Comparative biochemistry and physiology. Toxicology and pharmacology : CBP This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Iopanoic acid alters thyroid hormone-related gene expression, thyroid hormone levels, swim bladder inflation, and swimming performance in Japanese medaka
This study confirmed that IOP inhibits dio expression (a molecular initiating event), affects T3 and T4 levels (a key event), and reduces swim bladder inflation (a key event) and swimming performance (an adverse outcome) in Japanese medaka.PMID:38663833 | DOI:10.1016/j.cbpc.2024.109930 (Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP)
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 25, 2024 Category: Biochemistry Authors: Yoshifumi Horie Ayaka Sawada Uaciquete Dorcas Babu Rajendran Ramaswamy Taisen Iguchi Source Type: research

Melittin-The principal toxin of honeybee venom-Is also produced in the honeybee fat body
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Apr 20;281:109928. doi: 10.1016/j.cbpc.2024.109928. Online ahead of print.ABSTRACTMelittin is a powerful toxin present in honeybee venom that is active in a wide range of animals, from insects to humans. Melittin exerts numerous biological, toxicological, and pharmacological effects, the most important of which is destruction of the cell membrane. The phospholipase activity of melittin and its ability to activate phospholipases in the venom contribute to these actions. Using analytical methods, we discovered that the honeybee Apis mellifera produces melittin not only in the ve...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 22, 2024 Category: Biochemistry Authors: Mark éta Hejníková Ale š Tomčala Jan Černý Dalibor Kodr ík Source Type: research

Melittin-The principal toxin of honeybee venom-Is also produced in the honeybee fat body
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Apr 20:109928. doi: 10.1016/j.cbpc.2024.109928. Online ahead of print.ABSTRACTMelittin is a powerful toxin present in honeybee venom that is active in a wide range of animals, from insects to humans. Melittin exerts numerous biological, toxicological, and pharmacological effects, the most important of which is destruction of the cell membrane. The phospholipase activity of melittin and its ability to activate phospholipases in the venom contribute to these actions. Using analytical methods, we discovered that the honeybee Apis mellifera produces melittin not only in the venom ...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 22, 2024 Category: Biochemistry Authors: Mark éta Hejníková Ale š Tomčala Jan Černý Dalibor Kodr ík Source Type: research

Review: Mechanism of herbivores synergistically metabolizing toxic plants through liver and intestinal microbiota
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Apr 19:109925. doi: 10.1016/j.cbpc.2024.109925. Online ahead of print.ABSTRACTInterspecific interactions are central to ecological research. Plants produce toxic plant secondary metabolites (PSMs) as a defense mechanism against herbivore overgrazing, prompting their gradual adaptation to toxic substances for tolerance or detoxification. P450 enzymes in herbivore livers bind to PSMs, whereas UDP-glucuronosyltransferase and glutathione S-transferase increase the hydrophobicity of the bound PSMs for detoxification. Intestinal microorganisms such as Bacteroidetes metabolize cellul...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 21, 2024 Category: Biochemistry Authors: Yuchen Tan Kang An Junhu Su Source Type: research

Effects of four antibiotics on the photosynthetic light reactions in the green alga Chlorella pyrenoidosa
This study contributes to a better understanding of the risk of antibiotics on primary producers in aquatic environment.PMID:38643813 | DOI:10.1016/j.cbpc.2024.109927 (Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP)
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 21, 2024 Category: Biochemistry Authors: Feifan Wang Ping Liu Jiajun Li Siting Xu Hongxing Chen Lingtian Xie Source Type: research

Polystyrene nanoplastics synergistically exacerbate diclofenac toxicity in embryonic development and the health of adult zebrafish
In this study, we investigated the possible ecotoxicological effect of co-exposure to polystyrene nanoplastics (PS-NPs) and diclofenac (DCF) in zebrafish (Danio rerio). After six days of exposure, we noticed that the co-exposure to PS-NP (100 μg/L) and DCF (at 50 and 500 μg/L) decreased the hatching rate and increased the mortality rate compared to the control group. Furthermore, we noted that larvae exposed to combined pollutants showed a higher frequency of morphological abnormalities and increased oxidative stress, apoptosis, and lipid peroxidation. In adults, superoxide dismutase and catalase activities were also imp...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 19, 2024 Category: Biochemistry Authors: Karthikeyan Kandaswamy Ajay Guru Siva Prasad Panda Anahas Perianaika Matharasi Antonyraj Zulhisyam Abdul Kari Jayant Giri Bader O Almutairi Selvaraj Arokiyaraj Guilherme Malafaia Jesu Arockiaraj Source Type: research

