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Two-Year Efficacy and Safety of Botulinum a Toxin Intravesical Injections in Patients Affected by Refractory Painful Bladder Syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Intravesically injected BoNT/A is effective and safe in the medium-term management of patients with PBS. As the beneficial effect decreased progressively within a few months after treatment, repeat injections of the neurotoxin were needed over time. PMID: 19863481 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 29, 2009 Category: Drugs & Pharmacology Authors: Giannantoni A, Mearini E, Del Zingaro M, Proietti S, Porena M Tags: Curr Drug Deliv Source Type: journals

Gestational Exposure to Antidepressants and the Risk of Spontaneous Abortion: A Review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. This review suggests that gestational exposure to antidepressants, especially paroxetine and venlafaxine, can lead to spontaneous abortion. PMID: 19863482 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 29, 2009 Category: Drugs & Pharmacology Authors: Broy P, Bérard A Tags: Curr Drug Deliv Source Type: journals

The Potential of Polyphosphazenes for Delivery of Vaccine Antigens and Immunotherapeutic Agents.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Polyphosphazene polyelectrolytes are synthetic, biodegradable polymers that have shown great potential in vaccine and drug delivery applications. Numerous investigations in laboratory animals have revealed that polyphosphazenes are also potent immunological adjuvants that can dramatically enhance the magnitude, quality and duration of immune responses to a variety of bacterial and viral vaccine antigens. Evidence is accumulating that these polymers have potent adjuvant activity in large animals as well. Interestingly, polyphosphazenes can be combined with novel immune modulatory agents resulting in even more potent imm...
Source: Current Drug Delivery - October 29, 2009 Category: Drugs & Pharmacology Authors: Eng NF, Garlapati S, Gerdts V, Potter A, Babiuk LA, Mutwiri GK Tags: Curr Drug Deliv Source Type: journals

Development of Taste Masked Fast Disintegrating Films of Levocetirizine Dihydrochloride for Oral Use.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fast disintegrating films of levocetirizine dihydrochloride useful for the treatment of acute allergic rhinitis and chronic urticaria have been developed by using the taste masking ability of cyclodextrins. The fast disintegrating films were prepared by solvent casting method. The films contained water-soluble polymers such as Kollicoat IR or pullulan, aspartame and sucralose as sweeteners and pre-gelatinized starch as disintegrant. Levocetirizine dihydrochloride was incorporated into these films by in-situ complex formation with hydroxy beta;-propyl beta;-cyclodextrin. The optimized films were evaluated for weight var...
Source: Current Drug Delivery - October 29, 2009 Category: Drugs & Pharmacology Authors: Mahesh A, Shastri N, Sadanandam M Tags: Curr Drug Deliv Source Type: journals

A Mathematical Approach for the Simultaneous In Vitro Spectrophotometric Analysis of Rifampicin and Isoniazid from Modified-Release Anti-TB Drug Delivery Systems.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dissolution testing with subsequent analysis is considered as an imperative tool for quality evaluation of the combination rifampicin-isoniazid (RIF-INH) combination. Partial least squares (PLS) regression has been successfully undertaken to select suitable predictor variables and to identify outliers for the generation of equations for RIF and INH determination in fixed-dose combinations (FDCs). The aim of this investigation was to ascertain the applicability of the described technique in testing a novel oral FDC anti-TB drug delivery system and currently available two-drug FDCs, in comparison to the United States Pha...
Source: Current Drug Delivery - October 29, 2009 Category: Drugs & Pharmacology Authors: du Toit L, Pillay V, Choonara Y Tags: Curr Drug Deliv Source Type: journals

Preparation, Optimisation and Characterisation of Lyophilised Rapid Disintegrating Tablets Based on Gelatin and Saccharide.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite recent success, rapidly disintegrating lyophilized tablets still face problems of low mechanical strength and higher disintegration times resulting in poor patient compliance. The aim of the current work was to carry out a systematic study to understand the factors controlling mechanical properties of these formulations. The work investigated the influence of two bloom strengths of gelatin: low (60 bloom) and high (225 bloom) at different stock solution concentrations (2, 5, 7.5, and 10 %w/w). This was followed by investigation of addition of five saccharides (xylitol, glucose, trehalose, maltotriose and mannit...
Source: Current Drug Delivery - October 29, 2009 Category: Drugs & Pharmacology Authors: Alhusban F, Perrie Y, Mohammed AR Tags: Curr Drug Deliv Source Type: journals

Formulation of Controlled Release Gellan Gum Macro Beads of Amoxicillin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gellan gum has been reported to have wide pharmaceutical applications such as tablet binder, disintegrant, gelling agent and as a controlled release polymer. Multiparticulate delivery systems spread out more uniformly in the gastrointestinal tract and reduce the local irritation. The purpose of this study is to explore possible applicability of gellan macro beads as an oral controlled release system of a sparingly soluble drug, amoxicillin. Gellan gum beads were prepared by ionotropic gelation with calcium ions. The effect of drug loading, stirring time, polymer concentration, electrolyte (CaCl2) concentration, curing ...
Source: Current Drug Delivery - October 29, 2009 Category: Drugs & Pharmacology Authors: Babu RJ, Sathigari S, Kumar MT, Pandit JK Tags: Curr Drug Deliv Source Type: journals

