Current Treatment Options in Allergy Current Treatment Options in Allergy RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Impact of Cosmetics and Cleansers in Atopic Dermatitis —How to Advise Patients
AbstractPurpose of ReviewAtopic dermatitis (AD) or eczema is a frequent chronic inflammatory skin disease. Taking care of the eczematous skin is important to reduce the inflammation and return it to a healthier looking nourished skin. Beyond recommending topical anti-inflammatory drugs and the use of emollients, recommendations on the correct use of other everyday skin products, as cleansers or make-up products, are lacking.Recent FindingsThe dry, itchy, and inflamed eczematous skin causes anxiety, poor self-image, low self-esteem, decreased social skills, and an overall decrease in a patients ’ quality of life. The use ...
Source: Current Treatment Options in Allergy - April 8, 2024 Category: Allergy & Immunology Source Type: research

Effect of Hormones as Cofactors in Food Allergy
AbstractPurpose of reviewHormones such as estrogen, progesterone, and testosterone can contribute to differences in allergy prevalence and severity between men and women by affecting the immune system. This review aims to analyze what is currently known about the role of hormones as cofactors in food allergy.Recent findingsStudies on rodents indicate immunological differences between males and females, with females generally exhibiting a more robust immune response. Estrogens are associated with enhanced humoral immunity and antibody synthesis, while androgens and progesterone suppress immunity and inflammation. Studies su...
Source: Current Treatment Options in Allergy - February 26, 2024 Category: Allergy & Immunology Source Type: research

Correction: Drug Desensitization Update: Key Concepts and Mechanisms
(Source: Current Treatment Options in Allergy)
Source: Current Treatment Options in Allergy - February 12, 2024 Category: Allergy & Immunology Source Type: research

Allergic Contact Dermatitis in Children: Clinical Management and Emerging Allergens
AbstractPurpose of the ReviewThe purpose of this review is to introduce the reader to allergic contact dermatitis (ACD) in children and adolescents and provide an in-depth overview of the diagnostic work-up, the association between the distribution of eczema, child ’s age and allergens, differential diagnoses, common and emerging allergens, and the clinical management and available treatment options.Recent FindingsThere is an increased awareness in the scientific community of the impact of pediatric ACD. As a result, expert consensus-derived patch test series have been proposed and implemented in clinical practice, and a...
Source: Current Treatment Options in Allergy - January 10, 2024 Category: Allergy & Immunology Source Type: research

Drug Desensitization Update: Key Concepts and Mechanisms
We describe here the mechanisms and principles of drug desensitization, which are applicable to all drug classes and to selected classical and new drug allergy phenotypes. (Source: Current Treatment Options in Allergy)
Source: Current Treatment Options in Allergy - December 27, 2023 Category: Allergy & Immunology Source Type: research

Does a Dysbiotic Oral Microbiome Trigger the Risk of Chronic Inflammatory Disease?
AbstractPurpose of ReviewThis paper studies the different mechanisms that link oral dysbiosis and various inflammatory diseases.Recent FindingsOral bacteria have been found in atherosclerotic plaques. Experiments in mouse models have shown that after inoculation withPorphyromonas gingivalis, there is a higher brain barrier permeability.Fusobacterium nucleatum is present in higher amounts in patients with colorectal cancer than in healthy subjects.Porphyromonas gingivalis, along with other oral bacteria, has a strong capacity for peptide citrullination, which increases the risk of developing rheumatoid arthritis.SummaryDiff...
Source: Current Treatment Options in Allergy - December 27, 2023 Category: Allergy & Immunology Source Type: research

From Bacteria to Host: Deciphering the Impact of Sphingolipid Metabolism on Food Allergic Reactions
AbstractPurpose of ReviewAllergic diseases have become a burden in industrialized societies. Among children, food allergy (FA) constitutes a major impairment of quality of life. FA is partly due to a lack or loss of tolerance to food antigens at the level of the intestinal mucosa, where the microbiota plays a crucial role. Early changes in the composition of the gut microbiota may influence the development of the immune system and can be related to the risk of allergic diseases, including FA. This review will focus on the role of sphingolipids and the major bacteria involved in their metabolism, in the development of food ...
Source: Current Treatment Options in Allergy - December 26, 2023 Category: Allergy & Immunology Source Type: research

What is New in Alpha-Gal Syndrome?
AbstractPurpose of ReviewAlpha-gal ( α-gal) syndrome (AGS) represents a paradigm shift in food allergy since the allergen (α-gal), unlike most protein allergens, is an oligosaccharide found in mammalian meat and because of the delayed onset of allergic symptoms (3 to 6 h after consumption). Given the variability and non-specificity o f the symptoms, in addition to the lack of highly sensitive diagnostic tests, its diagnosis and management can be challenging. The aim of this review is to provide an overview of the current status of AGS, with a special focus on the new therapeutic strategies.Recent FindingsThe association ...
Source: Current Treatment Options in Allergy - November 22, 2023 Category: Allergy & Immunology Source Type: research

