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Real-life application and validation of flexible intensive insulin-therapy algorithms in type 1 diabetes patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In type 1 diabetic patients treated with FIT, the use of individualized parameters permits fast and accurate adjustment of mealtime insulin doses, leading to good control of the postprandial state. PMID: 19914853 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - November 13, 2009 Category: Endocrinology Authors: Franc S, Dardari D, Boucherie B, Riveline JP, Biedzinski M, Petit C, Requeda E, Leurent P, Varroud-Vial M, Hochberg G, Charpentier G Tags: Diabetes Metab Source Type: journals

Insulin detemir improves glycaemic control with less hypoglycaemia and no weight gain: 52-week data from the PREDICTIVE study in a cohort of French patients with type 1 or type 2 diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Patients treated with insulin detemir in a clinical healthcare setting improved their glycaemic control with no increases in hypoglycaemia, adverse events or weight compared with baseline. PMID: 19914118 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - November 12, 2009 Category: Endocrinology Authors: Marre M, Pinget M, Gin H, Thivolet C, Hanaire H, Robert JJ, Fontaine P Tags: Diabetes Metab Source Type: journals

The metabolic syndrome in early pregnancy and risk of gestational diabetes mellitus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These findings suggest that women with the metabolic syndrome in early pregnancy have a greater risk of developing GDM. PMID: 19897394 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - November 6, 2009 Category: Endocrinology Authors: Chatzi L, Plana E, Pappas A, Alegkakis D, Karakosta P, Daraki V, Vassilaki M, Tsatsanis C, Kafatos A, Koutis A, Kogevinas M Tags: Diabetes Metab Source Type: journals

Erectile dysfunction, microangiopathy and UKPDS risk in type 2 diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: IIEF-5-defined ED in men with T2DM is associated with a marked increase in the metabolic syndrome, central adiposity and microangiopathy. These data suggest that diagnosing ED in T2DM warrants detailed screening and monitoring for microangiopathy in target organs. PMID: 19897395 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - November 6, 2009 Category: Endocrinology Authors: Hermans MP, Ahn SA, Rousseau MF Tags: Diabetes Metab Source Type: journals

Epidemiology of diabetic retinopathy: Expected vs reported prevalence of cases in the French population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Further implementation of screening programmes is the key to improving DR diagnosis and preventing vision loss in the French diabetic population. PMID: 19892578 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - November 3, 2009 Category: Endocrinology Authors: Delcourt C, Massin P, Rosilio M Tags: Diabetes Metab Source Type: journals

Lipase maturation factor 1: Its expression in Zucker diabetic rats, and effects of metformin and fenofibrate.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: LMF1 expression was not altered in this experimental animal model of obesity, insulin resistance and diabetes in the presence of raised TG levels. However, metformin increased LMF1 expression in the heart, suggesting that stimulation of LMF1 may play a part in its TG-lowering action. PMID: 19854668 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - October 23, 2009 Category: Endocrinology Authors: Forcheron F, Basset A, Del Carmine P, Beylot M Tags: Diabetes Metab Source Type: journals

Profound weight loss in a type 2 diabetic patient with diabetic neuropathic cachexia: A case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 35-year-old morbidly obese man, diagnosed with type 2 diabetes in 2006, lost nearly 100kg extremely rapidly soon after the diagnosis, with dramatic painful paraesthesia and autonomic neuropathy, and poor diabetes control. Investigations to find a tumour, or an infectious, endocrinological or digestive disease, to explain his clinical features were all negative. However, with insulin and analgesic treatment, the patient's symptoms improved markedly within a few months; the patient gained 50kg, while insulin was tapered and then withdrawn, to be replaced by metformin, which maintained perfect diabetes control. Also, th...
Source: Diabetes and Metabolism - October 14, 2009 Category: Endocrinology Authors: Al-Hajeri T, El-Gebely S, Abdella N Tags: Diabetes Metab Source Type: journals

Pulse pressure strongly predicts cardiovascular disease risk in patients with type 2 diabetes from the Swedish National Diabetes Register (NDR).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Increased PP is a powerful independent risk predictor of CVD in type 2 diabetic patients, and lowering PP can lead to a marked reduction in risk. PMID: 19819740 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - October 8, 2009 Category: Endocrinology Authors: Nilsson PM, Cederholm J, Eeg-Olofsson K, Eliasson B, Zethelius B, Gudbjörnsdóttir S, Tags: Diabetes Metab Source Type: journals

