoub and Giuliano Ramadori Source Type: journals

Successful rescue therapy with tenofovir in a patient with hepatic decompensation and adefovir resistant HBV mutantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In patients with cirrhosis, adefovir resistance can lead to severe hepatitis. Tenofovir appears to be an effective treatment of adefovir resistant mutants. Incomplete control of viral replication with adefovir requires monitoring for viral resistance and should prompt a change in antiviral treatment.
Source: Comparative Hepatology - January 11, 2006 Category: Gastroenterology Authors: Vlad Ratziu, Vincent Thibault, Yves Benhamou and Thierry Poynard Source Type: journals

The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: SteatoTest is a simple and non-invasive quantitative estimate of liver steatosis and may reduce the need for liver biopsy, particularly in patients with metabolic risk factor.
Source: Comparative Hepatology - December 23, 2005 Category: Gastroenterology Authors: Thierry Poynard, Vlad Ratziu, Sylvie Naveau, Dominique Thabut, Frederic Charlotte, Djamila Messous, Dominique Capron, Annie Abella, Julien Massard, Yen Ngo, Mona Munteanu, Anne Mercadier, Michael Manns and Janice Albrecht Source Type: journals

Kinetics of hepatitis C virus RNA load during pegylated interferon alpha-2a and ribavirin treatment in naïve genotype 1 patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: During treatment with Peg-IFN alpha-2a plus ribavirin in genotype 1 patients, when the main objective of the treatment is viral eradication, viral kinetics showed that week 2 appeared to be the best time point for predicting SVR. Our results must be further confirmed on a larger cohort.
Source: Comparative Hepatology - December 21, 2005 Category: Gastroenterology Authors: Denis Ouzan, Hacène Khiri, Guillaume Pénaranda, Hélène Joly and Philippe Halfon Source Type: journals

Current views concerning the influences of murine hepatic endothelial adhesive and cytotoxic properties on interactions between metastatic tumor cells and the liverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Substantial recent experimental evidence has demonstrated the existence of reciprocal interactions between the microvascular bed of a specific organ and intravascular metastatic tumor cells through expression of adhesion molecules and nitric oxide release, resulting in a significant impact upon metastatic outcomes.This review summarizes the current findings of adhesive and cytotoxic endothelial-tumor cell interactions in the liver, the inducibility, zonal distribution and sinusoidal structural influences on the hepatic endothelial regulatory functions, and the effects of these functions on the formation of liver cancer met...
Source: Comparative Hepatology - December 9, 2005 Category: Gastroenterology Authors: Hui Helen Wang, Hongming Qiu, Ke Qi and F William Orr Source Type: journals

Regenerative and fibrotic pathways in canine hepatic portosystemic shunt and portal vein hypoplasia, new models for clinical hepatocyte growth factor treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The pathophysiological differences between CPSS and PPVH can adequately be explained by the Q-PCR measurements and Western blots. Although c-MET levels were reduced, downstream signaling seemed to be functional and provides a rational for HGF-supplementation in controlled studies with CPSS and PPVH. Furthermore both diseases may serve as simplified models for comparison with more complex chronic inflammatory diseases and cirrhosis.
Source: Comparative Hepatology - December 7, 2005 Category: Gastroenterology Authors: Bart Spee, Louis C Penning, Ted SGAM van den Ingh, Brigitte Arends, Jooske IJzer, Frederik J van Sluijs and Jan Rothuizen Source Type: journals

Accuracy of hyaluronic acid level for predicting liver fibrosis stages in patients with hepatitis C virusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In the validation set, HA was accurate in predicting significant fibrosis, severe fibrosis, and cirrhosis with AUCs of 0.73, 0.77, and 0.97, respectively. Moreover, accurate HA level cut-offs were defined for predicting significant fibrosis, severe fibrosis, and cirrhosis. Thus, the study supports that HA level may be clinically useful as a non-invasive marker for liver fibrosis and/or cirrhosis.
Source: Comparative Hepatology - July 11, 2005 Category: Gastroenterology Authors: Philippe Halfon, Marc Bourlière, Guillaume Pénaranda, Romaric Deydier, Christophe Renou, Danielle Botta-Fridlund, Albert Tran, Isabelle Portal, Isabelle Allemand, Alessandra Rosenthal-Allieri and Denis Ouzan Source Type: journals

Hypervascular nodule in a fibrotic liver overloaded with iron: identification of a premalignant area with preserved liver architectureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In spite of the absence of architectural distortion, and a normal proliferative index, the possibility of premalignancy or malignancy should be considered in this type of hypervascular and hyposiderotic nodule, occurring in the context of an iron overloaded liver.
Source: Comparative Hepatology - May 4, 2005 Category: Gastroenterology Authors: António Sá Cunha, Jean-Frédéric Blanc, Hervé Trillaud, Victor De Ledinghen, Charles Balabaud and Paulette Bioulac-Sage Source Type: journals

Effects of redox cycling compounds on DT diaphorase activity in the liver of rainbow trout (Oncorhynchus mykiss)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Since rainbow trout hepatic DTD activity is inducible by both monofunctional and bifunctional inducers, it is suggested that rainbow trout DTD may be regulated by the same mechanisms, as in mammals. The fact that DTD is inducible in rainbow trout suggests that the enzyme may be suitable as a part of a biomarker battery when rainbow trout is used in environmental studies. It appears as if DTD activity in rainbow trout is higher and inducible compared to the other fish species studied.
Source: Comparative Hepatology - May 4, 2005 Category: Gastroenterology Authors: Joachim Sturve, Eiríkur Stephensen and Lars Förlin Source Type: journals

Differential expression of copper-associated and oxidative stress related proteins in a new variant of copper toxicosis in Doberman pinschersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In the DH group the expression of gene products involved in copper efflux was significantly reduced, which might explain the high hepatic copper levels in this disease. ROS defences were most likely impaired in the CASH and DH group. Overall, this study describes a new variant of primary copper toxicosis and could provide a molecular basis for equating future treatments in dog and in man.
Source: Comparative Hepatology - March 24, 2005 Category: Gastroenterology Authors: Bart Spee, Paul JJ Mandigers, Brigitte Arends, Peter Bode, Ted SGAM van den Ingh, Gaby Hoffmann, Jan Rothuizen and Louis C Penning Source Type: journals

Interactions between xenoestrogens and ketoconazole on hepatic CYP1A and CYP3A, in juvenile Atlantic cod (Gadus morhua)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Ketoconazole, nonylphenol and ethynylestradiol all interacted with CYP1A and CYP3A activities and protein expression in Atlantic cod. However, mechanisms of interactions on CYP1A and CYP3A differ between theses substances and combined exposure had different effects than exposure to single compounds. Thus, CYP1A and CYP3A mediated clearance may be impaired in situations of mixed exposure to those types of compounds.
Source: Comparative Hepatology - February 8, 2005 Category: Gastroenterology Authors: Linda Hasselberg, Bjørn E Grøsvik, Anders Goksøyr and Malin C Celander Source Type: journals