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Relationship between albuminuria and hemoglobin levelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Adetunji et al. remarkably observed a significant increase in the prevalence of anemia in diabetic patients with microalbuminuria and macroalbuminuria . Although early detection and correction of anemia is pivotal in people with diabetes, it might also be important in subjects with normal glucose metabolism. To investigate the association between anemia, glucose metabolism and urinary albumin creatinine ratio (ACR), we performed a retrospective analysis on the database of the Laboratory Information System of the Clinical Laboratory at the Verona University Hospital, to retrieve results of fasting plasma glucose (FPG), ACR ...
Source: Diabetes Research and Clinical Practice - October 16, 2009 Category: Endocrinology Authors: Giuseppe Lippi, Gian Cesare Guidi, Giovanni Targher Tags: Letters to the editor Source Type: journals

Risk factors associated with the presence of diabetes in Chinese communities in BeijingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Age, diabetes family history, obesity, dyslipidemia and hypertension were all associated with the presence of diabetes in this study population. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - October 16, 2009 Category: Endocrinology Authors: Xianghai Zhou, Linong Ji, Yingying Luo, Xueyao Han, Xiuying Zhang, Xiuqin Sun, Qian Ren, Qing Qiao Tags: Epidemiology Source Type: journals

Role of asymmetric-dimethyl-l-arginine (ADMA) and nitrite/nitrate (NOx) in the pathogenesis of oxidative stress in female subjects with uncomplicated type 1 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Aims: To explore the role of asymmetric-dimethyl-l-arginine (ADMA), an endogenous nitric oxide synthetases (NOS) inhibitor, and nitrite/nitrate (NOx) in the pathogenesis of oxidative stress in early stages of type 1 diabetes mellitus.Methods: We measured in 99 female subjects with uncomplicated type 1 diabetes (duration disease (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - October 16, 2009 Category: Endocrinology Authors: Dario Pitocco, Francesco Zaccardi, Enrico Di Stasio, Federica Romitelli, Francesca Martini, Giovanni Luca Scaglione, Dorina Speranza, Stefano Santini, Cecilia Zuppi, Giovanni Ghirlanda Tags: Basic research Source Type: journals

Improvements in risk factor control among persons with diabetes in the United States: Evidence and implications for remaining life expectancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Risk factor control has improved in the United States. Persons newly diagnosed with type 2 diabetes in 2005 have a better prognosis than persons diagnosed with diabetes 11 years earlier. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - October 15, 2009 Category: Endocrinology Authors: Thomas J. Hoerger, Ping Zhang, Joel E. Segel, Edward W. Gregg, K.M. Venkat Narayan, Katherine A. Hicks Tags: Epidemiology Source Type: journals

Evaluation of the association between the PPARGC1A genetic polymorphisms and type 2 diabetes in Han Chinese populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present study provides evidence that a common haplotype of PPARGC1A genetic polymorphisms are moderately associated with T2D in Han Chinese population. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - October 15, 2009 Category: Endocrinology Authors: Shuying Zhu, Yang Liu, Xin Wang, Xiaopan Wu, Xilin Zhu, Jingyun Li, Juan Ma, Harvest F. Gu, Ying Liu Tags: Basic research Source Type: journals

Serum superoxide dismutase activity correlates with the components of metabolic syndrome or carotid artery intima-media thicknessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The activities of the enzymes to eliminate reactive oxygen species prevent the progression of atherosclerosis. We conducted a cross-sectional study among 3234 people that underwent total health check-up service, and studied the relationship between the serum superoxide dismutase (SOD) activity and risk factors of atherosclerosis or carotid artery intima-media thickness (IMT). Serum SOD activity negatively correlated with body mass index (BMI), systolic and diastolic blood pressure, serum triglyceride (TG) concentration and serum glucose concentration. Low serum SOD activity positively correlated with the carotid ...
Source: Diabetes Research and Clinical Practice - October 12, 2009 Category: Endocrinology Authors: Akihiro Isogawa, Minoru Yamakado, Masao Yano, Teruo Shiba Tags: Clinical care and education Source Type: journals

Contents pagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - October 10, 2009 Category: Endocrinology Source Type: journals

