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Relationship between uric acid and hepatic steatosis among Koreans.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Hyperuricaemia is independently associated with hepatic steatosis regardless of BMI category or the presence of the MetS in Korean adults. Further research into the causal relationship is needed. PMID: 19879789 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - October 29, 2009 Category: Endocrinology Authors: Lee K Tags: Diabetes Metab Source Type: journals

Early-stage atherosclerosis in newly diagnosed, untreated type 2 diabetes mellitus and impaired glucose tolerance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Early-stage atherosclerosis is present in newly diagnosed, untreated T2DM and IGT patients, and it may be that its early assessment, along with good control of hypertension and hyperglycaemia, will help to delay its progression. PMID: 19879790 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - October 29, 2009 Category: Endocrinology Authors: Gong W, Lu B, Yang Z, Ye W, Du Y, Wang M, Li Q, Zhang W, Pan Y, Feng X, Zhou W, Zhang Y, Yang Z, Yang Y, Zhu X, Hu R Tags: Diabetes Metab Source Type: journals

[Biochemical markers of bone turnover ; New aspect. Bone collagen metabolism : new biological markers for estimation of bone quality.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Collagen cross-links play important roles in the expression of bone strength and the proper biological function of bone. The cross-links of collagen can be roughly divided into two types : lysyl oxidase mediated cross-links (enzymatic immature and mature cross-links) and advanced glycation end-products (AGEs ; nonenzymatic cross-links, pentosidine) . Recently, we show that reduction in enzymatic cross-links and excessive formation of nonenzymatic crossl-links, pentosidine in bone could be important for explaining the variation of fracture susceptibility in osteoporosis (Osteoporos Int 17 (7) : 986-995, 2006) and diabet...
Source: Diabetes Metab - July 31, 2009 Category: Endocrinology Authors: Saito M Tags: Clin Calcium Source Type: journals

The novel 2Fe-2S outer mitochondrial protein mitoNEET displays conformational flexibility in its N-terminal cytoplasmic tethering domain.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A primary role for mitochondrial dysfunction is indicated in the pathogenesis of insulin resistance. A widely used drug for the treatment of type 2 diabetes is pioglitazone, a member of the thiazolidinedione class of molecules. MitoNEET, a 2Fe-2S outer mitochondrial membrane protein, binds pioglitazone [Colca et al. (2004), Am. J. Physiol. Endocrinol. Metab. 286, E252-E260]. The soluble domain of the human mitoNEET protein has been expressed C-terminal to the superfolder green fluorescent protein and the mitoNEET protein has been isolated. Comparison of the crystal structure of mitoNEET isolated from cleavage of the fu...
Source: Diabetes Metab - June 30, 2009 Category: Endocrinology Authors: Conlan AR, Paddock ML, Axelrod HL, Cohen AE, Abresch EC, Wiley S, Roy M, Nechushtai R, Jennings PA Tags: Acta Crystallogr Sect F Struct Biol Cryst Commun Source Type: journals

Clustered metabolic abnormalities blunt regression of hypertensive left ventricular hypertrophy: the LIFE study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Clusters of metabolic abnormalities resembling phenotypes of metabolic syndrome are related to greater initial ECG LVH in hypertensive patients with value of blood pressure similar to individuals without metabolic abnormalities, and are associated with less reduction of ECG LVH during antihypertensive therapy, potentially contributing to the reported adverse prognosis of metabolic syndrome. PMID: 19361968 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - April 7, 2009 Category: Endocrinology Authors: de Simone G, Okin PM, Gerdts E, Olsen MH, Wachtell K, Hille DA, Dahlöf B, Kjeldsen SE, Devereux RB Tags: Nutr Metab Cardiovasc Dis Source Type: journals

