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Noncoding RNAs in Alzheimer's Disease: Overview of Functional and Therapeutic Significance
Curr Top Med Chem. 2024 Apr 9. doi: 10.2174/0115680266293212240405042540. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a multifactorial disorder resulting from the complex interaction between genetic, epigenetic, and environmental factors. It represents an impending epidemic and lacks effective pharmacological interventions. The emergence of high throughput sequencing techniques and comprehensive genome evaluation has uncovered a diverse spectrum of non-- coding RNA (ncRNA) families. ncRNAs are the critical modulators of an eclectic array of biological processes and are now transpiring as imperative players in...
Source: Current Topics in Medicinal Chemistry - April 15, 2024 Category: Chemistry Authors: Divya Adiga Sangavi Eswaran S Sriharikrishnaa Nadeem G Khan Dileep Kumar Shama Prasada Kabekkodu Source Type: research

Alleviating Neurodegenerative Diseases Associated with Mitochondrial Defects by Therapeutic Biomolecules
Curr Top Med Chem. 2024 Apr 5. doi: 10.2174/0115680266299148240329062647. Online ahead of print.ABSTRACTNeurodegenerative diseases are emerging as a global health concern in the current sce-nario, and their association with mitochondrial defects has been a potential area of research. Mi-tochondria, one of the essential organelles of the cell, serve as the cell's powerhouse, producing energy and ensuring cellular health. Neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and Pelizaeus-Merzbacher disease have been found to be primarily triggered by mitochondrial malfunct...
Source: Current Topics in Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Tanmoy Roy Swarupanjali Padhi Rupa Mazumder Chandana Majee Saumya Das Monika Monika Rashmi Mishra Bhupinder Kapoor Source Type: research

Quinolone Derivatives as Anticancer Agents: Importance in Medicinal Chemistry
Curr Top Med Chem. 2024 Apr 8. doi: 10.2174/0115680266300736240403075307. Online ahead of print.ABSTRACTQuinolone is a heterocyclic compound containing carbonyl at the C-2 or C-4 positions with nitrogen at the C-1 position. The scaffold was first identified for its antibacterial properties, and the derivatives were known to possess many pharmacological activities, including anticancer. In this review, the quinolin-2(H)-one and quinolin-4(H)-one derivatives were identified to inhibit several various proteins and enzymes involved in cancer cell growth, such as topoisomerase, mi-crotubules, protein kinases, phosphoinositide 3...
Source: Current Topics in Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Nursyuhada Azzman Sirajudheen Anwar Wan Ahmad Syazani Mohamed Nafees Ahemad Source Type: research

Prominent Perspective on Existing Biological Hallmarks of Alzheimer's Disease
Curr Top Med Chem. 2024 Apr 8. doi: 10.2174/0115680266292514240404040341. Online ahead of print.ABSTRACTBiomarkers are the most significant diagnosis tools tending towards unique approaches and solutions for the prevention and cure of Alzheimer's Disease (AD). The current report provides a clear perception of the concept of various biomarkers and their prominent features through analysis to provide a possible solution for the inhibition of events in AD. Scientists around the world truly believe that crucial hallmarks can serve as critical tools in the early diagnosis, cure, and prevention, as well as the future of medicine...
Source: Current Topics in Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Namrata Singh Srishti Sharma Kallol K Ghosh Bhanushree Gupta Kamil Kuca Source Type: research

Nanomaterial-based Electrochemical Sensors for Multiplex Medicinal Applications
Curr Top Med Chem. 2024 Apr 4. doi: 10.2174/0115680266304711240327072348. Online ahead of print.ABSTRACTThis review explores the advancements in nanomaterial-based electrochemical sensors for the multiplex detection of medicinal compounds. The growing demand for efficient and selective detection methods in the pharmaceutical field has prompted significant research into the development of electrochemical sensors employing nanomaterials. These materials, defined as functional materials with at least one dimension between 1 and 100 nanometers, encompass metal nanoparticles, polymers, carbon-based nanocomposites, and nano-biop...
Source: Current Topics in Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Surinya Traipop Whitchuta Jesadabundit Wisarut Khamcharoen Tavechai Pholsiri Sarida Naorungroj Sakda Jampasa Orawon Chailapakul Source Type: research