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Genotype at increased risk of developing asthma after tobacco smoke exposureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11882-009-0074-6Authors Christina E. Ciaccio, Children’s Mercy Hospitals and Clinics Section of Allergy, Asthma, and Immunology Kansas USAJay M. Portnoy, Children’s Mercy Hospitals and Clinics Section of Allergy, Asthma, and Immunology Kansas USA Journal Current Allergy and Asthma ReportsOnline ISSN 1534-6315Print ISSN 1529-7322 Journal Volume Volume 9 Journal Issue Volume 9, Number 6 / November, 2009 (Source: Current Allergy and Asthma Reports)
Source: Current Allergy and Asthma Reports - October 13, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Self-management improves asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11882-009-0072-8Authors Christina E. Ciaccio, Children’s Mercy Hospitals and Clinics Section of Allergy, Asthma, and Immunology Kansas USAJay M. Portnoy, Children’s Mercy Hospitals and Clinics Section of Allergy, Asthma, and Immunology Kansas USA Journal Current Allergy and Asthma ReportsOnline ISSN 1534-6315Print ISSN 1529-7322 Journal Volume Volume 9 Journal Issue Volume 9, Number 6 / November, 2009 (Source: Current Allergy and Asthma Reports)
Source: Current Allergy and Asthma Reports - October 13, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Should antibiotics be given to children with otitis media to prevent mastoiditis?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11882-009-0075-5Authors David P. Skoner, Drexel University College of Medicine Philadelphia USA Journal Current Allergy and Asthma ReportsOnline ISSN 1534-6315Print ISSN 1529-7322 Journal Volume Volume 9 Journal Issue Volume 9, Number 6 / November, 2009 (Source: Current Allergy and Asthma Reports)
Source: Current Allergy and Asthma Reports - October 13, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Potential new paradigm for treatment of atopic dermatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11882-009-0073-7Authors Christina E. Ciaccio, Children’s Mercy Hospitals and Clinics Section of Allergy, Asthma, and Immunology Kansas USAJay M. Portnoy, Children’s Mercy Hospitals and Clinics Section of Allergy, Asthma, and Immunology Kansas USA Journal Current Allergy and Asthma ReportsOnline ISSN 1534-6315Print ISSN 1529-7322 Journal Volume Volume 9 Journal Issue Volume 9, Number 6 / November, 2009 (Source: Current Allergy and Asthma Reports)
Source: Current Allergy and Asthma Reports - October 13, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Otitis media and antihistaminesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Otitis media with effusion (OME) and acute otitis media (AOM) continue to be a significant source of morbidity in the United States, as they account for more than 3.5 billion dollars in annual costs, and OME is the sixth most common reason for an emergency department visit. The efficacy of antihistamines in the treatment of OME/AOM has been thoroughly refuted in the literature during the past three decades. However, most studies to date have used first-generation antihistamines with or without decongestants. We propose that second-generation antihistamines may have increased efficacy in the treatmen...
Source: Current Allergy and Asthma Reports - October 13, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Role of adenoids and adenoiditis in children with allergy and otitis mediaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Adenoids and/or tonsil inflammation with concomitant obstructive hypertrophy is one of the oldest and most common pediatric problems. Adenoids are a component of Waldeyer’s ring and because of their anatomic position can be relevant in the pathogenesis of otitis media when they are inflamed and/or enlarged. Adenoid pads can create mechanical eustachian tube obstruction. Therefore, in some cases, adenoidectomy may have a role in the clinical management of otitis media with effusion. However, eustachian tube dysfunction related to the adenoids may also have an allergy-related functional component. A...
Source: Current Allergy and Asthma Reports - October 13, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Relationship between pediatric obesity and otitis media with effusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Although eustachian tube dysfunction and bacterial infection have been shown to cause otitis media with effusion (OME), other etiologies are possible. One of the most common medical conditions in children is obesity, which can have effects throughout the body. Little is known, however, about the relationship between obesity and OME. Obesity may result in altered cytokine expression, gastroesophageal reflux disease, or fat accumulation, all of which may contribute to OME. Conversely, OME may induce taste changes through middle ear cavity inflammation, thus contributing to obesity. A similar pattern o...