Impact of metabolic syndrome on the progression of intima-media thickening in Japanese—A follow-up studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The presence of metabolic syndrome (MetS) and its individual components is related to an increased IMT. MetS and increasing numbers of individual MetS components predicted future progression of IMT. Improvement of MetS was related to smaller increases in IMT, especially in females. These findings may suggest a benefit of intervention for MetS, which needs to be confirmed by prospective studies. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - October 9, 2009 Category: Endocrinology Authors: Yuka Matoba, Toyoshi Inoguchi, Shizu Suzuki, Shigeru Nasu, Toshihiko Hashimoto, Toshihiko Yanase, Hajime Nawata, Ryoichi Takayanagi Tags: Brief reports Source Type: journals

Association of PTPN22 C1858T and CTLA-4 A49G polymorphisms with type 1 diabetes in CroatiansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In this case–control study the association between the PTPN22 1858T and CTLA-4 49G gene variants and T1D in Croatian population was examined. We found that distribution of PTPN22 C1858T and CTLA-4 A49G genotypes between T1D patient (n=102) and control (n=193) groups differ significantly (p (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - October 8, 2009 Category: Endocrinology Authors: Marina Korolija, Ivana Pavlić Renar, Mirko Hadžija, Edita Pape Medvidović, Pajica Pavković, Mladen Jokić, Marijana Popović Hadžija Tags: Brief reports Source Type: journals

Ultrastructural changes in the glomerular filtration barrier and occurrence of proteinuria in Chinese patients with type 2 diabetic nephropathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Podocyte and GBM change more obviously during the development of proteinuria. Besides, proteinuria was inversely related to podocyte density, and directly related to GBM and glomerular volume. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - October 8, 2009 Category: Endocrinology Authors: Wei-wei Zhu, Hui-ping Chen, Yong-chun Ge, Hong-lang Xie, Cai-hong Zeng, Lei-shi Li, Zhi-hong Liu Tags: Basic research Source Type: journals

Intra-renal hemodynamics and carotid intima-media thickness in the metabolic syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Aims: Metabolic syndrome (MetS) is associated with increased cardiovascular risk. We hypothesize that early vascular changes are already present at the time of diagnosis of MetS. The relationship of different measures of early vascular impairment with body fat distribution and the natural progression of MetS was examined in newly diagnosed subjects non-pharmacologically treated.Methods: 246 consecutively enrolled subjects were categorized according to the presence of MetS and type 2 diabetes (T2D). Intra-renal Doppler flow was used to ascertain resistive (RI) and pulsatility (PI) indices as markers of vascular re...
Source: Diabetes Research and Clinical Practice - October 8, 2009 Category: Endocrinology Authors: Silvio Buscemi, Salvatore Verga, John A. Batsis, Santina Cottone, Alessandro Mattina, Andrea Re, Mariangela Arnone, Salvatore Citarda, Giovanni Cerasola Tags: Basic research Source Type: journals

Early insulin response and insulin sensitivity are equally important as predictors of glucose tolerance after correction for measurement errorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: : Due to higher ME effect of EIR on glycaemia is underestimated as compared with M/I. By correcting for ME valid estimates of relative contributions of insulin secretion and insulin sensitivity on glycaemia are obtained. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - October 7, 2009 Category: Endocrinology Authors: Lars Berglund, Christian Berne, Kurt Svärdsudd, Hans Garmo, Björn Zethelius Tags: Epidemiology Source Type: journals

Synergistic effects of ACE (I/D) and ApoE (HhaI) gene polymorphisms among the adult Asian Indians with and without metabolic syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A total of 350 (184 males and 166 females) adults participated in the study. A sample of 138 individuals was selected randomly for genotyping. The synergistic effect of ACE (I/D) and ApoE (HhaI) on metabolic syndrome (MS) showed that individuals with e4/4+D/D combination had the highest occurrence of metabolic abnormalities. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - October 5, 2009 Category: Endocrinology Authors: Mithun Das, Susil Pal, Arnab Ghosh Tags: Brief reports Source Type: journals

Effect of treatment with losartan on salt sensitivity and SGLT2 expression in hypertensive diabetic ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Sodium-glucose cotransporters (SGLTs) in the kidney, may be involved in hypertension, diabetes and salt sensitivity. We evaluate the effect of losartan on blood pressure (BP) and SGLT2 expression in diabetic rats with high or normal salt diet. Losartan prevented an increase in BP and SGLT2 expression in diabetic rats. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - October 5, 2009 Category: Endocrinology Authors: Horacio Osorio, Rocío Bautista, Amelia Rios, Martha Franco, José Santamaría, Bruno Escalante Tags: Brief reports Source Type: journals

