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Pregabalin as treatment for fibromyalgia: The rest of the story?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11916-009-0079-9Authors Andrew J. Holman, Department of Internal Medicine/Rheumatology at the University of Washington School of Medicine Washington USA Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 Journal Volume Volume 13 Journal Issue Volume 13, Number 6 / December, 2009 (Source: Current Pain and Headache Reports)
Source: Current Pain and Headache Reports - November 4, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Memantine for the prophylaxis of chronic tension-type headacheEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s11916-009-0080-3Authors Katherine A. Henry, New York University Langone Medical Center Department of Neurology New York USA Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 Journal Volume Volume 13 Journal Issue Volume 13, Number 6 / December, 2009 (Source: Current Pain and Headache Reports)
Source: Current Pain and Headache Reports - November 4, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Update on the management of pain in arthritis and the use of cyclooxygenase-2 inhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Chronic pain from arthritis continues to be one of the biggest causes of disability and loss of function in the United States today. This is still the case despite many new insights into the pathophysiology of pain, effective treatment approaches, and new, safer medications that can be used long-term. There are many different types of arthritic problems. New disease-modifying agents that are available for some of these types of arthritic diseases, such as rheumatoid arthritis, have the potential to have a substantial impact on improvement in the long-term prognosis. Despite this optimistic outlook, ...
Source: Current Pain and Headache Reports - November 4, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Tension-type headache in the elderlyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article presents an update on the epidemiology and prognosis of TTH in the elderly. Content Type Journal ArticleDOI 10.1007/s11916-009-0076-zAuthors Sara C. Crystal, NYU School of Medicine Department of Neurology 462 First Avenue, Suite NBV-7W11 New York NY 10016 USABrian M. Grosberg Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 Journal Volume Volume 13 Journal Issue Volume 13, Number 6 / December, 2009 (Source: Current Pain and Headache Reports)
Source: Current Pain and Headache Reports - November 4, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Does exercise therapy improve headache? A systematic review with meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Current Reports / Pain & Headache / Invited CommentaryDOI 10.1007/s11916-009-0081-2Authors James Fricton, University of Minnesota School of Dentistry Department of Diagnostic and Surgical Science 515 Delaware Street SE Minneapolis MN 55455 USAAna VellyWei OuyangJohn O. Look Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 Journal Volume Volume 13 Journal Issue Volume 13, Number 6 / December, 2009 (Source: Current Pain and Headache Reports)
Source: Current Pain and Headache Reports - November 4, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Joint hypermobility syndrome painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Joint hypermobility syndrome (JHS) was initially defined as the occurrence of musculoskeletal symptoms in the presence of joint laxity and hypermobility in otherwise healthy individuals. It is now perceived as a commonly overlooked, underdiagnosed, multifaceted, and multisystemic heritable disorder of connective tissue (HDCT), which shares many of the phenotypic features of other HDCTs such as Marfan syndrome and Ehlers-Danlos syndrome. Whereas the additional flexibility can confer benefits in terms of mobility and agility, adverse effects of tissue laxity and fragility can give rise to clinical con...
Source: Current Pain and Headache Reports - November 4, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Viscosupplementation treatment of arthritis painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract With the aging of the baby boomer generation, the number of patients with osteoarthritis (OA) is expected to swell, posing treatment challenges. Viscosupplementation, in which hyaluronic acid (HA) is injected into the knee joint, has evolved into an important part of our current therapeutic regimen in addressing the patient with knee pain due to OA. Although suffering from lack of an “evidence-based” approach, and largely funded by industry, there is a growing body of outcome data demonstrating the efficacy of HA in decreasing pain and improving function in patients with knee OA, although no evi...
Source: Current Pain and Headache Reports - November 4, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Tension-type headache with medication overuse: Pathophysiology and clinical implicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Tension-type headache (TTH) is the most prevalent primary headache disorder. An important factor in the long-term prognosis of TTH is the overuse of acute medications used to treat headache. There are many reasons why patients with TTH overuse acute medications, including biobehavioral influences, dependency, and a lack of patient education. Chronic daily headache occurs in 4.1% of the general population, and chronic tension-type headache and medication overuse headache (MOH) occur in approximately 2.2% and 1.5%, respectively. A proper diagnosis is essential for the treatment of these patients. Trea...