Independent factors associated with depression in type 1 diabetes mellitus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Diabetes has been associated with depression since Thomas Willis' work in 1684 (Rubin and Peyrot in Diabetes Metab Rev 18:173-175, 2002). The aim of this study is to identify social and clinical factors independently associated with depression in individuals with type 1 diabetes. We carried out a descriptive transversal study with 110 type 1 diabetes patients, administered a questionnaire and obtained demographical and diabetes-related data (number of years from diagnosis, initial admission at diagnosis, glycated hemoglobin, number of complications, insulin dose, number of insulin injections per day, admission for keto...
Source: Diabetes Metab - March 20, 2009 Category: Endocrinology Authors: Manarte LF, Dias S, Góis C, Boavida JM Tags: Acta Diabetol Source Type: journals

Comparative effects of Citrullus colocynthis, sunflower and olive oil-enriched diet in streptozotocin-induced diabetes in rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Citrullus colocynthis (colocynth) seeds are traditionally used as antidiabetic medication in Mediterranean countries. The present study evaluated the differential effects of diets enriched with C. colocynthis, sunflower or olive oils on the pancreatic beta-cell mass in streptozotocin (STZ)-induced diabetes in rats. STZ injection induced rapid hyperglycaemia in all animals. However, 2months later, hyperglycaemia was significantly less pronounced in the rats fed a C. colocynthis oil-enriched diet compared with other rat groups (7.9mM versus 12mM and 16mM with colocynth versus olive and sunflower oils, respectively). Asse...
Source: Diabetes Metab - March 3, 2009 Category: Endocrinology Authors: Sebbagh N, Cruciani-Guglielmacci C, Ouali F, Berthault MF, Rouch C, Sari DC, Magnan C Tags: Diabetes Metab Source Type: journals

Association of macronutrient intake patterns with being overweight in a population-based random sample of men in France.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Consistent negative associations between carbohydrate intake and BMI and WC were seen in this random representative sample of the general male population. The associations between fat intake and these measures of being overweight were attenuated on adjusting for carbohydrate intake. Thus, the balance of carbohydrate-to-fat intake is an important element in obesity in a general male population, and should be highlighted in dietary guidelines. PMID: 19251447 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - February 27, 2009 Category: Endocrinology Authors: Ahluwalia N, Ferrières J, Dallongeville J, Simon C, Ducimetière P, Amouyel P, Arveiler D, Ruidavets JB Tags: Diabetes Metab Source Type: journals

Safety of recreational scuba diving in type 1 diabetic patients: The Deep Monitoring programme.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Experienced, well-controlled, complication-free young diabetic patients can safely go scuba diving, provided that they apply a rigorous protocol based on serial pre-dive BG measurements. The specific variables of underwater diving do not appear to involve significant additional risks of hypoglycaemia. PMID: 19251448 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - February 27, 2009 Category: Endocrinology Authors: Bonomo M, Cairoli R, Verde G, Morelli L, Moreo A, Grottaglie MD, Brambilla MC, Meneghini E, Aghemo P, Corigliano G, Marroni A Tags: Diabetes Metab Source Type: journals

Functional pancreatic beta-cell mass: Involvement in type 2 diabetes and therapeutic intervention.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the adult, the pancreatic beta-cell mass adapts insulin secretion to meet long-term changes in insulin demand and, in particular, in the presence of insulinresistance that is either physiological, such as pregnancy, or pathophysiological, such as obesity. The failure of beta cells to compensate for insulinresistance is a major component of impaired glucose homeostasis and overt diabetes. This defect is clearly the consequence of a decline of insulin response to glucose due to functional beta-cell deficiency. It is also the consequence of an inability of the endocrine pancreas to adapt the beta-cell mass to insulin d...
Source: Diabetes Metab - February 27, 2009 Category: Endocrinology Authors: Karaca M, Magnan C, Kargar C Tags: Diabetes Metab Source Type: journals