Glibenclamide-related excess in total and cardiovascular mortality risks: Data from large Ukrainian observational cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Objective: To compare mortality risks among type 2 diabetes (T2D) patients being treated with glibenclamide, gliclazide, or glimepiride.Methods: Retrospective observational cohort studies of primary care-based diabetes register were carried out. Risk of total and cardiovascular (CVD) mortality was evaluated in cohort of T2D patients that were treated with either glibenclamide (n=50341), glimepiride (n=2479) or gliclazide (n=11368). Cox regression was used for multifactor evaluation. A cross-sectional evaluation of oral anti-diabetic drug (OAD) structure for 2005 and 2007 was also performed, as well as age at the ...
Source: Diabetes Research and Clinical Practice - October 5, 2009 Category: Endocrinology Authors: Mykola Khalangot, Mykola Tronko, Victor Kravchenko, Vladimir Kovtun Tags: Epidemiology Source Type: journals

Oral health knowledge and behavior among adults with diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The purpose of this study was to determine levels of oral health knowledge and factors associated with adequate oral health knowledge in adults with diabetes. A convenience sample of 253 adult US residents with diabetes completed an oral health survey to assess their knowledge. Results showed that only 47% of the participants answered five or more (out of a maximum of seven) oral health knowledge items related to diabetes correctly. Participants who received oral health information related to diabetes have 2.9 times the odds of possessing adequate oral health knowledge (i.e., answered five or more items correctly...
Source: Diabetes Research and Clinical Practice - October 5, 2009 Category: Endocrinology Authors: Hon K. Yuen, Bethany J. Wolf, Dipankar Bandyopadhyay, Kathryn M. Magruder, Carlos F. Salinas, Steven D. London Tags: Epidemiology Source Type: journals

Innovative research for equitable diabetes care in IndiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe how systematic research may help to reconcile India's data deficits and may be applied towards prioritizing resource allocation and addressing shortfalls in disease prevention and control efforts. Expanding the scope of and contextualizing NCD health research in India may also have tremendous benefits for resource allocation and planning in other developing countries. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - October 5, 2009 Category: Endocrinology Authors: Mohammed K. Ali, K.M. Venkat Narayan, Viswanathan Mohan Tags: Review article Source Type: journals

Utilization of Frontal Assessment Battery and Executive Interview 25 in assessing for dysexecutive syndrome and its association with diabetes self-care in elderly patients with type 2 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Aims: Executive function (EF) comprises a set of cognitive skills that controls the execution of complex activities. In the context of diabetes, this may include patients’ self-monitoring and daily management of their condition. We compared two different measures of EF in a population of elderly patients with type 2 diabetes mellitus (T2DM) and studied its relationship with diabetes self-care.Methods: Fifty patients (34 males) had EF assessed using Frontal Assessment Battery (FAB) and Executive Interview 25 (EXIT25). Diabetes self-care was assessed using the Summary of Diabetes Self-Care Activities (SDSCA) scal...
Source: Diabetes Research and Clinical Practice - September 28, 2009 Category: Endocrinology Authors: H. Thabit, S.M. Kennelly, A. Bhagarva, M. Ogunlewe, P.M.E. McCormack, J.H. McDermott, S. Sreenan Tags: Clinical care and education Source Type: journals

A pooled analysis of 29 patients with fulminant type 1 diabetes in Korea: A comparison with a nationwide survey in JapanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We performed a retrospective pooled analysis of 29 patients who had been diagnosed with fulminant type 1 diabetes in Korea and compared the results with 161 patients’ data from a nationwide survey in Japan. Fulminant type 1 diabetic patients in Korea have a similar phenotype compared with Japanese patients. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 27, 2009 Category: Endocrinology Authors: Nam Hoon Kim, Hee Young Kim, Ji A Seo, Nan Hee Kim, Kyoung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Sin Gon Kim Tags: Brief reports Source Type: journals

Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women. It is characterized by chronic anovulation, hyperandrogenism, obesity and a predisposition to type 2 diabetes mellitus (T2DM). Since obesity plays an important role in the etiology of PCOS, we sought to determine if variants in the perilipin gene (PLIN), a gene previously implicated in the development of obesity, were also associated with PCOS. We typed six single nucleotide polymorphisms (haplotype tagging and/or previously associated with obesity or related metabolic traits) in PLIN in 305 unrelated non-Hispanic white women...
Source: Diabetes Research and Clinical Practice - September 27, 2009 Category: Endocrinology Authors: Toshihide Kawai, Maggie C.Y. Ng, M. Geoffrey Hayes, Issei Yoshiuchi, Takafumi Tsuchiya, Heather Robertson, Nancy J. Cox, Kenneth S. Polonsky, Graeme I. Bell, David A. Ehrmann Tags: Basic research Source Type: journals

