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A biotin-coupled bifunctional enzyme exhibiting both glutamine synthetase activity and glutamate decarboxylase activity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: p42 was purified from chick retinal protein solution using molecular filtration in the presence of sodium chloride. The protein was a biotin-coupled bifunctional enzyme that contained glutamine synthetase activity and glutamate decarboxylase activity. Biotin was possibly involved in these activities. Mn(2+) showed different effects on the two activities. PMID: 19895308 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - October 1, 2009 Category: Opthalmology Authors: Arunchaipong K, Sattayasai N, Sattayasai J, Svasti J, Rimlumduan T Tags: Curr Eye Res Source Type: journals

Antibodies to endogenous tear protein in normal human tears.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Normal human ocular tears contain antibodies to endogenous tear protein. PMID: 19895309 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - October 1, 2009 Category: Opthalmology Authors: Remington SG, Crow JM, Nelson JD Tags: Curr Eye Res Source Type: journals

Characterization of Human Meibum Lipid using Raman Spectroscopy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Principal component analysis shows that a component containing carotenoid-like bands may be a promising spectral feature that could be used to distinguish differences between the Raman spectra of donors from normal and those with meibomian gland dysfunction. This study demonstrates the wealth of structural and compositional information that Raman spectra of human meibum provide. PMID: 19895310 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - October 1, 2009 Category: Opthalmology Authors: Oshima Y, Sato H, Zaghloul A, Foulks GN, Yappert MC, Borchman D Tags: Curr Eye Res Source Type: journals

Proinflammatory Effect of TWEAK/Fn14 Interaction in Human Retinal Pigment Epithelial Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: TWEAK/Fn14 interaction may have proinflammatory effects in RPE cells. PMID: 19895311 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - October 1, 2009 Category: Opthalmology Authors: Ebihara N, Nakayama M, Tokura T, Iwatsu M, Ushio H, Murakami A Tags: Curr Eye Res Source Type: journals

Effect of Curcumin on Lung Resistance-Related Protein (LRP) in Retinoblastoma Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results demonstrate that curcumin modulated the expression of LRP in the Y79 retinoblastoma cell line. Thus, curcumin may be used as a chemosensitizer to make the retinoblastoma cells more sensitive to the effects of chemotherapy. PMID: 19895312 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - October 1, 2009 Category: Opthalmology Authors: Thiyagarajan S, Thirumalai K, Nirmala S, Biswas J, Krishnakumar S Tags: Curr Eye Res Source Type: journals

Modulation of Migration and Ca(2+) Signaling in Retinal Pigment Epithelium Cells by Recombinant Human CTGF.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The CTGF expression could be induced by an in vitro model of scrape wounding. rhCTGF stimulated the migration and Ca(2+) signal pathway in RPE cells in a dose-dependent manner, and DEX and 8-Br-cAMP suppressed this effect. Our results indicate that CTGF is involved in the wound-healing process and plays an important role in the pathogenesis of intraocular proliferative diseases. PMID: 19895313 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - October 1, 2009 Category: Opthalmology Authors: Guo CM, Wang YS, Hu D, Han QH, Wang JB, Hou X, Hui YN Tags: Curr Eye Res Source Type: journals

The Association between Self-Reported Cataracts and St. John's Wort.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results of the current study provide support for an association between SJW use and cataracts. Based on the methodological limitations of this study, further investigation is required. PMID: 19895314 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - October 1, 2009 Category: Opthalmology Authors: Booth JN, McGwin G Tags: Curr Eye Res Source Type: journals

MAP Kinase Pathway is Involved in IGF-1-Stimulated Proliferation of Human Retinal Pigment Epithelial Cells (hRPE).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These studies suggest that IGF-1 is a mitogen for hRPE cells and also stimulates production of the angiogenic factor, VEGF. Additionally, PD98059 inhibits the production of VEGF, suggesting that the MAP kinase pathway is involved in IGF-1-mediated angiogenesis. PMID: 19895315 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - October 1, 2009 Category: Opthalmology Authors: Weng CY, Kothary PC, Verkade AJ, Reed DM, Del Monte MA Tags: Curr Eye Res Source Type: journals