The level and determinants of diabetes knowledge in Kuwaiti adults with type 2 diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Knowledge of diabetes in a T2D population with a high prevalence of illiteracy was poor. Limited family income and lack of self-care are other predictors of knowledge deficits. Efforts need to be focused on educational programmes with strategies to assist T2D patients of limited education and income to manage their disease more effectively. PMID: 19250850 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - February 26, 2009 Category: Endocrinology Authors: Al-Adsani AM, Moussa MA, Al-Jasem LI, Abdella NA, Al-Hamad NM Tags: Diabetes Metab Source Type: journals

Long-term improvement of metabolic control with pioglitazone in a woman with diabetes mellitus related to Dunnigan syndrome: A case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 54-year-old woman was referred to hospital because of poor metabolic control. Clinical examination revealed marked acanthosis nigricans, and a striking lack of adipose tissue on the limbs, and excess fat deposits on the neck and face. She had been treated for diabetes since 2001 with high doses of insulin along with metformin. Clinical tests showed hypertriglyceridaemia with low high density lipoprotein (HDL) cholesterol, and cholestasis with mild cytolysis. Dunnigan syndrome (familial partial lipodystrophy type 2) was suspected and confirmed by molecular genetics. Pioglitazone was added to her treatment, and follow-...
Source: Diabetes Metab - February 25, 2009 Category: Endocrinology Authors: Collet-Gaudillat C, Billon-Bancel A, Beressi JP Tags: Diabetes Metab Source Type: journals

Childhood growth and future risk of the metabolic syndrome in normal-weight men and women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Among normal-weight men, those who developed the metabolic syndrome in adulthood had smaller gains in BMI during infancy and were thinner at age 7 years. These results support findings that early growth may play an important role in the development of the metabolic syndrome. PMID: 19246227 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - February 24, 2009 Category: Endocrinology Authors: Salonen MK, Kajantie E, Osmond C, Forsén T, Ylihärsilä H, Paile-Hyvärinen M, Barker DJ, Eriksson JG Tags: Diabetes Metab Source Type: journals

Role of childhood growth on the risk of metabolic syndrome in obese men and women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Among obese individuals, those who develop the metabolic syndrome were lighter and thinner from the age of two to 11 years compared with those who did not. These findings support the importance of early childhood growth in determining the metabolic consequences of obesity. PMID: 19246228 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - February 24, 2009 Category: Endocrinology Authors: Salonen MK, Kajantie E, Osmond C, Forsén T, Ylihärsilä H, Paile-Hyvärinen M, Barker DJ, Eriksson JG Tags: Diabetes Metab Source Type: journals

Cardiometabolic determinants of mortality in a geriatric population: Is there a "reverse metabolic syndrome"?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In very old patients, low BMI, low DBP, low total and HDL cholesterol, and high insulin sensitivity predict total mortality, indicating a "reverse metabolic syndrome" that is probably attributable to malnutrition and/or chronic disorders. These inverse associations limit the relevance of conventional risk factors. Previous CV events and HDL cholesterol remain strong predictors of mortality. Future studies should determine if and when the prevention and treatment of malnutrition in the elderly should be incorporated into conventional CV prevention. PMID: 19237305 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - February 21, 2009 Category: Endocrinology Authors: Vischer UM, Safar ME, Safar H, Iaria P, Le Dudal K, Henry O, Herrmann FR, Ducimetiere P, Blacher J Tags: Diabetes Metab Source Type: journals

The consumption of bread enriched with betaglucan reduces LDL-cholesterol and improves insulin resistance in patients with type2 diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Betaglucan enriched bread may contribute to the improvement of the lipid profile and insulin resistance in patients with T2D. PMID: 19230737 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - February 19, 2009 Category: Endocrinology Authors: Liatis S, Tsapogas P, Chala E, Dimosthenopoulos C, Kyriakopoulos K, Kapantais E, Katsilambros N Tags: Diabetes Metab Source Type: journals