Usefulness of Drug Allergy Alert Systems: Present and Future
AbstractPurpose of ReviewThe goal of this paper is to review drug allergy alert systems (DAAS), to summarise their key components, and to overview potential benefits and challenges associated with these tools. Methods for validation of their effects on patient safety, alternative uses, and strategies to streamline DAAS ’ functions and reduce system fatigue are discussed.Recent FindingsDAAS are clinical decision support systems (CDSS) that focus on preventing drug adverse events within healthcare settings. The advent of electronic medical records has facilitated the development of digital DAAS. Existing versions use diffe...
Source: Current Treatment Options in Allergy - November 18, 2023 Category: Allergy & Immunology Source Type: research

Tree-Pollen-Related Food Allergies: Birch Pollen and More
ConclusionThe review emphasizes complex interactions between tree pollen reactivity and food allergies, highlighting the need for thorough molecular reactivity diagnostics and detailed medical histories to understand these intricate connections. It underscores cross-reactivity among homologous allergens, the significance of structural similarity in causing adverse reactions, and the influence of co-factors on clinical outcomes. Ultimately, the review provides insights into the intricate nature of tree-related reactivity, offering implications for clinical diagnosis and management. (Source: Current Treatment Options in Allergy)
Source: Current Treatment Options in Allergy - November 16, 2023 Category: Allergy & Immunology Source Type: research

Severe Asthma Patients: Can We Really Wean Them off of Oral Corticosteroids
Opinion statementWe aim to find the role of systemic corticosteroids and if viable to reduce or discontinue its use in severe asthma patients. Asthma, as a chronic inflammatory disease, is considered an important public health problem worldwide. Particularly, severe asthma has the biggest and most important impact both for patients and institutions. Despite the advance understanding of severe asthma pathophysiology and the development and availability of more biological therapies, the use of systemic corticosteroids is still a mainstay in the treatment of severe asthma and they are widely used to manage asthma exacerbation...
Source: Current Treatment Options in Allergy - October 11, 2023 Category: Allergy & Immunology Source Type: research

Microbiome in Atopic Dermatitis: Is It All About Staphylococcus aureus?
AbstractPurpose of ReviewThere are many recent informative reviews about the skin microbiome in atopic dermatitis (AD) highlighting the prominent role ofStaphylococcus aureus (S. aureus) in the pathogenesis of this skin disease. The aim of the current review is to compile and discuss the findings of original studies describing other microbiota alterations contributing to atopic skin inflammation. Moreover, we will discuss the feasibility of using these identified alterations as future diagnostic or therapeutic strategies.Recent FindingsBesidesS. aureus, there is evidence that other species could also be deleterious in AD, ...
Source: Current Treatment Options in Allergy - September 29, 2023 Category: Allergy & Immunology Source Type: research

The Roots and Growth of Allergen Immunotherapy
AbstractPurpose of ReviewThe purpose of this review is to present the history of allergen immunotherapy.Recent FindingsAn overview of allergen immunotherapy suggests its roots comes from the immunological treatment of contagious disease. The idea, beginning in the 18th century, that one could be protected against certain illnesses was extended to the field of allergy successfully in 1911.SummaryThis review presents highlights of the advances by many of the individuals who have contributed to the science of allergen immunotherapy. (Source: Current Treatment Options in Allergy)
Source: Current Treatment Options in Allergy - September 28, 2023 Category: Allergy & Immunology Source Type: research

Triggers of Anaphylaxis in Mastocytosis Patients: Evidence of the Current Drug-Avoidance Recommendation
Opinion statementMastocytosis is associated with a high risk of anaphylaxis, in part due to drug hypersensitivity reactions (DHR). Drugs associated with mast cell activation include nonsteroidal anti-inflammatory drugs (NSAIDs), drugs used in the perioperative setting, including general anesthetics, neuromuscular blocking agents (NMBAs) and opiates/opioids, radiocontrast media (RCM), vaccines, and antibiotics such as quinolones and vancomycin. To protect patients against DHR and anaphylaxis, general avoidance of potential drug triggers is common practice, which often deprives patients of important drugs at times of need an...
Source: Current Treatment Options in Allergy - September 20, 2023 Category: Allergy & Immunology Source Type: research

Respiratory Exposure Tests in Aspirin Exacerbated Respiratory Disease
AbstractPurpose of reviewControlled oral provocation test with aspirin is considered the “gold standard” for diagnosing hypersensitivity to NSAIDs (non-steroid anti-inflammatory drugs). Newer techniques of respiratory exposure tests, bronchial and nasal respectively, have been nonetheless developed, as they are safer, less likely to cause a systemic reaction, and less time-consuming than the oral provocation test with aspirin (acetyl-salicylic acid). These tests are also particularly useful when oral challenge testing is contraindicated. The aim of this paper is to review and update the detailed protocols of bronchial ...
Source: Current Treatment Options in Allergy - August 30, 2023 Category: Allergy & Immunology Source Type: research