MCP-1 gene A-2518G polymorphism and carotid artery atherosclerosis in patients with type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to evaluate the relation between the genotypes of the MCP-1 A-2518G polymorphism and the development of carotid atherosclerosis in patients with type 2 diabetes.Methods: The subjects were 303 unrelated patients who were diagnosed with type 2 diabetes mellitus. To evaluate macroangiopathy, we measured carotid artery intima-media thickness (IMT) by ultrasonography. The MCP-1 A-2518G polymorphism was determined by TaqMan PCR method.Results: IMT in patients with the MCP-1 −2518 AG or GG genotype was significantly greater than the AA-genotype (P=0.007). Simple regression analysis showed that ag...
Source: Diabetes Research and Clinical Practice - September 25, 2009 Category: Endocrinology Authors: Sachiko Yuasa, Taro Maruyama, Yukihiro Yamamoto, Hiroshi Hirose, Toshihide Kawai, Seiko Matsunaga-Irie, Hiroshi Itoh Tags: Basic research Source Type: journals

Improvements in life expectancy in type 1 diabetes patients in the last six decadesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Aims: To investigate the survival with diabetes in patients treated with insulin from diagnosis.Subjects and methods: We analyzed 845 subjects, 55.9% males, registered at “I. Pavel” Bucharest Diabetes Centre, insulin-treated from diagnosis, aged (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 23, 2009 Category: Endocrinology Authors: Sorin Ioacara, Radu Lichiardopol, Constantin Ionescu-Tirgoviste, Dan Cheta, Sorin Sabau, Cristian Guja, Eugenia Farcasiu, Cristina Tiu Tags: Epidemiology Source Type: journals

Microvascular diabetic complications are more prevalent in India compared to Mauritius and the UK due to poorer diabetic controlEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Type 2 diabetes mellitus (T2DM) is a growing worldwide problem with WHO estimates suggesting that 300 million people will be affected by 2025. T2DM could result in both microvascular and macrovascular complications but the presentation of these complications could vary globally and be influenced by diabetic control. We investigated the prevalence of these complications by surveying 787 patients of south-Asian origin in diabetic clinics in the UK (n=351), Mauritius (n=173) and India (n=263). We found the prevalence of microvascular complications such as retinopathy (India 16.3%; Mauritius 2.3%; UK 2.6%), nephropat...
Source: Diabetes Research and Clinical Practice - September 21, 2009 Category: Endocrinology Authors: Rahul Potluri, Yanish Purmah, Mohammad Dowlut, Nilesh Sewpaul, Deepthi Lavu Tags: Letters to the Editor Source Type: journals

The relation of ADMA and apelin to endothelial dysfunction and angiogenesis in patients with type 2 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Yonem et al. reported that the concentrations of circulating asymmetric dimethylarginine (ADMA) and apelin are not altered as the type 2 diabetes mellitus (T2DM) progresses to microvascular complications . Although the number of patients in the subgroups was relatively small to make clearer comments, the results are interesting concerning several previous reports. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 21, 2009 Category: Endocrinology Authors: Ilker Tasci, Gokhan Erdem, Serkan Tapan Tags: Letters to the Editor Source Type: journals

The incidence of type 2 diabetes mellitus in the Philippines: A 9-year cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The study shows the alarming growth of diabetes, IFG, and IGT in our country that warrants early aggressive intervention for prevention and management. We encourage the use of 2h post-glucose load aside from FBG in screening for true diabetics, IFGs, and IGTs. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 21, 2009 Category: Endocrinology Authors: Maria Luz B. Soria, Rody G. Sy, Bernard S. Vega, Tommy Ty-Willing, Angela Abenir-Gallardo, Felicidad Velandria, Felix Eduardo Punzalan Tags: Epidemiology Source Type: journals

