Transfusion practices in intensive care units: An Australian and New Zealand point prevalence study
CONCLUSIONS: Non-RBC transfusion decisions are often not aligned with guidelines and VHA is commonly available but rarely used to guide transfusions. Better evidence to guide transfusions in ICUs is needed.PMID:38234319 | PMC:PMC10790088 | DOI:10.1016/j.ccrj.2023.10.006 (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - January 18, 2024 Category: Intensive Care Authors: Andrew W J Flint Karina Brady Erica M Wood Le Thi Phuong Thao Naomi Hammond Serena Knowles Conrad Nangla Michael C Reade Zoe K McQuilten George Institute for Global Health, the Australian and New Zealand Intensive Care Society Clinical Trials Group and th Source Type: research

Perceptions of intensive care triage in Australia and New Zealand in 2009 and 2023
CONCLUSIONS: Our study suggests that New Zealand intensivists may apply more restrictive ICU admission criteria than Australian intensivists. Changes in attitudes to admission since 2009 may reflect increased awareness of the importance of facilitating organ donation and the role of ICU as providers of palliative care.PMID:38234320 | PMC:PMC10790017 | DOI:10.1016/j.ccrj.2023.10.001 (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - January 18, 2024 Category: Intensive Care Authors: William B Blackburne Paul J Young Source Type: research

Remi-fent 1-A pragmatic randomised controlled study to evaluate the feasibility of using remifentanil or fentanyl as sedation adjuncts in mechanically ventilated patients
CONCLUSIONS: We demonstrated the feasibility of enrolling patients for a pRCT comparing remifentanil and fentanyl as sedation adjuncts in mechanically ventilated patients. We failed to attain the study-opioid compliance target, likely because of patients with complex sedative/analgesic requirements. Secondary outcomes suggest that remifentanil may reduce mechanical ventilation duration and decrease the incidence of complications. An adequately powered multicentric phase 2 study is required to evaluate these results.PMID:38234321 | PMC:PMC10790007 | DOI:10.1016/j.ccrj.2023.10.012 (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - January 18, 2024 Category: Intensive Care Authors: Arvind Rajamani Ashwin Subramaniam Brian Lung Kristy Masters Rebecca Gresham Christina Whitehead Julie Lowrey Ian Seppelt Hemant Kumar Jayashree Kumar Anwar Hassan Sam Orde Pranav Arun Bharadwaj Hemamalini Arvind Stephen Huang SPARTAN Collaborative Source Type: research

Breaches of pre-medical emergency team call criteria in an Australian hospital
CONCLUSIONS: Four-fifths of MET calls were preceded by pre-MET criteria breaches, which were present for many hours. Such patients were older, had more limits of treatment, and experienced worse outcomes. There is a need to improve goals of care documentation and pre-MET management of clinical deterioration.PMID:38234322 | PMC:PMC10790013 | DOI:10.1016/j.ccrj.2023.11.002 (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - January 18, 2024 Category: Intensive Care Authors: Daryl Jones Kartik Kishore Glenn Eastwood Stephanie K Sprogis Neil J Glassford Source Type: research

Masking of an intravenous preparation of ceftriaxone for use in clinical trials: A technical report
CONCLUSIONS: 1 g of ceftriaxone can be effectively masked by dilution in 100mL of sodium chloride.PMID:38234323 | PMC:PMC10790008 | DOI:10.1016/j.ccrj.2023.10.002 (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - January 18, 2024 Category: Intensive Care Authors: David M Golding Tak Wai Chan Nikola G Orozov Paul J Young Source Type: research

Cerebrospinal fluid and plasma ascorbate concentrations following subarachnoid haemorrhage
CONCLUSION: Post aSAH there is a marked reduction in CSF ascorbate concentration that is most prominent in those who develop vasospasm.PMID:38234324 | PMC:PMC10790009 | DOI:10.1016/j.ccrj.2023.10.003 (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - January 18, 2024 Category: Intensive Care Authors: Natasha Turner Brodie Farrow Ashenafi H Betrie Mark E Finnis Yugeesh R Lankadeva Jeremy Sharman Patrick Tan Yasmine Ali Abdelhamid Adam M Deane Mark P Plummer Source Type: research

The impact of body mass index on long-term survival after ICU admission due to COVID-19: A retrospective multicentre study
CONCLUSIONS: The obesity paradox appears to exist beyond hospital discharge in critically ill patients with COVID-19 admitted in Australian and New Zealand ICUs. A BMI ≥40 kg/m2 was associated with a higher survival time of up to two years.PMID:38234325 | PMC:PMC10790021 | DOI:10.1016/j.ccrj.2023.10.004 (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - January 18, 2024 Category: Intensive Care Authors: Ashwin Subramaniam Ryan Ruiyang Ling Emma J Ridley David V Pilcher Source Type: research

Protocol and statistical analysis plan for the identification and treatment of hypoxemic respiratory failure  and acute respiratory distress syndrome with protection, paralysis, and proning: A type-1 hybrid stepped-wedge cluster randomised effectiveness-implementation study
CONCLUSIONS: TheraPPP will evaluate the effectiveness and implementation of an HRF and ARDS care pathway.PMID:38234326 | PMC:PMC10790012 | DOI:10.1016/j.ccrj.2023.10.008 (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - January 18, 2024 Category: Intensive Care Authors: Ken Kuljit S Parhar Andrea Soo Gwen Knight Kirsten Fiest Daniel J Niven Gordon Rubenfeld Damon Scales Henry T Stelfox Danny J Zuege Sean Bagshaw Source Type: research