Development of Conformational Mimetics of Conserved Streptococcus Pyogenes Minimal Epitope as Vaccine Candidates.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One of the factors responsible for the poor immunogenicity of synthetic peptide antigens is the lack of conformational integrity. Embedding the minimal epitopes in helix-promoting peptide sequences has successfully enhanced the immunogenicity of the epitopes derived from the alpha-helical regions of the M protein of group A streptococci (Streptococcus pyogenes, GAS). However, the introduction of "foreign" peptide sequences is believed to have an unfavourable impact on the antigen specificity. In the current study, we employed a non-peptide approach, using topological carbohydrate templates, to induce helical conformati...
Source: Current Drug Delivery - October 29, 2009 Category: Drugs & Pharmacology Authors: Zhong W, Skwarczynski M, Toth I Tags: Curr Drug Deliv Source Type: journals

Application of Simplex Lattice Design and Desirability Function for the Formulation Development of Mouth Dissolving Film of Salbutamol Sulphate.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the present investigation was to prepare and optimize the formulation of mouth dissolving film of salbutamol sulphate by applying experimental design technique. The films were prepared using hydroxypropyl methylcellulose, polyvinyl pyrrolidone and polyvinyl alcohol by solvent evaporation technique. Simplex lattice design and desirability function were adopted for the preparation of film possessing desirable and optimized characteristics. Tensile strength, elastic modulus, percentage strain, load at yield, and percentage drug release were selected as dependent variables. Regression equations and contour plots...
Source: Current Drug Delivery - October 29, 2009 Category: Drugs & Pharmacology Authors: Gohel MC, Parikh RK, Aghara PY, Nagori SA, Delvadia RR, Dabhi MR Tags: Curr Drug Deliv Source Type: journals

Development and Evaluation of In situ Gel Forming System for Sustained Delivery of Cyclosporine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Phase-sensitive in situ gel forming controlled release formulations of cyclosporine were prepared using poly (lactide-co-glycolide) and a solvent system consisting of various proportions of benzyl benzoate and benzyl alcohol. Uniformity of content of cyclosporine in the formulation and in vitro release samples was determined by radio immune assay (RIA). FTIR and CD spectroscopy ratified the conformational stability of cyclosporine in the formulation and in vitro release samples, respectively. Rheological properties of the formulations, assessed under isothermal conditions, showed dilatant behavior of all the formulatio...
Source: Current Drug Delivery - October 29, 2009 Category: Drugs & Pharmacology Authors: Dhawan S, Kapil R, Kapoor DN, Kumar M Tags: Curr Drug Deliv Source Type: journals

In Vitro and In Vivo Assessment of Matrix Type Transdermal Therapeutic System of Labetalol Hydrochloride.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The above TTS holds promise for improved bioavailability and better management of hypertension on long term basis. PMID: 19863491 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 29, 2009 Category: Drugs & Pharmacology Authors: Mittal A, Parmar S, Singh B Tags: Curr Drug Deliv Source Type: journals

Preparation and Characterization of Superporous Hydrogels as pH-Sensitive Drug Delivery System for Pantoprazole Sodium.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the present study is to develop Superporous Hydrogel (SPH) and SPH composites (SPHC) as pH-sensitive drug delivery system for Pantaprazole sodium. In this investigation, Superporous hydrogels containing poly(methacrylic acid-co-acrylamide) with interconnected pores of several hundreds of micrometer were prepared using radical polymerization of methacrylic acid and acrylamide in the presence of N,N-methylene-bis-acrylamide as crosslinking agent. A gas blowing method using bicarbonate as a foaming agent was applied to introduce the porous structure. SPH composite polymers were made in the same way, except fo...
Source: Current Drug Delivery - October 29, 2009 Category: Drugs & Pharmacology Authors: Gupta NV, Shivakumar HG Tags: Curr Drug Deliv Source Type: journals

Gastroretentive Drug Delivery of Metformin Hydrochloride: Formulation and In Vitro Evaluation using 32 Full Factorial Design.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study indicated that the MF GR tablets prepared using sodium alginate and sodium carboxymethylcellulose can successfully be employed as a once-a-day oral controlled release drug delivery system. PMID: 19863493 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 29, 2009 Category: Drugs & Pharmacology Authors: Boldhane SP, Kuchekar BS Tags: Curr Drug Deliv Source Type: journals