Source: Current Allergy and Asthma Reports - October 13, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Asthma phenotypesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The many roads leading to the syndrome of asthma have proven to be intricately interconnected. The chronic inflammation of asthma is characterized by airway hyperreactivity and variable reversibility. Past classification systems relied on assessment of daily impairment and the distinction between intrinsic (nonallergic) and extrinsic (allergic). With more precise asthma phenotypes, association studies likely will have greater significance. In addition, patients at higher risk for severe disease can be more effectively managed, and treatments can be directed to responders. In this review, we look at ...
Source: Current Allergy and Asthma Reports - October 13, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Home and school environmental assessment and remediationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews and discusses evidence for the assessment and remediation of indoor allergens commonly found in homes and schools. A literature review was performed using the PubMed database for English-language articles published between January 1, 1980, and February 2009. Additional information was obtained from a review of recent textbooks and one professional society’s webpage. Content Type Journal ArticleDOI 10.1007/s11882-009-0062-xAuthors Thomas A. Lupoli, Children’s Mercy Hospital 2401 Gillham Road Kansas City MO 64108 USAChristina E. CiaccioJay M. Portnoy Journal Current Allergy and Asthma ...
Source: Current Allergy and Asthma Reports - October 13, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Immunomodulators in asthma therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract New developments in the field of allergy and immunology have yielded a variety of novel therapeutic approaches in recent years, and more agents are at the clinical trial stage. Among the therapeutic approaches discussed in this review are Toll-like receptor agonists, immunostimulatory oligodeoxynucleotides, orally and parenterally administered cytokine blockers, and specific cytokine receptor antagonists. Transcription factor modulators targeting syk kinase, peroxisome proliferator-activated receptor-γ, and nuclear factor-κB are also being evaluated in the treatment of asthma. The anti-IgE monoclo...
Source: Current Allergy and Asthma Reports - October 13, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

An update on exercise-induced bronchoconstriction with and without asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Exercise-induced bronchoconstriction (EIB) is defined as transient, reversible bronchoconstriction that develops after strenuous exercise. It is a heterogeneous syndrome made up of a spectrum of phenotypes ranging from the asymptomatic military recruit whose condition is detected by diagnostic exercise challenge to the athlete with known asthma to the elite athlete for whom EIB represents an overuse or injury syndrome. If exercise is the only identified trigger for bronchoconstriction, it is called EIB. However, when it is associated with known asthma, then it is defined as EIB with asthma. This rev...
Source: Current Allergy and Asthma Reports - October 13, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Neural control of airway inflammationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Abnormal neural function contributes to the pathogenesis of airway disease. In addition to affecting airway physiology, the nerves produce and release inflammatory mediators, contributing to the recruitment and activation of leukocytes. Activated inflammatory cells in turn affect the function of airway nerves, changing the production and release of neurotransmitters. Cross-talk between airway nerves and leukocytes helps to maintain chronic inflammation and accentuates neural control of the airways. Content Type Journal ArticleDOI 10.1007/s11882-009-0071-9Authors Kirsten C. VerheinAllison D. Fry...
Source: Current Allergy and Asthma Reports - October 13, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Biofilms in pediatric respiratory and related infectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Bacteria can grow as free-floating, planktonic bacteria or complex communities called biofilms. Biofilms promote bacterial growth and diversity and offer bacteria unique environments, including aerobic and anaerobic layers, that facilitate resistance to antimicrobial therapies. Respiratory and related structures provide ideal environments for the development of bacterial biofilms, which predispose patients to recurrent and chronic infections. Biofilms are important for the persistence of chronic rhinosinusitis, pulmonary infections in cystic fibrosis, chronic otitis media, and device-related infecti...
Source: Current Allergy and Asthma Reports - October 13, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Effects of allergens: Beyond IgEEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11882-009-0076-4Authors Robert K. Bush, University of Wisconsin-Madison Wisconsin-Madison USA Journal Current Allergy and Asthma ReportsOnline ISSN 1534-6315Print ISSN 1529-7322 Journal Volume Volume 9 Journal Issue Volume 9, Number 6 / November, 2009 (Source: Current Allergy and Asthma Reports)
Source: Current Allergy and Asthma Reports - October 13, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Personalized medicine: A pediatric perspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of pediatric personalized medicine is to uniquely combine genetic variation with developmental stage and environmental exposure to provide a tailored preventive, diagnostic, and therapeutic regimen. Recent advances in genomic research have identified many genetic variants that may be related to allergic and inflammatory disease and therapeutic response. These include variants involved in immune response, barrier proteins, and medication response. Current evidence also suggests that the effect of genetic variation often depends on the developmental stage of a child and environmental exposure ...
