Exploring the Role of Non-synonymous and Deleterious Variants Identified in Colorectal Cancer: A Multi-dimensional Computational Scrutiny of Exomes
CONCLUSION: Our work provides insights into the various alterations that might possibly lead to colorectal cancer and suggests the possibility of utilizing the most important genes identified for wet-lab experimentation.PMID:38544823 | PMC:PMC10964087 | DOI:10.2174/0113892029285310231227105503 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Chandrashekar Karunakaran Vidya Niranjan Anagha S Setlur Dhanya Pradeep Jitendra Kumar Source Type: research
Preface 25 Years of Current Genomics
Curr Genomics. 2024 Feb 23;25(1):1. doi: 10.2174/138920292501240205235837.NO ABSTRACTPMID:38544824 | PMC:PMC10964086 | DOI:10.2174/138920292501240205235837 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Fabio Copped è Source Type: research
Molecular Determination of Tumor Necrosis Factor-alpha, Interleukin-8, Interleukin-10, and C-X-C Chemokine Receptor-2 Genetic Variations and their Association with Disease Susceptibility and Mortality in COVID-19 Patients
CONCLUSION: The findings of this study provide important insights into the COVID-19 disease and susceptibility risk. The polymorphisms in TNFα -308 G>A (rs1800629), IL-8 -251T>A (rs4073), IL-10 (-1082 G>A), rs1800896 and CXCR2 +785 C>T (rs2230054) are associated with the risk of susceptibility to COVID-19 and with mortality in COVID-19 patients. Further studies with larger sample sizes are necessary to confirm our findings.PMID:38544825 | PMC:PMC10964085 | DOI:10.2174/0113892029272497240103052359 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Badr A Alsayed Rashid Mir Mohammad M Mir Tarig M S Alnour Shereen Fawzy Mesaik M Ahmed Dnyanesh Amle Source Type: research
Analysis of the Expression of < em > PRDX6 < /em > in Patients with Hepatocellular Carcinoma and its Effect on the Phenotype of Hepatocellular Carcinoma Cells
CONCLUSION: The expression of PRDX6 may be closely related to the prognosis of HCC. Lentivirus-mediated PRDX6 knockdown can inhibit the proliferation, migration and invasion of HCC cells, which may be related to its regulating the PI3K/Akt/mTOR and Notch1 signaling pathways. PRDX6 is expected to be a new target for the diagnosis and treatment of liver cancer.PMID:38544826 | PMC:PMC10964084 | DOI:10.2174/0113892029273682240111052317 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Runhong Mu Mingzhu Chang Chuanbo Feng Yunhe Cui Tingyu Li Chang Liu Yilin Wang Xiao Guo Source Type: research
A Novel Methylation-based Model for Prognostic Prediction in Lung Adenocarcinoma
CONCLUSION: This research successfully identified a novel eight-site methylation signature for predicting the overall survival of LUAD patients through bioinformatic integrated analysis of gene methylation markers used in the early diagnosis of lung cancer.PMID:38544827 | PMC:PMC10964088 | DOI:10.2174/0113892029277397231228062412 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Manyuan Li Xufeng Deng Dong Zhou Xiaoqing Liu Jigang Dai Quanxing Liu Source Type: research
Exploring the Role of Non-synonymous and Deleterious Variants Identified in Colorectal Cancer: A Multi-dimensional Computational Scrutiny of Exomes
CONCLUSION: Our work provides insights into the various alterations that might possibly lead to colorectal cancer and suggests the possibility of utilizing the most important genes identified for wet-lab experimentation.PMID:38544823 | PMC:PMC10964087 | DOI:10.2174/0113892029285310231227105503 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Chandrashekar Karunakaran Vidya Niranjan Anagha S Setlur Dhanya Pradeep Jitendra Kumar Source Type: research
Preface 25 Years of Current Genomics
Curr Genomics. 2024 Feb 23;25(1):1. doi: 10.2174/138920292501240205235837.NO ABSTRACTPMID:38544824 | PMC:PMC10964086 | DOI:10.2174/138920292501240205235837 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Fabio Copped è Source Type: research
Molecular Determination of Tumor Necrosis Factor-alpha, Interleukin-8, Interleukin-10, and C-X-C Chemokine Receptor-2 Genetic Variations and their Association with Disease Susceptibility and Mortality in COVID-19 Patients
CONCLUSION: The findings of this study provide important insights into the COVID-19 disease and susceptibility risk. The polymorphisms in TNFα -308 G>A (rs1800629), IL-8 -251T>A (rs4073), IL-10 (-1082 G>A), rs1800896 and CXCR2 +785 C>T (rs2230054) are associated with the risk of susceptibility to COVID-19 and with mortality in COVID-19 patients. Further studies with larger sample sizes are necessary to confirm our findings.PMID:38544825 | PMC:PMC10964085 | DOI:10.2174/0113892029272497240103052359 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Badr A Alsayed Rashid Mir Mohammad M Mir Tarig M S Alnour Shereen Fawzy Mesaik M Ahmed Dnyanesh Amle Source Type: research