A Review on Mouth Dissolving Films.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The ultimate goal of any drug delivery system is the successful delivery of the drug to the body; however, patient compliance must not be overlooked. Fast dissolving drug delivery systems, such as, Mouth Dissolving Films (MDF), offer a convenient way of dosing medications, not only to special population groups with swallowing difficulties such as children and the elderly, but also to the general population. MDF are the novel dosage forms that disintegrate and dissolve within the oral cavity. Intra-oral absorption permits rapid onset of action and helps by-pass first-pass effects, thereby reducing the unit dose required...
Source: Current Drug Delivery - September 14, 2009 Category: Drugs & Pharmacology Authors: Dahiya M, Saha S, Shahiwala AF Tags: Curr Drug Deliv Source Type: journals

Gastroretentive Drug Delivery Systems: Current Developments in Novel System Design and Evaluation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The task of achieving efficient delivery of drugs that have poor bioavailability or narrow absorption windows have plagued the pharmaceutically industry for decades. Thus, much research has been dedicated to the development of novel polymeric-based gastroretentive drug delivery technologies that may optimize the bioavailability and subsequent therapeutic efficacy of such drugs. An effective approach of achieving this is through the prolongation of the gastric residence time employing several gastroretentive drug delivery mechanisms such as the use of buoyant systems, high density systems, magnetic systems, mucoadhesive...
Source: Current Drug Delivery - September 14, 2009 Category: Drugs & Pharmacology Authors: Murphy CS, Pillay V, Choonara YE, du Toit LC Tags: Curr Drug Deliv Source Type: journals

Passive and Iontophoretic Permeation of Glipizide Gel: An in vitro and in vivo Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of the present work was to formulate and evaluate skin permeability of a glipizide gel to assess its suitability for transdermal delivery. A polymer gel was prepared by soaking hydroxypropyl methyl cellulose (5 g) overnight in phosphate buffer: ethanol (50:50, v/v) and mixing it with separately prepared glipizide solution in the same vehicle to bring the concentration to 2 mg /ml. In vitro skin permeability was assessed in full thickness skin of rabbits and pigs. For in vivo studies New Zealand rabbits were used. In vitro passive permeation was carried out in Franz diffusion cell but for iontophoresis, diff...
Source: Current Drug Delivery - September 14, 2009 Category: Drugs & Pharmacology Authors: Ghosh B, Jainb A, Ashokc P, Patela B, Tarafdara K Tags: Curr Drug Deliv Source Type: journals

Preparation and Evaluation of Gastroretentive Floating Tablets of Acyclovir.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The present study performed by preparation and evaluation of floating tablets of Acyclovir as model drug for prolongation of gastric residence time. Floating effervescent tablets were formulated by various materials like hydroxypropyl methylcellulose K 4M, K 15M, psyllium husk, swelling agent as crospovidone and microcrystalline cellulose and gas generating agent like sodium bicarbonate and citric acid and evaluated for floating properties, swelling characteristics and in vitro drug release studies. Floating noneffervescent tablets were prepared by polypropylene foam powder and different matrix forming polymers like HP...
Source: Current Drug Delivery - September 14, 2009 Category: Drugs & Pharmacology Authors: Garg R, Gupta GD Tags: Curr Drug Deliv Source Type: journals

Effectiveness of Various Drug Carriers in Controlled Release Formulations of Raloxifene HCl Prepared by Melt Mixing.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the present study solid dispersions of Raloxifene HCl were prepared by melt mixing. As drug carriers, biodegradable/biocompatible aliphatic polyesters were used. These formulations were compared to those based on extensively used drug carriers such as PEG and Gelucire 50/13. The used aliphatic polyesters namely poly(propylene succinate) (PPSu) and poly(propylene adipate) (PPAd) were prepared by melt polycondensation. The polyesters have melting points close to human body temperature and were used for first time as drug carries. Polymer cytocompatibility based on HUVEC cells viability in the presence of increasing co...
Source: Current Drug Delivery - September 14, 2009 Category: Drugs & Pharmacology Authors: Bikiaris D, Karavelidis V, Karavas E Tags: Curr Drug Deliv Source Type: journals

In-situ Formation of Liposome of Rifampicin: Better Availability for Better Treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed at the preparation and characterization of preformed and in-situ formed liposomes for controlled delivery to the lungs. Two different liposome formulations were prepared and subjected to characterization of physical parameters (vesicle size, appearance, discharge rate, spray pattern and internal pressure) and drug release profile (% cumulative drug release and % drug retained). Formulations were then subjected to accelerated stability studies as per ICH guidelines. It was observed that vesicle size ranged between 2.35 +/- 0.23 - 2.41+/- 0.3 microm and 1.22 +/- 0.22- 1.34 +/- 0.15 microm respectively for pr...
Source: Current Drug Delivery - September 14, 2009 Category: Drugs & Pharmacology Authors: Gaur PK, Mishra S, Gupta VB, Rathod MS, Purohit S, Savla BA Tags: Curr Drug Deliv Source Type: journals

