The IFT80/Hedgehog Pathway Regulates the Osteogenic-adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells
CONCLUSION: There is a dysregulation of the balance of osteogenic-adipogenic differentiation in SANFH. IFT80 may inhibit adipogenic differentiation while promoting osteogenic differentiation in rabbit BM-MSCs by activating the Hedgehog pathway.PMID:38644709 | DOI:10.2174/0109298673300113240418050128 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 22, 2024 Category: Chemistry Authors: Mingyang Jiang Ke Zhang Yang Hu Shenyi Lu Guiqing Wei Kaicheng Liu Chuanliang Chen Xiaochong Zou Yongheng Dai Ying Gui Jing Wu Huan Bo Zhandong Bo Source Type: research
Geniposide Attenuates Oxygen-glucose Deprivation/Recovery-induced Retinal Ganglion Cell Injury via Akt/Nrf-2 Signaling Pathway
CONCLUSION: Hence, it can be suggested that Gen provides neuroprotection against the OGD/R-induced injury of R28 cells by activating the Akt/Nrf-2 signaling pathway, which is beneficial for the clinical treatment of glaucoma.PMID:38644710 | DOI:10.2174/0109298673272406231212054710 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 22, 2024 Category: Chemistry Authors: Minghai Hu Dekun Chen Xiuyu Wu Guo-Feng Ren Source Type: research
Alpha-lipoic Acid: An Antioxidant with Anti-Aging Properties for Disease Therapy
Curr Med Chem. 2024 Apr 19. doi: 10.2174/0109298673300496240416114827. Online ahead of print.ABSTRACTThe anti-aging effects of alpha-lipoic acid (αLA), a natural antioxidant synthesized in human tissues, have attracted a growing interest in recent years. αLA is a short- -chain sulfur-containing fatty acid occurring in the mitochondria of all kinds of eukaryotic cells. Both the oxidized disulfide of αLA and its reduced form (dihydrolipoic acid, DHLA) exhibit prominent antioxidant function. The amount of αLA inside the human body gradually decreases with age resulting in various health disorders. Its lack can be compensa...
Source: Current Medicinal Chemistry - April 22, 2024 Category: Chemistry Authors: Mariia Shanaida Roman Lysiuk Olha Mykhailenko Nataliia Hudz Abdullateef Abdulsalam Tetiana Gontova Oleksandra Oleshchuk Yana Ivankiv Volodymyr Shanaida Dmytro Lytkin Geir Bj ørklund Source Type: research
N-Methyl-D-Aspartate (NMDA) Receptor Antagonists and Their Pharmacological Implication: A Medicinal Chemistry-Oriented Perspective Outline
Curr Med Chem. 2024 Apr 17. doi: 10.2174/0109298673288031240405061759. Online ahead of print.ABSTRACTN-methyl-D-aspartate (NMDA) receptors, i.e., inotropic glutamate receptors, are important in synaptic plasticity, brain growth, memory, and learning. The activation of NMDA is done by neurotransmitter glutamate and co-agonist (glycine or D-serine) binding. However, the over-activation of NMDA elevates the intracellular calcium influx, which causes various neurological diseases and disorders. Therefore, to prevent excitotoxicity and neuronal death, inhibition of NMDA must be done using its antagonist. This review delineates ...