Source: Current Allergy and Asthma Reports - October 13, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Role of mouse allergens in allergic diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Mouse allergen has long been recognized as an important cause of occupational allergy and asthma, but only recently has it been implicated in asthma and allergic diseases in community settings. Recent studies have established that mouse allergen is detectable in most US homes, with strikingly high levels in some inner cities. Inner city homes in major northeastern and midwestern US urban centers have levels as much as 100-fold higher than those found in other geographic regions. In addition, about 25% of inner city children with asthma have evidence of IgE sensitization to mouse. Several studies hav...
Source: Current Allergy and Asthma Reports - August 11, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Autoimmunity in common variable immunodeficiencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Common variable immunodeficiency (CVID) is the most common clinically significant primary immune defect. Although the hallmark of CVID is hypogammaglobulinemia, the intrinsic dysregulation of the immune system leads to defective T-cell activation and proliferation, as well as dendritic cell and cytokine defects. Although 70% to 80% of patients have had recurrent sinopulmonary infections, autoimmunity and inflammatory complications are also common. The most common autoimmune conditions are immune thrombocytopenic purpura and hemolytic anemia, but other autoimmune complications arise, including rheuma...
Source: Current Allergy and Asthma Reports - August 11, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Allergens and thunderstorm asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Thunderstorm-related asthma is increasingly recognized in many parts of the world. This review focuses on important advances in the understanding of the mechanism of the role of allergens, in particular fungal spores such as Alternaria, in asthma epidemics associated with thunderstorms. From our observations, we have proposed that the prerequisites for this phenomenon are as follows: 1) a sensitized, atopic, asthmatic individual; 2) prior airway hyperresponsiveness before a sudden, large allergen exposure; 3) a large-scale thunderstorm with cold outflow occurring at a time and location during an alle...
Source: Current Allergy and Asthma Reports - August 11, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Severe asthma: What makes it so hard to manage?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Severe asthma presents significant management challenges. Patients can be difficult to control despite use of current standard-of-care therapy, including inhaled corticosteroids and long-acting β-agonists. Alternative diagnoses, noncompliance, and comorbidities all can influence asthma control, future risk, and response to currently available therapy. Definitions of severe asthma evaluate and address these confounding variables, and yet patients are still symptomatic despite aggressive, appropriate therapy. Severe asthma has a distinct pathophysiology including airway remodeling that contributes to...
Source: Current Allergy and Asthma Reports - August 11, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Mast cell modulation of the immune responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Mast cells are present in nearly all vascularized tissues, but not the blood. They are best known for the prominent role they play in atopic disease. However, our current understanding of their direct and indirect roles in the immune response offers a more nuanced picture of both villain and hero. Although they are implicated in many inflammatory disorders, they also defend us from bacterial pathogens, prevent dangerous overreactions by the immune system, and even protect us from snake venom. Perhaps there is more to these maligned cells than we thought. Content Type Journal ArticleDOI 10.1007/s1...
Source: Current Allergy and Asthma Reports - August 11, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Levalbuterol versus albuterolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Albuterol has been used for more than 40 years to treat acute asthma exacerbations as a racemic mixture of isomers: the active form, (R)-albuterol, or levalbuterol, and (S)-albuterol, classically considered inert. The single-isomer formulation, levalbuterol, has been synthesized recently and used therapeutically when the racemate is deemed less desirable. Basic investigations indicate that racemic albuterol and levalbuterol can produce effects that favor asthma remediation, including corticosteroid amplification and reduction of inflammatory mediators; in contrast, (S)-albuterol produces opposite ef...
Source: Current Allergy and Asthma Reports - August 11, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Prevention of allergic sensitization by environmental controlEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present published results, focusing on the most recent. There is great heterogeneity of results that cannot be explained by the variety of study designs alone. We propose that the next generation of primary prevention studies will be informed by epidemiologic studies of gene-environment interactions and will investigate the effects of tailor-made measures targeting individuals with specific susceptibilities who may benefit from specified interventions. Content Type Journal ArticleDOI 10.1007/s11882-009-0053-yAuthors Angela Simpson, University of Manchester University Hospital of South Manchester National Health...
