Pediatric dysautonomia: Much ‐maligned, often overmedicated, but not as complex as you think
AbstractDysautonomia is an increasingly recognized yet still poorly understood disease within the field of pediatrics. Symptoms, including dizziness, headaches, fatigue, joint pain, anxiety, and intolerance of heat or cold, are often significant and difficult to sort, especially in terms of their relation to each other. This often leads to referral to multiple subspecialists, who then proceed to treat seemingly familiar symptoms in kind. In the authors ’ experience, this leads to more frustration on the part of the patients and their physicians when symptom improvement does not follow (or can even worsen). On the other h...
Source: Congenital Heart Disease - November 28, 2018 Category: Cardiology Authors: Camden L. Hebson, Michael E. McConnell, David W. Hannon Tags: REVIEW ARTICLE Source Type: research

The relationship between serum apelin levels and aortic dilatation in bicuspid aortic valve patients
ConclusionLow serum apelin level was associated with dilatation of ascending aortic in BAV patients. However, apelin was not relevant to BAV without aortic dilatation. (Source: Congenital Heart Disease)
Source: Congenital Heart Disease - November 28, 2018 Category: Cardiology Authors: Ersin Çagrı Şimşek, Selcen Yakar Tülüce, Kamil Tülüce, Sadık Volkan Emren, Serap Çuhadar, Cem Nazlı Tags: ORIGINAL ARTICLE Source Type: research

Molecular and mechanical factors contributing to ductus arteriosus patency and closure
AbstractRegulation of the ductus arteriosus, an essential fetal vessel connecting the pulmonary artery and aorta, is complex. Failure of this vessel to close after birth may result in a persistent left ‐to‐right shunt through the patent ductus arteriosus, a condition associated with significant morbidities. Numerous factors contribute to the shift from fetal ductus patency to postnatal closure, requiring precise coordination of molecular cues with biomechanical forces and underlying genetic in fluences. Despite significant advances, questions remain regarding signaling dynamics and the natural time course of ductus clo...
Source: Congenital Heart Disease - November 23, 2018 Category: Cardiology Authors: Stacey L. Crockett, Courtney D. Berger, Elaine L. Shelton, Jeff Reese Tags: REVIEW ARTICLE Source Type: research

The long ‐term functional outcome in Mustard patients study: Another decade of follow‐up
ConclusionCardiac mortality for Mustard patients remains high, and over time, systemic right ventricular ejection fraction, rhythm, exercise tolerance, and quality of life assessments show deterioration. There does not appear to be a single clear predictor of poor outcome. (Source: Congenital Heart Disease)
Source: Congenital Heart Disease - November 23, 2018 Category: Cardiology Authors: Nayan T. Srivastava, Roger Hurwitz, W. Aaron Kay, George J. Eckert, Alisha Kuhlenhoelter, Nicole DeGrave, Eric S. Ebenroth Tags: ORIGINAL ARTICLE Source Type: research

Historical investigation of medical treatment for adult congenital heart disease: A Canadian perspective
ConclusionsThe insights provided behoove the community of stakeholders to think creatively on how to draw attention to the inadequacy of resources and the unique and diverse needs of this population. (Source: Congenital Heart Disease)
Source: Congenital Heart Disease - November 19, 2018 Category: Cardiology Authors: Jennifer L. Lapum, Suzanne Fredericks, Barbara Bailey, Terrence M. Yau, Jennifer Graham, Ariane J. Marelli Tags: ORIGINAL ARTICLE Source Type: research

Vasopressor magnitude predicts poor outcome in adults with congenital heart disease after cardiac surgery
ConclusionsMaxVIS score strongly predicted adverse outcomes and can be used as a risk prediction tool to facilitate early intervention that may improve outcome and assist with clinical decision making for ACHD patients after cardiac surgery. (Source: Congenital Heart Disease)
Source: Congenital Heart Disease - November 19, 2018 Category: Cardiology Authors: Joseph T. Poterucha, Saraschandra Vallabhajosyula, Alexander C. Egbe, Joseph S. Krien, Devon O. Aganga, Kimberly Holst, Adele W. Golden, Joseph A. Dearani, Sheri S. Crow Tags: ORIGINAL ARTICLE Source Type: research

