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15 records returned

Effect of Resistance Training on Hematological Blood Markers in Older Men and Women: A Pilot StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to examine the effects of resistance training on hematological blood markers in older individuals. Twenty-nine men and women participated to this study. Subjects were randomized in 2 groups: (1) control (n=13) and (2) resistance training (n=16). At baseline and after the intervention, subjects were submitted to a blood sample to determine their hematological profile (red blood cells, hemoglobin, hematocrit, platelets, leukocytes, neutrophils, lymphocytes, monocytes, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red cell distribution width). At bas...
Source: Current Gerontology and Geriatrics Research - October 27, 2009 Category: Geriatrics Source Type: journals

Asthma in the ElderlyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bronchial asthma is a common problem with enormous medical and economics impacts. It is an inflammatory disease of the airways associated with intermittent episodes of bronchospasm. Asthma is not uncommon in the elderly patients. Prevalence of asthma is similar in older and younger adults. Asthma in the elderly patient is underdiagnosed because of false perceptions by both patient and physician. The high incidence of comorbid conditions in the elderly patient makes the diagnosis and management more difficult. Correct diagnosis is demonstrated with spirometry. The goals of asthma treatment are to achieve and maintain contro...
Source: Current Gerontology and Geriatrics Research - October 27, 2009 Category: Geriatrics Source Type: journals

Impaired Perinatal Growth and Longevity: A Life History PerspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Life history theory proposes that early-life cues induce highly integrated responses in traits associated with energy partitioning, maturation, reproduction, and aging such that the individual phenotype is adaptively more appropriate to the anticipated environment. Thus, maternal and/or neonatally derived nutritional or endocrine cues suggesting a threatening environment may favour early growth and reproduction over investment in tissue reserve and repair capacity. These may directly affect longevity, as well as prioritise insulin resistance and capacity for fat storage, thereby increasing susceptibility to metabolic dysfu...
Source: Current Gerontology and Geriatrics Research - September 6, 2009 Category: Geriatrics Source Type: journals

Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in MiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Genetic and biochemical studies have shown that PARP-1 and poly(ADP-ribosyl)ation play an important role in DNA repair, genomic stability, cell death, inflammation, telomere maintenance, and suppressing tumorigenesis, suggesting that the homeostasis of poly(ADP-ribosyl)ation and PARP-1 may also play an important role in aging. Here we show that PARP-1-/- mice exhibit a reduction of life span and a significant increase of population aging rate. Analysis of noninvasive parameters, including body weight gain, body temperature, estrous function, behavior, and a number of biochemical indices suggests the acceleration of biologi...
Source: Current Gerontology and Geriatrics Research - June 9, 2009 Category: Geriatrics Source Type: journals

Cobalamin Deficiency in Elderly Patients: A Personal ViewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cobalamin (vitamin B12) deficiency is particularly common in the elderly (>65 years of age) but is often unrecognized because its clinical manifestations are subtle; however, they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. In the elderly, the main causes of cobalamin deficiency are pernicious anemia and food-cobalamin malabsorption. Food-cobalamin malabsorption syndrome is a disorder characterized by the inability to release cobalamin from food or its binding proteins. This syndrome is usually caused by atrophic gastritis, related or unrelated to Helicobacter p...
Source: Current Gerontology and Geriatrics Research - June 9, 2009 Category: Geriatrics Source Type: journals

Personality Characteristics Determine Health-Related Quality of Life as an Outcome Indicator of Geriatric Inpatient RehabilitationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. It is probable in old and very old individuals who are on their highest level of maturity that the character represents the most important regulatory system in the encounter with challenges of daily life, which necessitates rehabilitation. (Source: Current Gerontology and Geriatrics Research)
Source: Current Gerontology and Geriatrics Research - June 9, 2009 Category: Geriatrics Source Type: journals

Thyroid Function and Cognition during AgingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We summarize here the studies examining the association between thyroid function and cognitive performance from an aging perspective. The available data suggest that there may be a continuum in which cognitive dysfunction can result from increased or decreased concentrations of thyroid hormones. Clinical and subclinical hypothyroidism as well as hyperthyroidism in middle-aged and elderly adults are both associated with decreased cognitive functioning, especially memory, visuospatial organization, attention, and reaction time. Mild variations of thyroid function, even within normal limits, can have significant con...
Source: Current Gerontology and Geriatrics Research - June 9, 2009 Category: Geriatrics Source Type: journals