Source: Current Allergy and Asthma Reports - August 11, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

T-regulatory cells in common variable immunodeficiencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11882-009-0059-5Authors Ashwini Komarla, Washington University School of Medicine Houston TX USAJulie Y. Patel, Texas A&M Health Science Center College of Medicine Houston TX USADavid P. Huston, Texas A&M Health Science Center College of Medicine Houston TX USA Journal Current Allergy and Asthma ReportsOnline ISSN 1534-6315Print ISSN 1529-7322 Journal Volume Volume 9 Journal Issue Volume 9, Number 5 / September, 2009 (Source: Current Allergy and Asthma Reports)
Source: Current Allergy and Asthma Reports - August 11, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Autophagy in immune cell regulation and dysregulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Autophagy is an ancient pathway required for cell and tissue homeostasis and differentiation. Initially thought to be a process leading to cell death, autophagy is currently viewed as a beneficial catabolic process that promotes cell survival under starvation conditions by sequestering components of the cytoplasm, including misfolded proteins, protein aggregates, and damaged organelles, and targeting them for lysosome-mediated degradation. In this way, autophagy plays a role in maintaining a balance between degradation and recycling of cellular material. The importance of autophagy is underscored by...
Source: Current Allergy and Asthma Reports - August 11, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Carbohydrate moieties as important allergensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11882-009-0061-yAuthors Robert K. Bush, University of Wisconsin-Madison Madison WI USA Journal Current Allergy and Asthma ReportsOnline ISSN 1534-6315Print ISSN 1529-7322 Journal Volume Volume 9 Journal Issue Volume 9, Number 5 / September, 2009 (Source: Current Allergy and Asthma Reports)
Source: Current Allergy and Asthma Reports - August 11, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Allergen databases: Current status and perspectivesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract An increasing number of studies on allergenic molecules have been published during the past 20 years, and the number of proteins reported as allergens is close to 1500 (http://www.allergome.org). Collecting, organizing, and displaying data reported in the scientific literature is becoming the major commitment of Web-based databases that organize this knowledge in heterogeneous ways. This heterogeneity prevents the databases from being connected to each other, something that has been done in several other biomedical fields. This review reports on the current status of allergen databases and available...
Source: Current Allergy and Asthma Reports - August 11, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Clinical relevance of cross-reactive fungal allergensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11882-009-0060-zAuthors Robert K. Bush, University of Wisconsin-Madison Madison WI USA Journal Current Allergy and Asthma ReportsOnline ISSN 1534-6315Print ISSN 1529-7322 Journal Volume Volume 9 Journal Issue Volume 9, Number 5 / September, 2009 (Source: Current Allergy and Asthma Reports)
Source: Current Allergy and Asthma Reports - August 11, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Methotrexate for moderate to severe adult atopic eczemaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11882-009-0048-8Authors Allen P. Kaplan, Medical University of South Carolina Department of Medicine Charleston SC USA Journal Current Allergy and Asthma ReportsOnline ISSN 1534-6315Print ISSN 1529-7322 Journal Volume Volume 9 Journal Issue Volume 9, Number 4 / July, 2009 (Source: Current Allergy and Asthma Reports)
Source: Current Allergy and Asthma Reports - July 25, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

The relationship of intranasal steroids to intraocular pressureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Intranasal corticosteroids have become a gold standard in therapy for allergic rhinoconjunctivitis. A direct relationship between topical and systemic corticosteroids and elevated intraocular pressure (IOP) has been recognized for more than 50 years. However, this steroid-induced response is highly variable. Glaucoma is an eye disease caused by an increase in IOP and results in optic nerve cell death and vision loss. Intranasal corticosteroids are absorbed systemically albeit in small measurable amounts. Some studies suggest a relationship between intranasal steroids and increased IOP. Large prospec...
