Renal implications of coronavirus disease 2019: insights into viral tropism and clinical outcomes
Curr Opin Microbiol. 2024 Apr 13;79:102475. doi: 10.1016/j.mib.2024.102475. Online ahead of print.ABSTRACTIn recent years, multiple coronaviruses have emerged, with the latest one, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing a global pandemic. Besides respiratory symptoms, some patients experienced extrapulmonary effects, such as cardiac damage or renal injury, indicating the broad tropism of SARS-CoV-2. The ability of the virus to effectively invade the renal cellular environment can eventually cause tissue-specific damage and disease. Indeed, patients with severe coronavirus disease 2019 exhibit...
Source: Current Opinion in Microbiology - April 14, 2024 Category: Microbiology Authors: Valentin A B ärreiter Toni L Meister Source Type: research
Neuroinvasion and neurotropism of severe acute respiratory syndrome coronavirus 2 infection
In conclusion, SARS-CoV-2 can infect numerous cells within the peripheral and central nervous system, provoke inflammatory responses, and induce neuropathological changes.PMID:38615394 | DOI:10.1016/j.mib.2024.102474 (Source: Current Opinion in Microbiology)
Source: Current Opinion in Microbiology - April 14, 2024 Category: Microbiology Authors: Michelle Jagst Lilli Pottk ämper Andr é Gömer Kalliopi Pitarokoili Eike Steinmann Source Type: research
Renal implications of coronavirus disease 2019: insights into viral tropism and clinical outcomes
Curr Opin Microbiol. 2024 Apr 13;79:102475. doi: 10.1016/j.mib.2024.102475. Online ahead of print.ABSTRACTIn recent years, multiple coronaviruses have emerged, with the latest one, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing a global pandemic. Besides respiratory symptoms, some patients experienced extrapulmonary effects, such as cardiac damage or renal injury, indicating the broad tropism of SARS-CoV-2. The ability of the virus to effectively invade the renal cellular environment can eventually cause tissue-specific damage and disease. Indeed, patients with severe coronavirus disease 2019 exhibit...
Source: Current Opinion in Microbiology - April 14, 2024 Category: Microbiology Authors: Valentin A B ärreiter Toni L Meister Source Type: research
Neuroinvasion and neurotropism of severe acute respiratory syndrome coronavirus 2 infection
In conclusion, SARS-CoV-2 can infect numerous cells within the peripheral and central nervous system, provoke inflammatory responses, and induce neuropathological changes.PMID:38615394 | DOI:10.1016/j.mib.2024.102474 (Source: Current Opinion in Microbiology)
Source: Current Opinion in Microbiology - April 14, 2024 Category: Microbiology Authors: Michelle Jagst Lilli Pottk ämper Andr é Gömer Kalliopi Pitarokoili Eike Steinmann Source Type: research
The menace within: bacterial amyloids as a trigger for autoimmune and neurodegenerative diseases
Curr Opin Microbiol. 2024 Apr 10;79:102473. doi: 10.1016/j.mib.2024.102473. Online ahead of print.ABSTRACTBacteria are known to produce amyloids, proteins characterized by a conserved cross-beta sheet structure, which exhibit structural and functional similarities to human amyloids. The deposition of human amyloids into fibrillar plaques within organs is closely linked to several debilitating human diseases, including Alzheimer's and Parkinson's disease. Recently, bacterial amyloids have garnered significant attention as potential initiators of human amyloid-associated diseases as well as autoimmune diseases. This review a...
Source: Current Opinion in Microbiology - April 12, 2024 Category: Microbiology Authors: Molly Elkins Neha Jain Çagla Tükel Source Type: research
Histone code: a common language and multiple dialects to meet the different developmental requirements of apicomplexan parasites
Curr Opin Microbiol. 2024 Apr 5;79:102472. doi: 10.1016/j.mib.2024.102472. Online ahead of print.ABSTRACTApicomplexan parasites have complex life cycles, often requiring transmission between two different hosts, facing periods of dormancy within the host or in the environment to maximize chances of transmission. To support survival in these different conditions, tightly regulated and correctly timed gene expression is critical. The modification of histones and nucleosome composition makes a significant contribution to this regulation, and as eukaryotes, the fundamental mechanisms underlying this process in apicomplexans ar...
Source: Current Opinion in Microbiology - April 6, 2024 Category: Microbiology Authors: Victoria Jeffers Source Type: research
The intricate organizational strategy of nucleus-forming phages
Curr Opin Microbiol. 2024 Apr 5;79:102457. doi: 10.1016/j.mib.2024.102457. Online ahead of print.ABSTRACTNucleus-forming phages (chimalliviruses) encode numerous genes responsible for creating intricate structures for viral replication. Research on this newly appreciated family of phages has begun to reveal the mechanisms underlying the subcellular organization of the nucleus-based phage replication cycle. These discoveries include the structure of the phage nuclear shell, the identification of a membrane-bound early phage infection intermediate, the dynamic localization of phage RNA polymerases, the phylogeny and core gen...
Source: Current Opinion in Microbiology - April 6, 2024 Category: Microbiology Authors: Amy Prichard Joe Pogliano Source Type: research
Histone code: a common language and multiple dialects to meet the different developmental requirements of apicomplexan parasites
Curr Opin Microbiol. 2024 Apr 5;79:102472. doi: 10.1016/j.mib.2024.102472. Online ahead of print.ABSTRACTApicomplexan parasites have complex life cycles, often requiring transmission between two different hosts, facing periods of dormancy within the host or in the environment to maximize chances of transmission. To support survival in these different conditions, tightly regulated and correctly timed gene expression is critical. The modification of histones and nucleosome composition makes a significant contribution to this regulation, and as eukaryotes, the fundamental mechanisms underlying this process in apicomplexans ar...