Self Micro-Emulsifying Drug Delivery System: Formulation Development and Biopharmaceutical Evaluation of Lipophilic Drugs.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several methods are being employed to improve the oral bioavailability of lipophilic drugs like using inert lipid vehicles such as Oils, Surfactant dispersions, Self Microemulsifying Drug Delivery Systems (SMEDDS) and Liposomes. SMEDDS is formulated with the help of oil or suitable lipid materials, Surfactants and hydrophilic Co-surfactants. Mixture of above ingredients can be filled in a soft capsule and ingested. When the mixture comes in contact with gastrointestinal fluid it forms a stable O/W Microemulsion. A pseudo ternary phase diagram is used for identifying the efficient Self micro-emulsification region. SMEDD...
Source: Current Drug Delivery - June 27, 2009 Category: Drugs & Pharmacology Authors: Patel D, Sawant KK Tags: Curr Drug Deliv Source Type: journals

Evaluation of the Pharmacodynamic Activity of Insulin from Bilosomal Formulation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, bilosome as a drug delivery system for insulin was studied. Two bilosomal preparations were formulated and assessed. One was prepared using a lipid extract from Soya beans seed (SBE), Palmitic acid (PA) and cholesterol (CH ) in the ratio of 0.25:1:1 w/w designated as BI while the other (BII) contained PA and CH as the lipid entity at the ratio of 1:1 w/w. Each of the preparations contained 0.5% of sodium deoxycholate (SDC) and soluble insulin. BI was given orally only, while BII was administered subcutaneously, intraperitoneally and orally to different groups of streptozotocin-induced diabetic male rats, and...
Source: Current Drug Delivery - June 27, 2009 Category: Drugs & Pharmacology Authors: Ayogu IJ, Ogbonna O, Ayolugbe CI, Attama AA Tags: Curr Drug Deliv Source Type: journals

Drug Nanocarriers and Functional Nanoparticles: Applications in Cancer Therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Extending on recent progress in control of matter at the nanoscale, functional nanoparticles and drug nanocarriers are being actively developed with the promise of improved delivery of therapeutic agents. Nanotechnology-enabled drug delivery approaches usually aim at reducing the systemic distribution and associated side-effects typically observed with conventional chemotherapeutic molecules as well as increasing the therapeutic index of the active agents. The enhanced permeation and retention effect has been exploited with notable success to passively deliver nanostructured drug carriers and therapeutic nanoparticles ...
Source: Current Drug Delivery - June 27, 2009 Category: Drugs & Pharmacology Authors: Thierry B Tags: Curr Drug Deliv Source Type: journals

Recent Advances in Controlled Release Pulmonary Therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Delivering therapeutic agents to the airways maximizes their concentration in lung tissue, decreasing systemic exposure or facilitating systemic absorption as desired. Many formulations exist for the treatment of respiratory illnesses however, no controlled release inhalation formulation exists to-date. This review is an update of the current advances in controlled release inhalation formulations and evaluation. The major successful particle engineering strategies are discussed along with potential in vitro and in vivo methodologies required for their characterisation. Controlled release formulation has many challenges...
Source: Current Drug Delivery - June 27, 2009 Category: Drugs & Pharmacology Authors: Salama R, Traini D, Chan HK, Young PM Tags: Curr Drug Deliv Source Type: journals

Controlled Release Drug Delivery in Farmed Animals: Commercial Challenges and Academic Opportunities.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Currently there is a lack of new active pharmaceutical ingredients (APIs) appearing on the veterinary market. In the short term this problem can be offset by developing controlled release drug delivery technologies to extend the commercial life of existing drugs. However, such a commercial opportunity does not come without its challenges. These generally revolve around financial factors, which include limited budgets assigned to conduct veterinary R&D, the cost-competitive amount that can be charged for the finished product and the expensive time-consuming registration process. In addition, the gap between the perc...
Source: Current Drug Delivery - June 27, 2009 Category: Drugs & Pharmacology Authors: Rathbone M, Brayden D Tags: Curr Drug Deliv Source Type: journals

Applying Thermodynamic and Kinetic Parameters to Predict the Physical Stability of Two Differently Prepared Amorphous Forms of Simvastatin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, quench-cooled and cryo-milled simvastatin were compared with regards to their configurational thermodynamic parameters (entropy, enthalpy and Gibbs free energy) and mobility (relaxation times calculated using the Adam-Gibbs and Kohlrausch-Williams-Watts method). Stability studies showed quench-cooled simvastatin to be more stable than cryo-milled simvastatin. This was reflected in the calculated parameters although their absolute values did not agree with the stability behaviour. Relaxation time parameters of tau = 6.9104 s for quench-cooled and tau = 1.7104 s for cryo-milled simvastatin were calculated. The...
Source: Current Drug Delivery - June 27, 2009 Category: Drugs & Pharmacology Authors: Graeser KA, Patterson JE, Rades T Tags: Curr Drug Deliv Source Type: journals