Identification of alpha-Gal and non-Gal Epitopes in Pig Corneal Endothelial Cells and Keratocytes by Using Mass Spectrometry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: As well as alpha-Gal epitopes, several promising non-Gal antigens were widely expressed on both pig corneal endothelial cells and keratocytes. The detailed structural information of the alpha-Gal and non-Gal epitopes would be a tremendous value to develop a new strategy for the successful corneal xenotransplantation in future. PMID: 19895316 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - October 1, 2009 Category: Opthalmology Authors: Kim YG, Oh JY, Gil GC, Kim MK, Ko JH, Lee S, Lee HJ, Wee WR, Kim BG Tags: Curr Eye Res Source Type: journals

Expression of Herpes Virus Entry Mediator (HVEM) in the Cornea and Trigeminal Ganglia of Normal and HSV-1 Infected Mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: HVEM is expressed in the cornea and TG and therefore may serve as an HSV entry receptor in these tissues. Furthermore, these findings raise the possibility that changes in HVEM expression following ocular HSV-1 infection can modulate HSV spread and infection-induced inflammation in the cornea and TG. PMID: 19895317 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - October 1, 2009 Category: Opthalmology Authors: Kovacs SK, Tiwari V, Prandovszky E, Dosa S, Bacsa S, Valyi-Nagy K, Shukla D, Valyi-Nagy T Tags: Curr Eye Res Source Type: journals

Effect of diabetes mellitus on acinar morphology, peroxidase concentration, and release in isolated rat lacrimal glands.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results indicate that diabetes is associated with lacrimal gland insufficiency as a result of abnormal acinar morphology and reduced peroxidase content and secretion. PMID: 19895318 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - October 1, 2009 Category: Opthalmology Authors: Shetty R, Saeed T, Rashed H, Adeghate E, Singh J Tags: Curr Eye Res Source Type: journals

Effect of pseudophakia on standard perimetry parameters.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Even monofocal spheric acrylic IOLs have relatively insignificant effect on visual acuity, and foveal threshold may influence global indices such as MD on VF testing. Possible causes of reduction in VF sensitivity should be clarified by further studies in pseudophakics. PMID: 19839864 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - August 31, 2009 Category: Opthalmology Authors: Mutlu FM, Akay F, Bayer A Tags: Curr Eye Res Source Type: journals

A vitreous hemorrhage animal model in rabbits using force percussion injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A reproducible experimental model of VH in rabbit eye has been successfully made. Massive VH was demonstrated on clinical observations and echography and was confirmed by histopathological examinations. VH was totally absorbed two months after the ocular trauma in our model. Our model is a simple, reliable, reproducible, and stable tool for the research on the mechanism and treatment of VH. PMID: 19839865 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - August 31, 2009 Category: Opthalmology Authors: Yan H, Ahmed AS, Han J, Cui J, Yu J Tags: Curr Eye Res Source Type: journals

Role of IL-1beta on the glutamine synthetase in retinal Müller cells under high glucose conditions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Interleukin-1beta decreases expression of glutamine synthetase via activation of c-Jun. The data suggested that interleukin-1beta may play a role in the development of diabetic retinopathy. PMID: 19839866 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - August 31, 2009 Category: Opthalmology Authors: Shen X, Xu G Tags: Curr Eye Res Source Type: journals

Genotoxic effects of carotenoid breakdown products in human retinal pigment epithelial cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our results suggest that breakdown products of dietary carotenoids could be genotoxic in ARPE-19 cells. LBP-induced genotoxic effects could worsen oxidative stress. The intracellular GSH pool in ARPE-19 cells might play a critical role in carotenoid breakdown products-induced genotoxicity. PMID: 19839867 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - August 31, 2009 Category: Opthalmology Authors: Kalariya NM, Ramana KV, Srivastava SK, van Kuijk FJ Tags: Curr Eye Res Source Type: journals

Potential application of adult stem cells in retinal repair--challenge for regenerative medicine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stem cells (SCs) maintain the balance among somatic cell populations in various tissues and are responsible for organ regeneration. The remarkable progress of regenerative medicine in the last few years indicates promise for the use of SCs in ophthalmic disorder treatment. This review describes the current view on hierarchy in the SC compartment and presents the latest attempts to use adult SCs in the regeneration of the retina. Research performed primarily in animal models gives hope for using similar strategies in humans. However, the search for the optimal source of SCs for cell therapy continues. We briefly discuss...
Source: Current Eye Research - August 31, 2009 Category: Opthalmology Authors: Machalińska A, Baumert B, Kuprjanowicz L, Wiszniewska B, Karczewicz D, Machaliński B Tags: Curr Eye Res Source Type: journals