Mesenchymal stem cells: Stem cell therapy perspectives for type 1 diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mesenchymal stem cells (MSCs) are multipotent non-haematopoietic progenitor cells that are being explored as a promising new treatment for tissue regeneration. Although their immunomodulatory properties are not yet completely understood, their low immunogenic potential together with their effects on immune response make them a promising therapeutic tool for severe refractory autoimmune diseases. Type 1 diabetes is characterized by T cell-mediated autoimmune destruction of pancreatic beta cells. While insulin replacement represents the current therapy for type 1 diabetes, its metabolic control remains difficult, as exog...
Source: Diabetes Metab - February 18, 2009 Category: Endocrinology Authors: Vija L, Farge D, Gautier JF, Vexiau P, Dumitrache C, Bourgarit A, Verrecchia F, Larghero J Tags: Diabetes Metab Source Type: journals

Endothelial microparticles in patients with insulin resistance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19124261 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - January 3, 2009 Category: Endocrinology Authors: Jung C, Shemyakin A, Böhm F, Pernow J Tags: Diabetes Metab Source Type: journals

Screening for diabetic retinopathy in a rural French population with a mobile non-mydriatic camera.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Screening improved the quality of the ocular follow-up in diabetics in this rural area. However, improvements in management are needed to lower the cost of such a programme. PMID: 19097818 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 19, 2008 Category: Endocrinology Authors: Beynat J, Charles A, Astruc K, Metral P, Chirpaz L, Bron AM, Creuzot-Garcher C Tags: Diabetes Metab Source Type: journals

Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, human insulin promoter was activated by Smad2, Smad3 and the pancreatic and duodenal homeobox factor-1 (PDX-1) in the ALK7 pathway. A conserved Smad binding element was related to the promoter activation. Phosphorylated Smad2/Smad3 and PDX-1 were bound to insulin gene with Nodal and Activin AB, and the phosphorylated Smad2/Smad3 interacted with PDX-1. These results indicate that one of the direct target genes of Nodal and Activin AB signals is the insulin gene in pancreatic beta-cells and that PDX-1 is directly involved in the ALK7-Smad pathway. PMID: 18951876 [PubMed - indexed for MEDLINE] (Source: Diabetes Metab)
Source: Diabetes Metab - December 18, 2008 Category: Endocrinology Authors: Watanabe R, Shen ZP, Tsuda K, Yamada Y Tags: Biochem Biophys Res Commun Source Type: journals

The polymorphism Arg585Gln in the gene of the sterol regulatory element binding protein-1 (SREBP-1) is not a determinant of ketosis prone type 2 diabetes (KPD) in Africans.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The results of this exploratory study show that the polymorphism Arg585Gln in SREBF-1 is not associated with the KPD phenotype. Further studies in larger populations are needed to confirm our findings. PMID: 19062325 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 3, 2008 Category: Endocrinology Authors: Choukem SP, Boudou P, Sobngwi E, Villette JM, Ibrahim F, Moulin P, Hadjadj S, Eberle D, Foufelle F, Vexiau P, Gautier JF Tags: Diabetes Metab Source Type: journals

Prevalence of diagnosed type 2 diabetes mellitus in the French general population: The INSTANT study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The prevalence of treated and untreated type 2 diabetes mellitus in France was 4.57%. PMID: 19046913 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 27, 2008 Category: Endocrinology Authors: Bringer J, Fontaine P, Detournay B, Nachit-Ouinekh F, Brami G, Eschwege E Tags: Diabetes Metab Source Type: journals

Metabolic disorders and chronic HIV and HCV infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The importance of metabolic disorders in the pathophysiology of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections is becoming increasingly apparent. Metabolic anomalies, with their potential for multiple-organ involvement, are to be expected, given the chronic nature of these diseases, and the intracellular dysregulation associated with them. Not only have the endocrine and cytokine metabolic anomalies seen in HIV and HCV infections been linked with the metabolic syndrome, but they also appear to have some pathways in common. Studying the differences and similarities between these metabolic anom...
Source: Diabetes Metab - November 27, 2008 Category: Endocrinology Authors: Slama L, Le Camus C, Serfaty L, Pialoux G, Capeau J, Gharakhanian S Tags: Diabetes Metab Source Type: journals

Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Although there was no evidence of an association between the ENPP1 K121Q variant and the general phenotype of T2D, we did find an association with adult obesity and T2D. The Q121 allele frequency in Morocco is 37.3%, placing it between European Caucasians (15%) and Black Africans (79%). This study is the first to report an association between K121Q and metabolic diseases in the Moroccan population. PMID: 19046915 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 27, 2008 Category: Endocrinology Authors: El Achhab Y, Meyre D, Bouatia-Naji N, Berraho M, Deweirder M, Vatin V, Delplanque J, Serhier Z, Lyoussi B, Nejjari C, Froguel P, Chikri M Tags: Diabetes Metab Source Type: journals

Association of metabolic syndrome with depression and anxiety in Japanese men.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A positive relationship was found between MetS and depression, but not between MetS and anxiety, in male Japanese workers. The specific factors comprising MetS, such as waist circumference, may be a reflection of the depression. PMID: 19046916 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 27, 2008 Category: Endocrinology Authors: Takeuchi T, Nakao M, Nomura K, Yano E Tags: Diabetes Metab Source Type: journals

Strategies for the diagnosis and treatment of neuropathic pain secondary to diabetic peripheral sensory polyneuropathy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article proposes a strategy for the diagnosis and treatment of neuropathic pain due to diabetic peripheral sensory neuropathy, based on 15 years of experience in French pain-management centres and on the available literature. In the diabetic patient with chronic pain in the lower limbs, the first step in the diagnostic process is to identify the neuropathic origin of the pain. The second step is to evaluate the patient's medical history and make a rigorous baseline assessment of the neuropathic pain symptoms to determine an effective pain-management strategy. In the third step, adequate and well-tolerated treatment di...
Source: Diabetes Metab - November 27, 2008 Category: Endocrinology Authors: Guastella V, Mick G Tags: Diabetes Metab Source Type: journals

Glycaemic dysregulation in nondiabetic patients after major lower limb prosthetic surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This study showed that nearly 75% of nondiabetic patients experience a moderate, but significant, increase in either fasting or postprandial BG levels in the first two days following major arthroplasty. PMID: 19038564 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 25, 2008 Category: Endocrinology Authors: Pili-Floury S, Mitifiot F, Penfornis A, Boichut N, Tripart MH, Christophe JL, Garbuio P, Samain E Tags: Diabetes Metab Source Type: journals

The incretins: From the concept to their use in the treatment of type 2 diabetes. Part A: Incretins: Concept and physiological functions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This paper briefly reviews the concept of incretins and describes the biological effects of the two incretins identified so far: the glucose-dependent insulinotropic polypeptide (GIP); and the glucagon-like peptide-1 (GLP-1). GIP is released by the Kcells of the duodenum, while GLP-1 is released by the Lcells of the distal ileum, in response to nutrient absorption. GIP and GLP-1 stimulate insulin biosynthesis and insulin secretion in a glucose-dependent manner. In addition, they increase beta-cell mass. GIP has a specific effect on adipose tissue to facilitate the efficient disposal of absorbed fat and, thus, may be in...
Source: Diabetes Metab - November 24, 2008 Category: Endocrinology Authors: Girard J Tags: Diabetes Metab Source Type: journals

Biballism due to non-ketotic hyperglycaemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we discuss the association between non-ketotic hyperglycaemia and ballism along with a review of the literature. PMID: 19027337 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 20, 2008 Category: Endocrinology Authors: Boughammoura-Bouatay A, Chebel S, Younes-Mhenni S, Frih-Ayed M Tags: Diabetes Metab Source Type: journals

