Proportion of Brazilian diabetes patients that achieve treatment goals: implications for better quality of care.
CONCLUSIONS: The achievement of goals of good clinical practice varies among the parameters evaluated. Almost no patients achieved all targets. Many patients are overweight and do not achieve targets for HbA1c, lipid profile, or blood pressure control. PMID: 26672722 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - December 21, 2015 Category: Endocrinology Authors: Baptista DR, Thieme RD, Reis WC, Pontarolo R, Correr CJ Tags: Diabetol Metab Syndr Source Type: research

Diabetes Metab; +118 new citations
118 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Diabetes Metab These pubmed results were generated on 2015/12/17PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Diabetes Metab)
Source: Diabetes Metab - December 18, 2015 Category: Endocrinology Tags: Report Source Type: research

A case of severe ectopic ACTH syndrome from an occult primary - diagnostic and management dilemmas.
We present the case of a 66-year-old gentleman with ectopic ACTH syndrome from an occult primary tumour with multiple significant complications from hypercortisolaemia. Ectopic nature of his ACTH-dependent Cushing's syndrome was confirmed by non-suppression with high-dose dexamethasone suppression test and bilateral inferior petrosal sinus sampling. The primary ectopic source remained unidentified in spite of extensive anatomical and functional imaging studies, including CT scans and Dotatate-PET scan. Medical adrenolytic treatment at maximum tolerated doses failed to control his hypercortisolaemia, which led to recurrent ...
Source: Diabetes Metab - December 12, 2015 Category: Endocrinology Authors: Venugopal H, Griffin K, Amer S Tags: Endocrinol Diabetes Metab Case Rep Source Type: research

Erratum to: The association between periodontal disease and metabolic syndrome among outpatients with diabetes in Jordan.
Abstract [This corrects the article DOI: 10.1186/s40200-015-0192-8.]. PMID: 26649285 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 12, 2015 Category: Endocrinology Authors: Alhabashneh R, Khader Y, Herra Z, Asa'ad F Tags: J Diabetes Metab Disord Source Type: research

ACTH stimulation tests for the diagnosis of adrenal insufficiency: Systematic review and meta-analysis.
CONCLUSION: Both high and low dose ACTH stimulation tests had similar diagnostic accuracy. Both tests are adequate to rule in, but not rule out, primary and secondary adrenal insufficiency. Our confidence in these estimates is low to moderate due to the likely risk of bias, heterogeneity and imprecision. PMID: 26649617 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 9, 2015 Category: Endocrinology Authors: Ospina NS, Al Nofal A, Bancos I, Javed A, Khalid B, Kapoor E, Lteif AN, Natt N, Murad MH Tags: J Clin Endocrinol Metab Source Type: research

Beta cell glucose sensitivity is linked to insulin/glucagon bihormonal cells in non-diabetic humans.
CONCLUSIONS: Our data suggest that poor β-cell glucose sensitivity is linked to islet trans-differentiation, possibly from α cells to β cells, in an attempt to cope with higher demands for insulin secretion. Understanding the mechanism(s) that underlies the adaptive response of the islet cells to insulin resistance is a potential approach to design tools to enhance functional β-cell mass for diabetes therapy. PMID: 26649619 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 9, 2015 Category: Endocrinology Authors: Mezza T, Sorice GP, Conte C, Sun VA, Cefalo CM, Moffa S, Pontecorvi A, Mari A, Kulkarni RN, Giaccari A Tags: J Clin Endocrinol Metab Source Type: research

Cosyntropin-stimulated serum free cortisol in healthy, adrenally-insufficient, and mildly cirrhotic populations.
CONCLUSION: We provide normative data for SFF values in HV and AI during the CST. Normal CBG levels in mild cirrhosis did not affect interpretation of the CST. PMID: 26647150 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 8, 2015 Category: Endocrinology Authors: Rauschecker M, Abraham SB, Abel BS, Wesley R, Saverino E, Trivedi A, Heller T, Nieman LK Tags: J Clin Endocrinol Metab Source Type: research

Diurnal cortisol patterns, future diabetes and impaired glucose metabolism in the Whitehall II cohort study.
CONCLUSIONS: In this non-clinical population, alterations in diurnal cortisol patterns were predictive of future glucose disturbance. PMID: 26647151 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 8, 2015 Category: Endocrinology Authors: Hackett RA, Kivimäki M, Kumari M, Steptoe A Tags: J Clin Endocrinol Metab Source Type: research

The sodium-glucose cotransporter 2 inhibitor luseogliflozin improves glycaemic control assessed by continuous glucose monitoring even on a low-carbohydrate diet.
Abstract This randomized, double-blind, placebo-controlled, crossover study was the first to determine the effects of luseogliflozin in combination with a low-carbohydrate diet (LCD) on 24-h glucose variability assessed by continuous glucose monitoring (CGM). Eighteen Japanese patients with type 2 diabetes were randomized into two groups in which patients first received luseogliflozin 2.5 mg once-daily then placebo for 8 days each, or vice versa. Patients took luseogliflozin or placebo with a normal-carbohydrate diet (NCD) on Day 7 and with the LCD on Day 8. CGM was performed on both days. Luseogliflozin s...
Source: Diabetes Metab - December 6, 2015 Category: Endocrinology Authors: Nishimura R, Omiya H, Sugio K, Ubukata M, Sakai S, Samukawa Y Tags: Diabetes Obes Metab Source Type: research