Racial differences in the discussion and treatment of depressive symptoms accompanying type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Compared to their White counterparts, African Americans with depressive symptoms accompanying diabetes are unlikely to discuss depression with healthcare professionals, be prescribed antidepressant medication, or be seen by a psychiatrist. Minority diabetes patients’ medical and psychiatric outcomes may improve if healthcare providers more actively initiate these discussions, provide culturally tailored education about the nature of depression and its management, incorporate patient preferences into treatment plans, and establish relationships with persons more likely to learn about African American patient ...
Source: Diabetes Research and Clinical Practice - September 21, 2009 Category: Endocrinology Authors: Julie A. Wagner, Denise White Perkins, John D. Piette, Bonnie Lipton, James E. Aikens Tags: Clinical care and Education Source Type: journals

Aortic distensibility indices and coronary flow velocity reserve in patients with different kinds of single-vessel coronary artery disease with versus without diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to evaluate CFR and aortic distensibility indices in patients with different kinds of single-vessel coronary artery disease (SVD) with and without DM. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 17, 2009 Category: Endocrinology Authors: Attila Nemes, Miklós Csanády, Tamás Forster Tags: Letters to the Editor Source Type: journals

Gender differences in the socioeconomic gradient in self-reported diabetes: Does health service access play a role?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings suggest that health service access may explain some of the gender difference in the socioeconomic gradient of self-reported diabetes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 13, 2009 Category: Endocrinology Authors: Cláudia M. Coeli, Eduardo Faerstein, Dóra Chor, Cláudia S. Lopes, Guilherme L. Werneck Tags: Epidemiology Source Type: journals

Relations of lysophosphatidylcholine in low-density lipoprotein with serum lipoprotein-associated phospholipase A2, paraoxonase and homocysteine thiolactonase activities in patients with type 2 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Increased lyso-PC contents in LDL were associated with the suppressed HTLase activity, and serum Lp-PLA2 and HTLase activities may be related to lyso-PC in type 2 diabetic patients. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 13, 2009 Category: Endocrinology Authors: Kazuo Sonoki, Masanori Iwase, Nobuhiro Sasaki, Shigehiro Ohdo, Shun Higuchi, Naoto Matsuyama, Mitsuo Iida Tags: Clinical care and Education Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 11, 2009 Category: Endocrinology Source Type: journals

Dual onset of type 1 diabetes mellitus and Graves’ disease during treatment with pegylated interferon α-2b and ribavirin for chronic hepatitis CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe here a case of dual onset of type 1 DM accompanied by ketoacidosis, and Graves’ disease during the combination therapy via the autoimmune process. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 10, 2009 Category: Endocrinology Authors: Masayuki Hayashi, Yuko Kataoka, Kazushige Tachikawa, Hiroki Koguchi, Hiroshi Tanaka Tags: Brief Reports Source Type: journals

Fasting plasma glucose variability as a marker of nocturnal hypoglycemia in diabetes: Evidence from the PREDICTIVE™ studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The relationship between fasting glucose (FG) variability and nocturnal hypoglycemia was assessed using longitudinal data from PREDICTIVE™, the large-scale observational study of insulin detemir. An HbA1c-corrected correlation was found between these endpoints, suggesting FG variability can serve as a useful marker for this risk in clinical practice. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 10, 2009 Category: Endocrinology Authors: Leo Niskanen, Antti Virkamäki, Jes B. Hansen, Tero Saukkonen Tags: Brief Reports Source Type: journals

CCR5Δ32 genotype is associated with outcome in type 2 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The presence of CCR5Δ32 is associated with better survival in type 2 diabetes patients. These data suggest that it is worthwhile to explore the protective potential of pharmacological blockade of CCR5 in type 2 diabetic patients. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 10, 2009 Category: Endocrinology Authors: Friso L.H. Muntinghe, Sascha Gross, Stephan J.L. Bakker, Gijs W.D. Landman, Pim van der Harst, Henk J.G. Bilo, Gerjan Navis, Mike W. Zuurman Tags: Epidemiology Source Type: journals

Low plasma adiponectin level, white blood cell count and Helicobacter pylori titre independently predict abnormal pancreatic β-cell functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Adiponectin is an adipocytokine with insulin sensitizing effect while chronic inflammation damages pancreatic β-cells leading to reduced insulin response. We aimed to prove the hypothesis that adiponectin levels and inflammatory markers (white blood cell counts [WCC], Helicobacter pylori [HP] titers, high sensitivity C-reactive protein [hs-CRP]) may interact to affect risk of diabetes. We studied 288 Chinese men (age-median: 41.0 years, IQR: 35.3–46.0 years) being recruited from the community in Hong Kong. The mean adiponectin level was 5.39±2.81μg/ml and 40.9% (n=107) had low adiponectin level ( (Source: Di...
Source: Diabetes Research and Clinical Practice - September 10, 2009 Category: Endocrinology Authors: Wing-Yee So, Peter C. Tong, Gary T. Ko, Ronald C. Ma, Risa Ozaki, Alice P. Kong, Xilin Yang, Chung-Shun Ho, Christopher C. Lam, Juliana C. Chan Tags: Basic research Source Type: journals