Role of extracellular phospholipase B of Candida albicans as a virulent factor in experimental keratomycosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: PLB can play a role as a virulent factor in triggering fungal invasion in corneas immediately after fungal adherence by decomposing membrane phospholipids and leading to cell lysis. However, its virulent effect does not appear to be as critical as in the hematogenous model of disseminated candidiasis. PMID: 19839869 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - August 31, 2009 Category: Opthalmology Authors: Ma L, Xie L, Dong X, Shi W Tags: Curr Eye Res Source Type: journals

Vehicle used for triamcinolone acetonide is toxic to ocular tissues of the pigmented rabbit.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Vehicle used for TA is toxic to the lens, ciliary body, and retina of pigmented rabbit eyes after injection of intravitreal TA. PMID: 19839870 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - August 31, 2009 Category: Opthalmology Authors: Zhengyu S, Fang W, Ying F Tags: Curr Eye Res Source Type: journals

Hydrocortisone suppression of the expression of VEGF may relate to toll-like receptor (TLR) 2 and 4.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Hydrocortisone may decrease the expression of VEGF through inhibiting TLR2, 4 activity in cultured human corneal fibroblasts. PMID: 19839871 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - August 31, 2009 Category: Opthalmology Authors: Gao T, Lin Z, Jin X Tags: Curr Eye Res Source Type: journals

Toxic effect of methamphetamine on the retina of CD1 mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: A single large dose of METH induces an increase in short-term protein expression of GFAP and S-100 and in microglial activation. The results suggest that METH has a neurotoxic effect on CD1 mouse retina. PMID: 19839872 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - August 31, 2009 Category: Opthalmology Authors: Lai H, Zeng H, Zhang C, Wang L, Tso MO, Lai S Tags: Curr Eye Res Source Type: journals

Rescue of photoreceptors by BDNF gene transfer using in vivo electroporation in the RCS rat of retinitis pigmentosa.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These findings provide evidence that electroporation is an effective method for gene transfer into retinal pigment epithelial cells, and the rescue of photoreceptors can be achieved by BDNF gene transfection with electroporation. PMID: 19839873 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - August 31, 2009 Category: Opthalmology Authors: Zhang M, Mo X, Fang Y, Guo W, Wu J, Zhang S, Huang Q Tags: Curr Eye Res Source Type: journals

Impact of the transfer of sFlt-1 gene fragments on the ERK1/2 pathway of VEGF in vitro.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Both sFlt-1(2-3) and sFlt-1(2-4) gene fragments inhibited the proliferation and migration of HUVECs, as well as signal transduction in the ERK1/2 pathway of VEGF. PMID: 19839874 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - August 31, 2009 Category: Opthalmology Authors: Jiang D, Gu H, Wu Q, Wang X, Zhang M, Song B Tags: Curr Eye Res Source Type: journals

Ferric reducing ability of tears in healthy subjects-diurnal variation and dependence on defined demographic data.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The significance of age-matched controls and the specific time of the day for tears collection should be considered in the trial design and investigations with FRAT as a marker of the ocular antioxidant defense system. PMID: 19401875 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - April 30, 2009 Category: Opthalmology Authors: Kowalski M, Bielecka-Kowalska A, Bielecka-Roszkiewicz K, Dziankowska-Zaborszczyk E, de Graft-Johnson J, Szemraj J, Zwolinska A, Nowak D Tags: Curr Eye Res Source Type: journals

A novel scraping cytology score system (SCSS) grades inflammation in dry eye patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: SCSS can be applied in any trained laboratory. It is correlated with clinical signs and symptoms, and it shows a diagnostic performance to grade inflammation in dry eye, comparable to more expensive cytokine assay. PMID: 19401876 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - April 30, 2009 Category: Opthalmology Authors: Versura P, Profazio V, Fresina M, Campos EC Tags: Curr Eye Res Source Type: journals

The effects of dexamethasone on the Na,K-ATPase activity and pump function of corneal endothelial cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our results suggest that dexamethasone stimulates Na,K-ATPase activity in mouse corneal endothelial cells. The effect of dexamethasone activation in these cells is mediated by Na,K-ATPase synthesis and increase in an enzymatic activity by dephosphorylation of Na,K-ATPase alpha(1)-subunits. PMID: 19401877 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - April 30, 2009 Category: Opthalmology Authors: Hatou S, Yamada M, Mochizuki H, Shiraishi A, Joko T, Nishida T Tags: Curr Eye Res Source Type: journals

