Nanotechnology in Orthodontics: Unveiling Pain Mechanisms, Innovations, and Future Prospects of Nanomaterials in Drug Delivery
Curr Pharm Des. 2024 Apr 19. doi: 10.2174/0113816128298451240404084605. Online ahead of print.ABSTRACTOrthodontic pain is characterized by sensations of tingling, tooth discomfort, and intolerance. According to the oral health report, over forty percent of children and adolescents have undergone orthodontic treatment. The efficacy of orthodontic treatment involving braces can be compromised by the diverse levels of discomfort and suffering experienced by patients, leading to suboptimal treatment outcomes and reduced patient adherence. Nanotechnology has entered all areas of science and technology. This review provides an o...
Source: Current Pharmaceutical Design - April 22, 2024 Category: Drugs & Pharmacology Authors: Divya Sharma Shiv Kumar Yogesh Garg Shruti Chopra Amit Bhatia Source Type: research
Construction of GPC3-modified Lipopolymer SiRNA Delivery System
CONCLUSION: GLPS could potentially serve as an effective carrier for liver-targeted MRI monitoring and siRNA delivery.PMID:38644723 | DOI:10.2174/0113816128258852231204102044 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 22, 2024 Category: Drugs & Pharmacology Authors: Dandan Sun Xiaoyu Li Yaru Liu Jishan Quan Guangyu Jin Source Type: research
Recent Advances in the Treatment Strategies of Friedreich's Ataxia: A Review of Potential Drug Candidates and their Underlying Mechanisms
CONCLUSION: While there has been significant progress in the development of treatment strategies for FRDA, further research is needed to optimize these approaches and identify the most effective and safe treatment options for patients. The integration of multiple therapeutic strategies may be necessary to achieve the best outcomes in FRDA management.PMID:38638052 | DOI:10.2174/0113816128288707240404051856 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 19, 2024 Category: Drugs & Pharmacology Authors: Aman Kumar Saini Neha Anil Ardra N Vijay Bharti Mangla Shamama Javed Pankaj Kumar Waquar Ahsan Source Type: research
The Therapeutic Application of Hydrogen in Cancer: The Potential and Challenges
Curr Pharm Des. 2024 Apr 17. doi: 10.2174/0113816128296710240404040232. Online ahead of print.ABSTRACTHydrogen therapy has emerged as a possible approach for both preventing and treating cancer. Cancers are often associated with oxidative stress and chronic inflammation. Hydrogen, with its unique physiological functions and characteristics, exhibits antioxidant, anti-inflammatory, and anti-apoptotic properties, making it an attractive candidate for cancer treatment. Through its ability to mitigate oxidative damage, modulate inflammatory responses, and sustain cellular viability, hydrogen demonstrates significant potential ...
Source: Current Pharmaceutical Design - April 19, 2024 Category: Drugs & Pharmacology Authors: Morteza Nazari Khiji Faezeh Arghidash Ghazaleh Khalili Tanha Rasoul Hossein Zadeh Elnaz Ghorbani Majid Khazaei Seyed Mahdi Hassanian Ibrahim Saeed Gataa Alfred King-Yin Lam Elisa Giovannetti Gordon A Ferns Elham Nazari Amir Avan Source Type: research
The Impact of Spironolactone Co-administration on Cyclosporin Initial Dosage Optimization for Pediatric Refractory Nephrotic Syndrome
CONCLUSION: The cyclosporin dosing regimen for PRNS based on Monte Carlo simulation was systematically developed and the initial dosage optimization of cyclosporin in PRNS was recommended for the first time.PMID:38639271 | DOI:10.2174/0113816128307797240416053723 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 19, 2024 Category: Drugs & Pharmacology Authors: Huan-Huan Han Min Rui Yang Yang Jia-Fang Cui Xue-Ting Huang Shi-Jia Zhang Su-Mei He Dong-Dong Wang Xiao Chen Source Type: research
Effect of Statins on Serum Levels of TNF-alpha and Interleukin-6 in Patients with Kidney Disease: A Meta-analysis of Randomized Clinical Trials
CONCLUSION: Statins only marginally decreased the concentration of IL-6 in patients with kidney disease, but neither high-intensity nor moderate/low-intensity statin treatment could significantly influence the level of IL6. However, statins reduced serum levels of TNF-α in patients with kidney disease.PMID:38629355 | DOI:10.2174/0113816128299493240403084905 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 17, 2024 Category: Drugs & Pharmacology Authors: Bahman Razi Saeed Aslani Danyal Imani Sajad Salehiyeh Mahdieh Fasihi Željko Reiner Amirhossein Sahebkar Source Type: research
Network Pharmacology Combined with Molecular Docking Approach to Investigate the Mechanism of ChuShiWeiLing Decoction Against Perianal Eczema
CONCLUSION: Our results indicated that the bioactives, potential targets, and molecular mechanism of CSWLD against PE.PMID:38629356 | DOI:10.2174/0113816128298780240329075340 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 17, 2024 Category: Drugs & Pharmacology Authors: Ying Liu Min Hao Xinyue Fang Yifei Qian Yahui Wang Shuai Yan Source Type: research
Lipase and Protease Production Ability of Multi-drug Resistant Bacteria Worsens the Outcomes of Wound Infections