Source: Current Allergy and Asthma Reports - July 25, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Ocular allergic disorders: Disease entities and differential diagnosesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article describes the spectrum of disorders classified as ocular allergy and outlines pathogenetic mechanisms underlying the various disorders. This forms the basis for a rational approach to management strategies. Content Type Journal ArticleDOI 10.1007/s11882-009-0042-1Authors Gregg J. Berdy, Ophthalmology Associates 12990 Manchester Road, Suite 200 St. Louis MO 63131 USASusan S. Berdy Journal Current Allergy and Asthma ReportsOnline ISSN 1534-6315Print ISSN 1529-7322 Journal Volume Volume 9 Journal Issue Volume 9, Number 4 / July, 2009 (Source: Current Allergy and Asthma Reports)
Source: Current Allergy and Asthma Reports - July 25, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

A 42-year-old woman with chronic rhinosinusitis and allergic mucinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Case StudyDOI 10.1007/s11882-009-0047-9Authors Kimberly C. SalazarMichael R. Nelson, Walter Reed Army Medical Center Division of Allergy and Immunology 6900 Georgia Avenue NW Washington, DC 20307 USAKelly D. Stone Journal Current Allergy and Asthma ReportsOnline ISSN 1534-6315Print ISSN 1529-7322 Journal Volume Volume 9 Journal Issue Volume 9, Number 4 / July, 2009 (Source: Current Allergy and Asthma Reports)
Source: Current Allergy and Asthma Reports - July 25, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Intranasal corticosteroids: Do they improve ocular allergy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Allergic rhinoconjunctivitis (ARC) is a common allergic condition associated with high financial costs and decreased quality of life. Medical treatment options are extensive and include oral, ophthalmic, and intranasal agents. Intranasal corticosteroids (INS) have traditionally been used for chronic management of nasal symptoms, but have also demonstrated an impact on decreasing ocular symptoms of itching, tearing, and redness. Study design, including the method and timing of scoring ocular symptoms, is an important factor affecting whether changes in ocular symptoms are detected in INS clinical tri...
Source: Current Allergy and Asthma Reports - July 25, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Hereditary angioedema with normal C1 inhibitionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Until recently, it was assumed that hereditary angioedema was a disease resulting exclusively from a genetic deficiency of the C1 inhibitor. In 2000, families with hereditary angioedema, normal C1 inhibitor activity, and protein in plasma were described. Since then, numerous patients and families with this condition have been reported. Most of the patients were women. In many of the affected women, oral contraceptives, hormone replacement therapy containing estrogens, and pregnancies triggered the clinical symptoms. In some families, mutations in the coagulation factor XII (Hageman factor) gene were...
Source: Current Allergy and Asthma Reports - July 25, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

New concepts of hive formation in cholinergic urticariaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Patients with cholinergic urticaria (CU) show a number of small, short-lasting hives when their body core temperature increases, usually during sweating following exercise or bathing. The precise mechanism(s) of hive formation in CU has been unclear except for the involvement of acetylcholine. We recently reported that most CU patients show immediate-type skin responses to their own sweat, whereas the rest of CU patients have positive autologous serum skin tests (ASSTs). The former group produced satellite wheals following acetylcholine injection, whereas the latter group produced hives in conjuncti...
Source: Current Allergy and Asthma Reports - July 25, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Basophil responsiveness in chronic urticariaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Chronic urticaria is a common skin disease without an etiology in the majority of cases. The similarity of symptoms and pathology to allergen-induced skin reactions supports the idea that skin mast cell and blood basophil IgE receptor activation is involved; however, no exogenous allergen trigger has been identified. Recent evidence supports a role for blood basophils in disease expression. Specifically, blood basopenia is noted in active disease with the recruitment of blood basophils to skin lesional sites. In addition, blood basophils display altered IgE receptor-mediated degranulation that rever...
Source: Current Allergy and Asthma Reports - July 25, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

The impact of air pollutants as an adjuvant for allergic sensitization and asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the evidence supporting the fundamental role of air pollutants in fostering allergic inflammation of the airways, with emphasis on the molecular and genetic pathways that link ambient particulate matter (PM) exposure to the induction of proinflammatory changes and proallergic effects in the respiratory tract. We propose that the link between PM exposure and proallergic effects involves organic PM components that generate oxygen radicals capable of perturbing the redox equilibrium mucosal immune cells. Content Type Journal ArticleDOI 10.1007/s11882-009-0046-xAuthors Loida VieraKarin ChenAndre N...