Predictors and rates of recurrence of atrial arrhythmias following catheter ablation in adults with congenital heart disease
ConclusionsIn our cohort of ACHD patients, BMI was a significant risk factor for arrhythmia recurrence postablation, independent of Fontan status. These findings may help guide treatment decisions for persistent arrhythmias in the ACHD population. (Source: Congenital Heart Disease)
Source: Congenital Heart Disease - November 19, 2018 Category: Cardiology Authors: Matthew Lewis, William Whang, Angelo Biviano, Kathleen Hickey, Hasan Garan, Marlon Rosenbaum Tags: ORIGINAL ARTICLE Source Type: research

Prenatal heart block screening in mothers with SSA/SSB autoantibodies: Targeted screening protocol is a cost ‐effective strategy
ConclusionWhile the efficacy of fetal intervention for first or second degree AV block remains unclear, this analysis supports utilizing antibody levels to stratify this population for optimized surveillance for CHB. SS is cost ‐ineffective and results in resource overutilization. (Source: Congenital Heart Disease)
Source: Congenital Heart Disease - November 16, 2018 Category: Cardiology Authors: Patrick D. Evers, Tarek Alsaied, Jeffrey B. Anderson, James F. Cnota, Allison A. Divanovic Tags: ORIGINAL ARTICLE Source Type: research

Bifid T waves on the ECG and genetic variation in calcium channel voltage ‐dependent beta 2 subunit gene (CACNB2) in acute Kawasaki disease
Congenital Heart Disease, EarlyView. (Source: Congenital Heart Disease)
Source: Congenital Heart Disease - November 5, 2018 Category: Cardiology Authors: Jun Oyamada, Chisato Shimizu, Jihoon Kim, Matthew R. Williams, Eileen Png, Martin L. Hibberd, Adriana H. Tremoulet, James C. Perry, Jane C. Burns Source Type: research

Diastolic velocity half time is associated with aortic coarctation gradient at catheterization independent of echocardiographic and clinical blood pressure gradients
Congenital Heart Disease, EarlyView. (Source: Congenital Heart Disease)
Source: Congenital Heart Disease - November 5, 2018 Category: Cardiology Authors: Adam B. Christopher, Abraham Apfel, Tao Sun, Jackie Kreutzer, David S. Ezon Source Type: research

The utility of cardiac magnetic resonance imaging in post ‐Fontan surveillance
Congenital Heart Disease, EarlyView. (Source: Congenital Heart Disease)
Source: Congenital Heart Disease - October 31, 2018 Category: Cardiology Authors: Neil C. Zaki, Michael S. Kelleman, W. James Parks, Timothy C. Slesnick, Michael E. McConnell, Matthew E. Oster Source Type: research

A restrictive ventilatory pattern is common in patients with univentricular heart after Fontan palliation and associated with a reduced exercise capacity and quality of life
Congenital Heart Disease, EarlyView. (Source: Congenital Heart Disease)
Source: Congenital Heart Disease - October 31, 2018 Category: Cardiology Authors: Alessia Callegari, Rhoia Neidenbach, Ornella Milanesi, Biagio Castaldi, Martin Christmann, Masamichi Ono, Jan M üller, Peter Ewert, Alfred Hager Source Type: research

Bioelectrical impedance analysis in the management of heart failure in adult patients with congenital heart disease
Congenital Heart Disease, EarlyView. (Source: Congenital Heart Disease)
Source: Congenital Heart Disease - October 23, 2018 Category: Cardiology Authors: Masaki Sato, Kei Inai, Mikiko Shimizu, Hisashi Sugiyama, Toshio Nakanishi Source Type: research

Application of pediatric Appropriate Use Criteria for initial outpatient evaluation of asymptomatic patients with abnormal electrocardiograms
Congenital Heart Disease, EarlyView. (Source: Congenital Heart Disease)
Source: Congenital Heart Disease - October 23, 2018 Category: Cardiology Authors: Soham Dasgupta, Shae Anderson, Michael Kelleman, Ritu Sachdeva Source Type: research

Frontiers in Fontan failure: Innovation and improving outcomes: A conference summary
Congenital Heart Disease, EarlyView. (Source: Congenital Heart Disease)
Source: Congenital Heart Disease - October 21, 2018 Category: Cardiology Authors: Georges Ephrem, Camden Hebson, Anitha John, Estella Moore, Maan Jokhadar, Ryan Ford, Gruschen Veldtman, Yoav Dori, Michelle Gurvitz, Brian Kogon, Adrienne Kovacs, Meghan Roswick, Michael McConnell, Wendy M. Book, Fred Rodriguez Source Type: research