A short-term economic evaluation of early insulin therapy compared to oral anti-diabetic drugs in order to reduce the major adverse events in type 2 diabetes patients in Iran
CONCLUSION: In terms of cost-effectiveness, early insulin therapy was not cost-effective compared to OADs for managing newly diagnosed T2DM patients. Future studies in this regard, utilizing more comprehensive evidence, can yield more accurate results.PMID:38533582 | DOI:10.1080/03007995.2024.2333425 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 27, 2024 Category: Research Authors: Ramin Heshmat Ali Darvishi Ramin Abdi Dezfouli Adeleh Nikkhah Ramin Radmanesh Elham Moslemi Source Type: research

Assessment of algorithms for identifying patients with triple-class refractory multiple myeloma using real-world data
Conclusion: In RW settings, progressions from both IMWG-derived data and physician reports may be used to identify patients with TCR MM.PMID:38523576 | DOI:10.1080/03007995.2024.2333439 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 25, 2024 Category: Research Authors: Liliya Sinyavskaya Aster Meche Ariane Faucher Patrick Hlavacek Sarasa Ma Johnson Marco DiBonaventura Francis Vekeman Jinma Ren Alex Schepart Source Type: research

Methamphetamine intoxication and suicidal ideation/behavior in the Emergency Department
CONCLUSION: These results underscore the urgent need for targeted interventions to address the complex interplay between MA use and suicidal risks in the emergency department setting, as well as broader public health strategies to combat the increasing prevalence of MA use.PMID:38511972 | DOI:10.1080/03007995.2024.2333429 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 21, 2024 Category: Research Authors: Huseyin Bayazit Regina Baronia Sarah M Wakefield Source Type: research

The use of routinely collected healthcare records for outcome assessment in clinical trials: a UK perspective
This article discusses the key considerations that trialists should take into account when incorporating EHR into their trials. These include considerations of the clinical relevance of the outcome, data timeliness and quality, ethical and regulatory issues, and some practical considerations for clinical trials units.In addition, this article describes the benefits of using EHR which include cost, reduced trial burden for participants and staff, follow up efficiencies, and improved health economic evaluation procedures. We also describe the major regulatory and start up costs of using EHR in clinical trials.This article fo...
Source: Current Medical Research and Opinion - March 21, 2024 Category: Research Authors: Abilash Sathyanarayana Source Type: research

Diabetes: a review of its pathophysiology, and advanced methods of mitigation
Curr Med Res Opin. 2024 Mar 21:1-24. doi: 10.1080/03007995.2024.2333440. Online ahead of print.ABSTRACTDiabetes mellitus (DM) is a long-lasting metabolic non-communicable disease often characterized by an increase in the level of glucose in the blood or hyperglycemia. Approximately, 415 million people between the ages of 20 and 79 years had DM in 2015 and this figure will rise by 200 million by 2040. In a study conducted by CARRS, it's been found that in Delhi the prevalence of diabetes is around 27% and for prediabetic cases, it is more than 46%. The disease DM can be both short-term and long-term and is often associated ...
Source: Current Medical Research and Opinion - March 21, 2024 Category: Research Authors: Sarika Gupta Nitin Sharma Sandeep Arora Saurabh Verma Source Type: research

Methamphetamine intoxication and suicidal ideation/behavior in the Emergency Department
CONCLUSION: These results underscore the urgent need for targeted interventions to address the complex interplay between MA use and suicidal risks in the emergency department setting, as well as broader public health strategies to combat the increasing prevalence of MA use.PMID:38511972 | DOI:10.1080/03007995.2024.2333429 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 21, 2024 Category: Research Authors: Huseyin Bayazit Regina Baronia Sarah M Wakefield Source Type: research

The use of routinely collected healthcare records for outcome assessment in clinical trials: a UK perspective
This article discusses the key considerations that trialists should take into account when incorporating EHR into their trials. These include considerations of the clinical relevance of the outcome, data timeliness and quality, ethical and regulatory issues, and some practical considerations for clinical trials units.In addition, this article describes the benefits of using EHR which include cost, reduced trial burden for participants and staff, follow up efficiencies, and improved health economic evaluation procedures. We also describe the major regulatory and start up costs of using EHR in clinical trials.This article fo...
Source: Current Medical Research and Opinion - March 21, 2024 Category: Research Authors: Abilash Sathyanarayana Source Type: research