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CONCLUSION: These data confirm the influential role of the FTO gene in obesity in the French female population and, in addition, revealed the role of FTO in insulin resistance and MetS. These effects appeared to be independent of IRS-2, which is directly involved in insulin action. This study may offer new insights into the genetic determinants of obesity and MetS in women. PMID: 19818665 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - October 6, 2009 Category: Endocrinology Authors: Attaoua R, Ait El Mkadem S, Lautier C, Kaouache S, Renard E, Brun JF, Fedou C, Gris JC, Bringer J, Grigorescu F Tags: Diabetes Metab Source Type: journals

Fetal origins of insulin resistance and the metabolic syndrome: A key role for adipose tissue?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For several years now, the epidemiological data have shown an inverse relationship between birth-weight and the development in later life of cardiovascular disease and metabolic disorders. The term "small for gestational age" (SGA) describes a neonate whose birth-weight is two standard deviations (SD) below the reference mean, corrected for gestational age and gender. SGA is associated with increased risks of developing hypertension, insulin resistance and type2 diabetes. However, the association with an atherogenic lipid profile is less clear. Nevertheless, all of the components of the metabolic syndrome are present. ...
Source: Diabetes and Metabolism - October 5, 2009 Category: Endocrinology Authors: Meas T Tags: Diabetes Metab Source Type: journals

Differential effect of plasma or erythrocyte AGE-ligands of RAGE on expression of transcripts for receptor isoforms.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Receptor engagement by distinct AGEs differentially enhances expression of RAGE isoforms and DRBC adhesion. The CML-adduct, by facilitating adhesion, has more deleterious effects than MG-derived AGEs. PMID: 19815443 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - October 5, 2009 Category: Endocrinology Authors: Grossin N, Wautier MP, Picot J, Stern DM, Wautier JL Tags: Diabetes Metab Source Type: journals

Optimal nephroprotection: Use, misuse and misconceptions about blockade of the renin-angiotensin system. Lessons from the ONTARGET and other recent trials.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Results from the ONTARGET trial remind us that acute haemodynamically mediated renal dysfunction, triggered by low arterial pressure or volume depletion, can occur in high-risk cardiovascular patients (who usually have some degree of diseased intrarenal vessels) treated with renin-angiotensin system (RAS) blockers (especially in combination). However, nephroprotection could not be properly assessed in the trial, as the population was at low renal risk. Although albuminuria remains a useful marker in many patients, it can neither predict acute renal dysfunction nor replace end-stage renal disease (ESRD) as the endpoint ...
Source: Diabetes and Metabolism - September 25, 2009 Category: Endocrinology Authors: Halimi JM, Asmar R, Ribstein J Tags: Diabetes Metab Source Type: journals

Evaluation of a simple management protocol for hyperglycaemic crises using intramuscular insulin in a resource-limited setting.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The proposed protocol using IM insulin can be safely used to treat hyperglycaemic crises, with mortality rates comparable to those in specialized centres in developed countries. PMID: 19766032 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - September 15, 2009 Category: Endocrinology Authors: Sobngwi E, Lekoubou AL, Dehayem MY, Nouthe BE, Balti EV, Nwatsock F, Akwo EA, Effoe VS, Balla VT, Mamdjokam AS, Siaha V, Tabi CA, Mvom A, Djam I, Mbanya JC Tags: Diabetes Metab Source Type: journals

Supervised home-based exercise may attenuate the decline of glucose tolerance in obese pregnant women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Regular aerobic exercise begun during pregnancy may have favourable effects on glucose tolerance and fitness in obese women, and warrants further investigation in a larger sample population. PMID: 19747869 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - September 8, 2009 Category: Endocrinology Authors: Ong MJ, Guelfi KJ, Hunter T, Wallman KE, Fournier PA, Newnham JP Tags: Diabetes Metab Source Type: journals

Validation of a simple index (SI(is)OGTT) of insulin sensitivity in a population of sedentary men.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The new index proposed by Bastard et al. is as good a predictor of IS in sedentary men as the other commonly used indices, and appears to be as reliable in this population as it was in the original study of postmenopausal women. PMID: 19734081 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - September 3, 2009 Category: Endocrinology Authors: Pigeon E, Riou ME, St-Onge J, Couillard E, Tremblay A, Marette A, Weisnagel SJ, Joanisse DR Tags: Diabetes Metab Source Type: journals