Source: Current Pain and Headache Reports - November 4, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Enhanced pain perception in rheumatoid arthritis: Novel considerationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Enhanced pain perception is common among patients with rheumatoid arthritis (RA). Given the putative role of proinflammatory cytokines in the development of hyperalgesia, a greater understanding of factors that facilitate increased cytokine expression in RA stands to increase understanding of the sources of enhanced pain perception. Patients with RA have significantly greater stress-induced proinflammatory cytokine release. Although absolute deficiencies in cortisol have not been demonstrated, functional abnormalities have been described, including “abnormally normal” cortisol levels in the face...
Source: Current Pain and Headache Reports - November 4, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Advances in the pathophysiology of tension-type headache: From stress to central sensitizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Tension-type headache (TTH) is the most common and most socioeconomically costly headache. Yet our knowledge regarding TTH pathophysiological mechanisms is still in its early stages. Psychological stress and weak coping mechanisms may initiate and propagate physiological pain via activation of second messengers in downstream substrates involved in pain. It seems that peripheral mechanisms are predominant in the episodic type (ETTH), whereas central mechanisms are involved in the chronic type (CTTH) of tension headache. The conversion from ETTH to CTTH is most relevant to the clinician and the patien...
Source: Current Pain and Headache Reports - November 4, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Mechanisms by which sleep disturbance contributes to osteoarthritis pain: A conceptual modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the extant literature on sleep disturbance and hyperalgesia in patients with OA. We propose a conceptual working model describing pathways by which sleep disturbance interacts directly with central pain processing mechanisms and inflammatory processes, and indirectly with mood and physical functioning to augment clinical OA pain. The clinical and research implications of the model are discussed. Content Type Journal ArticleDOI 10.1007/s11916-009-0073-2Authors Michael T. Smith, Johns Hopkins Bayview Medical Center 5510 Nathan Shock Drive, Suite 100 Baltimore MD 21224 USAPhillip J. QuartanaRenata...
Source: Current Pain and Headache Reports - November 4, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Chronic tension-type headacheEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews CTTH, as well as the current pathophysiology and treatment, and discusses controversial issues in the diagnosis of CTTH and CM. Content Type Journal ArticleDOI 10.1007/s11916-009-0077-yAuthors Jessica Ailani, Georgetown University Hospital Department of Neurology 3800 Reservoir Road NW, 7-PHC Washington, DC 20007 USA Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 Journal Volume Volume 13 Journal Issue Volume 13, Number 6 / December, 2009 (Source: Current Pain and Headache Reports)
Source: Current Pain and Headache Reports - November 4, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Current studies on myofascial pain syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Recent studies have clarified the nature of myofascial trigger points (MTrPs). In an MTrP region, multiple hyperirritable loci can be found. The sensory components of the MTrP locus are sensitized nociceptors that are responsible for pain, referred pain, and local twitch responses. The motor components are dysfunctional endplates that are responsible for taut band formation as a result of excessive acetylcholine (ACh) leakage. The concentrations of pain- and inflammation-related substances are increased in the MTrP region. It has been hypothesized that excessive ACh release, sarcomere shortening, an...
Source: Current Pain and Headache Reports - September 18, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Neuroendocrine dysfunction in fibromyalgia and migraineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews several common aspects of the pathophysiology regarding pain control mechanisms and neuroendocrine dysfunction occurring in FM and migraine, particularly in the chronic form of the latter. We also discuss the participation of hypothalamic and brainstem centers of pain control, the putative role played by neurotransmitters or neuromodulators on central sensitization, and changes in their levels in the cerebrospinal fluid. Understanding their mechanisms will help to establish new treatment strategies for treating these disabling brain disorders. Content Type Journal ArticleDOI 10.1007/s11916-009-...