Diabetes: a review of its pathophysiology, and advanced methods of mitigation
Curr Med Res Opin. 2024 Mar 21:1-24. doi: 10.1080/03007995.2024.2333440. Online ahead of print.ABSTRACTDiabetes mellitus (DM) is a long-lasting metabolic non-communicable disease often characterized by an increase in the level of glucose in the blood or hyperglycemia. Approximately, 415 million people between the ages of 20 and 79 years had DM in 2015 and this figure will rise by 200 million by 2040. In a study conducted by CARRS, it's been found that in Delhi the prevalence of diabetes is around 27% and for prediabetic cases, it is more than 46%. The disease DM can be both short-term and long-term and is often associated ...
Source: Current Medical Research and Opinion - March 21, 2024 Category: Research Authors: Sarika Gupta Nitin Sharma Sandeep Arora Saurabh Verma Source Type: research

Methamphetamine intoxication and suicidal ideation/behavior in the Emergency Department
CONCLUSION: These results underscore the urgent need for targeted interventions to address the complex interplay between MA use and suicidal risks in the emergency department setting, as well as broader public health strategies to combat the increasing prevalence of MA use.PMID:38511972 | DOI:10.1080/03007995.2024.2333429 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 21, 2024 Category: Research Authors: Huseyin Bayazit Regina Baronia Sarah M Wakefield Source Type: research

The use of routinely collected healthcare records for outcome assessment in clinical trials: a UK perspective
This article discusses the key considerations that trialists should take into account when incorporating EHR into their trials. These include considerations of the clinical relevance of the outcome, data timeliness and quality, ethical and regulatory issues, and some practical considerations for clinical trials units.In addition, this article describes the benefits of using EHR which include cost, reduced trial burden for participants and staff, follow up efficiencies, and improved health economic evaluation procedures. We also describe the major regulatory and start up costs of using EHR in clinical trials.This article fo...
Source: Current Medical Research and Opinion - March 21, 2024 Category: Research Authors: Abilash Sathyanarayana Source Type: research

Diabetes: a review of its pathophysiology, and advanced methods of mitigation
Curr Med Res Opin. 2024 Mar 21:1-24. doi: 10.1080/03007995.2024.2333440. Online ahead of print.ABSTRACTDiabetes mellitus (DM) is a long-lasting metabolic non-communicable disease often characterized by an increase in the level of glucose in the blood or hyperglycemia. Approximately, 415 million people between the ages of 20 and 79 years had DM in 2015 and this figure will rise by 200 million by 2040. In a study conducted by CARRS, it's been found that in Delhi the prevalence of diabetes is around 27% and for prediabetic cases, it is more than 46%. The disease DM can be both short-term and long-term and is often associated ...
Source: Current Medical Research and Opinion - March 21, 2024 Category: Research Authors: Sarika Gupta Nitin Sharma Sandeep Arora Saurabh Verma Source Type: research

Methamphetamine intoxication and suicidal ideation/behavior in the Emergency Department
CONCLUSION: These results underscore the urgent need for targeted interventions to address the complex interplay between MA use and suicidal risks in the emergency department setting, as well as broader public health strategies to combat the increasing prevalence of MA use.PMID:38511972 | DOI:10.1080/03007995.2024.2333429 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 21, 2024 Category: Research Authors: Huseyin Bayazit Regina Baronia Sarah M Wakefield Source Type: research

The use of routinely collected healthcare records for outcome assessment in clinical trials: a UK perspective
This article discusses the key considerations that trialists should take into account when incorporating EHR into their trials. These include considerations of the clinical relevance of the outcome, data timeliness and quality, ethical and regulatory issues, and some practical considerations for clinical trials units.In addition, this article describes the benefits of using EHR which include cost, reduced trial burden for participants and staff, follow up efficiencies, and improved health economic evaluation procedures. We also describe the major regulatory and start up costs of using EHR in clinical trials.This article fo...
Source: Current Medical Research and Opinion - March 21, 2024 Category: Research Authors: Abilash Sathyanarayana Source Type: research

Diabetes: a review of its pathophysiology, and advanced methods of mitigation
Curr Med Res Opin. 2024 Mar 21:1-24. doi: 10.1080/03007995.2024.2333440. Online ahead of print.ABSTRACTDiabetes mellitus (DM) is a long-lasting metabolic non-communicable disease often characterized by an increase in the level of glucose in the blood or hyperglycemia. Approximately, 415 million people between the ages of 20 and 79 years had DM in 2015 and this figure will rise by 200 million by 2040. In a study conducted by CARRS, it's been found that in Delhi the prevalence of diabetes is around 27% and for prediabetic cases, it is more than 46%. The disease DM can be both short-term and long-term and is often associated ...
Source: Current Medical Research and Opinion - March 21, 2024 Category: Research Authors: Sarika Gupta Nitin Sharma Sandeep Arora Saurabh Verma Source Type: research