Chloral hydrate anesthesia and lens opacification in mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We show that chloral hydrate, when used intraperitoneally, induces acute and reversible lens opacification in all animals. In addition, we found that instillation of hypromellose solution does not prevent the lens opacification caused by chloral hydrate injection. We hypothesized some plausible explanations for these findings. PMID: 19401878 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - April 30, 2009 Category: Opthalmology Authors: Vieira AC, Vicente AF, Perez R, Gonzalez F Tags: Curr Eye Res Source Type: journals

Characteristics of ethylnitrosourea-induced cataracts.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Together, the results suggest that various proteins affect the formation and specific phenotypes of ENU-induced cataract mouse. PMID: 19401879 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - April 30, 2009 Category: Opthalmology Authors: Lee MJ, Kim JY, Kim YJ, Cho JW, Cho KH, Song CW, Jung HS Tags: Curr Eye Res Source Type: journals

24-hour intraocular pressure and blood pressure levels with latanoprost/timolol fixed combination versus timolol.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Neither timolol or evening-dosed LTFC reduced SBP, DBP, MBP, OPP, or increased nocturnal dipping. LTFC was more effective than timolol in decreasing IOP. PMID: 19401880 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - April 30, 2009 Category: Opthalmology Authors: Konstas AG, Pikilidou MI, Tsironi S, Mikropoulos D, Kozobolis VP, Sarafidis PA, Lasaridis AN, Nelson LA, Stewart WC Tags: Curr Eye Res Source Type: journals

Distribution of photopic pupil diameter in the Tehran eye study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: While the mean PPD measured with the Orbscan II was 3.70 mm in a sample derived from a population-based survey in Tehran, the scarcity of similar studies and reports concerning the pupil diameter measured with the Orbscan II makes it difficult to draw eligible comparisons. The pupil diameter has reverse correlations with age and spherical equivalent, a direct correlation with ACD, but is not correlated with gender. PMID: 19401881 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - April 30, 2009 Category: Opthalmology Authors: Hashemi H, Yazdani K, Khabazkhoob M, Mehravaran S, Mohammad K, Fotouhi A Tags: Curr Eye Res Source Type: journals

Expression of the multi-drug resistance proteins and the pregnane X receptor in treated and untreated retinoblastoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our results indicate selection, rather than induction, of chemoresistant cells as a cause for treatment failure in managing retinoblastoma with primary systemic chemotherapy. PMID: 19401882 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - April 30, 2009 Category: Opthalmology Authors: Wilson MW, Fraga CH, Rodriguez-Galindo C, Hagedorn N, Leggas ML, Stewart C Tags: Curr Eye Res Source Type: journals

Case report: autofluorescence imaging and phenotypic variance in a sibling pair with early-onset retinal dystrophy due to defective CRB1 function.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Leber congenital amaurosis caused by CRB1 is a unique form of early-onset retinal dystrophy because it spares the para-arteriolar RPE and causes abnormal retinal lamination with thickening. These findings, detectable with AF imaging and high-resolution OCT, can be combined with electrophysiology and genetic testing to molecularly classify retinal degenerations efficiently. PMID: 19401883 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - April 30, 2009 Category: Opthalmology Authors: Tosi J, Tsui I, Lima LH, Wang NK, Tsang SH Tags: Curr Eye Res Source Type: journals

Lentivirus-mediated sFlt-1 gene fragment transfer suppresses retinal neovascularization.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Lentivirus-mediated sFlt-1 gene transfer significantly inhibits retinal neovascularization in OIR. Thus, sFlt-1 gene transfer may represent a potential therapeutic strategy for preventing retinal neovascularization. PMID: 19401884 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - April 30, 2009 Category: Opthalmology Authors: Min Z, Qiang W, Benwen S, Bin L, Xinhua D Tags: Curr Eye Res Source Type: journals

Fibrae medullares in the retina of the RD mouse: a case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Even in this highly degenerated retina the potency of the optic nerve fibres to become myelinated still remained. The source of the appropriate glia cells is discussed. PMID: 19401885 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - April 30, 2009 Category: Opthalmology Authors: May CA Tags: Curr Eye Res Source Type: journals

