Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer
CONCLUSION: Finally, the analysis of regulon networks revealed several promising candidates for cell-specific transcription factors (TFs). This study focused on the immune molecular mechanism under intestinal diseases. It contributed to the novel insight of depicting a detailed immune landscape and revealing T-cell responding mechanisms in CD and CRC.PMID:38682449 | DOI:10.2174/0115665232294568240201073417 (Source: Current Gene Therapy)
Source: Current Gene Therapy - April 29, 2024 Category: Genetics & Stem Cells Authors: Tianming Jiang Jie Zheng Nana Li Xiaodong Li Jixing He Junde Zhou Boshi Sun Qiang Chi Source Type: research
Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer
CONCLUSION: Finally, the analysis of regulon networks revealed several promising candidates for cell-specific transcription factors (TFs). This study focused on the immune molecular mechanism under intestinal diseases. It contributed to the novel insight of depicting a detailed immune landscape and revealing T-cell responding mechanisms in CD and CRC.PMID:38682449 | DOI:10.2174/0115665232294568240201073417 (Source: Current Gene Therapy)
Source: Current Gene Therapy - April 29, 2024 Category: Genetics & Stem Cells Authors: Tianming Jiang Jie Zheng Nana Li Xiaodong Li Jixing He Junde Zhou Boshi Sun Qiang Chi Source Type: research
Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer
CONCLUSION: Finally, the analysis of regulon networks revealed several promising candidates for cell-specific transcription factors (TFs). This study focused on the immune molecular mechanism under intestinal diseases. It contributed to the novel insight of depicting a detailed immune landscape and revealing T-cell responding mechanisms in CD and CRC.PMID:38682449 | DOI:10.2174/0115665232294568240201073417 (Source: Current Gene Therapy)
Source: Current Gene Therapy - April 29, 2024 Category: Genetics & Stem Cells Authors: Tianming Jiang Jie Zheng Nana Li Xiaodong Li Jixing He Junde Zhou Boshi Sun Qiang Chi Source Type: research
Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer
CONCLUSION: Finally, the analysis of regulon networks revealed several promising candidates for cell-specific transcription factors (TFs). This study focused on the immune molecular mechanism under intestinal diseases. It contributed to the novel insight of depicting a detailed immune landscape and revealing T-cell responding mechanisms in CD and CRC.PMID:38682449 | DOI:10.2174/0115665232294568240201073417 (Source: Current Gene Therapy)
Source: Current Gene Therapy - April 29, 2024 Category: Genetics & Stem Cells Authors: Tianming Jiang Jie Zheng Nana Li Xiaodong Li Jixing He Junde Zhou Boshi Sun Qiang Chi Source Type: research
Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer
CONCLUSION: Finally, the analysis of regulon networks revealed several promising candidates for cell-specific transcription factors (TFs). This study focused on the immune molecular mechanism under intestinal diseases. It contributed to the novel insight of depicting a detailed immune landscape and revealing T-cell responding mechanisms in CD and CRC.PMID:38682449 | DOI:10.2174/0115665232294568240201073417 (Source: Current Gene Therapy)
Source: Current Gene Therapy - April 29, 2024 Category: Genetics & Stem Cells Authors: Tianming Jiang Jie Zheng Nana Li Xiaodong Li Jixing He Junde Zhou Boshi Sun Qiang Chi Source Type: research
Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer
CONCLUSION: Finally, the analysis of regulon networks revealed several promising candidates for cell-specific transcription factors (TFs). This study focused on the immune molecular mechanism under intestinal diseases. It contributed to the novel insight of depicting a detailed immune landscape and revealing T-cell responding mechanisms in CD and CRC.PMID:38682449 | DOI:10.2174/0115665232294568240201073417 (Source: Current Gene Therapy)
Source: Current Gene Therapy - April 29, 2024 Category: Genetics & Stem Cells Authors: Tianming Jiang Jie Zheng Nana Li Xiaodong Li Jixing He Junde Zhou Boshi Sun Qiang Chi Source Type: research
Optogenetics: Illuminating the Future of Hearing Restoration and Understanding Auditory Perception
Curr Gene Ther. 2024;24(3):208-216. doi: 10.2174/0115665232269742231213110937.ABSTRACTHearing loss is a prevalent sensory impairment significantly affecting communication and quality of life. Traditional approaches for hearing restoration, such as cochlear implants, have limitations in frequency resolution and spatial selectivity. Optogenetics, an emerging field utilizing light-sensitive proteins, offers a promising avenue for addressing these limitations and revolutionizing hearing rehabilitation. This review explores the methods of introducing Channelrhodopsin- 2 (ChR2), a key light-sensitive protein, into cochlear cells...