Nanoparticle Coated Emulsions as Novel Dermal Delivery Vehicles.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The dermal delivery characteristics of hydrophilic silica nanoparticle coated medium chain triglyceride oil-in-water emulsions are reported and correlated with the physicochemical and interfacial properties of the emulsion based drug carriers. The synergistic drug/stabiliser/nanoparticle interactions are demonstrated to be a function of the charge and concentration of the initial emulsion stabiliser; charge and initial loading phase of nanoparticles and physicochemical properties of the drug molecule. The improved physical stability of the emulsions and the chemical stability of two model lipophilic agents (all-trans-r...
Source: Current Drug Delivery - June 27, 2009 Category: Drugs & Pharmacology Authors: Eskandar NG, Simovic S, Prestidge CA Tags: Curr Drug Deliv Source Type: journals

Oral Bioavailability Assessment and Intestinal Lymphatic Transport of Org 45697 and Org 46035, Two Highly Lipophilic Novel Immunomodulator Analogues.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Org 45697 (MW 600.7, clogP 7.92, soybean oil solubility 50 mg/g) and Org 46035 (MW 601.6, clog P 8.46, soybean oil solubility 40 mg/g) are two poorly water soluble (%lt;0.1microg/ml), highly lipophilic drug candidates with immunomodulator activity and highly analogous chemical structures. After oral administration to conscious ambulatory rats in an aqueous-based methylcellulose/Tween(R) 80 suspension, the bioavailability of both compounds was low (%lt; 2% of administered dose). However, bioavailability was significantly increased (%gt; 5 fold) after oral administration in a long chain triglyceride lipid (olive oil) for...
Source: Current Drug Delivery - June 27, 2009 Category: Drugs & Pharmacology Authors: Caliph SM, Faassen WA, Vogel GM, Porter CJ Tags: Curr Drug Deliv Source Type: journals

Oral Vaccine Delivery - New Strategies and Technologies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although most commercial vaccines are delivered by injection, there is an increasing interest in needle-free vaccine delivery for reasons including the ability to elicit immune responses at mucosal surfaces, ease of administration, and the ability to administer vaccines without the need for trained medical professionals. This review summarizes strategies and technologies that are being used to improve oral vaccine absorption. Peptides and proteins, which comprise important vaccine components, exhibit unfavorable physicochemical properties including degradation in the gastrointestinal tract, and poor transport across th...
Source: Current Drug Delivery - June 27, 2009 Category: Drugs & Pharmacology Authors: Simerska P, Moyle PM, Olive C, Toth I Tags: Curr Drug Deliv Source Type: journals

Cracking the Code for H5N1-bird Flu and Beyond.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Influenza virus remains a significant threat to humanity despite the discovery of novel anti-viral therapies and the continuing development of seasonal vaccines. The reason for this ongoing concern is that the development of drug resistance to anti-virals has rapidly occurred and the currently developed vaccines are typically only effective against a specific influenza virus strain. The continual emergence of new influenza virus strains that may lead to the next human pandemic has inspired much research into a better understanding of the virus, particularly the role(s) of carbohydrates in the virus' lifecycle. Much of ...
Source: Current Drug Delivery - June 27, 2009 Category: Drugs & Pharmacology Authors: Thomson RJ, Haselhorst T, Dyason JC, von Itzstein M Tags: Curr Drug Deliv Source Type: journals

Dendritic Peptide-Based Carriers for Gene Delivery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gene delivery research has come a long way in recent years but there are still a number of barriers preventing therapeutic gene-based drugs reaching the market. Dendrimers or multi-component carriers may provide a means to overcome the issues of gene degradation and transport to the target site by employing different entities in the same carrier. We will discuss some recent approaches to gene delivery using modified dendrimers. We also discuss our work to deliver oligonucleotides and genes using dendritic peptide-based carriers. PMID: 19534714 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - June 27, 2009 Category: Drugs & Pharmacology Authors: Coles DJ, Toth I Tags: Curr Drug Deliv Source Type: journals

Liquid Crystalline Coated Drug Particles as a Potential Route to Long Acting Intravitreal Steroids.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to investigate the potential for coating drug particles with liquid crystalline lipids with a view to modifying drug dissolution behaviour in the particle form. Firstly, dissolution of a simple salicylic acid layer on a microscope slide, as a model system was shown to be hindered by the liquid crystal layer and was sensitive to the type of liquid crystal nanostructure present. Particles of sodium salicylate (hydrophilic) and triamcinolone acetonide (hydrophobic) were produced, and lipids applied to the drug surface using either mechanofusion or co-spray drying approaches. The coated sodium sal...
Source: Current Drug Delivery - June 27, 2009 Category: Drugs & Pharmacology Authors: Tilley A, Morton DA, Hanley T, Boyd BJ Tags: Curr Drug Deliv Source Type: journals

Fabrication and Physical-Chemical Characterisation of Polyelectrolyte Microparticles: Platform for Controlled Release of Bioactives.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Porous CaCO(3) microparticles were fabricated by colloidal crystallization. Two oppositely charged polyelectrolytes, poly (styrene sulfonate, PSS) and poly (allylamine hydrochloride, PAH) were adsorbed layer-by-layer on the CaCO(3) templates. Polyelectrolyte microcapsules were then obtained by removing the CaCO(3) core. Scanning electron microscopy (SEM), energy-dispersion X-ray analysis (EDX), laser diffraction particle sizing and Raman spectroscopy were employed to characterize the physico-chemical properties of the constructed microcapsules. In vitro drug release studies were conducted using the model water-soluble ...
Source: Current Drug Delivery - June 27, 2009 Category: Drugs & Pharmacology Authors: Sun Y, Travas-Sejdic J, Wen J, Alany RG Tags: Curr Drug Deliv Source Type: journals