Source: Current Pain and Headache Reports - September 18, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Biomarkers in fibromyalgiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews several objective abnormalities or measures that have been identified or used in fibromyalgia, and indicates which of these may be most promising to eventually use as biomarkers to follow the response to treatment or progress of disease over time. Content Type Journal ArticleDOI 10.1007/s11916-009-0056-3Authors Jacob N. AblinDan BuskilaDaniel J. Clauw, University of Michigan Chronic Pain and Fatigue Research Center 24 Frank Lloyd Wright Drive PO Box 385 Ann Arbor MI 48106 USA Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 Journal Volume Volume 13 ...
Source: Current Pain and Headache Reports - September 18, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Brain manifestation and modulation of pain from myofascial trigger pointsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The brain plays a prominent role in the generation and modulation of pain. It contains powerful endogenous pain modulatory systems that can be engaged in a beneficial way by therapeutical intervention. In contrast, pain chronification is associated with maladaptive structural and functional changes that may shift the balance of the modulatory systems. Although pain from myofascial trigger points (MTrPs) is highly prevalent, little is known about its brain manifestations and modulation. Recent neuroimaging data suggest that hyperalgesia from MTrPs is processed in similar regions as hyperalgesia from ...
Source: Current Pain and Headache Reports - September 18, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Psychological trauma in chronic pain: Implications of PTSD for fibromyalgia and headache disordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The association of traumatic exposures with posttraumatic stress disorder (PTSD) and other mental health conditions is well known. Patients with chronic pain, particularly headache disorders and fibromyalgia (FM), associated with psychological traumas need a special management strategy. Diagnosis of headache disorders and FM in traumatized patients and collecting the clinical history of a traumatic event or diagnosing PTSD in chronic pain patients is of great importance. Psychotherapy and pharmacotherapeutic options should be started on patients with comorbid PTSD and headache disorders and/or FM. ...
Source: Current Pain and Headache Reports - September 18, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Medication overuse and chronic migraineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11916-009-0068-zAuthors Vincent T. Martin, University of Cincinnati College of Medicine Division of General Internal Medicine Cincinnati USA Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 Journal Volume Volume 13 Journal Issue Volume 13, Number 5 / October, 2009 (Source: Current Pain and Headache Reports)
Source: Current Pain and Headache Reports - September 18, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Migraine as a potential risk factor for ischemic lesions: Recent findingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Current Reports / Pain & Headache / Invited CommentaryDOI 10.1007/s11916-009-0069-yAuthors Julio Pascual, University Hospital Marqués de Valdecilla Service of Neurology 39008 Santander SpainAgustín Oterino Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 Journal Volume Volume 13 Journal Issue Volume 13, Number 5 / October, 2009 (Source: Current Pain and Headache Reports)
Source: Current Pain and Headache Reports - September 18, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

The associations between migraine, unipolar psychiatric comorbidities, and stress-related disorders and the role of estrogenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article offers an in-depth review of several studies linking psychiatric disorders and stress-related disorders with migraine. We also discuss the role of estrogen in the pathophysiologic overlap between these disorders. Finally, we briefly touch on where future research may be headed, in light of these data. Content Type Journal ArticleDOI 10.1007/s11916-009-0066-1Authors B. Lee Peterlin, Drexel University College of Medicine 245 North 15th Street, MS 423 Philadelphia PA 19102 USAMichael J. KatsnelsonAnne H. Calhoun Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 J...
Source: Current Pain and Headache Reports - September 18, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

New techniques for the quantification of fibromyalgia and myofascial painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Myofascial pain and fibromyalgia share a number of common features: the patient is uncomfortable; abnormalities can be detected on physical examination; and there is a lack of an objective means to either quantify or visualize their core features. This has undoubtedly contributed to a slowed acceptance of their importance by the medical community. Fortunately, the situation is beginning to change. Although progress may be somewhat slower in fibromyalgia, in which attention appears to focus on pain sensitivity and functional brain imaging, a number of approaches now seem promising in their ability to...