Lipid disorders in type 1 diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with type 1 diabetes (T1D) also present with lipid disorders. Quantitative abnormalities of lipoproteins are observed in T1D patients with poor glycaemic control (increased plasma triglycerides and low-density lipoprotein [LDL] cholesterol) or nephropathy (increased triglycerides and LDL cholesterol, low level of high density lipoprotein [HDL] cholesterol). In cases of T1D with optimal glycaemic control, plasma triglycerides and LDL cholesterol are normal or slightly decreased, while HDL cholesterol is normal or slightly increased. Several qualitative abnormalities of lipoproteins, which are potentially athero...
Source: Diabetes and Metabolism - September 2, 2009 Category: Endocrinology Authors: Vergès B Tags: Diabetes Metab Source Type: journals

Hypoglycaemia? Not guilty! Decreased HbA(1c)? Not guilty!Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19716740 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - August 26, 2009 Category: Endocrinology Authors: Roussel R, Cosson E Tags: Diabetes Metab Source Type: journals

Telmisartan attenuates fatty-acid-induced oxidative stress and NAD(P)H oxidase activity in pancreatic beta-cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These findings indicate that telmisartan attenuated fatty-acid-induced oxidative stress and NAD(P)H oxidase activity in pancreatic beta-cells. Our observations pave the way to the possible use of ARB as a means of protecting beta-cell survival and preserving insulin secretion capacity in patients with diabetes mellitus. PMID: 19713141 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - August 24, 2009 Category: Endocrinology Authors: Saitoh Y, Hongwei W, Ueno H, Mizuta M, Nakazato M Tags: Diabetes Metab Source Type: journals

Psychosocial problems in adolescents with type 1 diabetes mellitus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Adolescents with diabetes are at increased risk of developing psychiatric (10-20%) or eating disorders (8-30%), as well as substance abuse (25-50%), leading to non-compliance with treatment and deterioration of diabetic control. At high risk are female adolescents with family problems and other comorbid disorders. Impaired cognitive function has also been reported among children with diabetes, mainly in boys, and especially in those with early diabetes diagnosis (< 5 years), or with episodes of severe hypoglycaemia or prolonged hyperglycaemia. Type 1 diabetes mellitus contributes to the development of problems in pa...
Source: Diabetes and Metabolism - August 20, 2009 Category: Endocrinology Authors: Kakleas K, Kandyla B, Karayianni C, Karavanaki K Tags: Diabetes Metab Source Type: journals

Prevalence and predictive factors of sleep apnoea syndrome in type 2 diabetic patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In type 2 diabetic patients with poor diabetic control, obstructive SAS is highly prevalent and related to abdominal obesity, and should be systematically screened for, as it cannot be predicted by the clinical data. PMID: 19683953 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - August 13, 2009 Category: Endocrinology Authors: Laaban JP, Daenen S, Léger D, Pascal S, Bayon V, Slama G, Elgrably F Tags: Diabetes Metab Source Type: journals

Prevalence and determinants of diabetes and impaired fasting glucose among urban community-dwelling adults in Guangzhou, China.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The prevalences of diabetes and IFG have increased dramatically over the past decade. Yet, a large proportion of cases go undiagnosed. These results suggest an urgent need to establish regular population-based diabetes screening in Guangzhou. PMID: 19665414 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - August 5, 2009 Category: Endocrinology Authors: Wang H, Qiu Q, Tan LL, Liu T, Deng XQ, Chen YM, Chen W, Yu XQ, Hu BJ, Chen WQ Tags: Diabetes Metab Source Type: journals

Effects of 1-year treatment with metformin on metabolic and cardiovascular risk factors in non-diabetic upper-body obese subjects with mild glucose anomalies: A post-hoc analysis of the BIGPRO1 trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In subjects at high risk of developing diabetes, the use of metformin showed beneficial and no untoward effects on cardiometabolic risk factors. PMID: 19665415 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - August 5, 2009 Category: Endocrinology Authors: Fontbonne A, Diouf I, Baccara-Dinet M, Eschwege E, Charles MA Tags: Diabetes Metab Source Type: journals