Source: Current Medicinal Chemistry - April 19, 2024 Category: Chemistry Authors: Vikas Rana Shayantan Ghosh Akanksha Bhatt Damini Bisht Gaurav Joshi Priyank Purohit Source Type: research
A Novel Disulfidptosis-related lncRNAs Prognostic Signature for Prognosis Predicting and Immune Microenvironment Characterization in Breast Cancer
CONCLUSION: The abnormal expressions of selected DPLs were further validated by the BRCA cell line experiment. Our results shed new light on the role of DPLs in BRCA.PMID:38638037 | DOI:10.2174/0109298673294711240405090150 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 19, 2024 Category: Chemistry Authors: Xi Chen Chen Yang Source Type: research
Astaxanthin as an Anticancer Agent against Breast Cancer: An < em > In Vivo < /em > and < em > In Vitro < /em > Investigation
CONCLUSION: ASX can be considered a promising alternative treatment for breast cancer.PMID:38638038 | DOI:10.2174/0109298673288774240406053607 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 19, 2024 Category: Chemistry Authors: Maryam Shokrian Zeini Seyyed Mohammad Pakravesh Seyed Mostafa Jalili Kolour Shahrad Soghala Mohammad Amin Dabbagh Ohadi Haniyeh Ghanbar Ali Akhavan Zeinab Sayyahi Lena Mahya Saleheh Jahani Sadegh Shojaei Baghini Tahereh Farkhondeh Mahboubeh Kabiri Saeed S Source Type: research
CLDN18: Clinical, Pathological, and Genetic Signatures with Drug Screening in Gastric Adenocarcinoma
CONCLUSION: Our study provides a comprehensive understanding of the biological role of CLDN18-based bioinformatics and machine learning analysis in STAD, shedding light on its prognostic significance and potential therapeutic implications. To fully elucidate the molecular intricacies of CLDN18, further investigation is warranted, particularly through in vitro and in vivo studies.PMID:38639279 | DOI:10.2174/0109298673288604240408065715 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 19, 2024 Category: Chemistry Authors: Joon Young Hur Kyueng-Whan Min Yung-Kyun Noh Young-Woong Won Yoomi Yeo Dong-Hoon Kim Byoung Kwan Son Mi Jung Kwon Jung Soo Pyo Source Type: research
Therapeutic Strategies to Improve the Treatment of Pleural Mesothelioma
Curr Med Chem. 2024 Apr 16. doi: 10.2174/0109298673268206240405084558. Online ahead of print.ABSTRACTPleural mesothelioma is a rare neoplastic disease with aggressive features. Patient survival is poor due to the lack of early symptoms and the absence of effective therapeutic strategies. The development of pleural mesothelioma is mainly associated with asbestos exposure and related chronic inflammation. From a molecular-based perspective, this disease is a heterogeneous tumor lacking actionable alterations. The median overall survival of patients affected by this tumor does not exceed 16 months from diagnosis. Molecular an...
Source: Current Medicinal Chemistry - April 17, 2024 Category: Chemistry Authors: Luca Mirra Giovanni L Beretta Daniela Lisini Angela Marcianti Eleonora Spampinato Cristina Corno Matteo Costantino Angelo Corsico Giulia Maria Stella Paola Perego Source Type: research
Therapeutic Strategies to Improve the Treatment of Pleural Mesothelioma
Curr Med Chem. 2024 Apr 16. doi: 10.2174/0109298673268206240405084558. Online ahead of print.ABSTRACTPleural mesothelioma is a rare neoplastic disease with aggressive features. Patient survival is poor due to the lack of early symptoms and the absence of effective therapeutic strategies. The development of pleural mesothelioma is mainly associated with asbestos exposure and related chronic inflammation. From a molecular-based perspective, this disease is a heterogeneous tumor lacking actionable alterations. The median overall survival of patients affected by this tumor does not exceed 16 months from diagnosis. Molecular an...
Source: Current Medicinal Chemistry - April 17, 2024 Category: Chemistry Authors: Luca Mirra Giovanni L Beretta Daniela Lisini Angela Marcianti Eleonora Spampinato Cristina Corno Matteo Costantino Angelo Corsico Giulia Maria Stella Paola Perego Source Type: research
Therapeutic Strategies to Improve the Treatment of Pleural Mesothelioma
Curr Med Chem. 2024 Apr 16. doi: 10.2174/0109298673268206240405084558. Online ahead of print.ABSTRACTPleural mesothelioma is a rare neoplastic disease with aggressive features. Patient survival is poor due to the lack of early symptoms and the absence of effective therapeutic strategies. The development of pleural mesothelioma is mainly associated with asbestos exposure and related chronic inflammation. From a molecular-based perspective, this disease is a heterogeneous tumor lacking actionable alterations. The median overall survival of patients affected by this tumor does not exceed 16 months from diagnosis. Molecular an...