Waist circumference and impaired fasting glucose screening in a Mediterranean populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We evaluate the merits of routine waist circumference measurements for screening of impaired fasting glucose (IFG). Waist circumference and body mass index showed a strong association with the risk of IFG. The present data indicate the need for routine anthropometric measurements in clinical practice screening for IFG. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 9, 2009 Category: Endocrinology Authors: José M. Baena-Díez, Roberto Elosua, Juan F. Cano, Rafael Masiá, Joan Sala, Jaume Marrugat, Helmut Schröder Tags: Brief Reports Source Type: journals

Insulin increases shedding of syndecan-1 in the serum of patients with type 2 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Chronic inflammation and exogenous insulin usage increases serum syndecan-1 level. Exogenous insulin can promote shedding of syndecan-1 ectodomains to the serum in a time-dependent manner. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 6, 2009 Category: Endocrinology Authors: Jing-bo Wang, Juan Guan, Jing Shen, Li Zhou, Yan-jun Zhang, Yan-fang Si, Li Yang, Xiao-hong Jian, Yu Sheng Tags: Basic research Source Type: journals

Ethnicity, race, and clinically significant macular edema in the Veterans Affairs Diabetes Trial (VADT)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Objective: To determine risk factors in clinically significant macular edema (CSME) and if increased CSME in minorities is due to ethnicity or other factors in the Veterans Affairs Diabetes Trial (VADT).Methods: CSME prevalence based on 7-field stereo fundus photographs in 1268 patients with type 2 diabetes was related to ethnicity, demographics and biochemistries by univariate and multivariate analyses.Results: Hispanics (H) made up 17.5% and African Americans (AA) 17.7% of the cohort. CSME prevalence was 10%. In univariate analysis, CSME was more prevalent in H, 18%, and AA, 15.6% than in non-Hispanic Whites (N...
Source: Diabetes Research and Clinical Practice - August 31, 2009 Category: Endocrinology Authors: Nicholas Emanuele, Thomas Moritz, Ronald Klein, Matthew D. Davis, Kathleen Glander, Anuradha Khanna, Lizy Thottapurathu, Gideon Bahn, William Duckworth, Carlos Abraira, the VADT Study Group Tags: Clinical care and Education Source Type: journals

Depression, depression treatment, and insulin sensitivity in adults at risk for type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data suggest that in adults at high risk for T2DM, depression treatment may improve insulin resistance observed in depression. Healthcare practitioners are encouraged to screen, treat, or refer their patients with depression for treatment. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 31, 2009 Category: Endocrinology Authors: Julie Wagner, Nancy A. Allen, Leah M. Swalley, Gail D. Melkus, Robin Whittemore Tags: Clinical care and Education Source Type: journals

Diabetes and impaired fasting glucose in Mongolian population, Inner Mongolia, ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: IFG were common among Mongolian people living in the northeast of China. IFG has partly same risk factors as diabetes, and prevalence of some cardiovascular risk factors and number of risk factor in diabetes were higher than that in IFG. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 26, 2009 Category: Endocrinology Authors: Shaoyan Zhang, Weijun Tong, Tan Xu, Burenbatu Wu, Yonghong Zhang Tags: Epidemiology Source Type: journals

CDK4 IVS4-nt40G→A SNP and type 2 diabetes in ItaliansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: As cyclin-dependant kinase 4 (CDK4) regulates beta cell proliferation, it may confer T2D risk. We tested the CDK4 IVS4-nt40A→G SNP for association with T2D in Italians (230 cases, 204 control subjects) and excluded a role of the variant in our dataset. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 19, 2009 Category: Endocrinology Authors: Ramachandran Meenakshisundaram, Nunzia Piumelli, Laura Pierpaoli, Claudia Gragnoli Tags: Brief Reports Source Type: journals