Conjunctival flora in patients with Parkinson's disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Coagulase-negative Staphylococcus, Staphylococcus aureus, and Corynebacterium species were the most commonly isolated bacterial species in the PD group. Among all bacterial isolates, only Staphylococcus aureus was significantly higher in the conjunctival flora of patients with PD than in those in the control group. PMID: 19373572 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - March 31, 2009 Category: Opthalmology Authors: Kusbeci T, Kusbeci OY, Aktepe OC, Yavas G, Ermis SS Tags: Curr Eye Res Source Type: journals

Ocular pharmacokinetics and availability of topically applied baicalein in rabbits.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Bai-CD formulation is superior to Bai-SP for increasing ocular bioavailability. PMID: 19373573 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - March 31, 2009 Category: Opthalmology Authors: Zhang L, Zhang J, Wang L, Xia H Tags: Curr Eye Res Source Type: journals

Anticataractogenic effect of an extract of the oyster mushroom, Pleurotus ostreatus, in an experimental animal model.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Extract of P. ostreatus prevents experimental selenite-induced cataractogenesis. PMID: 19373574 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - March 31, 2009 Category: Opthalmology Authors: Isai M, Elanchezhian R, Sakthivel M, Chinnakkaruppan A, Rajamohan M, Jesudasan CN, Thomas PA, Geraldine P Tags: Curr Eye Res Source Type: journals

Elevated Expression of indoleamine 2,3-dioxygenase (IDO) and accumulation of kynurenic acid in the pathogenesis of STZ-induced diabetic cataract in Wistar rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Production of IDO was induced in STZ-induced diabetic cataractous lenses, possibly by locally produced IFN- gamma. IDO-mediated oxidation of Trp may partly explain the increase in lens KYNA and may thus be implicated in cataractogenesis in concert with the non-enzymic oxidation of Trp by glycated lens proteins. PMID: 19373575 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - March 31, 2009 Category: Opthalmology Authors: Kanth VR, Lavanya K, Srinivas J Tags: Curr Eye Res Source Type: journals

The effect of the H-1152P, a potent Rho-associated coiled coil-formed protein kinase inhibitor, in rabbit normal and ocular hypertensive eyes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Topical administration of H-1152P potently decreased rabbit normotensive IOPs in a dose-dependent manner, and the duration of the IOP lowering was also elongated in a dose-dependent manner. In addition, H-1152P has a potent IOP-lowering effect on an ocular hypertension model. These result suggested that H-1152P could be a candidate for the next generation of glaucoma therapy. PMID: 19373576 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - March 31, 2009 Category: Opthalmology Authors: Nishio M, Fukunaga T, Sugimoto M, Ikesugi K, Sumi K, Hidaka H, Uji Y Tags: Curr Eye Res Source Type: journals

Effect of moxonidine on the uveoscleral outflow: role of alpha2-adrenoceptors or i1 imidazoline receptors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These results suggest that topical, unilateral administration of moxonidine causes a bilateral increase of aqueous humor via the uveoscleral outflow pathway. The moxonidine-induced increase of uveoscleral outflow is mediated by alpha2 adrenergic receptors, not by I1 imidazoline receptors. PMID: 19373577 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - March 31, 2009 Category: Opthalmology Authors: Yang J, Sun N, Xiong Q, Yang R Tags: Curr Eye Res Source Type: journals

Suppression of experimental autoimmune uveoretinitis by Anti-IL-17 antibody.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These findings demonstrate that blockade of endogenous IL-17 activity by treatment with anti-IL-17 antibody attenuates EAU in rats. IL-17 rather than IFN-gamma plays a crucial role in the development of EAU, and that antagonism of IL-17 could be useful for the treatment of human intraocular autoimmune diseases. PMID: 19373578 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - March 31, 2009 Category: Opthalmology Authors: Zhang R, Qian J, Guo J, Yuan YF, Xue K Tags: Curr Eye Res Source Type: journals

Statins do not decrease the risk for wet age-related macular degeneration.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study does not support a beneficial effect of statin use for reducing the risk for wet AMD requiring PDT. PMID: 19373579 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - March 31, 2009 Category: Opthalmology Authors: Kaiserman N, Vinker S, Kaiserman I Tags: Curr Eye Res Source Type: journals