Source: Current Opinion in Microbiology - April 6, 2024 Category: Microbiology Authors: Victoria Jeffers Source Type: research
The intricate organizational strategy of nucleus-forming phages
Curr Opin Microbiol. 2024 Apr 5;79:102457. doi: 10.1016/j.mib.2024.102457. Online ahead of print.ABSTRACTNucleus-forming phages (chimalliviruses) encode numerous genes responsible for creating intricate structures for viral replication. Research on this newly appreciated family of phages has begun to reveal the mechanisms underlying the subcellular organization of the nucleus-based phage replication cycle. These discoveries include the structure of the phage nuclear shell, the identification of a membrane-bound early phage infection intermediate, the dynamic localization of phage RNA polymerases, the phylogeny and core gen...
Source: Current Opinion in Microbiology - April 6, 2024 Category: Microbiology Authors: Amy Prichard Joe Pogliano Source Type: research
Histone code: a common language and multiple dialects to meet the different developmental requirements of apicomplexan parasites
Curr Opin Microbiol. 2024 Apr 5;79:102472. doi: 10.1016/j.mib.2024.102472. Online ahead of print.ABSTRACTApicomplexan parasites have complex life cycles, often requiring transmission between two different hosts, facing periods of dormancy within the host or in the environment to maximize chances of transmission. To support survival in these different conditions, tightly regulated and correctly timed gene expression is critical. The modification of histones and nucleosome composition makes a significant contribution to this regulation, and as eukaryotes, the fundamental mechanisms underlying this process in apicomplexans ar...
Source: Current Opinion in Microbiology - April 6, 2024 Category: Microbiology Authors: Victoria Jeffers Source Type: research
The intricate organizational strategy of nucleus-forming phages
Curr Opin Microbiol. 2024 Apr 5;79:102457. doi: 10.1016/j.mib.2024.102457. Online ahead of print.ABSTRACTNucleus-forming phages (chimalliviruses) encode numerous genes responsible for creating intricate structures for viral replication. Research on this newly appreciated family of phages has begun to reveal the mechanisms underlying the subcellular organization of the nucleus-based phage replication cycle. These discoveries include the structure of the phage nuclear shell, the identification of a membrane-bound early phage infection intermediate, the dynamic localization of phage RNA polymerases, the phylogeny and core gen...
Source: Current Opinion in Microbiology - April 6, 2024 Category: Microbiology Authors: Amy Prichard Joe Pogliano Source Type: research
Histone code: a common language and multiple dialects to meet the different developmental requirements of apicomplexan parasites
Curr Opin Microbiol. 2024 Apr 5;79:102472. doi: 10.1016/j.mib.2024.102472. Online ahead of print.ABSTRACTApicomplexan parasites have complex life cycles, often requiring transmission between two different hosts, facing periods of dormancy within the host or in the environment to maximize chances of transmission. To support survival in these different conditions, tightly regulated and correctly timed gene expression is critical. The modification of histones and nucleosome composition makes a significant contribution to this regulation, and as eukaryotes, the fundamental mechanisms underlying this process in apicomplexans ar...
Source: Current Opinion in Microbiology - April 6, 2024 Category: Microbiology Authors: Victoria Jeffers Source Type: research
The intricate organizational strategy of nucleus-forming phages
Curr Opin Microbiol. 2024 Apr 5;79:102457. doi: 10.1016/j.mib.2024.102457. Online ahead of print.ABSTRACTNucleus-forming phages (chimalliviruses) encode numerous genes responsible for creating intricate structures for viral replication. Research on this newly appreciated family of phages has begun to reveal the mechanisms underlying the subcellular organization of the nucleus-based phage replication cycle. These discoveries include the structure of the phage nuclear shell, the identification of a membrane-bound early phage infection intermediate, the dynamic localization of phage RNA polymerases, the phylogeny and core gen...
Source: Current Opinion in Microbiology - April 6, 2024 Category: Microbiology Authors: Amy Prichard Joe Pogliano Source Type: research
Histone code: a common language and multiple dialects to meet the different developmental requirements of apicomplexan parasites
Curr Opin Microbiol. 2024 Apr 5;79:102472. doi: 10.1016/j.mib.2024.102472. Online ahead of print.ABSTRACTApicomplexan parasites have complex life cycles, often requiring transmission between two different hosts, facing periods of dormancy within the host or in the environment to maximize chances of transmission. To support survival in these different conditions, tightly regulated and correctly timed gene expression is critical. The modification of histones and nucleosome composition makes a significant contribution to this regulation, and as eukaryotes, the fundamental mechanisms underlying this process in apicomplexans ar...
Source: Current Opinion in Microbiology - April 6, 2024 Category: Microbiology Authors: Victoria Jeffers Source Type: research
The intricate organizational strategy of nucleus-forming phages
Curr Opin Microbiol. 2024 Apr 5;79:102457. doi: 10.1016/j.mib.2024.102457. Online ahead of print.ABSTRACTNucleus-forming phages (chimalliviruses) encode numerous genes responsible for creating intricate structures for viral replication. Research on this newly appreciated family of phages has begun to reveal the mechanisms underlying the subcellular organization of the nucleus-based phage replication cycle. These discoveries include the structure of the phage nuclear shell, the identification of a membrane-bound early phage infection intermediate, the dynamic localization of phage RNA polymerases, the phylogeny and core gen...
Source: Current Opinion in Microbiology - April 6, 2024 Category: Microbiology Authors: Amy Prichard Joe Pogliano Source Type: research