What is known, new and controversial about GLP-1? Minutes of the 1st European GLP-1 Club Meeting, Marseille, 28-29 May 2008.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The first antidiabetic agent was a hormone-insulin-and ever since, all therapeutic strategies have been based on the synthesis of chemical compounds to bind its receptors or transcription factors, or to trigger its intracellular mechanisms. Eighty years on, new therapeutic molecules are available for the treatment of diabetes and, again, are based on a hormone-glucagon-like peptide-1 (GLP-1). Whereas the theoretical benefit of insulin is based on normalization of functional physiology, therapeutic strategies based on GLP-1 aim to increase the circulating concentration of a natural component-the hormone GLP-1. There ar...
Source: Diabetes Metab - November 19, 2008 Category: Endocrinology Authors: , Burcelin R Tags: Diabetes Metab Source Type: journals

sRAGE and esRAGE.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19019716 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 17, 2008 Category: Endocrinology Authors: Wautier JL, Grossin N Tags: Diabetes Metab Source Type: journals

Abdominal obesity is associated with ineffective control of cardiovascular risk factors in primary care in France.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In primary care, a lack of control of triglycerides, HbA(1c) and, to a lesser extent, blood pressure increases with waist circumference independently of confounders. This suggests that abdominal obesity is associated of poor results in the treatment of diabetes and hypertriglyceridaemia. PMID: 19019717 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 17, 2008 Category: Endocrinology Authors: Dallongeville J, Bringer J, Bruckert E, Charbonnel B, Dievart F, Komajda M, Pouchain D, Amouyel P Tags: Diabetes Metab Source Type: journals

Mitochondrial DNA A3243G mutation involved in familial diabetes, chronic intestinal pseudo-obstruction and recurrent pancreatitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The mtDNA A3243G mutation associated with the gastrointestinal manifestations observed in the affected family should be regarded as a possible cause of CIPO and unexplained recurrent pancreatitis. However, the mutation is probably only weakly involved in cases of isolated recurrent pancreatitis. PMID: 18955007 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - October 25, 2008 Category: Endocrinology Authors: Verny C, Amati-Bonneau P, Letournel F, Person B, Dib N, Malinge MC, Slama A, Le Maréchal C, Ferec C, Procaccio V, Reynier P, Bonneau D Tags: Diabetes Metab Source Type: journals

The growing incidence of type 1 diabetes in children: The 17-year French experience in Aquitaine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These results indicate a doubling of the incidence of type 1 diabetes in children every 30 years in Aquitaine, with an even steeper increase among younger children, thus underscoring the need for appropriate adaptation of the system of healthcare provision. PMID: 18952477 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - October 24, 2008 Category: Endocrinology Authors: Barat P, Valade A, Brosselin P, Alberti C, Maurice-Tison S, Lévy-Marchal C Tags: Diabetes Metab Source Type: journals

Efficacy of periodontal treatment on glycaemic control in diabetic patients: A meta-analysis of interventional studies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The present meta-analysis represents the best information available to date that addresses this issue, and suggests that periodontal treatment could improve glycaemic control. Nevertheless, these results need to be viewed with caution because of a lack of robustness, and deficiencies in the design of some of the studies included. A randomized controlled trial with sufficient statistical power would help to confirm the results of this meta-analysis. PMID: 18948050 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - October 21, 2008 Category: Endocrinology Authors: Darré L, Vergnes JN, Gourdy P, Sixou M Tags: Diabetes Metab Source Type: journals

Risk factors and management of diabetes in elderly French patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Complications and/or associated diseases were more frequent in this cohort of elderly diabetic patients compared with those in studies not based on clinical examinations. Our results highlight the inadequate management, given the frequent discrepancy between day-to-day HbA(1c) and HbA(1c) targets, of such patients. PMID: 18945633 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - October 20, 2008 Category: Endocrinology Authors: Doucet J, Druesne L, Capet C, Gréboval E, Landrin I, Moirot P, Micaud G Tags: Diabetes Metab Source Type: journals