Source: Current Allergy and Asthma Reports - July 25, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Abnormal skin barrier in the etiopathogenesis of atopic dermatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews emerging evidence that the inflammation in AD results from inherited and acquired insults to the barrier, as well as the therapeutic implications of this new paradigm. Content Type Journal ArticleDOI 10.1007/s11882-009-0037-yAuthors Peter M. Elias, VA Medical Center Dermatology Service (190) 4150 Clement Street San Francisco CA 94121 USAMatthias Schmuth Journal Current Allergy and Asthma ReportsOnline ISSN 1534-6315Print ISSN 1529-7322 Journal Volume Volume 9 Journal Issue Volume 9, Number 4 / July, 2009 (Source: Current Allergy and Asthma Reports)
Source: Current Allergy and Asthma Reports - July 25, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Orbital myositis: Diagnosis and managementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Orbital myositis is an inflammatory process that primarily involves the extraocular muscles and most commonly affects young adults in the third decade of life, with a female predilection. Clinical characteristics of orbital myositis include orbital and periorbital pain, ocular movement impairment, diplopia, proptosis, swollen eyelids, and conjunctival hyperemia. The most common presentation is acute and unilateral, which initially responds to systemic corticosteroid therapy. However, chronic and recurrent cases may involve both orbits. Many inflammatory, vascular, neoplastic, and infectious conditio...
Source: Current Allergy and Asthma Reports - July 25, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Pathogenesis of atopic dermatitis: New developmentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Atopic dermatitis (AD) is a paradigmatic skin disease in which multiple gene-gene and gene-environment interactions play a pivotal role. Although the complex pathophysiologic network of AD explains the large spectrum of risk and trigger factors, it is far from being comprehensively understood. Hence, genetic modifications underlying the dysfunction of the epidermal skin barrier as well as the close interaction of innate and adaptive immune mechanisms were the focus of intensive research studies. This review aims to summarize the most recent findings in this field. Content Type Journal ArticleDOI ...
Source: Current Allergy and Asthma Reports - July 25, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Mycophenolate mofetil for severe childhood atopic dermatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11882-009-0049-7Authors Allen P. Kaplan, Medical University of South Carolina Department of Medicine Charleston SC USA Journal Current Allergy and Asthma ReportsOnline ISSN 1534-6315Print ISSN 1529-7322 Journal Volume Volume 9 Journal Issue Volume 9, Number 4 / July, 2009 (Source: Current Allergy and Asthma Reports)
Source: Current Allergy and Asthma Reports - July 25, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Building better mouse models of asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Allergic asthma is a complex disease that has been modeled extensively in small rodents. Airway eosinophilia and changes in lung function have been documented using a variety of protocols. However, recent efforts have improved these models by trying to replicate the structural remodeling that occurs in the lung as a consequence of chronic allergen-driven inflammation. This review documents the recent developments in protocols and systems designed to examine pathways leading to allergen-induced airway remodeling. Content Type Journal ArticleDOI 10.1007/s11882-007-0077-0Authors Clare M. Lloyd, Im...
Source: Current Allergy and Asthma Reports - May 30, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

The potential of Mycobacterium to protect against allergy and asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The increase in the global incidence of atopic disease and asthma during the past few decades has been ascribed to environmental factors, including the reduction in exposure to serious infections. The hypothetical framework to explain the inverse relationship between infections and atopic disease and asthma has been called the “hygiene hypothesis.” Animal and experimental models have identified Mycobacteria as important potential candidates in the hygiene hypothesis by demonstrating that exposure to Mycobacteria or mycobacterial proteins led to subsequent reduction in different atopic manifestati...
Source: Current Allergy and Asthma Reports - May 30, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Progress in surgical management of chronic rhinosinusitis and nasal polyposisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Endoscopic sinus surgery (ESS) remains the treatment (CRS) with or without nasal polyposis (NP). ESS has undergone review, reassessment, and substantial refinement. Several advances (eg, powered instrumentation, image guidance, adjunctive intraoperative procedures) have expanded the scope of cases amenable to ESS, decreased operative time and intraoperative blood loss, and improved safety. Procoagulant nasal/sinus packing and refinements of technique have decreased the need for postoperative removal of packing, thus decreasing morbidity. Methods to reduce synechia formation (ie, mitomycin-c) have be...
