Controversies in Post-Prostatectomy Incontinence Management: Role of Urodynamics Testing and Sequence of Continence Surgery with Salvage Radiation Therapy
AbstractPurpose of ReviewThis paper evaluates the current evidence on the role of urodynamics in prostatectomy incontinence (PPI) and should male sling (MS) or artificial urinary sphincter (AUS) surgery be performed before or after patients receiving radiation therapy in terms of continence outcomes.Recent FindingsThe prevalence of PPI is more common in patients undergoing radical prostatectomy than benign prostatic surgery, and the presence of postoperatively de novo overactive bladder and urge incontinence is not common even without the addition of radiation therapy. Hence, the question arises whether patients presenting...
Source: Current Bladder Dysfunction Reports - April 19, 2024 Category: Urology & Nephrology Source Type: research

Experimental Animal Models for IC/BPS
AbstractPurpose of ReviewInterstitial cystitis/bladder pain syndrome (IC/BPS) is a disease that causes bladder symptoms such as pelvic pain and frequent urination and is often an intractable disease affecting a patient ’s quality of life. The etiology of IC/BPS remains elusive, and treatment strategies are still not fully established. To better understand the underlying pathophysiology, many studies have strived to recreate an animal model of IC/BPS to help further expand the treatment options of this difficult disease.Recent FindingsBasic animal studies of IC/BPS have often been conducted by provoking inflammation in th...
Source: Current Bladder Dysfunction Reports - April 12, 2024 Category: Urology & Nephrology Source Type: research

Urological Surgery Training in Low- and Low-Middle-Resource Settings: a Model for Success!
AbstractPurpose of ReviewThis review addresses the growing need for enhanced surgical —and specifically urological—training in low- and low-middle-income countries (LLMICs). Outlined are the challenges host and visiting teams face in facilitating such training, the role of international collaborations and the various urological pathologies that necessitate attention.Recent FindingsMany challenges exist for the successful implementation of urological training in LLMICs. There is a clear need for specific, collaborative and sustainable approaches to address the gap in expertise between high-income countries (HICs) and LL...
Source: Current Bladder Dysfunction Reports - April 10, 2024 Category: Urology & Nephrology Source Type: research

Transition Adolescent Functional Urology in 2024: Current Challenges and into the Future
AbstractPurpose of ReviewTo report on our experience in establishing a formal transition urology clinic in Victoria, Australia, and review current literature on transition urology processes, as well as identified challenges and future avenues for research and development in the field of transition and adolescent urology.Recent FindingsPaediatric to adult urology transition processes are increasingly reported and supported by the literature; however, to date, there is no consensus on a best model. In 2013, a formal urology transition clinic was established between The Royal Children ’s Hospital and The Royal Melbourne Hos...
Source: Current Bladder Dysfunction Reports - April 8, 2024 Category: Urology & Nephrology Source Type: research

Bladder Cancer Diagnosis and Treatment for Patients with Neurogenic Bladder: Does the Literature Support a Different Approach?
AbstractPurpose of ReviewIn this review, the current literature available to patients and providers on the diagnosis and management of bladder cancer in patients with neurogenic bladder will be discussed. Topics include bladder cancer epidemiology in the neurogenic population and unique features of this tumor in this subset of patients, current screening recommendations, and differences in the treatment for this patient population, outlining specific changes in the surgical approach.Recent FindingsNeurogenic lower urinary tract dysfunction (NLUTD) patients are living longer due to better care, and cancer is becoming more f...
Source: Current Bladder Dysfunction Reports - April 2, 2024 Category: Urology & Nephrology Source Type: research

Prostate Cancer Diagnosis and Treatment for Patients with Neurogenic Bladder: Does the Literature Support a Different Approach?
AbstractPurpose of ReviewIn this review, the current literature available to patients and providers on the diagnosis and management of prostate cancer in patients with neurogenic bladder will be discussed. Topics include prostate cancer screening and diagnosis, radical prostatectomy and radiotherapy for prostate cancer, as well as surveillance.Recent FindingsNeurogenic lower urinary tract dysfunction (NLUTD) patients are living longer due to better care, and cancer is becoming more frequent. This is partly due to the aging of this population, as well as intrinsic factors related to the underlying condition or urinary diver...
Source: Current Bladder Dysfunction Reports - April 2, 2024 Category: Urology & Nephrology Source Type: research

Management of Neurogenic Stress Urinary Incontinence: An Updated Review
AbstractPurpose of ReviewManaging neurogenic stress urinary incontinence (NSUI) remains a significant challenge. Multiple issues contribute to this, including challenges in accurate diagnosis, coexistence of bladder and bowel dysfunctions, lack of robust scientific evidence supporting various treatment modalities, the diverse preferences of patients, and the need to tailor interventions to an individual's social circumstances. This review aims to update the current alternatives for the surgical management of patients with NSUI.Recent FindingsThe scientific landscape in the field of neurogenic stress urinary incontinence (N...
Source: Current Bladder Dysfunction Reports - March 28, 2024 Category: Urology & Nephrology Source Type: research