IDE Gene Polymorphism Influences on BPSD in Mild Dementia of Alzheimer's TypeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Insulin degrading enzyme (IDE) degrades amyloid β (Aβ), which may inhibit the accumulation of Aβ in a brain affected with dementia of Alzheimer's type (DAT). A decrease in the activity of IDE results in changes in glucose utilization in the brain, which could affect the cognitive and psychiatric symptoms of DAT. We investigated a possible association of IDE gene polymorphism and the behavioral and psychological symptoms of dementia (BPSD) in mild DAT. The genotyping for IDE and apolipoprotein E (ApoE) was determined in 207 patients with mild DAT and 215 controls. The occurrence of BPSD was demonstr...
Source: Current Gerontology and Geriatrics Research - June 9, 2009 Category: Geriatrics Source Type: journals

Ten-Year Survival in 75-Year-Old Men and Women: Predictive Ability of Total Cholesterol, HDL-C, and LDL-CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. HDL-C was associated with dismal prognosis in men but not in women. Elderly men with HDL-C <40 mg/dL deserve particular attention for cardiovascular prevention. (Source: Current Gerontology and Geriatrics Research)
Source: Current Gerontology and Geriatrics Research - June 9, 2009 Category: Geriatrics Source Type: journals

IDE Gene Polymorphism Influences on BPSD in Mild Dementia of Alzheimer's TypeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Insulin degrading enzyme (IDE) degrades amyloid β (Aβ), which may inhibit the accumulation of Aβ in a brain affected with dementia of Alzheimer's type (DAT). A decrease in the activity of IDE results in changes in glucose utilization in the brain, which could affect the cognitive and psychiatric symptoms of DAT. We investigated a possible association of IDE gene polymorphism and the behavioral and psychological symptoms of dementia (BPSD) in mild DAT. The genotyping for IDE and apolipoprotein E (ApoE) was determined in 207 patients with mild DAT and 215 controls. The occurrence of BPSD was demonstr...
Source: Current Gerontology and Geriatrics Research - December 4, 2008 Category: Geriatrics Source Type: journals

Thyroid Function and Cognition during AgingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We summarize here the studies examining the association between thyroid function and cognitive performance from an aging perspective. The available data suggest that there may be a continuum in which cognitive dysfunction can result from increased or decreased concentrations of thyroid hormones. Clinical and subclinical hypothyroidism as well as hyperthyroidism in middle-aged and elderly adults are both associated with decreased cognitive functioning, especially memory, visuospatial organization, attention, and reaction time. Mild variations of thyroid function, even within normal limits, can have significant con...
Source: Current Gerontology and Geriatrics Research - September 2, 2008 Category: Geriatrics Source Type: journals

Personality Characteristics Determine Health-Related Quality of Life as an Outcome Indicator of Geriatric Inpatient RehabilitationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. It is probable in old and very old individuals who are on their highest level of maturity that the character represents the most important regulatory system in the encounter with challenges of daily life, which necessitates rehabilitation. (Source: Current Gerontology and Geriatrics Research)
Source: Current Gerontology and Geriatrics Research - August 19, 2008 Category: Geriatrics Source Type: journals

Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in MiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Genetic and biochemical studies have shown that PARP-1 and poly(ADP-ribosyl)ation play an important role in DNA repair, genomic stability, cell death, inflammation, telomere maintenance, and suppressing tumorigenesis, suggesting that the homeostasis of poly(ADP-ribosyl)ation and PARP-1 may also play an important role in aging. Here we show that PARP-1-/- mice exhibit a reduction of life span and a significant increase of population aging rate. Analysis of noninvasive parameters, including body weight gain, body temperature, estrous function, behavior, and a number of biochemical indices suggests the acceleration of biologi...
Source: Current Gerontology and Geriatrics Research - June 3, 2008 Category: Geriatrics Source Type: journals

Cobalamin Deficiency in Elderly Patients: A Personal ViewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cobalamin (vitamin B12) deficiency is particularly common in the elderly (>65 years of age) but is often unrecognized because its clinical manifestations are subtle; however, they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. In the elderly, the main causes of cobalamin deficiency are pernicious anemia and food-cobalamin malabsorption. Food-cobalamin malabsorption syndrome is a disorder characterized by the inability to release cobalamin from food or its binding proteins. This syndrome is usually caused by atrophic gastritis, related or unrelated to Helicobacter p...
Source: Current Gerontology and Geriatrics Research - June 3, 2008 Category: Geriatrics Source Type: journals