Investigation of in vitro iontophoresis facilitated transdermal delivery of glycine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion it could be stated that it is possible to achieve appreciable control over the transdermal delivery of glycine by the low-cost portable iontophoretic drug delivery system developed. PMID: 19450220 [PubMed - indexed for MEDLINE] (Source: Current Drug Delivery)
Source: Current Drug Delivery - March 31, 2009 Category: Drugs & Pharmacology Authors: Dasgupta R, Banthia AK, Tibarewala DN Tags: Curr Drug Deliv Source Type: journals

A novel intravaginal delivery system for itraconazole: in vitro and in vivo evaluation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of the present study was to formulate and systematically evaluate in vitro, ex vivo and in vivo performances of itraconazole containing bioadhesive vaginal film. We introduce here a novel intravaginal delivery system for itraconazole based on solid dispersion of itraconazole and hydroxypropyl methylcellulose E15 that improve drug solubility and produce bioadhesive system in presence of other ingredients. Solid dispersions of itraconazole were prepared with hydroxypropyl methylcellulose by a spray drying method and characterized by X-ray diffraction and differential scanning calorimetry. The film was prepare...
Source: Current Drug Delivery - March 31, 2009 Category: Drugs & Pharmacology Authors: Dobaria NB, Mashru RC, Badhan AC, Thakkar AR Tags: Curr Drug Deliv Source Type: journals

Design and in vitro evaluation of a novel vaginal drug delivery system based on gelucire.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Carbamazepine indicated for the control of epilepsy, undergoes extensive hepatic first-pass metabolism after oral administration. A vaginal dosage form of carbamazepine is not commercially available. Conventional suppository having poor retention in the vaginal tract, as they are removed in a short time by the tract's self-cleansing action, having poor patient compliance. To overcome such problems, delivery system with mucoadhesive polymers polyox WSR N-60K and Ucarflock 302 that prolong drug permanence on the vaginal mucosa were developed. In the present study the suitability of gelucires to formulate vaginal pesserie...
Source: Current Drug Delivery - March 31, 2009 Category: Drugs & Pharmacology Authors: Geeta MP, Madhabhai MP Tags: Curr Drug Deliv Source Type: journals

Is relief from diabetes just a breath away?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pulmonary insulin delivery is steadily emerging as a promising solution for the treatment of diabetes mellitus. The large as well as thin absorptive area of the lungs has not been explored until now for the treatment of systemic disease like diabetes. With an understanding of the lung anatomy and physiology and the transport mechanism of insulin through lungs, diabetic treatment through the pulmonary route may well become the reality of the 21(st) century. Though the transport of insulin through the lungs itself appears quite encouraging, potential problems concerning the formulation of a peptide like insulin in the fo...
Source: Current Drug Delivery - March 31, 2009 Category: Drugs & Pharmacology Authors: Passey C, Bhardwaj SP, Majumdar DK Tags: Curr Drug Deliv Source Type: journals

Formulation and evaluation of lecithin organogel for topical delivery of fluconazole.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of the present study was to develop and investigate the suitability of microemulsion based lecithin organogel formulations for topical delivery of fluconazole in order to bypass its gastrointestinal adverse effects. The ternary phase diagrams were developed and various organogel formulations were prepared using pharmaceutically acceptable surfactant (lecithin) and ethyl oleate (EO). Solubility of fluconazole in EO and EO-lecithin reverse micellar system was determined. The transdermal permeability of fluconazole from different concentrations of lecithin organogels containing EO as oil phase was analyzed usi...
Source: Current Drug Delivery - March 31, 2009 Category: Drugs & Pharmacology Authors: Jadhav KR, Kadam VJ, Pisal SS Tags: Curr Drug Deliv Source Type: journals

Influence of poly (lactide-co-glycolide) type and gamma irradiation on the betamethasone acetate release from the in situ forming systems.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In situ forming biodegradable polymeric systems were prepared from Poly (DL-lactide-co-glycolide), RG504H (50:50, lactide:glycolide), RG756 (75:25) and mixture of them. They were dissolved in N-methyl-2-pyrrolidone (33% w/w) and mixed with betamethasone acetate (BTMA, 5 and 10% w/w) and ethyl heptanoate (5% w/w, as an additive). The effects of gamma irradiation, drug loading, type of polymers and solvent removal were evaluated on release profiles. Scanning electron microscopy (SEM) of RG756 samples loaded by BTMA did not show any degradation until two weeks. Differential scanning calorimeter (DSC) experiments confirmed...
Source: Current Drug Delivery - March 31, 2009 Category: Drugs & Pharmacology Authors: Rafienia M, Emami SH, Mirzadeh H, Mobedi H, Karbasi S Tags: Curr Drug Deliv Source Type: journals