Urodynamic Findings that Are Most Impactful for Patients with Neurogenic Bladder and the Literature that Supports This
AbstractPurpose of ReviewTo identify urodynamic risk factors that are most impactful in patients with neurogenic bladder (NGB) and review the recent literature on this, and summarize the historic evidence for those risk factors.Recent FindingsA systematic English language literature review was done between August 2018 and August 2023 to identify urodynamic risk factors for urologic complications in patients with NGB. A scoring method was developed and assessed to evaluate the quality of scientific literature concerning urodynamic risk factors. Ten studies met the inclusion criteria, of which 80% were retrospective. Eight o...
Source: Current Bladder Dysfunction Reports - March 21, 2024 Category: Urology & Nephrology Source Type: research

Long-Term Failure Rates Among Interventions for Benign Prostatic Obstruction
AbstractPurpose of ReviewAs novel approaches for treating bladder outlet obstruction due to benign prostatic hyperplasia proliferate, it is critical for urologists to have accurate information regarding the durability of these procedures as they counsel patients. We summarize the available data examining the rate and time course of treatment failure for common contemporary procedures.Recent FindingsThere is significant clinical variability between procedures for benign prostatic hyperplasia with lack of long-term evidence for several newer procedures.SummaryWhile numerous surgical approaches for benign prostatic hyperplasi...
Source: Current Bladder Dysfunction Reports - March 4, 2024 Category: Urology & Nephrology Source Type: research

The Clinical Reality of Granulomatous Prostatitis
AbstractPurpose of ReviewGranulomatous prostatitis is a rare inflammatory disease of the prostate. It is challenging for the clinician because it mimics prostate cancer and cannot be distinguished from prostate cancer clinically, biochemically, or radiologically. Granulomatous prostatitis can only be diagnosed by histopathological examination. To prevent overdiagnosis and overtreatment, it is an important disease to recognize.Recent FindingsThere are multiple case reports and studies describing granulomatous prostatitis.SummaryThis review aims to give an overview regarding the epidemiology, etiology, clinical presentation,...
Source: Current Bladder Dysfunction Reports - February 28, 2024 Category: Urology & Nephrology Source Type: research

Predictive Value of Urodynamic Studies for Overactive Bladder
AbstractPurpose of ReviewThe use of urodynamic studies (UDS) in overactive bladder (OAB) diagnosis is contested due to concerns of invasiveness, cost-effectiveness, and relative lack of impact on treatment strategy. We aimed to provide a comprehensive review of the role of UDS in the diagnosis of refractory OAB, while also providing a synthesis of recent studies on this topic.Recent FindingsRecent studies that endorse the use of UDS show that incorporation of UDS findings may increase patient compliance and satisfaction with OAB treatment. Studies suggest that this greater patient satisfaction may be attributed to the abil...
Source: Current Bladder Dysfunction Reports - February 24, 2024 Category: Urology & Nephrology Source Type: research

Stem Cell and Neural Progenitor Cell Therapy for Neurogenic Bladder —Where Are We in 2023?
AbstractPurpose of ReviewThis review aims to consolidate the currently available literature regarding the treatment of neurogenic bladder (NGB) with stem cells or neural progenitor cells (NPCs).Recent FindingsSeveral promising studies published in the past 5  years suggest therapeutic potential of stem cells in treating NGB. In vitro models of NGB have demonstrated the efficacy of stem cells from varying sources to induce nerve regeneration while simultaneously improving bladder function parameters. Additionally, mesenchymal stem cells (MSCs) were foun d to inhibit fibrosis through the TGF-β1 signaling pathway while thei...
Source: Current Bladder Dysfunction Reports - February 24, 2024 Category: Urology & Nephrology Source Type: research

Social Ecology of Neurogenic Lower Urinary Tract Dysfunction
AbstractPurpose of Review.To review the literature on the social ecology of neurogenic lower urinary tract dysfunction through a multi-level framework.Recent Findings.Neurogenic lower urinary tract dysfunction is a complex collection of symptoms, which significantly affects and is affected by various levels of the social experience across all levels, including individual, interpersonal, community, and societal. Individual factors include the profound effects on both overall and bladder-specific QOL, the significant psychosocial comorbidity, and the burden of unmet social needs. Interpersonal relationships —including soci...
Source: Current Bladder Dysfunction Reports - February 24, 2024 Category: Urology & Nephrology Source Type: research

Does Delaying Surgical Treatment of BPH Affect Long-Term Outcomes?
AbstractPurpose of ReviewLower urinary tract symptoms due to bladder outlet obstruction are a significant health issue affecting millions of men in the USA. Pharmacotherapy has been successfully used to control symptoms and is the first line therapy. However, prolonged medical therapy does not prevent disease progression and can lead to significant delays in transurethral surgery. The disease progression has shown to be associated with the development of complications such as acute urinary retention and the need for catheterization leading to worse long-term outcomes after BPH surgery. Herein, we review literature identify...
Source: Current Bladder Dysfunction Reports - February 20, 2024 Category: Urology & Nephrology Source Type: research

IBS and Chronic Prostatitis: Update on Chronic Pelvic Pain
AbstractPurpose of ReviewThe article aims to outline the pathogenesis, etiology, prevalence, and evaluation of chronic pelvic pain as it pertains to patients with two of the common causes: IBS and UCPPS.Recent FindingsBecause both diseases are diagnoses of exclusion, it is important to rule out other similar diagnoses. Biological markers are a new research frontier for identifying UCPP.SummaryA careful and multimodal approach is then taken to address the patient ’s goals and seek to optimize the QOL. (Source: Current Bladder Dysfunction Reports)
Source: Current Bladder Dysfunction Reports - February 17, 2024 Category: Urology & Nephrology Source Type: research