Analysis of the Expression of < em > PRDX6 < /em > in Patients with Hepatocellular Carcinoma and its Effect on the Phenotype of Hepatocellular Carcinoma Cells
CONCLUSION: The expression of PRDX6 may be closely related to the prognosis of HCC. Lentivirus-mediated PRDX6 knockdown can inhibit the proliferation, migration and invasion of HCC cells, which may be related to its regulating the PI3K/Akt/mTOR and Notch1 signaling pathways. PRDX6 is expected to be a new target for the diagnosis and treatment of liver cancer.PMID:38544826 | PMC:PMC10964084 | DOI:10.2174/0113892029273682240111052317 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Runhong Mu Mingzhu Chang Chuanbo Feng Yunhe Cui Tingyu Li Chang Liu Yilin Wang Xiao Guo Source Type: research
A Novel Methylation-based Model for Prognostic Prediction in Lung Adenocarcinoma
CONCLUSION: This research successfully identified a novel eight-site methylation signature for predicting the overall survival of LUAD patients through bioinformatic integrated analysis of gene methylation markers used in the early diagnosis of lung cancer.PMID:38544827 | PMC:PMC10964088 | DOI:10.2174/0113892029277397231228062412 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Manyuan Li Xufeng Deng Dong Zhou Xiaoqing Liu Jigang Dai Quanxing Liu Source Type: research
Exploring the Role of Non-synonymous and Deleterious Variants Identified in Colorectal Cancer: A Multi-dimensional Computational Scrutiny of Exomes
CONCLUSION: Our work provides insights into the various alterations that might possibly lead to colorectal cancer and suggests the possibility of utilizing the most important genes identified for wet-lab experimentation.PMID:38544823 | PMC:PMC10964087 | DOI:10.2174/0113892029285310231227105503 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Chandrashekar Karunakaran Vidya Niranjan Anagha S Setlur Dhanya Pradeep Jitendra Kumar Source Type: research
Preface 25 Years of Current Genomics
Curr Genomics. 2024 Feb 23;25(1):1. doi: 10.2174/138920292501240205235837.NO ABSTRACTPMID:38544824 | PMC:PMC10964086 | DOI:10.2174/138920292501240205235837 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Fabio Copped è Source Type: research
Molecular Determination of Tumor Necrosis Factor-alpha, Interleukin-8, Interleukin-10, and C-X-C Chemokine Receptor-2 Genetic Variations and their Association with Disease Susceptibility and Mortality in COVID-19 Patients
CONCLUSION: The findings of this study provide important insights into the COVID-19 disease and susceptibility risk. The polymorphisms in TNFα -308 G>A (rs1800629), IL-8 -251T>A (rs4073), IL-10 (-1082 G>A), rs1800896 and CXCR2 +785 C>T (rs2230054) are associated with the risk of susceptibility to COVID-19 and with mortality in COVID-19 patients. Further studies with larger sample sizes are necessary to confirm our findings.PMID:38544825 | PMC:PMC10964085 | DOI:10.2174/0113892029272497240103052359 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Badr A Alsayed Rashid Mir Mohammad M Mir Tarig M S Alnour Shereen Fawzy Mesaik M Ahmed Dnyanesh Amle Source Type: research
Analysis of the Expression of < em > PRDX6 < /em > in Patients with Hepatocellular Carcinoma and its Effect on the Phenotype of Hepatocellular Carcinoma Cells
CONCLUSION: The expression of PRDX6 may be closely related to the prognosis of HCC. Lentivirus-mediated PRDX6 knockdown can inhibit the proliferation, migration and invasion of HCC cells, which may be related to its regulating the PI3K/Akt/mTOR and Notch1 signaling pathways. PRDX6 is expected to be a new target for the diagnosis and treatment of liver cancer.PMID:38544826 | PMC:PMC10964084 | DOI:10.2174/0113892029273682240111052317 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Runhong Mu Mingzhu Chang Chuanbo Feng Yunhe Cui Tingyu Li Chang Liu Yilin Wang Xiao Guo Source Type: research
A Novel Methylation-based Model for Prognostic Prediction in Lung Adenocarcinoma
CONCLUSION: This research successfully identified a novel eight-site methylation signature for predicting the overall survival of LUAD patients through bioinformatic integrated analysis of gene methylation markers used in the early diagnosis of lung cancer.PMID:38544827 | PMC:PMC10964088 | DOI:10.2174/0113892029277397231228062412 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Manyuan Li Xufeng Deng Dong Zhou Xiaoqing Liu Jigang Dai Quanxing Liu Source Type: research