Exposure to hull cleaning wastewater induces mortality through oxidative stress and cholinergic disturbance in the marine polychaete Perinereis aibuhitensis
In this study, we provide evidence on acute harmful effects of hull cleaning wastewater in marine polychaete Perinereis aibuhitensis by analyzing physiological and biochemical parameters such as survival, burrowing activity, and oxidative status. Raw wastewater samples were collected during ship hull cleaning processes in the field. Two wastewater samples for the exposure experiment were prepared in the laboratory: 1) mechanically filtered in the in-water cleaning system (MF) and 2) additionally filtered with a 0.45 μm filter in the laboratory (LF). These wastewater samples contained high concentrations of metals (zinc an...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 14, 2024 Category: Biochemistry Authors: Somyeong Lee Jaehee Kim Jee-Hyun Jung Moonkoo Kim Hyun Park Jae-Sung Rhee Source Type: research

Multi-biomarker approach to evaluate the toxicity of chlorpyrifos (active ingredient and a commercial formulation) on different stages of Biomphalaria straminea
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Apr 12:109923. doi: 10.1016/j.cbpc.2024.109923. Online ahead of print.ABSTRACTBiomphalaria straminea is a freshwater gastropod native to South America and used in toxicological assessments. Our aim was to estimate 48 h-LC50 and sub-chronic effects after the exposure to low concentrations of chlorpyrifos as commercial formulation (CF) and active ingredient (AI) on B. straminea adult, embryos and juveniles. Concentrations between 1 and 5000 μg L-1 were chosen for acute exposures and 0.1 and 1 μg L-1 for the sub-chronic one. After 14 days biochemical parameters, viability and s...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 14, 2024 Category: Biochemistry Authors: A Bianco Karina N Martini Claudia J Tejedor Mar ía G Paredes Mar ía Kristoff Gisela Source Type: research

Comparison of developmental toxicity of graphene oxide and graphdiyne to zebrafish larvae
In this study, we compared with developmental toxicity of GO and GDY to zebrafish larvae. It was shown that exposure of zebrafish embryos from 5 h post fertilization to GO and GDY for up to 5 days decreased hatching rate and induced morphological deformity. Behavioral tests indicated that GO and GDY treatment led to hyperactivity of larvae. However, blood flow velocity was not significantly affected by GO or GDY. RNA-sequencing data revealed that both types of NMs altered gene expression profiles as well as gene ontology terms and KEGG pathways related with metabolism. We further confirmed that the NMs altered the expressi...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 14, 2024 Category: Biochemistry Authors: Wanyan Wu Weichao Zhao Chaobo Huang Yi Cao Source Type: research

Exposure to hull cleaning wastewater induces mortality through oxidative stress and cholinergic disturbance in the marine polychaete Perinereis aibuhitensis
In this study, we provide evidence on acute harmful effects of hull cleaning wastewater in marine polychaete Perinereis aibuhitensis by analyzing physiological and biochemical parameters such as survival, burrowing activity, and oxidative status. Raw wastewater samples were collected during ship hull cleaning processes in the field. Two wastewater samples for the exposure experiment were prepared in the laboratory: 1) mechanically filtered in the in-water cleaning system (MF) and 2) additionally filtered with a 0.45 μm filter in the laboratory (LF). These wastewater samples contained high concentrations of metals (zinc an...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 14, 2024 Category: Biochemistry Authors: Somyeong Lee Jaehee Kim Jee-Hyun Jung Moonkoo Kim Hyun Park Jae-Sung Rhee Source Type: research