Use of gastrointestinal proton pump inhibitors to regulate osteoclast-mediated resorption of calcium phosphate cements in vivo.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Osteoclasts degrade bone through the creation of an enclosed, acidic extracellular microenvironment adjacent to the bone surface. Membrane bound proton pumps in the osteoclast cell membrane function to create this acidified environment. Accordingly, this H(+) ion transport mechanism provides a potential target for a specific class of drugs, proton pump inhibitors (PPI), with a view to controlling osteoclast mediated bone resorption. Self setting calcium phosphate cements are common bone graft materials that are degraded by osteoclastic activity. We have already shown that incorporation of bafilomycin, a non-regulated P...
Source: Current Drug Delivery - March 31, 2009 Category: Drugs & Pharmacology Authors: Sheraly AR, Lickorish D, Sarraf F, Davies JE Tags: Curr Drug Deliv Source Type: journals

Development of Denticap, a matrix based sustained release formulation for treatment of toothache, dental infection and other gum problem.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Toothache is a serious problem worldwide. To give relief from this intolerable toothache, doctors prescribe painkillers along with antibiotics. Most of the painkillers, if not all, produce hyperacidity and gastric irritation upon oral administration. Oral antibiotics have slow onset of action and undergo hepatic "first-pass" effect. Moreover, available dental formulations are mostly liquid and last only few hours upon application, before being washed out by saliva. To overcome the above-mentioned problems, a soft polymeric mold containing antibiotic and analgesic drugs and having an appropriate consistency to adhere to...
Source: Current Drug Delivery - March 31, 2009 Category: Drugs & Pharmacology Authors: Mukherjee B, Roy G, Ghosh S Tags: Curr Drug Deliv Source Type: journals

Product development studies of amino acid conjugate of Aceclofenac.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The prodrugs designed by classical approach increase lipophilicity of the drug, which decreases the water solubility thus decreasing the concentration gradient, which controls drug absorption. To overcome the limitations of traditional prodrug approach, water soluble prodrugs can be designed by adding selected amino acid to the drug moiety that are the substrates for the enzyme located at the intestinal brush border thus overcoming pharmaceutical problem without compromising bioavailability. ACaa (Amino acid conjugate of Aceclofenac) was synthesized by conjugation with l-phenylalanine by conventional coupling method us...
Source: Current Drug Delivery - March 31, 2009 Category: Drugs & Pharmacology Authors: Singh AP, Ramadan WM, Dahiya R, Sarpal AS, Pathak K Tags: Curr Drug Deliv Source Type: journals

Aceclofenac organogels: in vitro and in vivo characterization.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PURPOSE: To develop and evaluate the suitability of lecithin organogels containing aceclofenac for topical application and compare its In vitro and In vivo effects with conventionally used hydrogels. METHODS: The components and their concentration necessary for organogels formation were evaluated using phase diagram. Solubility of aceclofenac was determined. The In vitro skin permeation ability of aceclofenac from ethyl oleate based lecithin organogels [EO/lecithin organogel] and hydrogel was investigated. The In vivo characterization of ethyl oleate based organogel study was compared with that of hydrogel.The alterati...
Source: Current Drug Delivery - January 1, 2009 Category: Drugs & Pharmacology Authors: Shaikh IM, Jadhav SL, Jadhav KR, Kadam VJ, Pisal SS Tags: Curr Drug Deliv Source Type: journals

Aerosol performance of large respirable particles of amikacin sulfate produced by spray and freeze drying techniques.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of the present study was to investigate the influence of method of preparation of large respirable particles of amikacin sulphate on traits and topography and in-vitro aerosol performance. Large respirable particles of amikacin sulfate (50%w/w) were produced by spray-drying and freeze-drying processes using hydrogenated soyaphosphatidylcholine, L-leucine and Poloxamer 188. Particles exhibited 0.04-0.08 g/cm3 tap densities, 7-20 microm geometric particle size, and 1 to 5 microm of mean aerodynamic diameter. Apart from the morphology and topographical features, spray-dried and freeze-dried particles had margi...
Source: Current Drug Delivery - January 1, 2009 Category: Drugs & Pharmacology Authors: Padhi BK, Chougule MB, Misra A Tags: Curr Drug Deliv Source Type: journals

Fluconazole mucoadhesive buccal films: in vitro/in vivo performance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fluconazole mucoadhesive buccal films were prepared using film forming polymers namely; hydroxypropyl methyl cellulose (HPMC), hydroxyethyl cellulose (HEC), chitosan, Eudragit and sodium alginate (SALG) either alone or in combination with bioadhesive polymers. The bioadhesive polymers studied were sodium carboxymethyl cellulose (SCMC), Carbopol 974P, and polycarbophil (AA-A). The prepared films were characterized by means of film thickness, surface pH, swelling capacity, in vitro adhesion, in vivo residence time, in vitro drug release and in vivo drug release to determine the amount of drug release from selected film f...
Source: Current Drug Delivery - January 1, 2009 Category: Drugs & Pharmacology Authors: Yehia SA, El-Gazayerly ON, Basalious EB Tags: Curr Drug Deliv Source Type: journals