Source: Current Allergy and Asthma Reports - May 30, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

The role of antileukotriene drugs in management of rhinitis and rhinosinusitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Antileukotriene drugs have been studied for more than 15 years. In his review we examine the role of leukotrienes in rhinitis and rhinosinusitis, and explore the clinical literature supporting the use of antileukotriene agents in these diseases. Although these medications clearly are efficacious in rhinitis, it is unclear where in the armamentarium they should be used. The evidence for use in sinusitis has not been well studied except in sinusitis-associated aspirin-exacerbated respiratory disease. In this circumstance there is information that allows use of antileukotriene agents to be considered e...
Source: Current Allergy and Asthma Reports - May 30, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Inflammatory mechanisms and remodeling in chronic rhinosinusitis and nasal polypsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Chronic rhinosinusitis (CRS) is presently classified into two subgroups: CRS without and CRS with nasal polyps. A variety of inflammatory mediators, including cytokines and chemokines, as well as adhesion molecules and matrix metalloproteinases, are upregulated in both subgroups of CRS; remodeling is also observed in both. However, there are also characteristic differences. Whereas CRS without nasal polyps has more neutrophilic infiltration, in CRS with nasal polyps (especially when associated with allergy/asthma) eosinophil infiltration is strikingly increased. Although several features of remodeli...
Source: Current Allergy and Asthma Reports - May 30, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Laryngopharyngeal reflux and chronic sinusitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract In patients with chronic and recurrent sinusitis, laryngopharyngeal reflux disease may play a significant role. Laryngopharyngeal reflux disease differs from gastroesophageal reflux disease in the extent of reflux (into the hypopharynx and above) as well as timing (occurring more often when the patient is upright). Most patients are unaware of the extent of their symptoms, and diagnostic tools such as pH probe, multichannel intraluminal impedance, and manometry are required for adequate diagnosis. Although therapy with lifestyle modification and acid-suppressive agents may improve reflux in the majo...
Source: Current Allergy and Asthma Reports - May 30, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Food allergy and autism spectrum disorders: Is there a link?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Gastrointestinal (GI) symptoms are common comorbidities in children with autism spectrum disorders (ASDs). Parents often attribute these GI symptoms to food allergy (FA), although an evaluation for IgE-mediated FA is often unrevealing. Our previous studies indicated a high prevalence of non-IgE-mediated FA in young children with ASDs. Therefore, non-IgE-mediated FA may account for some but not all GI symptoms observed in children with ASDs. This raises the question of what treatment measures are applicable to ASD children with GI symptoms. A wide variety of dietary supplements and dietary interventi...
Source: Current Allergy and Asthma Reports - April 5, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Fatal anaphylaxis to foods: Epidemiology, recognition, and preventionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article briefly reviews the epidemiology of fatal anaphylactic reactions to foods, discusses factors that may aid in identifying individuals at higher risk, emphasizes important aspects of patient education and prevention, and touches on the psychological impact of having a family member with food allergy. Content Type Journal ArticleDOI 10.1007/s11882-009-0027-0Authors Dan Atkins, National Jewish Health 1400 Jackson Street J301 Denver CO 80206 USAS. Allan Bock Journal Current Allergy and Asthma ReportsOnline ISSN 1534-6315Print ISSN 1529-7322 Journal Volume Volume 9 Journal Issue Volume 9, Numbe...
Source: Current Allergy and Asthma Reports - April 5, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Endoscopic sinus surgery and asthma outcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11882-009-0026-1Authors Marek L. Kowalski Journal Current Allergy and Asthma ReportsOnline ISSN 1534-6315Print ISSN 1529-7322 Journal Volume Volume 9 Journal Issue Volume 9, Number 3 / May, 2009 (Source: Current Allergy and Asthma Reports)
Source: Current Allergy and Asthma Reports - April 5, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Maxillary sinusitis of odontogenic originEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Odontogenic etiology accounts for 10% to 12% of cases of maxillary sinusitis. Although uncommon, direct spread of dental infections into the maxillary sinus is possible due to the close relationship of the maxillary posterior teeth to the maxillary sinus. If a periapical dental infection or dental/oral surgery procedure violates the schneiderian membrane integrity, infection will likely spread into the sinus, leading to sinusitis. An odontogenic source should be considered in individuals with symptoms of maxillary sinusitis and a history of dental or jaw pain; dental infection; oral, periodontal, or...
Source: Current Allergy and Asthma Reports - April 5, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals