Current Opinion in Endocrinology, Diabetes and ObesityThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Role of the pituitary-bone axis in skeletal pathophysiologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Purpose of review: Embedded within textbooks for decades is the hard fact that releasing hormones from the anterior pituitary, namely, follicle-stimulating hormone, thyroid-stimulating hormone and adrenocorticotropic hormone, stimulate master hormone secretion from target endocrine organs. We propose a paradigm shift in endocrine physiology, which is that these hormones act by design on bone directly, also now considered an endocrine organ. Recent findings: Complementary investigations using mouse genetic and cell biological approaches reveal that follicle-stimulating hormone and thyroid-stimulating hormone act on bone ce...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - October 30, 2009 Category: Endocrinology Tags: Parathyroids, bone and mineral metabolism: Edited by Vin Tangpricha Source Type: journals

Recurrent first trimester pregnancy loss: revised definitions and novel causesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Purpose of review: First trimester pregnancy loss affects up to 15% of clinically recognized pregnancies. Whereas most couples will proceed to have successful subsequent pregnancies, 2-4% will suffer recurrent losses, often with no identifiable cause. In fact, up to 40-50% of patients suffering recurrent pregnancy loss (RPL) will have no identifiable cause for their losses. Whereas the high incidence of spontaneous fetal aneuploidy will ensure that this number will never fall to zero, its level suggests that additional causes and appropriate diagnostic testing await discovery. The definition, diagnostic work-up and appropr...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - October 30, 2009 Category: Endocrinology Tags: Reproductive endocrinology: Edited by Wendy Kuohung Source Type: journals

Molecular markers of aggressiveness of thyroid cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Purpose of review: To review recent progress at defining molecular markers that predict the biological behavior of thyroid cancer. Recent findings: Thyroid cancer behavior is defined by the effects of the initiating oncogene as well as secondary events in tumor cells and the tumor microenvironment that are both genetic and epigenetic. Over the past several years, there has been intense focus on identifying molecular markers to better predict the aggressiveness of thyroid cancers and also to define therapeutic targets. The results of recent articles in this area of work are summarized with a focus of differentiated follicul...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - August 22, 2009 Category: Endocrinology Tags: Thyroid: Edited by Paul J. Davis Source Type: journals

Combination therapy for obesity and metabolic diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Purpose of review: There is a growing interest in developing combination therapies for treatment and management of obesity and related metabolic diseases. Recent findings: Emerging data from recently completed and ongoing randomized clinical trials suggest that certain combination-drug therapies in development have greater efficacy than currently available single-drug therapies in terms of achieved weight loss and reduction in risk factors. Summary: Combination-drug therapy may have a role in the treatment of obesity and related diseases as well as for prevention of risk factors. As we await safety data from studies with l...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - August 22, 2009 Category: Endocrinology Tags: Obesity and nutrition: Edited by Caroline M. Apovian and Jeff I. Mechanick Source Type: journals

Recent advances in the treatment of acromegalyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Purpose of review: Description of recent outcomes and approaches to the treatment of patients with de-novo and recurrent acromegaly. Recent findings: Radiosurgery for acromegaly results in a higher likelihood of remission and an earlier time to remission than does conventional radiotherapy. Somatostatin analogs results in control of acromegaly and one half of patients. Combining treatment with pegvisomant and somatostatin analogs results in overall improved quality of life. Summary: Existing treatments offer patients and their treating physicians opportunities to restore life expectancy to normal and reverse many of the sy...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - July 5, 2009 Category: Endocrinology Tags: Neuroendocrinology: Edited by William H. Ludlam Source Type: journals

Change you can B(cell)eive in: recent progress confirms a critical role for B cells in type 1 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Purpose of review: Here we review extant recent findings regarding the multiple roles of B cells in type 1 diabetes (T1D) and discuss how autoreactive B cells may become activated by a breach in B cell tolerance, and thereby initiate disease. Finally, we discuss the use of B cell-targeted therapies for treatment of autoimmunity. Recent findings: Anti-CD20-specific depletion of B cells prevents and reverses diabetes in human CD20/non-obese diabetic (NOD) mice. Correspondingly, in nontransgenic NOD mice, B cells are effectively depleted with high dose antimouse CD20 mAbs of varying isotypes, and this also prevents diabetes i...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - July 5, 2009 Category: Endocrinology Tags: Diabetes and the endocrine pancreas II: Edited by Peter A. Gottlieb Source Type: journals

Temporal trends in testosterone levels and treatment in older menEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the evidence in favor of such secular trends and discusses potential causes and implications. Recent findings: The magnitude of the proposed secular trend may be as much as 1% per calendar year in excess of per year cross-sectional trends. Current evidence suggests that body composition changes as expressed by BMI can in part account for the trend in testosterone. More speculative recent findings suggest a potential contributory role for environmental endocrine disruptors, but to date no longitudinal studies have examined this question. Symptomatic androgen deficiency as currently defined is associated...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - June 1, 2009 Category: Endocrinology Tags: Androgens: Edited by David Handelsman Source Type: journals

Androgen therapy for delayed male pubertyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Purpose of review: Delayed puberty in men is a commonly presenting problem to paediatricians and an understanding of the available evidence on cause, treatments and outcomes is important to guide practice. Recent findings: Understanding of the regulation of the onset of puberty is gradually unfolding, although the genetic factors that dictate the timing of puberty in individuals and families remain poorly elucidated. Mutations and polymorphisms in candidate genes are being actively studied and it is likely that there is significant overlap between traditional diagnostic categories. Also, environmental endocrine disruptors ...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - June 1, 2009 Category: Endocrinology Tags: Androgens: Edited by David Handelsman Source Type: journals

Adrenal incidentalomas and subclinical Cushing's syndrome: diagnosis and treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Purpose of review: Adrenal incidentaloma has become a frequent clinical dilemma. Even in the absence of specific clinical features of Cushing's syndrome, adrenocortical incidentalomas may display steroid secretory activity at different degrees. The recognition of endocrine and metabolic dysfunctions associated with subclinical hypercortisolism leads to current awareness about its potential consequences. Recent findings: Different protocols and threshold values to define normal cortisol secretion and diagnosis of subclinical Cushing's syndrome have been proposed, including recent practice guidelines for the diagnosis of ove...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - June 1, 2009 Category: Endocrinology Tags: Adrenal cortex: Edited by Robert Dluhy Source Type: journals