Zeaxanthin, a retinal carotenoid, protects retinal cells against oxidative stress.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our results suggest that zeaxanthin provides effective protection against oxidative stress-induced retinal cell damage. PMID: 19373580 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - March 31, 2009 Category: Opthalmology Authors: Nakajima Y, Shimazawa M, Otsubo K, Ishibashi T, Hara H Tags: Curr Eye Res Source Type: journals

Confocal scanning laser tomography analysis of choroidal neovascularization and correlation with quantitative fluorescein angiography.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The axial intensity profile of the cSLT and the edema index provide important information with respect to the neovascular membranes and correlate well with quantitative fluorescein angiography. The application of cSLT and the EI provide an important tool that could complement the investigation of new treatments of neovascular membranes. PMID: 19373581 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - March 31, 2009 Category: Opthalmology Authors: Pallikaris A, Skondra D, Karavvela M, Tsilimbaris M Tags: Curr Eye Res Source Type: journals

Constitutive pro-apoptotic molecules are differentially expressed in the fetal and adult mouse eye.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Different mechanisms of apoptosis are prominent at the fetal and mature stages of the mouse eye. PMID: 19373582 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - March 31, 2009 Category: Opthalmology Authors: Montalvo V, Gery I Tags: Curr Eye Res Source Type: journals

Cyclooxygenase (COX)-Inhibiting Drug Reduces HSV-1 Reactivation in the Mouse Eye Model.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Bromfenac Na eye drops can suppress HSV-1 reactivation. PMID: 19274523 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - March 1, 2009 Category: Opthalmology Authors: Higaki S, Watanabe K, Itahashi M, Shimomura Y Tags: Curr Eye Res Source Type: journals

Rho-Kinase, but not Protein Kinase C, is Involved in Generation of the Spontaneous Tone in the Resting Phase of the Isolated Pig Iris Sphincter Muscle.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results suggest that, in the isolated pig iris sphincter muscle, Rho-kinase plays an important role in the generation of spontaneous tone in the resting phase via the inhibition of MLCP activity. PMID: 19274524 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - March 1, 2009 Category: Opthalmology Authors: Okano M, Uchikawa Y, Tanaka N, Mutoh J, Ohkura M, Hisa H, Yamamoto R Tags: Curr Eye Res Source Type: journals

Bimatoprost-Induced Calcium Signaling in Human T-Cells does not Involve Prostanoid FP or TP Receptors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Molt-3 cells have been identified as a bimatoprost-sensitive preparation in which the activity of bimatoprost is independent of prostanoid FP receptors. PMID: 19274525 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - March 1, 2009 Category: Opthalmology Authors: Chen J, Lu RT, Lai R, Dinh T, Paul D, Venadas S, Wheeler LA Tags: Curr Eye Res Source Type: journals

Prevention of Selenite-Induced Cataractogenesis by N-Acetylcysteine in Rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: N-acetylcysteine appears to inhibit selenite-induced cataractogenesis in the rat model, and this seems to be caused by the prevention of oxidative damage. PMID: 19274526 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - March 1, 2009 Category: Opthalmology Authors: Aydin B, Yagci R, Yılmaz FM, Erdurmus M, Karadağ R, Keskin U, Durmus M, Yigitoglu R Tags: Curr Eye Res Source Type: journals

A comparison of 180 degrees of treatment with diode laser trabeculoplasty in primary open-angle glaucoma and exfoliation glaucoma: a short-term study of 22 patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The DLT outcome could be predicted as early as day 7 of the follow-up, and the maximum IOP decrease after DLT could be evident on day 30. This study suggests that diode laser trabeculoplasty is an effective and safe mode of treatment for eyes with open-angle glaucoma, and its outcome may be predicted earlier than previously thought. PMID: 19274527 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - March 1, 2009 Category: Opthalmology Authors: Andreic V, Miljkovic A, Babic N Tags: Curr Eye Res Source Type: journals

Expression of Matrix Metalloproteinases (MMP)-12 by Myofibroblasts during Alkali-Burned Corneal Wound Healing.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results indicate that, in alkali-burned corneas, myofibroblasts express both MMP-12 mRNA and protein. We suggest that MMP-12 may disintegrate some components of the ECM released after severe alkali burn, which may be involved in the ECM remodeling. PMID: 19274528 [PubMed - in process] (Source: Current Eye Research)
Source: Current Eye Research - March 1, 2009 Category: Opthalmology Authors: Iwanami H, Ishizaki M, Fukuda Y, Takahashi H Tags: Curr Eye Res Source Type: journals