Neonatal diabetes in a child positive for islet cell antibodies at onset and Kir6.2 activating mutationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In contrast to the autoimmune type 1 diabetes, patients with monogenic diabetes due to KCNJ11 mutations do not have pancreatic auto-antibodies at onset. Here we describe a patient diagnosed at the age of 12 weeks that showed ICA at diagnosis, yet has been tested with positive result for KCNJ11 mutation. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 18, 2009 Category: Endocrinology Authors: Agnieszka Gach, Krystyna Wyka, Iwona Pietrzak, Olga Wegner, Maciej T. Malecki, Wojciech Mlynarski Tags: Brief Reports Source Type: journals

Effect of sulfonylureas on switching to insulin therapy (twice-daily biphasic insulin aspart 30): Comparison of twice-daily biphasic insulin aspart 30 with or without glimepiride in type 2 diabetic patients poorly controlled with sub-maximal glimepirideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Aim: The aim of this study was to compare the effect of continuation or discontinuation of glimepiride upon starting insulin therapy in type 2 diabetic patients poorly controlled with sub-maximal glimepiride.Methods: This 48-week, randomized, observational, parallel-group study consisted of a 24-week screening period and a 24-week intervention period. During the screening period, we unified the sulfonylureas to glimepiride at 3mg/day for 8 weeks, and started biphasic insulin aspart 30 (Asp30Mix) once-daily injections for 16 weeks. At the start of the intervention period, we stepped up once- to twice-daily insulin...
Source: Diabetes Research and Clinical Practice - August 18, 2009 Category: Endocrinology Authors: C. Ebato, T. Shimizu, M. Arakawa, T. Mita, Y. Fujitani, H. Watada, R. Kawamori, T. Hirose Tags: Clinical care and education Source Type: journals

Effects of bed-time insulin versus pioglitazone on abdominal fat accumulation, inflammation and gene expression in adipose tissue in patients with type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Aims/hypothesis: Intra-abdominal fat (IAF) and inflammatory markers are correlated with cardio-vascular risk. We compared the impact of bed-time insulin versus pioglitazone treatment on these parameters in type 2 diabetic (T2D) patients.Methods: Twenty-eight T2D patients poorly controlled with metformin and sulfonylurea were randomized to receive add-on therapy with pioglitazone or bed-time NPH insulin. IAF and subcutaneous fat (SCF) content, systemic low-grade inflammation level and expression of inflammation related genes in SCF, were measured before and after 24 weeks of treatment.Results: Insulin and pioglita...
Source: Diabetes Research and Clinical Practice - August 16, 2009 Category: Endocrinology Authors: Agnès Hartemann-Heurtier, Marine Halbron, Jean-Louis Golmard, Sophie Jacqueminet, Jean-Philippe Bastard, Christine Rouault, Amine Ayed, Laurence Pieroni, Karine Clément, André Grimaldi Tags: Clinical care and education Source Type: journals

Aldose reductase inhibitor counteracts the attenuated adhesion of human corneal epithelial cells induced by high glucose through modulation of MMP-10 expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: ARI counteracts the decreased adhesion of HCECs induced by high glucose exposure, through the modulation of the expression of MMP-10. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 16, 2009 Category: Endocrinology Authors: Takeshi Tomomatsu, Yoshihiro Takamura, Eri Kubo, Yoshio Akagi Tags: Basic research Source Type: journals

Effect of tight control of HbA1c and blood pressure on cardiovascular diseases in type 2 diabetes: An observational study from the Swedish National Diabetes Register (NDR)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Aim: To estimate hazard ratio (HR) of first incident fatal/non-fatal cardiovascular diseases (CVD) in female/male type 2 diabetic patients, with tight versus adverse control of HbA1c and blood pressure (BP) at baseline, age 30–70 years, no baseline CVD, followed for mean 5.7 years.Methods: 2593 patients with tight control of HbA1c (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 12, 2009 Category: Endocrinology Authors: Jan Cederholm, Björn Zethelius, Peter M. Nilsson, Katarina Eeg-Olofsson, Björn Eliasson, Soffia Gudbjörnsdottir, on behalf of the Swedish National Diabetes Register Tags: Epidemiology Source Type: journals