Source: Current Gene Therapy - April 27, 2024 Category: Genetics & Stem Cells Authors: Namit Kant Singh Balaji Ramamourthy Neemu Hage Krishna Medha Kappagantu Source Type: research
Development of Cell and Gene Therapies for Clinical Use in the US and EU: Summary of Regulatory Guidelines
Curr Gene Ther. 2024 Apr 25. doi: 10.2174/0115665232306205240419091414. Online ahead of print.ABSTRACTRecent decades have seen advancements in the management and treatment of difficult-- to-treat diseases such as cancer. A special class of therapeutics called cell and gene therapy has been introduced in the past 10 years. Cell and gene therapy products have strengthened the treatment options for life-threatening diseases with unmet clinical needs and also provided the possibility of a potential cure for the disease in some of the patients. Cell and gene therapy products are gaining recognition, and the interest in clinical...
Source: Current Gene Therapy - April 27, 2024 Category: Genetics & Stem Cells Authors: Anand Rotte Source Type: research
Role of Non-coding RNAs on the Radiotherapy Sensitivity and Resistance in Cancer Cells
Curr Gene Ther. 2024 Apr 26. doi: 10.2174/0115665232301727240422092311. Online ahead of print.ABSTRACTRadiotherapy (RT) is an integral part of treatment management in cancer patients. However, one of the limitations of this treatment method is the resistance of cancer cells to radiotherapy. These restrictions necessitate the introduction of modalities for the radiosensitization of cancer cells. It has been shown that Noncoding RNAs (ncRNAs), along with modifiers, can act as radiosensitivity and radioresistant regulators in a variety of cancers by affecting double strand break (DSB), wnt signaling, glycolysis, irradiation i...
Source: Current Gene Therapy - April 27, 2024 Category: Genetics & Stem Cells Authors: Fatemeh Jalali-Zefrei Seyed Mehdi Mousavi Kourosh Delpasand Mohammad Shourmij Soghra Farzipour Source Type: research
Optogenetics: Illuminating the Future of Hearing Restoration and Understanding Auditory Perception
Curr Gene Ther. 2024;24(3):208-216. doi: 10.2174/0115665232269742231213110937.ABSTRACTHearing loss is a prevalent sensory impairment significantly affecting communication and quality of life. Traditional approaches for hearing restoration, such as cochlear implants, have limitations in frequency resolution and spatial selectivity. Optogenetics, an emerging field utilizing light-sensitive proteins, offers a promising avenue for addressing these limitations and revolutionizing hearing rehabilitation. This review explores the methods of introducing Channelrhodopsin- 2 (ChR2), a key light-sensitive protein, into cochlear cells...
Source: Current Gene Therapy - April 27, 2024 Category: Genetics & Stem Cells Authors: Namit Kant Singh Balaji Ramamourthy Neemu Hage Krishna Medha Kappagantu Source Type: research
Development of Cell and Gene Therapies for Clinical Use in the US and EU: Summary of Regulatory Guidelines
Curr Gene Ther. 2024 Apr 25. doi: 10.2174/0115665232306205240419091414. Online ahead of print.ABSTRACTRecent decades have seen advancements in the management and treatment of difficult-- to-treat diseases such as cancer. A special class of therapeutics called cell and gene therapy has been introduced in the past 10 years. Cell and gene therapy products have strengthened the treatment options for life-threatening diseases with unmet clinical needs and also provided the possibility of a potential cure for the disease in some of the patients. Cell and gene therapy products are gaining recognition, and the interest in clinical...
