Smart Nanobiomaterials for Gene Delivery in Localized Cancer Therapy: An Overview from Emerging Materials and Devices to Clinical Applications
Curr Cancer Drug Targets. 2024 Apr 19. doi: 10.2174/0115680096288917240404060506. Online ahead of print.ABSTRACTResearchers in various fields continue to discover improved ways of local delivery of drugs to specific locations and try to increase the efficiency of these methods. Extensive research has been done on smart nano-biomaterials for drug delivery systems (DDS) in different dimensions. With the advancement of biomedical nanotechnology, conventional smart DDS with stimuli- responsive capability has been developed. Smart nano-biomaterials can respond to environmental changes caused by endogenous or exogenous elements:...
Source: Current Cancer Drug Targets - April 22, 2024 Category: Cancer & Oncology Authors: Armin Shamaeizadeh Anahita Beigi Seyed Morteza Naghib Maryam Tajabadi Mehdi Rahmanian M R Mozafari Source Type: research
The HGF/Met Receptor Mediates Cytotoxic Effect of Bacterial Cyclodipeptides in Human Cervical Cancer Cells
CONCLUSION: Data provide new insights into the molecular mechanisms involved in CDPs cytotoxicity and antiproliferative effects, suggesting that the signal transduction mechanism may be related to the inhibition of the phosphorylation of the EGF/MET receptor at the level of substrate binding site by an inhibition mechanism similar to that of Gefitinib and foretinib anti-neoplastic drugs.PMID:38629372 | DOI:10.2174/0115680096285034240323035013 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - April 17, 2024 Category: Cancer & Oncology Authors: Laura Hern ández-Padilla Mayra X Dur án-Maldonado Lorena Mart ínez-Alcantar Jos é S Rodríguez-Zavala Jesus Campos-Garcia Source Type: research
The HGF/Met Receptor Mediates Cytotoxic Effect of Bacterial Cyclodipeptides in Human Cervical Cancer Cells
CONCLUSION: Data provide new insights into the molecular mechanisms involved in CDPs cytotoxicity and antiproliferative effects, suggesting that the signal transduction mechanism may be related to the inhibition of the phosphorylation of the EGF/MET receptor at the level of substrate binding site by an inhibition mechanism similar to that of Gefitinib and foretinib anti-neoplastic drugs.PMID:38629372 | DOI:10.2174/0115680096285034240323035013 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - April 17, 2024 Category: Cancer & Oncology Authors: Laura Hern ández-Padilla Mayra X Dur án-Maldonado Lorena Mart ínez-Alcantar Jos é S Rodríguez-Zavala Jesus Campos-Garcia Source Type: research
The HGF/Met Receptor Mediates Cytotoxic Effect of Bacterial Cyclodipeptides in Human Cervical Cancer Cells
CONCLUSION: Data provide new insights into the molecular mechanisms involved in CDPs cytotoxicity and antiproliferative effects, suggesting that the signal transduction mechanism may be related to the inhibition of the phosphorylation of the EGF/MET receptor at the level of substrate binding site by an inhibition mechanism similar to that of Gefitinib and foretinib anti-neoplastic drugs.PMID:38629372 | DOI:10.2174/0115680096285034240323035013 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - April 17, 2024 Category: Cancer & Oncology Authors: Laura Hern ández-Padilla Mayra X Dur án-Maldonado Lorena Mart ínez-Alcantar Jos é S Rodríguez-Zavala Jesus Campos-Garcia Source Type: research
Early Detection, Precision Treatment, Recurrence Monitoring: Liquid Biopsy Transforms Colorectal Cancer Therapy
This study investigates the world of liquid biopsy, a rapidly growing field. We want to understand how it can help us better recognize the molecular aspects of cancer, improve and diagnostics, tailor treatments to individual patients, and keep track of the disease over the long-term. We explored specific components of liquid biopsy, like extracellular vesicles and cell-free DNA, and how they are used to detect CRC. This review sheds light on the current state of knowledge and the many ways a liquid biopsy can be used in treating colorectal cancer. It can transform patient care, disease management, and clinical outcomes by ...
