Current Opinion in Supportive and Palliative Care This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Systemic therapy in metastatic hormone-sensitive prostate cancer
Purpose of review The landscape of metastatic hormone sensitive prostate cancer (mHSPC) has evolved rapidly in recent years with new data from landmark trials supporting upfront treatment intensification. The developments come not only on the fronts of systemic agents but also in area of therapy to primary tumour and metastases. Recent findings More recently, the ARASENS and PEACE trials have taken the concept of treatment intensification further by demonstrating survival benefit from combination of chemotherapy (docetaxel) and androgen receptor pathway inhibitors (abiraterone and darolutamide) in addition to ba...
Source: Current Opinion in Supportive and Palliative Care - November 15, 2022 Category: Palliative Care Tags: RENAL AND UROLOGICAL PROBLEMS: Edited by Fred Saad and Andrea Kokorovic Source Type: research

Fertility preservation in uro-oncology
Purpose of review The purpose of this review is to highlight the demand for fertility preservation among cancer survivors and to draw attention to areas where healthcare workers need to improve. As technology advances, maximizing cryopreservation rates will be paramount to increase the ability individuals to conceive after cancer treatment. Recent findings Guidelines recommending discussion of fertility for those diagnosed with cancer have been shown to increase patient satisfaction and overall quality of life. Our review demonstrated that increasing counseling rates remains an ongoing challenge and should remai...
Source: Current Opinion in Supportive and Palliative Care - November 15, 2022 Category: Palliative Care Tags: RENAL AND UROLOGICAL PROBLEMS: Edited by Fred Saad and Andrea Kokorovic Source Type: research

Metastatic castrate-resistant prostate cancer: a new horizon beyond the androgen receptors
Purpose of review Systemic chemotherapy and second-generation androgen receptor-axis targeted therapies have been in the forefront of management for metastatic castrate-resistant prostate cancer (mCRPC) patients with low or high symptom burden. However, in the recent past, due to improvement in molecular characterization, management of mCRPC has witnessed long strides of advancement. We aim to review the novel nonhormonal and nonchemotherapeutic treatment options. Recent findings Poly (ADP-ribose) polymerase inhibitors (PARPis) such as olaparib and rucaparib have been recently approved by the US FDA for use in m...
Source: Current Opinion in Supportive and Palliative Care - November 15, 2022 Category: Palliative Care Tags: RENAL AND UROLOGICAL PROBLEMS: Edited by Fred Saad and Andrea Kokorovic Source Type: research

Cardiometabolic side effects of androgen deprivation therapy in prostate cancer
Purpose of review Androgen-deprivation therapy (ADT) is widely employed for treatment of advanced prostate cancer and it is considered the frontline therapy. However, the numerous adverse reactions associated with this treatment option are concerning and its potential association with cardiovascular diseases (CVD) should not be overlooked. In this review, we examine the literature on the cardiovascular side effects of ADT and the physiologic mechanisms underpinning the association with CVD. We will also specifically discuss the different findings regarding the interesting potential disparity in major cardiovascular eve...
Source: Current Opinion in Supportive and Palliative Care - November 15, 2022 Category: Palliative Care Tags: RENAL AND UROLOGICAL PROBLEMS: Edited by Fred Saad and Andrea Kokorovic Source Type: research

Burden of respiratory problems in low-income and middle-income countries
We report global estimates of respiratory problems amongst adults in LMICs and recent findings relating to community prevalence and impact of respiratory problems. We conclude by identifying research priorities for improved recognition and palliation of respiratory problems. Recent findings We report findings from 16 studies, highlighting key issues relevant to burden of respiratory problems in LMICs. COPD and associated symptoms are identified as important drivers of increasing respiratory problems in LMICs, with an estimated prevalence of 7.2%. Negative impacts of respiratory diseases include: reduced physical fun...
Source: Current Opinion in Supportive and Palliative Care - November 15, 2022 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by Magnus Ekström and Morag Farquhar Source Type: research

Post-COVID-19 respiratory problems: burden and management
Purpose of review To describe the burden of post-COVID respiratory sequelae in posthospital and nonhospitalized COVID-19 survivors and to describe the priorities of clinical management. Recent findings Due to varying definitions of ‘Long COVID’ or ‘Post-COVID’, the prevalence of post-COVID sequelae or persisting symptoms is challenging to estimate but ranges from 2.3 to 51%. Risk factors for persistent post-COVID symptoms include age, female sex, deprivation, presence of comorbidities; and in posthospital COVID-19 survivors, the severity of acute infection. Common post-COVID respiratory symptoms include ...
Source: Current Opinion in Supportive and Palliative Care - November 15, 2022 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by Magnus Ekström and Morag Farquhar Source Type: research

Social dimensions of chronic respiratory disease: stigma, isolation, and loneliness
Purpose of review Social wellbeing is a core component of heath. However, people with chronic respiratory disease report unmet social needs, particularly in relation to stigma, social isolation, and loneliness. This review considers recent advances in understanding these social concepts within the context of chronic respiratory disease. Recent findings A growing body of qualitative work illustrates the detrimental impacts of stigma in chronic respiratory disease, contributing towards poorer psychological health and self-management, and reduced engagement with professional support. Stigma, alongside physical limi...
Source: Current Opinion in Supportive and Palliative Care - November 15, 2022 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by Magnus Ekström and Morag Farquhar Source Type: research