Multi-biomarker approach to evaluate the toxicity of chlorpyrifos (active ingredient and a commercial formulation) on different stages of Biomphalaria straminea
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Apr 12:109923. doi: 10.1016/j.cbpc.2024.109923. Online ahead of print.ABSTRACTBiomphalaria straminea is a freshwater gastropod native to South America and used in toxicological assessments. Our aim was to estimate 48 h-LC50 and sub-chronic effects after the exposure to low concentrations of chlorpyrifos as commercial formulation (CF) and active ingredient (AI) on B. straminea adult, embryos and juveniles. Concentrations between 1 and 5000 μg L-1 were chosen for acute exposures and 0.1 and 1 μg L-1 for the sub-chronic one. After 14 days biochemical parameters, viability and s...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 14, 2024 Category: Biochemistry Authors: A Bianco Karina N Martini Claudia J Tejedor Mar ía G Paredes Mar ía Kristoff Gisela Source Type: research

Comparison of developmental toxicity of graphene oxide and graphdiyne to zebrafish larvae
In this study, we compared with developmental toxicity of GO and GDY to zebrafish larvae. It was shown that exposure of zebrafish embryos from 5 h post fertilization to GO and GDY for up to 5 days decreased hatching rate and induced morphological deformity. Behavioral tests indicated that GO and GDY treatment led to hyperactivity of larvae. However, blood flow velocity was not significantly affected by GO or GDY. RNA-sequencing data revealed that both types of NMs altered gene expression profiles as well as gene ontology terms and KEGG pathways related with metabolism. We further confirmed that the NMs altered the expressi...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 14, 2024 Category: Biochemistry Authors: Wanyan Wu Weichao Zhao Chaobo Huang Yi Cao Source Type: research

Exposure to hull cleaning wastewater induces mortality through oxidative stress and cholinergic disturbance in the marine polychaete Perinereis aibuhitensis
In this study, we provide evidence on acute harmful effects of hull cleaning wastewater in marine polychaete Perinereis aibuhitensis by analyzing physiological and biochemical parameters such as survival, burrowing activity, and oxidative status. Raw wastewater samples were collected during ship hull cleaning processes in the field. Two wastewater samples for the exposure experiment were prepared in the laboratory: 1) mechanically filtered in the in-water cleaning system (MF) and 2) additionally filtered with a 0.45 μm filter in the laboratory (LF). These wastewater samples contained high concentrations of metals (zinc an...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 14, 2024 Category: Biochemistry Authors: Somyeong Lee Jaehee Kim Jee-Hyun Jung Moonkoo Kim Hyun Park Jae-Sung Rhee Source Type: research

Multi-biomarker approach to evaluate the toxicity of chlorpyrifos (active ingredient and a commercial formulation) on different stages of Biomphalaria straminea
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Apr 12:109923. doi: 10.1016/j.cbpc.2024.109923. Online ahead of print.ABSTRACTBiomphalaria straminea is a freshwater gastropod native to South America and used in toxicological assessments. Our aim was to estimate 48 h-LC50 and sub-chronic effects after the exposure to low concentrations of chlorpyrifos as commercial formulation (CF) and active ingredient (AI) on B. straminea adult, embryos and juveniles. Concentrations between 1 and 5000 μg L-1 were chosen for acute exposures and 0.1 and 1 μg L-1 for the sub-chronic one. After 14 days biochemical parameters, viability and s...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 14, 2024 Category: Biochemistry Authors: A Bianco Karina N Martini Claudia J Tejedor Mar ía G Paredes Mar ía Kristoff Gisela Source Type: research

Comparison of developmental toxicity of graphene oxide and graphdiyne to zebrafish larvae
In this study, we compared with developmental toxicity of GO and GDY to zebrafish larvae. It was shown that exposure of zebrafish embryos from 5 h post fertilization to GO and GDY for up to 5 days decreased hatching rate and induced morphological deformity. Behavioral tests indicated that GO and GDY treatment led to hyperactivity of larvae. However, blood flow velocity was not significantly affected by GO or GDY. RNA-sequencing data revealed that both types of NMs altered gene expression profiles as well as gene ontology terms and KEGG pathways related with metabolism. We further confirmed that the NMs altered the expressi...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 14, 2024 Category: Biochemistry Authors: Wanyan Wu Weichao Zhao Chaobo Huang Yi Cao Source Type: research