Orally administered microencapsulated lysozyme downregulates serum AGE and reduces the severity of early-stage diabetic nephropathy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our study supports a relationship between serum AGE and nephropathy in diabetes, and suggests that orally administered microencapsulated LZ can exert kidney-protective activity in a diabetic animal model. PMID: 18926757 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - October 14, 2008 Category: Endocrinology Authors: Cocchietto M, Zorzin L, Toffoli B, Candido R, Fabris B, Stebel M, Sava G Tags: Diabetes Metab Source Type: journals

Prognostic value of nocturnal blood pressure and reverse-dipping status on the occurrence of cardiovascular events in hypertensive diabetic patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These findings suggest that nighttime systolic BP per se appeared to be a stronger predictor of an excess risk of CV events compared with reverse-dipping status. PMID: 18926758 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - October 14, 2008 Category: Endocrinology Authors: Bouhanick B, Bongard V, Amar J, Bousquel S, Chamontin B Tags: Diabetes Metab Source Type: journals

No relationship between mean plasma glucose and glycated haemoglobin in patients with cystic fibrosis-related diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Unlike in type 1 diabetes, HbA(1c) did not correlate with mean plasma glucose in CFRD subjects. Thus, having a normal HbA(1c) may not be sufficient to indicate a low risk of diabetes complications in CFRD. Further studies are required to explain such a discrepancy. PMID: 18922724 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - October 13, 2008 Category: Endocrinology Authors: Godbout A, Hammana I, Potvin S, Mainville D, Rakel A, Berthiaume Y, Chiasson JL, Coderre L, Rabasa-Lhoret R Tags: Diabetes Metab Source Type: journals

A lipid-parameter-based index for estimating insulin sensitivity and identifying insulin resistance in a healthy population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A lipid-parameter-based index using fasting samples provides a simple means of screening for insulin resistance in the healthy population. PMID: 18922725 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - October 13, 2008 Category: Endocrinology Authors: Disse E, Bastard JP, Bonnet F, Maitrepierre C, Peyrat J, Louche-Pelissier C, Laville M Tags: Diabetes Metab Source Type: journals

The prevalence of abnormal eating behaviour in a representative sample of the French diabetic population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: AEB is present in French diabetic patients at levels that are probably higher than among the general population. These results highlight the need for: (1) greater awareness among diabetes clinicians of the problem; (2) regular screening of diabetic patients for AEB; and (3) adaptation of therapeutic and dietary recommendations for this patient subgroup. PMID: 18922726 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - October 13, 2008 Category: Endocrinology Authors: Ryan M, Gallanagh J, Livingstone MB, Gaillard C, Ritz P Tags: Diabetes Metab Source Type: journals

A prospective study of quality of life in 77 type 1 diabetic patients 12 months after a hospital therapeutic educational programme.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: QOL assessed by DQOL improved after therapeutic education and during the following year. The improvement in DQOL score at three months correlated with a reduction in HbA(1c) levels and appeared to particularly benefit to those who had severe hypoglycaemia before the programme. PMID: 18829362 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - September 29, 2008 Category: Endocrinology Authors: Debaty I, Halimi S, Quesada JL, Baudrant M, Allenet B, Benhamou PY Tags: Diabetes Metab Source Type: journals

Fulminant type 1 diabetes in Caucasians: A report of three cases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These are the first cases of fulminant type 1 diabetes reported in Caucasians. These cases reveal new perspectives as regards the worldwide distribution of this intriguing clinical entity. PMID: 18829363 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - September 29, 2008 Category: Endocrinology Authors: Moreau C, Drui D, Arnault-Ouary G, Charbonnel B, Chaillous L, Cariou B Tags: Diabetes Metab Source Type: journals