Source: Current Cancer Drug Targets - April 16, 2024 Category: Cancer & Oncology Authors: Harshvardhan Raval Sankha Bhattacharya Source Type: research
The Necroptotic Process-Related Signature Predicts Immune Infiltration and Drug Sensitivity in Kidney Renal Papillary Cell Carcinoma
CONCLUSION: The novel 4-NPRGs risk signature can predict the prognosis, immune infiltration, and therapeutic sensitivity of KIRP.PMID:38616744 | DOI:10.2174/0115680096286503240321040556 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - April 15, 2024 Category: Cancer & Oncology Authors: Wenfeng Lin Ruizhi Xue Hideo Ueki Peng Huang Source Type: research
The Necroptotic Process-Related Signature Predicts Immune Infiltration and Drug Sensitivity in Kidney Renal Papillary Cell Carcinoma
CONCLUSION: The novel 4-NPRGs risk signature can predict the prognosis, immune infiltration, and therapeutic sensitivity of KIRP.PMID:38616744 | DOI:10.2174/0115680096286503240321040556 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - April 15, 2024 Category: Cancer & Oncology Authors: Wenfeng Lin Ruizhi Xue Hideo Ueki Peng Huang Source Type: research
L-lysine Increases the Anticancer Effect of Doxorubicin in Breast Cancer by Inducing ROS-Dependent Autophagy
CONCLUSION: These findings suggest that L-lysine can increase DOX cytotoxicity through autophagy modulation. Thus, L-lysine, in combination with DOX, may facilitate the development of novel adjunct therapy for cancer.PMID:38584530 | DOI:10.2174/0115680096288665240315072646 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - April 8, 2024 Category: Cancer & Oncology Authors: Mozhgan Jahani Reza Yarani Davood Rezazadeh Hadis Tahmasebi Zohreh Hoseinkhani Sara Kiani Kamran Mansouri Source Type: research
L-lysine Increases the Anticancer Effect of Doxorubicin in Breast Cancer by Inducing ROS-Dependent Autophagy
CONCLUSION: These findings suggest that L-lysine can increase DOX cytotoxicity through autophagy modulation. Thus, L-lysine, in combination with DOX, may facilitate the development of novel adjunct therapy for cancer.PMID:38584530 | DOI:10.2174/0115680096288665240315072646 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - April 8, 2024 Category: Cancer & Oncology Authors: Mozhgan Jahani Reza Yarani Davood Rezazadeh Hadis Tahmasebi Zohreh Hoseinkhani Sara Kiani Kamran Mansouri Source Type: research
L-lysine Increases the Anticancer Effect of Doxorubicin in Breast Cancer by Inducing ROS-Dependent Autophagy
CONCLUSION: These findings suggest that L-lysine can increase DOX cytotoxicity through autophagy modulation. Thus, L-lysine, in combination with DOX, may facilitate the development of novel adjunct therapy for cancer.PMID:38584530 | DOI:10.2174/0115680096288665240315072646 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - April 8, 2024 Category: Cancer & Oncology Authors: Mozhgan Jahani Reza Yarani Davood Rezazadeh Hadis Tahmasebi Zohreh Hoseinkhani Sara Kiani Kamran Mansouri Source Type: research
L-lysine Increases the Anticancer Effect of Doxorubicin in Breast Cancer by Inducing ROS-Dependent Autophagy
CONCLUSION: These findings suggest that L-lysine can increase DOX cytotoxicity through autophagy modulation. Thus, L-lysine, in combination with DOX, may facilitate the development of novel adjunct therapy for cancer.PMID:38584530 | DOI:10.2174/0115680096288665240315072646 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - April 8, 2024 Category: Cancer & Oncology Authors: Mozhgan Jahani Reza Yarani Davood Rezazadeh Hadis Tahmasebi Zohreh Hoseinkhani Sara Kiani Kamran Mansouri Source Type: research
L-lysine Increases the Anticancer Effect of Doxorubicin in Breast Cancer by Inducing ROS-Dependent Autophagy
CONCLUSION: These findings suggest that L-lysine can increase DOX cytotoxicity through autophagy modulation. Thus, L-lysine, in combination with DOX, may facilitate the development of novel adjunct therapy for cancer.PMID:38584530 | DOI:10.2174/0115680096288665240315072646 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - April 8, 2024 Category: Cancer & Oncology Authors: Mozhgan Jahani Reza Yarani Davood Rezazadeh Hadis Tahmasebi Zohreh Hoseinkhani Sara Kiani Kamran Mansouri Source Type: research
L-lysine Increases the Anticancer Effect of Doxorubicin in Breast Cancer by Inducing ROS-Dependent Autophagy
CONCLUSION: These findings suggest that L-lysine can increase DOX cytotoxicity through autophagy modulation. Thus, L-lysine, in combination with DOX, may facilitate the development of novel adjunct therapy for cancer.PMID:38584530 | DOI:10.2174/0115680096288665240315072646 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - April 8, 2024 Category: Cancer & Oncology Authors: Mozhgan Jahani Reza Yarani Davood Rezazadeh Hadis Tahmasebi Zohreh Hoseinkhani Sara Kiani Kamran Mansouri Source Type: research
Clinical Progress of Targeted Therapy for Breast Cancer: A Comprehensive Review
This study aims to facilitate researchers in conducting a comparative analysis of different targets to select single and multi- targeted drug discovery approaches for breast cancer.PMID:38566384 | DOI:10.2174/0115680096289260240311062343 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - April 3, 2024 Category: Cancer & Oncology Authors: Abhijit Debnath Rupa Mazumder Source Type: research
Clinical Progress of Targeted Therapy for Breast Cancer: A Comprehensive Review
This study aims to facilitate researchers in conducting a comparative analysis of different targets to select single and multi- targeted drug discovery approaches for breast cancer.PMID:38566384 | DOI:10.2174/0115680096289260240311062343 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - April 3, 2024 Category: Cancer & Oncology Authors: Abhijit Debnath Rupa Mazumder Source Type: research