CONCLUSION: In conclusion, the findings suggest that lipases and proteases produced by bacteria could contribute to drug resistance and act as virulence factors in the development of surgical site infections. Understanding the role of these enzymes may inform strategies for preventing and managing post-surgical wound infections more effectively.PMID:38629357 | DOI:10.2174/0113816128302189240402043330 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 17, 2024 Category: Drugs & Pharmacology Authors: Attaur Rahman Saiqa Sardar Zeeshan Niaz Asif Khan None Sheheryar Abdulwahed Fahad Alrefaei Muhammad Hamayun Sajid Ali Source Type: research
Effect of Statins on Serum Levels of TNF-alpha and Interleukin-6 in Patients with Kidney Disease: A Meta-analysis of Randomized Clinical Trials
CONCLUSION: Statins only marginally decreased the concentration of IL-6 in patients with kidney disease, but neither high-intensity nor moderate/low-intensity statin treatment could significantly influence the level of IL6. However, statins reduced serum levels of TNF-α in patients with kidney disease.PMID:38629355 | DOI:10.2174/0113816128299493240403084905 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 17, 2024 Category: Drugs & Pharmacology Authors: Bahman Razi Saeed Aslani Danyal Imani Sajad Salehiyeh Mahdieh Fasihi Željko Reiner Amirhossein Sahebkar Source Type: research
Network Pharmacology Combined with Molecular Docking Approach to Investigate the Mechanism of ChuShiWeiLing Decoction Against Perianal Eczema
CONCLUSION: Our results indicated that the bioactives, potential targets, and molecular mechanism of CSWLD against PE.PMID:38629356 | DOI:10.2174/0113816128298780240329075340 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 17, 2024 Category: Drugs & Pharmacology Authors: Ying Liu Min Hao Xinyue Fang Yifei Qian Yahui Wang Shuai Yan Source Type: research
Lipase and Protease Production Ability of Multi-drug Resistant Bacteria Worsens the Outcomes of Wound Infections
CONCLUSION: In conclusion, the findings suggest that lipases and proteases produced by bacteria could contribute to drug resistance and act as virulence factors in the development of surgical site infections. Understanding the role of these enzymes may inform strategies for preventing and managing post-surgical wound infections more effectively.PMID:38629357 | DOI:10.2174/0113816128302189240402043330 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 17, 2024 Category: Drugs & Pharmacology Authors: Attaur Rahman Saiqa Sardar Zeeshan Niaz Asif Khan None Sheheryar Abdulwahed Fahad Alrefaei Muhammad Hamayun Sajid Ali Source Type: research
Evaluating the Imperative Role of Pre- and Post-eCTD Standards in Dossier Validation: An Inevitable Outlook
Curr Pharm Des. 2024 Apr 15. doi: 10.2174/0113816128301122240403053217. Online ahead of print.NO ABSTRACTPMID:38623971 | DOI:10.2174/0113816128301122240403053217 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 16, 2024 Category: Drugs & Pharmacology Authors: Niraj S Patil Animesh Ranjan Raj Kumar Narang Amandeep Singh Source Type: research
Colorectal Cancer Stem Cell Biomarkers: Biological Traits and Prognostic Insights
Curr Pharm Des. 2024 Apr 15. doi: 10.2174/0113816128291321240329050945. Online ahead of print.ABSTRACTDue to self-renewal, differentiation, and limitless proliferation properties, Cancer Stem Cells (CSCs) increase the probability of tumor development. These cells are identified by using CSC markers, which are highly expressed proteins on the cell surface of CSCs. Recently, the therapeutic application of CSCs as novel biomarkers improved both the prognosis and diagnosis outcome of colorectal Cancer. In the present review, we focused on a specific panel of colorectal CSC markers, including LGR5, ALDH, CD166, CD133, and CD44,...
Source: Current Pharmaceutical Design - April 16, 2024 Category: Drugs & Pharmacology Authors: Atena Soleimani Nikoo Saeedi Abdulridha Mohammed Al-Asady Elnaz Nazari Reyhane Hanaie Majid Khazaei Elnaz Ghorbani Hamed Akbarzade Mikhail Ryzhikov Amir Avan Seyed Mahdi Hasanian Mehr Source Type: research
Synthesis of Rupestonic Acid L-Ephedrine Derivatives with Preliminary In vitro Anti-influenza Viral Activity
CONCLUSION: The rupestonic acid L-ephedrine ester (A) and rupestonic acid L-ephedrine complex (B) were synthesized and characterized using 1H NMR and 13C NMR. Moreover, their purity was determined by HPLC. Both compounds A and B exhibited more potent activities against the strains of A/PR/8/34 (H1N1) and A/FM/1/47 (H1N1) than rupestonic acid. Compound A can be regarded as a very promising lead compound for the development of anti-influenza inhibitors. Based on these results, more rupestonic acid derivatives will be designed and synthesized in the future for the development of anti-influenza inhibitors.PMID:38623973 | DOI:1...
Source: Current Pharmaceutical Design - April 16, 2024 Category: Drugs & Pharmacology Authors: Jianping Yong Canzhong Lu Source Type: research
Preclinical Pharmacokinetics and Pharmacology Study of RC98: A Programmed Cell Death Ligand 1 Monoclonal Antibody in Cynomolgus Monkeys
CONCLUSION: These data indicate that the immune system was clearly activated. In addition, the non-clinical data could provide a basis for its efficacy evaluation in clinical trials.PMID:38623974 | DOI:10.2174/0113816128248929230920071937 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 16, 2024 Category: Drugs & Pharmacology Authors: Ling Wang Qiaoning Li Chenglian Deng Zhihao Liu Fang Wang Shenjun Li Lihou Dong Jing Jiang Source Type: research