The metabolic syndrome, diabetes and lung dysfunction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sleep-disordered breathing and sleep apnoea are conditions frequently associated with comorbidity, including obesity, diabetes, hypertension, insulin resistance (metabolic syndrome) and cardiovascular disease. The diabetic state (type 1 and type 2 diabetes) may be associated to diminished lung function and, in particular, decreased vital capacity, and the association between chronic obstructive pulmonary disease (COPD) and type 2 diabetes may be due to a shared inflammatory process. Also, the alteration in circulating endothelial progenitor cells found in respiratory disease, the metabolic syndrome and cardiovascular d...
Source: Diabetes Metab - September 29, 2008 Category: Endocrinology Authors: Tiengo A, Fadini GP, Avogaro A Tags: Diabetes Metab Source Type: journals

Can glycaemic variability, as calculated from blood glucose self-monitoring, predict the development of complications in type 1 diabetes over a decade?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We conclude that variability of blood glucose may be important in the development of peripheral neuropathy in patients with type 1 diabetes, and that the nervous system may be particularly vulnerable to glycaemic variability. PMID: 18824382 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - September 26, 2008 Category: Endocrinology Authors: Bragd J, Adamson U, Bäcklund LB, Lins PE, Moberg E, Oskarsson P Tags: Diabetes Metab Source Type: journals

Methodological aspects of crossover and maximum fat-oxidation rate point determination.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This study shows that, in fit healthy subjects, the analytical device, reference used to build the protocol and ventilation responses affect metabolic indices. In this population, and particularly to obtain interpretable metabolic indices, we recommend a protocol based on the true MAP or one adapted to include the transition from fat to carbohydrate. The correlation between metabolic indices and lactate/ventilation thresholds suggests that shorter, classical maximum progressive exercise testing may be an alternative means of estimating these indices in relatively fit subjects. However, this needs to be confirme...
Source: Diabetes Metab - September 25, 2008 Category: Endocrinology Authors: Michallet AS, Tonini J, Regnier J, Guinot M, Favre-Juvin A, Bricout V, Halimi S, Wuyam B, Flore P Tags: Diabetes Metab Source Type: journals

Does family cohesiveness and parental alexithymia predict glycaemic control in children and adolescents with diabetes?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The maternal perception of family cohesiveness and maternal alexithymia predict on glycaemic control in children and adolescents with diabetes. PMID: 18783976 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - September 8, 2008 Category: Endocrinology Authors: Meunier J, Dorchy H, Luminet O Tags: Diabetes Metab Source Type: journals

Patient non-adherence and healthcare-provider inertia are clinical myopia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The efficient implementation of healthcare is often jeopardized by the lack of patient adherence to medical recommendations and by inadequate healthcare-provider adherence to current guidelines, a phenomenon recently described as "clinical inertia". We propose here a theoretical model, based on concepts developed in the field of analytical philosophy of mind, that describes the mental mechanisms shared by the two phenomena, thus explaining their synergistically deleterious influence on the efficiency of care. We suggest that a failure to give preference to the long-term benefits of treatment intensification may represe...
Source: Diabetes Metab - August 13, 2008 Category: Endocrinology Authors: Reach G Tags: Diabetes Metab Source Type: journals

Cystatin C improves the diagnosis and stratification of chronic kidney disease, and the estimation of glomerular filtration rate in diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The recommended creatinine-based estimations of GFR need to be improved. CysC assay helps in the diagnosis and stratification of CKD and leads to better estimates of GFR in diabetic patients without any substantial increase in complexity. PMID: 18703370 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - August 12, 2008 Category: Endocrinology Authors: Rigalleau V, Beauvieux MC, Le Moigne F, Lasseur C, Chauveau P, Raffaitin C, Perlemoine C, Barthe N, Combe C, Gin H Tags: Diabetes Metab Source Type: journals

Severity of diabetic microvascular complications is associated with a low soluble RAGE level.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The association of low sRAGE with high CML-protein levels in diabetic patients who developed severe diabetic complications supports the hypothesis that sRAGE protects vessels against AGE-mediated diabetic microvascular damage. PMID: 18701333 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - August 11, 2008 Category: Endocrinology Authors: Grossin N, Wautier MP, Meas T, Guillausseau PJ, Massin P, Wautier JL Tags: Diabetes Metab Source Type: journals