Tests to uncover and assess breathlessness: a proposed framework
Purpose of Review Breathlessness is a common, distressing, and limiting symptom that many people avoid by reducing their activity. This review discusses exertional tests that can be used for uncovering and assessing breathlessness depending on the person's severity of illness, function, the setting, and aim of the assessment. Recent Findings Standardized exertional tests are useful to uncover ‘hidden’ breathlessness earlier in people who may have adapted their physical activity to limit their breathing discomfort. In ‘more fit’ ambulatory people and outpatients, cardiopulmonary exercise testing is the go...
Source: Current Opinion in Supportive and Palliative Care - November 15, 2022 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by Magnus Ekström and Morag Farquhar Source Type: research

The burden and impact of chronic cough in severe disease
Purpose of review Chronic cough is common in severe diseases, such as COPD, interstitial lung disease, lung cancer and heart failure, and has a negative effect on quality of life. In spite of this, patients with cough sometimes feel their cough is neglected by healthcare workers. This review aims to briefly describe cough mechanisms, highlight the burden chronic cough can be for the individual, and the clinical impact of chronic cough. Recent findings Chronic cough is likely caused by different mechanisms in different diseases, which may have therapeutic implications. Chronic cough, in general, has a significant...
Source: Current Opinion in Supportive and Palliative Care - November 15, 2022 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by Magnus Ekström and Morag Farquhar Source Type: research

Editorial: Advancing the management of respiratory problems
No abstract available (Source: Current Opinion in Supportive and Palliative Care)
Source: Current Opinion in Supportive and Palliative Care - November 15, 2022 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by Magnus Ekström and Morag Farquhar Source Type: research

Editorial introductions
No abstract available (Source: Current Opinion in Supportive and Palliative Care)
Source: Current Opinion in Supportive and Palliative Care - November 15, 2022 Category: Palliative Care Tags: EDITORIAL INTRODUCTIONS Source Type: research

Oral pain in the cancer patient
Purpose of review Oral pain is a common complaint in patients with cancer. This review aims to summarize the knowledge on the causes and approach to management of oral pain garnered over the past 2 years. Recent findings A systematic review and meta-analysis included in the review, assessed cannabinoid versus placebo and showed only a small effect on pain, physical function, and sleep quality. Another review showed that chemical neurolysis as an adjunctive therapy, is effective in patients with pain of shorter chronicity and refractory head and neck cancer-related pain. Summary Patients with cancer freque...
Source: Current Opinion in Supportive and Palliative Care - August 11, 2022 Category: Palliative Care Tags: SPECIAL COMMENTARY Source Type: research

Effects of coronavirus disease 19 on the gastrointestinal tract and the potential impact on gastrointestinal toxicities during cancer treatment
Purpose of review Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has resulted in a global pandemic, with people with other conditions at greater risk of severe infection with intensified symptoms across multiple organ systems. Patients with cancer are at greater risk, and it is likely that those receiving treatment will experience greater incidence and severity of gastrointestinal toxicities, such as gastrointestinal mucositis, due to SARS-CoV-2 binding to angiotensin-converting enzyme (ACE)2 in the intestine. Recent findings Recent studies have shown that SARS-CoV-2 patients experience gastro...
Source: Current Opinion in Supportive and Palliative Care - August 11, 2022 Category: Palliative Care Tags: GASTROINTESTINAL SYMPTOMS: Edited by Nicole Blijlevens and Andrea Stringer Source Type: research

Using real world data to advance the provision of supportive cancer care: mucositis as a case study
Purpose of review For decades, clinical decision making and practice has been largely informed by data generated through randomized clinical trials (RCTs). By design, RCTs are highly restricted in both scope and scale, resulting in narrow indications and iterative advances in clinical practice. With the transition to electronic health records, there are now endless opportunities to utilize these ‘real world’ data (RWD) to make more substantive advances in our understanding that are, by nature, more applicable to reality. This review discusses the current paradigm of using big data to advance and inform the provisio...
Source: Current Opinion in Supportive and Palliative Care - August 11, 2022 Category: Palliative Care Tags: GASTROINTESTINAL SYMPTOMS: Edited by Nicole Blijlevens and Andrea Stringer Source Type: research

Nonpharmacological approaches for improving gut resilience to chemotherapy
Purpose of review Mucositis of the gastrointestinal tract is a debilitating side effect of chemotherapy that negatively influences treatment tolerance and patient life quality. This review will evaluate the recent literature on nonpharmacological strategies that have the potential to improve chemotherapy-induced mucositis (CIM). Recent findings Alternatives to pharmacological approaches have shown great promise in preventing CIM. Natural products, including curcumin, ginseng, quercetin, and patchouli all show potential in mitigating CIM. In addition, dietary patterns, such as the elemental diet, high fiber diet,...
Source: Current Opinion in Supportive and Palliative Care - August 11, 2022 Category: Palliative Care Tags: GASTROINTESTINAL SYMPTOMS: Edited by Nicole Blijlevens and Andrea Stringer Source Type: research