Source: Current Pain and Headache Reports - September 18, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Hormonal therapies for menstrual migraineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Menstrual-related migraine (MRM) affects the majority of female migraineurs, with menstrual-associated attacks reported to be more disabling, longer lasting, and less responsive to traditional treatments than nonmenstrual attacks. Emerging evidence suggests that minimizing or eliminating monthly declines in estrogen concentration may be effective in preventing MRM. This article gives a practical overview of current hormonal options, both contraceptive and noncontraceptive. Our intent is to help the reader better understand the differences in currently available formulations and how some of these age...
Source: Current Pain and Headache Reports - September 18, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Medication use in the treatment of migraine during pregnancy and lactationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article explores the physiologic changes occurring during pregnancy that can affect pharmacokinetic properties of drugs and their metabolism. Acute and preventive treatment of migraine during pregnancy and lactation is discussed, with an emphasis on safety to the fetus and nursing infant. Safety and recommended use of medication during pregnancy may be different when use is considered during breastfeeding. A goal of treatment is to balance potential risk of treatment to the fetus and nursing infant with significant relief and return to normal function of the mother. Content Type Journal ArticleDOI 10.1007/s1191...
Source: Current Pain and Headache Reports - September 18, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Platelet dysfunction and stroke in the female migraineurEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Some studies suggest that platelet activation and aggregation are associated with migraine, likely secondary to changes occurring during the acute attack. Evidence also suggests that platelet clots can lodge in small cerebral vessels, and that the resultant is chemia and inflammation can induce cortical spreading depression with aura-like symptoms and pulsatile headache. Endothelial dysfunction, a result of numerous vascular, genetic, and environmental risk factors, is more common in women with migraine and leads to altered hemostasis. When associated with other factors, such as oral contraceptive u...
Source: Current Pain and Headache Reports - September 18, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Fibromyalgia and headache disordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11916-009-0067-0Authors Mario F. P. Peres, Instituto Israelita deEnsino e Pesquisa Hospital Albert Einstein Sao Paulo Brazil Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 Journal Volume Volume 13 Journal Issue Volume 13, Number 5 / October, 2009 (Source: Current Pain and Headache Reports)
Source: Current Pain and Headache Reports - September 18, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Migraine headache in perimenopausal and menopausal womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Perimenopause marks a time of change in a woman’s hormonal environment, which is apparent from the resultant irregular periods and vasomotor symptoms. These symptoms can start in the early 40s and continue through to the early 50s. Migraine is also affected by hormonal fluctuations, particularly the natural decline in estrogen in the late luteal phase of the menstrual cycle. This effect of estrogen “withdrawal” on migraine appears to become more predominant during perimenopause. Despite the increased prevalence of headache and migraine in women in their 40s, migraine is underdiagnosed in this ...
Source: Current Pain and Headache Reports - September 18, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Stereotactic radiosurgery in the management of cancer painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article discusses the biology, rationale, evolution, and future direction of radiosurgery for the treatment of pain related to bony metastatic disease. Content Type Journal ArticleDOI 10.1007/s11916-009-0044-7Authors Marsha Haley, University of Pittsburgh Cancer Institute Department of Radiation Oncology 5230 Centre Avenue Pittsburgh PA 15213 USAPeter C. Gerszten Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 Journal Volume Volume 13 Journal Issue Volume 13, Number 4 / August, 2009 (Source: Current Pain and Headache Reports)
Source: Current Pain and Headache Reports - July 14, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Percutaneous CT-guided C1–2 cordotomy for intractable cancer painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11916-009-0053-6Authors Dermot R. Fitzgibbon, University of Washington School of Medicine Department of Anesthesiology and Pain Medicine Washington USA Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 Journal Volume Volume 13 Journal Issue Volume 13, Number 4 / August, 2009 (Source: Current Pain and Headache Reports)
Source: Current Pain and Headache Reports - July 14, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Medical imaging in the diagnosis and management of cancer painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the role that various imaging modalities play in the management of cancer pain and provides an overview of the latest technological advances. Content Type Journal ArticleDOI 10.1007/s11916-009-0042-9Authors Carlos Cuevas, University of Washington Body Imaging Section, Department of Radiology Box 357115 1959 NE Pacific Street Seattle WA 98195 USADean Shibata Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 Journal Volume Volume 13 Journal Issue Volume 13, Number 4 / August, 2009 (Source: Current Pain and Headache Reports)
Source: Current Pain and Headache Reports - July 14, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Overuse of acute migraine medications and migraine chronificationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Among individuals with episodic migraine, the influence of excessive acute medication use on the development of chronic migraine depends upon within-person characteristics (eg, headache frequency), class of drug, and frequency of medication use. Available data suggest that opioids induce migraine chronification (progression), and the effect is dose dependent (critical dose around 8 days of exposure per month) and more pronounced in men. Barbiturates also induce migraine progression, and the effect is dose dependent (critical dose around 5 days of exposure per month) and more pronounced in women. Tri...