Design, optimization, preparation and evaluation of dispersion granules of valsartan and formulation into tablets.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion the statistical model enabled us to understand the effects of formulation variables on the dispersion granules of valsartan. PMID: 19418953 [PubMed - indexed for MEDLINE] (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 1, 2009 Category: Drugs & Pharmacology Authors: Shrivastava AR, Ursekar B, Kapadia CJ Tags: Curr Drug Deliv Source Type: journals

Aerosol devices and asthma therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aerosol delivery of asthma medications maximizes local effects in the lung and minimizes systemic effects compared with oral therapy. Both corticosteroids and bronchodilators are available in a variety of delivery devices for the treatment of asthma. The 1987 Montreal protocol requiring the phasing out of the chlorofluorocarbon (CFC) propellant in commonly used pressurized metered-dose inhalers (pMDIs) provided an impetus for the development of new technologies for the delivery of inhaled asthma medications. For pMDIs, CFC has been replaced with hydrofluoroalkane (HFA) propellant. New types of dry powder inhalers (DPIs...
Source: Current Drug Delivery - January 1, 2009 Category: Drugs & Pharmacology Authors: Berger W Tags: Curr Drug Deliv Source Type: journals

Design and evaluation of a bioadhesive patch for topical delivery of gentamicin sulphate.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of aminoglycoside antibiotics for the topical treatment of gram positive and gram negative infections especially bums and wounds has increased markedly in recent years. Patch formulation for topical delivery can be advantageously used as an alternative to conventional topical dosage forms. The present study aims to prepare and evaluate gentamicin sulphate patches for topical application and to study the effect of different bioadhesive polymers on diverse characteristics of prepared patches. Drug patches were evaluated for weight and thickness uniformity, moisture absorption capacity, tensile strength and percen...
Source: Current Drug Delivery - January 1, 2009 Category: Drugs & Pharmacology Authors: El-Gendy NA, Abdelbary GA, El-Komy MH, Saafan AE Tags: Curr Drug Deliv Source Type: journals

Efficacy of pegylated lyposomal anthracyclines and of intra-arterial carboplatin and doxorubicin combined with local hyperthermia in a case of malignant endovascular papillary angioendothelioma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Malignant vascular tumors are exceedingly rare in childhood. Generally, their prognosis is dependent from a microscopically complete surgical resection. We observed the case of a 4-year-old boy affected by malignant endovascular papillary angioendothelioma, a rare vascular tumor of intermediate malignancy, involving all his left leg and partially the pelvis. Its very large size hampered any surgical intervention. However, we could demonstrate high sensitivity of the tumor to lyposomal anthracyclines and the child was eventually cured by the intra-arterial administration of carboplatin and doxorubicin coupled with local...
Source: Current Drug Delivery - January 1, 2009 Category: Drugs & Pharmacology Authors: Fiorillo A, DeRosa G, Giugliano F, DeLillo ML, Sabbatino MS, Veneziano A Tags: Curr Drug Deliv Source Type: journals

Poly (D, L-lactide) nanosuspensions of risperidone for parenteral delivery: formulation and in-vitro evaluation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Risperidone, an "atypical" antipsychotic drug, having large scope for prolonged psychotic treatments through novel parenteral drug delivery systems. Polymeric nanoparticles suspensions containing risperidone made of poly (D, L-Lactide) were designed by nanoprecipitation method using polymeric stabilizer (Pluronic F-68 or Pluronic F-127). The prepared nanosuspensions were characterized for particle size by photon correlation spectroscopy and scanning electron microscopy. The free dissolved drug in the nanosuspension was determined by bulk equilibrium reverse dialysis bag technique. In vitro release studies were carried ...
Source: Current Drug Delivery - January 1, 2009 Category: Drugs & Pharmacology Authors: Muthu MS, Singh S Tags: Curr Drug Deliv Source Type: journals

Preparation and characterization of cephalexin loaded PLGA microspheres.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to evaluate the effects of emulsion type and process parameters on the properties of CPX-loaded PLGA microspheres in order to obtain delivery systems suitable for the treatment of dairy mastitis. The microsphere size was analyzed by photon correlation spectrophotometry. Determination of the drug loading was achieved by HPLC. It was found that CPX-loaded PLGA microspheres prepared using a w/o/w double emulsion technology were slightly larger (approximately 3-5 microm) but much higher in drug content (approximately 18% w/w) than those obtained using o/w single emulsion preparation technology (av...
Source: Current Drug Delivery - January 1, 2009 Category: Drugs & Pharmacology Authors: Chaisri W, Hennink WE, Okonogi S Tags: Curr Drug Deliv Source Type: journals