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Effect of proteinuria on the rapid kidney function decline in chronic kidney disease depends on the underlying disease: A post hoc analysis of the BRIGHTEN study
The rapidity of kidney function decline in patients with nephrosclerosis (NS) is less rapid than in those with diabetic kidney disease (DKD) presumably because of a relatively low level of proteinuria [1 –3]. Several studies demonstrated that chronic kidney disease (CKD) patients with NS undergo a favourable clinical course as compared with those with DKD [1–4]. The presence of diabetes and proteinuria, but not that of hypertension, were independent predictors for rapid kidney function decline i n Taiwanese CKD patients [5]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 25, 2024 Category: Endocrinology Authors: Tomohito Gohda, Maki Murakoshi, Yusuke Suzuki, Tatsuo Kagimura, Takashi Wada, Ichiei Narita Source Type: research

IDF/IAPB release joint policy brief for the early diagnosis, treatment and prevention of diabetic retinopathy
The International Diabetes Federation (IDF) and The International Alliance for the Prevention of Blindness (IAPB) have launched a new policy brief that calls for a joint approach to prevent and manage vision loss in people living with diabetes by integrating diabetic retinopathy (DR) care into diabetes policies and national health plans. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 25, 2024 Category: Endocrinology Tags: International Diabetes Federation Source Type: research

Association of 25-hydroxyvitamin D, lipoprotein-associated phospholipase A2 and asymptomatic coronary artery disease in patients with type 2 diabetes mellitus
To evaluate the relationship of 25-hydroxyvitamin D (25(OH)D), lipoprotein-associated phospholipase A2 (Lp-PLA2), and coronary artery disease (CAD) in type 2 diabetes mellitus (T2DM) patients with no history or symptoms of cardiovascular disease. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 24, 2024 Category: Endocrinology Authors: Qian Zhang, Qing-qing Zhang, Jiao-jiao He, Shu-qin Dong, Yu Lu Source Type: research

Are the cardiovascular properties of GLP-1 receptor agonists differentially modulated by sulfonylureas? insights from post-hoc analysis of EXSCEL
Cardiovascular outcome trials with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown that they have cardiovascular benefits [1]. Likely mechanisms are multifactorial (e.g., weight loss) [2 –4] and may include a direct GLP-1 RA effect on the vasculature [5–8]. GLP-1 receptors are expressed in the human vasculature [9–11], but it is uncertain whether they are involved in mediating the vascular actions of GLP-1 RAs [6,8] Proposed mediators underlying GLP-1 RA vascular actions inclu de nitric oxide, hydrogen sulfide, and potassium channels, particularly KATP channels [7,12,13] as well as the endothelin pat...
Source: Diabetes Research and Clinical Practice - April 24, 2024 Category: Endocrinology Authors: Kim M. Gooding, Susanna Stevens, Yuliya Lokhnygina, Anna Giczewska, Angela C. Shore, Rury R. Holman Source Type: research

Associations of the obesity gene FTO variant with complications and comorbidities in patients with type 1 diabetes
The increasing prevalence of childhood overweight and obesity is a severe health problem worldwide that contributes to the development of various comorbidities [1]. Type 1 diabetes (T1D) patients are especially vulnerable to such complications since the intensive insulin therapy is associated with weight gain, abdominal obesity, dyslipidaemia, hypertension, and the presence of atherosclerosis development features in imaging [2]. Although clinical factors associated with the disease and its treatment as well as lifestyle elements have been widely studied, various genetic loci are also known to play important role in the obe...
Source: Diabetes Research and Clinical Practice - April 23, 2024 Category: Endocrinology Authors: Bartosz S łomiński, Maria Skrzypkowska, Małgorzata Myśliwiec, Piotr Trzonkowski Source Type: research

Role of nutritional therapy on dietary habits and glycemic control in insulin-treated kidney transplant patients with diabetes
To evaluate the effect of nutritional therapy on glycemic compensation and key cardio-renal risk markers in patients with diabetes and kidney transplant, on insulin treatment by Multiple Daily Injection (MDI) or Continuous Subcutaneous Insulin Infusion (CSII). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 22, 2024 Category: Endocrinology Authors: G. Clemente, N. Della Pia, A. Bramanti, L. Cerbara, G. Russo, P. De Rosa, V. Marotta, A. Tortora, M. Riccio, M. Vitale Source Type: research

The causal relationship between metabolic syndrome and its components and cardiovascular disease: A mendelian randomization study causal relationship between MetS and CVDs
To investigate the causal relationship between metabolic syndrome (MetS) and its components and 14 cardiovascular diseases using Mendelian randomization (MR). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 19, 2024 Category: Endocrinology Authors: Zejia Wu, Songyuan Luo, Dongqin Cai, Wenhui Lin, Xiaolu Hu, Ting Zhou, Xuxing Zhang, Yingqing Feng, Jianfang Luo Source Type: research