Source: Current Pain and Headache Reports - July 14, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Assessment of neuropathic pain in cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Neuropathic pain is an increasingly common problem facing the cancer patient. Painful neuropathy can come from various sources and significantly impact quality of life. The most commonly observed scenario is paraesthesia and dysesthesia as a result of toxic effects of chemotherapies on the distal peripheral nerves. Neuropathic pain should be addressed ideally with the help of a neuro-oncologist, and it usually can be successfully treated with a variety of agents, including atypical analgesics such as antidepressants, newer drugs with analgesic benefit, and opioids for more refractory cases. Direct a...
Source: Current Pain and Headache Reports - July 14, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Temporomandibular disorders and migraine chronificationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article explores the potential comorbidity between migraine and TMD and the role of TMD as a potential factor to induce chronic migraine. We discuss the similarities between both conditions, review evidence to support the idea that both disorders are comorbid, and highlight the limited evidence suggesting that TMD influence migraine progression. Finally, we discuss the importance of cutaneous allodynia mediating the TMD/frequent headache relationship. Content Type Journal ArticleDOI 10.1007/s11916-009-0050-9Authors Debora Bevilaqua Grossi, University of Sao Paulo Department of Biomechanics Medicine and Rehabil...
Source: Current Pain and Headache Reports - July 14, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Radiation, chemotherapy, and symptom management in cancer-related cognitive dysfunctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Patients with cancer are concerned about their ability to interact with friends and family and to perform activities associated with daily living. The combined effects of the disease process, its treatment with surgery, radiation, and chemotherapy, and the medications used to manage symptoms may all impact cognitive function. Minimizing the effect of each treatment modality on cognitive processing requires an understanding of how these treatment modalities may impact cognition. Content Type Journal ArticleDOI 10.1007/s11916-009-0043-8Authors Christopher LoiselleJason Rockhill, University of Wash...
Source: Current Pain and Headache Reports - July 14, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Psychiatric comorbidities and migraine chronificationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article overviews literature on psychiatric comorbidities and migraine chronification, considers mechanisms underlying this relationship, and notes directions for future clinical and empirical work. Content Type Journal ArticleDOI 10.1007/s11916-009-0052-7Authors Todd A. Smitherman, University of Mississippi Department of Psychology 207 Peabody, University University MS 38677 USAJeanetta C. RainsDonald B. Penzien Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 Journal Volume Volume 13 Journal Issue Volume 13, Number 4 / August, 2009 (Source: Current Pain and Headache Reports)
Source: Current Pain and Headache Reports - July 14, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Chronic pain disorders and headache chronificationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract It is estimated that nearly half of the global adult population suffers from an active headache disorder, most of whom experience attacks on an episodic basis. The transition from episodic to chronic headache is a poorly understood process. Epidemiological findings demonstrating comorbidity and common risk factors suggest that headache progression or prognosis may be related to the presence of other chronic pain disorders. This review highlights findings from population-based studies on headache and other pain disorders and how they relate to each other, with a focus on understanding headache chroni...
Source: Current Pain and Headache Reports - July 14, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Vertebroplasty in the management of painful bony metastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Percutaneous vertebroplasty is the injection of bone cement, usually polymethylmethacrylate into the vertebral body. This procedure is most often performed in a percutaneous fashion on an outpatient (or short-stay) basis. Among other indications, the procedure is designated for painful vertebral compression fractures due to primary or metastatic spinal tumors. Published literature favors the use of this procedure in cancer pain management. The overall risk of the procedure is low, although serious complications (including spinal cord compression) can occur. Recent advances in technique and materials...