GLP-1 receptor agonist exenatide has no acute effect on MRI-measured exocrine pancreatic function in type 2 diabetes patients: a randomised trial.
CONCLUSIONS: Infusion of exenatide did not directly influence MRI-measured exocrine pancreatic excretion in patients with type 2 diabetes. Although long-term studies are warranted, these findings suggest that potential adverse pancreatic effects of GLP-1 receptor agonists are not mediated by changes in exocrine pancreatic secretion. (ClinicalTrials.gov:NCT01744236). PMID: 26640129 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 6, 2015 Category: Endocrinology Authors: Smits MM, Tonneijck L, Muskiet MH, Kramer MH, Diamant M, Pieters-van den Bos IC, van Raalte DH, Cahen DL Tags: Diabetes Obes Metab Source Type: research

The effect of transdermal nitroglycerin on pain control in diabetic patients with peripheral neuropathy.
CONCLUSIONS: It could be concluded that nitroglycerin plasters can effectively help alleviate pain in patients with diabetic neuropathy. TRIAL REGISTRATION: IRCT201308223213N1. PMID: 26629480 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 5, 2015 Category: Endocrinology Authors: Taheri A, Farbood A, Heshmat R, Samadi A, Khashayar P, Qorbani M, Ghorbani M, Ebrahimi Khaneqah G Tags: J Diabetes Metab Disord Source Type: research

Adiponectin, leptin and insulin levels at birth and in early postnatal life in neonates with hypoxic ischemic encephalopathy.
CONCLUSIONS: Neonates who are suffering from HIE had lower serum levels of adiponectin and higher serum levels of leptin and insulin than normal healthy neonates at birth and during the early postnatal period. The decline of leptin and increased the insulin levels after birth in all neonates may be important for the stimulation of feeding behavior and the acquisition of energy homeostasis during the early postnatal life. Positive significant correlations between adiponectin, leptin, body weight and body mass indices were present in normal healthy neonates but not in neonates with HIE reflecting the effect of hypoxia on the...
Source: Diabetes Metab - December 5, 2015 Category: Endocrinology Authors: El-Mazary AM, Nasif KA, Abdel-Hakeem GL, Sherif T, Farouk E, El-Gezawy EM Tags: J Diabetes Metab Disord Source Type: research

Uremic parkinsonism with atypical phenotypes and radiologic features.
Abstract Uremic encephalopathy with bilateral basal ganglia lesions has been reported as an acute neurometabolic disease which shows reversible clinical course and brain imaging features. The exact nature and pathophysiology have not been well established. We encountered two patients who showed a relapsing and aggravating course and an atypical phenotype including parkinsonism with paroxysmal dystonic head tremor and acute onset monoparesis of the lower extremity. They also showed unusual radiological findings which revealed combined lesions in the basal ganglia and cortex, persistent hemorrhagic transform...
Source: Diabetes Metab - December 3, 2015 Category: Endocrinology Authors: Yoon JE, Kim JS, Park JH, Lee KB, Roh H, Park ST, Cho JW, Ahn MY Tags: Metab Brain Dis Source Type: research

Polymorphisms in the P1 promoter of the IGF-1 gene in children with growth disorders.
CONCLUSIONS: This study demonstrated that SNP and (CA) n microsatellite repeat polymorphisms by themselves are not the primary regulatory elements of IGF-1 expression. However, our bioinformatics analysis has shown that the (CA) n microsatellite region in the P1 promoter of IGF-1 is able to form DNA loop structures which can modulate transcription. PMID: 26615580 [PubMed - in process] (Source: Diabetes Metab)
Source: Diabetes Metab - December 2, 2015 Category: Endocrinology Authors: Broniarczyk JK, Kędzia A, Nowak W, Kościński Ł, Lewandowski M, Goździcka-Józefiak A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[Prevalence of chronic complications in patients with over 30-year history of type 1 diabetes depending on the age of onset of diabetes].
CONCLUSIONS: The diagnosis of type 1 diabetes before or after the age of 18 had no significant effect on the lack of chronic complications. Patients with diabetes diagnosed in childhood, after 30 years of disease, presented a higher incidence of diabetic kidney disease. PMID: 26615581 [PubMed - in process] (Source: Diabetes Metab)
Source: Diabetes Metab - December 2, 2015 Category: Endocrinology Authors: Pisarczyk-Wiza D, Zozulińska-Ziółkiewicz D, Piłaciński S, Milcarek M, Wierusz-Wysocka B Tags: Pediatr Endocrinol Diabetes Metab Source Type: research