Intermittently scanned continuous glucose monitoring provides no benefit over structured self-monitoring of blood glucose in type 2 diabetes not on prandial insulin, in the context of diabetes self-management education: GLucose monitoring programme SingaporE (GLiMPSE)
We evaluated the impact of intermittently scanned continuous glucose monitoring(is-CGM)over self-monitoring of blood glucose(SMBG) in the context of diabetes self-management education (DSME) in sub-optimally controlled type 2 diabetes(T2D) in a multi-ethnicsetting. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 17, 2024 Category: Endocrinology Authors: Suresh Rama Chandran, Nabilah Rahman, Mihir Gandhi, Ngiap Chuan Tan, Ian K.Y. Phoon, Darren E.J. Seah, Ming Hann Cheah, Kathleen Sek, Daphne Su-Lyn Gardner Source Type: research

An 8-Week study on the effects of high and Moderate-Intensity interval exercises on mitochondrial MOTS-C changes and their relation to metabolic markers in male diabetic sand rats
This study explored the impact of high and moderate-intensity interval exercises on mitochondrial MOTS-C alterations and their correlation with metabolic markers in male diabetic sand rats. Thirty male sand rats were divided into six groups: control, MIIT, DM  + HIIT, DM + MIIT, DM, and HIIT (5 rats each). Diabetes was induced using a high-fat diet (HFD) combined with streptozotocin (STZ). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 16, 2024 Category: Endocrinology Authors: Sahar Parseh, Saeid Shakerian, Mohammad Reza Tabandeh, Abdolhamid Habibi Source Type: research

Incretin-based investigational therapies for the treatment of MASLD/MASH
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is the most common form of chronic liver disease. It exists as either simple steatosis or its more progressive form, metabolic dysfunction-associated steatohepatitis (MASH), formerly, non-alcoholic steatohepatitis (NASH). The global prevalence of MASLD is estimated to be 32% among adults and is projected to continue to rise with increasing rates of obesity, type 2 diabetes, and metabolic syndrome. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 16, 2024 Category: Endocrinology Authors: Bram Brouwers, Girish Rao, Yuanyuan Tang, Ángel Rodríguez, Leonard C Glass, Mark L Hartman Source Type: research

Corrigendum to “Once-weekly insulin as novel treatment for type 2 diabetes mellitus: A systematic review and meta-analysis of randomized clinical trials” [Diabetes Res. Clin. Practice 205 (2023) 110984]
The authors regret that the above-mentioned published article contained a number of errors in the statistical evaluation. The correct and final version follows. The authors would like to apologise for any inconvenience caused. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 12, 2024 Category: Endocrinology Source Type: research

Tissue-specific inflammation and insulin sensitivity in subjects with obesity
Obesity is associated with low-grade inflammation and insulin resistance (IR). The contribution of adipose tissue (AT) and hepatic inflammation to IR remains unclear. We conducted a study across three cohorts to investigate this relationship.The first cohort consists of six women with normal weight and twenty with obesity. In women with obesity, we found an upregulation of inflammatory markers in subcutaneous and visceral adipose tissue, isolated AT macrophages, and the liver, but no linear correlation with tissue-specific insulin sensitivity. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 12, 2024 Category: Endocrinology Authors: S.M. Oussaada, M. Kilicarslan, B.A. de Weijer, P.W. Gilijamse, A. Şekercan, S. Virtue, I.M.C. Janssen, A. van de Laar, A. Demirkiran, B.A. van Wagensveld, A.P.J. Houdijk, A. Jongejan, P.D. Moerland, J. Verheij, T.B. Geijtenbeek, V.W. Bloks, M.C. de Goffa Source Type: research

Disparities in prevalence and treatment of diabetes, cardiovascular and chronic kidney diseases – Recommendations from the taskforce of the guideline workshop
There is a mounting clinical, psychosocial, and socioeconomic burden worldwide as the prevalence of diabetes, cardiovascular disease (CVD), and chronic kidney disease (CKD) continues to rise. Despite the introduction of therapeutic interventions with demonstrated efficacy to prevent the development or progression of these common chronic diseases, many individuals have limited access to these innovations due to their race/ethnicity, and/or socioeconomic status (SES). However, practical guidance to providers and healthcare systems for addressing these disparities is often lacking. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 11, 2024 Category: Endocrinology Authors: James R. Gavin, Helena W. Rodbard, Tadej Battelino, Frank Brosius, Antonio Ceriello, Francesco Cosentino, Francesco Giorgino, Jennifer Green, Linong Ji, Monika Kellerer, Susan Koob, Mikhail Kosiborod, Nebojsa Lalic, Nikolaus Marx, T. Prashant Nedungadi, C Tags: Commentary Source Type: research

One abnormal value in oral glucose tolerance test during pregnancy and type 2 diabetes risk: Insights from a 5-Year Follow-Up study
To evaluate the risk of type 2 diabetes(T2D) following one abnormal value(OAbV) in an oral glucose tolerance test(oGTT) performed during pregnancy. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 10, 2024 Category: Endocrinology Authors: Rawia Hussein-Aro, Esther Maor-Sagie, Yoel Toledano, Mordechai Hallak, Rinat Gabbay-Benziv Source Type: research

Circulating immune cell phenotyping is potentially relevant for diabetic retinopathy risk assessment
Inflammation is believed to play a central role in the development of diabetes mellitus and is a common feature of type 2 diabetes mellitus (T2DM). However, the association with diabetic retinopathy (DR) remains a topic of debate. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 10, 2024 Category: Endocrinology Authors: Bo Li, Xu Zhao, Zhenzhen Hong, Yan Ding, Yi Zhang Source Type: research