Ventilator-associated pneumonia: A problematic outcome for clinical trials
Crit Care Resusc. 2023 Nov 22;25(4):159-160. doi: 10.1016/j.ccrj.2023.10.005. eCollection 2023 Dec.NO ABSTRACTPMID:38234327 | PMC:PMC10790014 | DOI:10.1016/j.ccrj.2023.10.005 (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - January 18, 2024 Category: Intensive Care Authors: Paul J Young Anthony Delaney Thomas Hills Source Type: research

The pressure reactivity index as a measure of cerebral autoregulation and its application in traumatic brain injury management
Crit Care Resusc. 2023 Dec 14;25(4):229-236. doi: 10.1016/j.ccrj.2023.10.009. eCollection 2023 Dec.ABSTRACTSevere traumatic brain injury (TBI) is a major cause of morbidity and mortality globally. The Brain Trauma Foundation guidelines advocate for the maintenance of a cerebral perfusion pressure (CPP) between 60 and 70 mmHg following severe TBI. However, such a uniform goal does not account for changes in cerebral autoregulation (CA). CA refers to the complex homeostatic mechanisms by which cerebral blood flow is maintained, despite variations in mean arterial pressure and intracranial pressure. Disruption to CA has becom...
Source: Critical Care and Resuscitation - January 18, 2024 Category: Intensive Care Authors: Zac A Tsigaras Mark Weeden Robert McNamara Toby Jeffcote Andrew A Udy PRECISION-TBI Investigators Source Type: research

Iron and erythropoietin to heal and recover after intensive care (ITHRIVE): A pilot randomised clinical trial
CONCLUSION: The iron and erythropoietin to heal and recover after intensive care (ITHRIVE) pilot demonstrated feasibility based on predefined participant recruitment, study drug administration, and follow-up thresholds.PMID:38236513 | PMC:PMC10790015 | DOI:10.1016/j.ccrj.2023.10.007 (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - January 18, 2024 Category: Intensive Care Authors: Edward Litton Craig French Alan Herschtal Simon Stanworth Susan Pellicano Anne Marie Palermo Samantha Bates Sarah Van Der Laan Ege Eroglu David Griffith Akshay Shah Source Type: research

Transfusion practices in intensive care units: An Australian and New Zealand point prevalence study
CONCLUSIONS: Non-RBC transfusion decisions are often not aligned with guidelines and VHA is commonly available but rarely used to guide transfusions. Better evidence to guide transfusions in ICUs is needed.PMID:38234319 | PMC:PMC10790088 | DOI:10.1016/j.ccrj.2023.10.006 (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - January 18, 2024 Category: Intensive Care Authors: Andrew W J Flint Karina Brady Erica M Wood Le Thi Phuong Thao Naomi Hammond Serena Knowles Conrad Nangla Michael C Reade Zoe K McQuilten George Institute for Global Health, the Australian and New Zealand Intensive Care Society Clinical Trials Group and th Source Type: research

Perceptions of intensive care triage in Australia and New Zealand in 2009 and 2023
CONCLUSIONS: Our study suggests that New Zealand intensivists may apply more restrictive ICU admission criteria than Australian intensivists. Changes in attitudes to admission since 2009 may reflect increased awareness of the importance of facilitating organ donation and the role of ICU as providers of palliative care.PMID:38234320 | PMC:PMC10790017 | DOI:10.1016/j.ccrj.2023.10.001 (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - January 18, 2024 Category: Intensive Care Authors: William B Blackburne Paul J Young Source Type: research

Remi-fent 1-A pragmatic randomised controlled study to evaluate the feasibility of using remifentanil or fentanyl as sedation adjuncts in mechanically ventilated patients
CONCLUSIONS: We demonstrated the feasibility of enrolling patients for a pRCT comparing remifentanil and fentanyl as sedation adjuncts in mechanically ventilated patients. We failed to attain the study-opioid compliance target, likely because of patients with complex sedative/analgesic requirements. Secondary outcomes suggest that remifentanil may reduce mechanical ventilation duration and decrease the incidence of complications. An adequately powered multicentric phase 2 study is required to evaluate these results.PMID:38234321 | PMC:PMC10790007 | DOI:10.1016/j.ccrj.2023.10.012 (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - January 18, 2024 Category: Intensive Care Authors: Arvind Rajamani Ashwin Subramaniam Brian Lung Kristy Masters Rebecca Gresham Christina Whitehead Julie Lowrey Ian Seppelt Hemant Kumar Jayashree Kumar Anwar Hassan Sam Orde Pranav Arun Bharadwaj Hemamalini Arvind Stephen Huang SPARTAN Collaborative Source Type: research

Breaches of pre-medical emergency team call criteria in an Australian hospital
CONCLUSIONS: Four-fifths of MET calls were preceded by pre-MET criteria breaches, which were present for many hours. Such patients were older, had more limits of treatment, and experienced worse outcomes. There is a need to improve goals of care documentation and pre-MET management of clinical deterioration.PMID:38234322 | PMC:PMC10790013 | DOI:10.1016/j.ccrj.2023.11.002 (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - January 18, 2024 Category: Intensive Care Authors: Daryl Jones Kartik Kishore Glenn Eastwood Stephanie K Sprogis Neil J Glassford Source Type: research