Source: Current Pain and Headache Reports - July 14, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Sinus problems as a cause of headache refractoriness and migraine chronificationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article explores some of the potential mechanisms and the available scientific studies that may explain how sinus headache can become chronic and present to the clinician as a refractory headache disorder. Content Type Journal ArticleDOI 10.1007/s11916-009-0051-8Authors Roger K. Cady, Headache Care Center 3805 Kansas Expressway Springfield MO 65807 USACurtis P. Schreiber Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 Journal Volume Volume 13 Journal Issue Volume 13, Number 4 / August, 2009 (Source: Current Pain and Headache Reports)
Source: Current Pain and Headache Reports - July 14, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

The role of botulinum neurotoxin in pain management—An ongoing controversyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Current Reports / Pain & Headache / Invited CommentaryDOI 10.1007/s11916-009-0055-4Authors Avi Ashkenazi, 233 South 6th Street, Apartment 705 Philadelphia PA 19106 USA Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 Journal Volume Volume 13 Journal Issue Volume 13, Number 4 / August, 2009 (Source: Current Pain and Headache Reports)
Source: Current Pain and Headache Reports - July 14, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

The management of sickle cell painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Treatment of pain in the setting of sickle cell disease remains unsatisfactory. The approach remains to treat the pain symptomatically with escalating doses of non-opioid and opioid medications while any underlying inciting process is investigated. For the majority of patients with sickle cell disease, pain will always be part of their lives. Advances in the treatment of sickle cell pain will depend on multiple approaches, including both pharmacologic and nonpharmacologic. Content Type Journal ArticleDOI 10.1007/s11916-009-0047-4Authors Robert E. Richard, University of Washington School of Medic...
Source: Current Pain and Headache Reports - July 14, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Diagnostic evaluation and treatment of trigeminal neuralgiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11916-009-0054-5Authors Marcelo E. Bigal, Merck Research Laboratories Whitehouse Station USA Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 Journal Volume Volume 13 Journal Issue Volume 13, Number 4 / August, 2009 (Source: Current Pain and Headache Reports)
Source: Current Pain and Headache Reports - July 14, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Role of skin biopsy in the diagnosis of peripheral neuropathic painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Evaluation of epidermal nerve fiber density (ENFD) allows objective, pathologic, and minimally invasive assessment of small myelinated and unmyelinated cutaneous axons. In addition to providing diagnostic confirmation of neuropathies affecting these “small fibers,” this procedure has advanced clinical care by dramatically increasing awareness of the role of small myelinated and unmyelinated axons in disorders of peripheral nerve and in neuropathic pain. This review highlights the technical aspects of skin biopsy for ENFD determination, the role of skin biopsy in the diagnosis of small-fiber neur...
Source: Current Pain and Headache Reports - May 10, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Fixed and flexible dosing of pregabalin for postherpetic neuralgia: Comparing tolerability and onset of pain reliefEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11916-009-0030-0Authors Tobias Moeller-BertramMark S. Wallace Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 Journal Volume Volume 13 Journal Issue Volume 13, Number 3 / June, 2009 (Source: Current Pain and Headache Reports)
Source: Current Pain and Headache Reports - May 10, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

The association between migraine and cardiovascular events in women is modified by baseline vascular risk statusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11916-009-0031-zAuthors Avi Ashkenazi Journal Current Pain and Headache ReportsOnline ISSN 1534-3081Print ISSN 1531-3433 Journal Volume Volume 13 Journal Issue Volume 13, Number 3 / June, 2009 (Source: Current Pain and Headache Reports)
Source: Current Pain and Headache Reports - May 10, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Basilar-type migraineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Initially described more than 40 years ago, basilar-type migraine has posed diagnostic and therapeutic dilemmas for medical practitioners. Defined by the coexistence of migraine headache with neurological symptoms emanating from either the brainstem or simultaneously from both cerebral hemispheres, basilar-type migraine has been categorized as “atypical” or “complicated” and has been considered more akin to hemiplegic migraine than to migraine with typical aura. Despite the absence of any data convicting basilar-type migraine as a vasospastic condition, the use of triptans in such patients h...