Source: Current Medicinal Chemistry - April 17, 2024 Category: Chemistry Authors: Luca Mirra Giovanni L Beretta Daniela Lisini Angela Marcianti Eleonora Spampinato Cristina Corno Matteo Costantino Angelo Corsico Giulia Maria Stella Paola Perego Source Type: research
Novel Natural Inhibitors for Glioblastoma by Targeting Epidermal Growth Factor Receptor and Phosphoinositide 3-kinase
CONCLUSION: This study has identified novel natural products that inhibit the progression of glioblastoma; however, further examinations of these molecules are required in animal and tissue models to better understand their downstream targeting mechanisms.PMID:38616761 | DOI:10.2174/0109298673293279240404080046 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 15, 2024 Category: Chemistry Authors: Atta Ullah Saeed Ullah Muhammad Waqas Majid Khan Najeeb Ur Rehman Asaad Khalid Afnan Jan Shahkar Aziz Muhammad Naeem Sobia Halim Ajmal Khan Ahmed Al-Harrasi Source Type: research
Novel Natural Inhibitors for Glioblastoma by Targeting Epidermal Growth Factor Receptor and Phosphoinositide 3-kinase
CONCLUSION: This study has identified novel natural products that inhibit the progression of glioblastoma; however, further examinations of these molecules are required in animal and tissue models to better understand their downstream targeting mechanisms.PMID:38616761 | DOI:10.2174/0109298673293279240404080046 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 15, 2024 Category: Chemistry Authors: Atta Ullah Saeed Ullah Muhammad Waqas Majid Khan Najeeb Ur Rehman Asaad Khalid Afnan Jan Shahkar Aziz Muhammad Naeem Sobia Halim Ajmal Khan Ahmed Al-Harrasi Source Type: research
Discovery of Novel Natural Inhibitors Against SARS-CoV-2 Main Protease: A Rational Approach to Antiviral Therapeutics
CONCLUSION: These findings highlight the effectiveness of combining computational and experimental approaches to identify potential lead compounds for SARS-CoV-2, with C1-C5 emerging as promising candidates for further drug development against this virus.PMID:38591207 | DOI:10.2174/0109298673292839240329081008 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Muhammad Waqas Saeed Ullah Sobia Ahsan Halim Inam Ullah None Najeeb Ur Rehman Afnan Jan Asaad Khalid Amjad Ali Ajmal Khan Ahmed Al-Harrasi Source Type: research
Discovery of Novel Natural Inhibitors Against SARS-CoV-2 Main Protease: A Rational Approach to Antiviral Therapeutics
CONCLUSION: These findings highlight the effectiveness of combining computational and experimental approaches to identify potential lead compounds for SARS-CoV-2, with C1-C5 emerging as promising candidates for further drug development against this virus.PMID:38591207 | DOI:10.2174/0109298673292839240329081008 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Muhammad Waqas Saeed Ullah Sobia Ahsan Halim Inam Ullah None Najeeb Ur Rehman Afnan Jan Asaad Khalid Amjad Ali Ajmal Khan Ahmed Al-Harrasi Source Type: research
Discovery of Novel Natural Inhibitors Against SARS-CoV-2 Main Protease: A Rational Approach to Antiviral Therapeutics
CONCLUSION: These findings highlight the effectiveness of combining computational and experimental approaches to identify potential lead compounds for SARS-CoV-2, with C1-C5 emerging as promising candidates for further drug development against this virus.PMID:38591207 | DOI:10.2174/0109298673292839240329081008 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Muhammad Waqas Saeed Ullah Sobia Ahsan Halim Inam Ullah None Najeeb Ur Rehman Afnan Jan Asaad Khalid Amjad Ali Ajmal Khan Ahmed Al-Harrasi Source Type: research