Effect of rosiglitazone, metformin and medical nutrition treatment on arterial stiffness, serum MMP-9 and MCP-1 levels in drug naive type 2 diabetic patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The aim of the study was to evaluate the long-term effect of rosiglitazone and metformin monotherapy with medical nutrition treatment (MNT) and of MNT alone on arterial stiffness, serum monocyte chemoattractant protein (MCP)-1 and matrix metalloproteinase (MMP)-9 in drug naive patients with type 2 diabetes mellitus. Fifty type 2 diabetic patients were randomized to receive rosiglitazone 4mg/day (n=19) or metformin 850mg/day (n=16) with MNT or MNT alone (n=15), for 52 weeks. Arterial stiffness was assessed by using large and small artery elasticity index (SAEI and LAEI, respectively). SAEI, LAEI, serum MCP-1 and M...
Source: Diabetes Research and Clinical Practice - August 12, 2009 Category: Endocrinology Authors: Sinem Kiyici, Canan Ersoy, Aysel Kaderli, Murat Fazlioglu, Ferah Budak, Cevdet Duran, Ozen Oz Gul, Deniz Sigirli, Ibrahim Baran, Ercan Tuncel, Erdinc Erturk, Sazi Imamoglu Tags: Clinical care and education Source Type: journals

Excellent effect of three-dimensional culture condition on pancreatic isletsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Aim: Culture of cells in simulated microgravity may be potentially beneficial to the fields of cell biology and somatic cell therapy. We aimed to examine three-dimensional culture condition on pancreatic islets.Methods: Islets of Langerhans were cultured in conditions of stasis, microgravity, and microgravity with a polyglycolic acid (PGA) fibrous scaffold. After 5 days in culture, islets were transplanted into the leg muscles of streptozotocin-treated diabetic Wistar rats. The blood glucose and insulin content were determined from the tail vein blood of recipients. The grafts were then frozen, dried, and coated ...
Source: Diabetes Research and Clinical Practice - August 12, 2009 Category: Endocrinology Authors: Yan Hou, Chun Song, Wan Jun Xie, Zheng Wei, Ren Ping Huang, Wei Liu, Zeng Ling Zhang, Yu Bo Shi Tags: Basic research Source Type: journals

Swinnen and DeVries: “Higher dose requirements with insulin detemir in type 2 diabetes—three cases and a review of the literature” [Diab. Res. Clin. Pract. 84 (May (2)) (2009) e24–6 (Epub 2009 February 28)]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Swinnen and DeVries raise the important issue of cost-effectiveness with basal insulins, but we feel their conclusion that detemir will regularly oblige relatively high unit doses is scientifically unsound. The trials they cite reported higher doses of detemir than comparators, but possible responsible methodological factors were explained in an earlier publication by DeVries et al. . (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 12, 2009 Category: Endocrinology Authors: Jaime Davidson, Christoph Koenen Tags: Letters to the editor Source Type: journals

The impact of family history of type 2 diabetes on pancreatic β-cell functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Aims: To study the impact of genetic factor on pancreatic β-cell function in the Chinese population.Methods: 233 first-degree relatives of patients with type 2 diabetes (T2D) with no history of blood glucose abnormalities and their 190 spouses, who did not have a family history of T2D, underwent a 75-g oral glucose tolerance test (OGTT). Based upon the OGTT, these two groups were further divided into three subgroups, including groups with normal glucose tolerance (NGT), impaired glucose regulation (IGR), and type 2 diabetes. Insulin resistance (IR) was evaluated using the homeostasis model assessment–IR (HOMA-...
Source: Diabetes Research and Clinical Practice - August 11, 2009 Category: Endocrinology Authors: Zhi-hong Wang, Su-Hua Zhang, Li-lin Gong, Wei Ren, Rong Li, Rui-zhi Zheng, Yu-feng Zhang, Mao-rong Wang, Qi-fu Li Tags: Clinical care and education Source Type: journals

Serum lipid and hsCRP levels in prediabetes – impaired fasting glucose (IFG) and impaired glucose tolerance (IGT)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Aim: To evaluate cardiovascular risk in prediabetes (IFG and IGT) assessed by serum lipid and hsCRP levels.Subjects and methods: 445 subjects with prediabetes (248 with IFG, 197 with IGT), 318 patients with newly-diagnosed diabetes (NDD) and a group of 477 age- and BMI-matched subjects with normal glucose tolerance (NGT) were enrolled. Glucose tolerance was studied during oral glucose tolerance test (OGTT) and 2006 WHO criteria were applied. Serum hsCRP and lipids (total cholesterol, triglycerides, HDL-cholesterol (HDL-c) and free fatty acids (FFAs) were measured.Results: Both IFG and IGT showed significantly ath...
Source: Diabetes Research and Clinical Practice - August 11, 2009 Category: Endocrinology Authors: Nevena Chakarova, Tsvetalina Tankova, Iliana Atanassova, Lilia Dakovska Tags: Clinical care and education Source Type: journals