Source: Current Pain and Headache Reports - May 10, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Behavioral medicine for migraine and medication overuse headacheEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews empirically supported and efficacious behavioral approaches to the treatment and management of headaches in general, with an emphasis on migraine and MOH from a biopsychosocial perspective. Evidence-based behavioral medicine treatments for migraine and MOH are reviewed, including patient education, cognitive behavioral therapy, and biobehavioral training (biofeedback, relaxation training, and stress management). Information regarding psychological comorbidities and risk factors for progression of migraine and the development of MOH is also reviewed. Strategies are provided for enhancing adherence ...
Source: Current Pain and Headache Reports - May 10, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Newest aspects on the association between migraine and cardiovascular disease: The role of modifying factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Migraine has been established as a risk factor for ischemic stroke. Further evidence suggests that migraine is also associated with other ischemic vascular events, including myocardial infarction and cardiovascular death. However, these associations appear to be limited to the subgroup of patients with migraine with aura (MA). Moreover, there is increasing evidence that among patients with MA, additional subgroups exist that carry particular increased risk. The association with ischemic stroke is, for example, particularly strong for younger women with MA who smoke and/or use oral contraceptives. Re...
Source: Current Pain and Headache Reports - May 10, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Migraine pain, meningeal inflammation, and mast cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Migraine pain has been attributed to an episode of local sterile meningeal inflammation and the subsequent activation of trigeminal primary afferent nociceptive neurons that supply the intracranial meninges and their related large blood vessels. However, the origin of this inflammatory insult and the endogenous factors that contribute to the activation of meningeal nociceptors remain largely speculative. A particular class of inflammatory cells residing within the intracranial milieu, known as meningeal mast cells, was suggested to play a role in migraine pathophysiology more than five decades ago, b...
Source: Current Pain and Headache Reports - May 10, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Contribution of primary afferent channels to neuropathic painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Neuropathic pain remains a serious medical problem because of patient morbidity and the absence of effective therapeutic interventions. Recent evidence suggests that this type of pain may be particularly difficult to manage because underlying mechanisms are influenced by a variety of factors, including type of injury, site of injury, and time after injury. This situation is exacerbated by the fact that different mechanisms may contribute to unique aspects of neuropathic pain, including ongoing pain as well as mechanical and thermal hypersensitivity. The different ion channels present in primary affe...
Source: Current Pain and Headache Reports - May 10, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

Spinal inhibitory neurotransmission in neuropathic painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Nerve injury increases the spinal cord expression and/or activity of voltage- and ligand-gated ion channels, peptide receptors, and neuroimmune factors, which then drive dorsal horn neuron hyperexcitability. The intensity and duration of this central sensitization is determined by the net activity of local excitatory and inhibitory neurotransmitter systems, together with ongoing/evoked primary afferent activity and descending supraspinal control. Spinal endogenous inhibitory systems serve as opposing compensatory influences and are gaining recognition for their powerful capacity to restrain allodyni...
Source: Current Pain and Headache Reports - May 10, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals

The evaluation of neuropathic components in low back painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Chronic low back pain is highly prevalent in Western societies. Large epidemiological studies show that 20% to 35% of patients with back pain suffer from a neuropathic pain component. Presently, chronic lumbar radicular pain is the most common neuropathic pain syndrome. The pathophysiology of back pain is complex and nociceptive, and neuropathic pain-generating mechanisms are thought to be involved, which established the term mixed pain syndrome. Neuropathic pain may be caused by lesions of nociceptive sprouts within the degenerated disc (local neuropathic), mechanical compression of the nerve root ...
Source: Current Pain and Headache Reports - May 10, 2009 Category: Neurology Tags: Current Pain and Headache Reports Source Type: journals