Source: Current Gene Therapy - April 27, 2024 Category: Genetics & Stem Cells Authors: Anand Rotte Source Type: research
Role of Non-coding RNAs on the Radiotherapy Sensitivity and Resistance in Cancer Cells
Curr Gene Ther. 2024 Apr 26. doi: 10.2174/0115665232301727240422092311. Online ahead of print.ABSTRACTRadiotherapy (RT) is an integral part of treatment management in cancer patients. However, one of the limitations of this treatment method is the resistance of cancer cells to radiotherapy. These restrictions necessitate the introduction of modalities for the radiosensitization of cancer cells. It has been shown that Noncoding RNAs (ncRNAs), along with modifiers, can act as radiosensitivity and radioresistant regulators in a variety of cancers by affecting double strand break (DSB), wnt signaling, glycolysis, irradiation i...
Source: Current Gene Therapy - April 27, 2024 Category: Genetics & Stem Cells Authors: Fatemeh Jalali-Zefrei Seyed Mehdi Mousavi Kourosh Delpasand Mohammad Shourmij Soghra Farzipour Source Type: research
Applications of L-Arginine in Pregnancy and Beyond: An Emerging Pharmacogenomic Approach
Curr Gene Ther. 2024 Apr 19. doi: 10.2174/0115665232262213240329034826. Online ahead of print.ABSTRACTL-arginine is a semi-essential amino acid that plays a critical role in various physiological processes, such as protein synthesis, wound healing, immune function, and cardiovascular regulation. The use of L-arginine in pregnancy has been an emerging topic in the field of pharmacogenomics. L-arginine, an amino acid, plays a crucial role in the production of nitric oxide, which is necessary for proper placental development and fetal growth. Studies have shown that L-arginine supplementation during pregnancy can have positiv...
Source: Current Gene Therapy - April 22, 2024 Category: Genetics & Stem Cells Authors: Sai Vaishnavi V Mahadevamma Lingaiah Bala Murali Mohan Sanku Sunil Kumar Kadri Manoj Kumar Mudigubba Source Type: research
Applications of L-Arginine in Pregnancy and Beyond: An Emerging Pharmacogenomic Approach
Curr Gene Ther. 2024 Apr 19. doi: 10.2174/0115665232262213240329034826. Online ahead of print.ABSTRACTL-arginine is a semi-essential amino acid that plays a critical role in various physiological processes, such as protein synthesis, wound healing, immune function, and cardiovascular regulation. The use of L-arginine in pregnancy has been an emerging topic in the field of pharmacogenomics. L-arginine, an amino acid, plays a crucial role in the production of nitric oxide, which is necessary for proper placental development and fetal growth. Studies have shown that L-arginine supplementation during pregnancy can have positiv...
Source: Current Gene Therapy - April 22, 2024 Category: Genetics & Stem Cells Authors: Sai Vaishnavi V Mahadevamma Lingaiah Bala Murali Mohan Sanku Sunil Kumar Kadri Manoj Kumar Mudigubba Source Type: research
Applications of L-Arginine in Pregnancy and Beyond: An Emerging Pharmacogenomic Approach
Curr Gene Ther. 2024 Apr 19. doi: 10.2174/0115665232262213240329034826. Online ahead of print.ABSTRACTL-arginine is a semi-essential amino acid that plays a critical role in various physiological processes, such as protein synthesis, wound healing, immune function, and cardiovascular regulation. The use of L-arginine in pregnancy has been an emerging topic in the field of pharmacogenomics. L-arginine, an amino acid, plays a crucial role in the production of nitric oxide, which is necessary for proper placental development and fetal growth. Studies have shown that L-arginine supplementation during pregnancy can have positiv...
Source: Current Gene Therapy - April 22, 2024 Category: Genetics & Stem Cells Authors: Sai Vaishnavi V Mahadevamma Lingaiah Bala Murali Mohan Sanku Sunil Kumar Kadri Manoj Kumar Mudigubba Source Type: research