Arterial stiffness and the autonomic nervous system during the development of Zucker diabetic fatty rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: During the development of disease of ZDF rats, sympathovagal balance might account for the lack of increase in PWV. PMID: 19648048 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - July 30, 2009 Category: Endocrinology Authors: Cosson E, Valensi P, Laude D, Mesangeau D, Dabire H Tags: Diabetes Metab Source Type: journals

Insulin treatment in IA-2A-positive relatives of type 1 diabetic patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Prophylactic injections of regular human insulin were well tolerated, but failed to prevent type 1 diabetes onset in IA-2A+ relatives. PMID: 19647467 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - July 29, 2009 Category: Endocrinology Authors: Vandemeulebroucke E, Gorus FK, Decochez K, Weets I, Keymeulen B, De Block C, Tits J, Pipeleers DG, Mathieu C, Tags: Diabetes Metab Source Type: journals

Impact of type 2 diabetes mellitus on diffuse inflammatory activation of de novo atheromatous lesions: Implications for systemic inflammation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In patients with DM, local inflammatory activation is diffuse and correlates with systemic inflammation. However, low systemic inflammatory activation does not always predict an increase in local thermal heterogeneity. PMID: 19646908 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - July 28, 2009 Category: Endocrinology Authors: Toutouzas K, Tsiamis E, Drakopoulou M, Synetos A, Karampelas J, Riga M, Tsioufis C, Tousoulis D, Stefanadi E, Vlassis C, Stefanadis C Tags: Diabetes Metab Source Type: journals

The FTO gene modifies weight, fat mass and insulin sensitivity in women with polycystic ovary syndrome, where its role may be larger than in other phenotypes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Variation in the FTO gene modifies weight, adiposity and other measures of obesity and insulin sensitivity in PCOS. The examined FTO gene variant appears to have a greater impact on obesity and related traits in PCOS than in other phenotypes. The effect on insulin sensitivity appears to be secondary to its influence on obesity and body fat. PMID: 19625203 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - July 19, 2009 Category: Endocrinology Authors: Kowalska I, Malecki MT, Straczkowski M, Skupien J, Karczewska-Kupczewska M, Nikolajuk A, Szopa M, Adamska A, Wawrusiewicz-Kurylonek N, Wołczynski S, Sieradzki J, Gorska M Tags: Diabetes Metab Source Type: journals

Early decrease in resting energy expenditure with bedtime insulin therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Bedtime insulin led to an early and specific reduction in REE. PMID: 19589712 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - July 6, 2009 Category: Endocrinology Authors: Fagour C, Gonzalez C, Suberville C, Higueret P, Rabemanantsoa C, Beauvieux MC, Gin H, Rigalleau V Tags: Diabetes Metab Source Type: journals

Combination of cardiorespiratory reflex parameters and heart rate variability power spectrum analysis for early diagnosis of diabetic cardiac autonomic neuropathy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Combining abnormal CR-R parameters (I - E and I/E the most specific) with HRV-PS (particularly the LF area with the subject standing) allowed diagnosis of diabetic CAN at an earlier stage. PMID: 19570704 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - June 28, 2009 Category: Endocrinology Authors: Cabezas-Cerrato J, Gonzalez-Quintela A, Perez-Rodriguez M, Calle A, Faure-Noguera E, Vazquez-Garcia JA, Tags: Diabetes Metab Source Type: journals

Multicentre, randomised, controlled study of the impact of continuous sub-cutaneous glucose monitoring (GlucoDay((R))) on glycaemic control in type 1 and type 2 diabetes patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This is the first randomised study showing that CGM improves glycaemic control in patients with T2D. PMID: 19560388 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - June 24, 2009 Category: Endocrinology Authors: Cosson E, Hamo-Tchatchouang E, Dufaitre-Patouraux L, Attali JR, Pariès J, Schaepelynck-Bélicar P Tags: Diabetes Metab Source Type: journals

Role of macrophage tissue infiltration in obesity and insulin resistance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Obesity is associated with systemic chronic low-grade inflammation, a major contributor to the aetiology of insulin resistance (IR). An inflammatory response in the presence of obesity appears to be triggered by, and to reside predominantly in, adipose tissue (AT). The discovery that the AT in obese mice and humans is infiltrated with macrophages has provided a major advance in our understanding of how obesity propagates inflammation. Interestingly, AT-infiltrating macrophages exhibit a proinflammatory phenotype (classical activation) whereas macrophages residing in AT have a reparative phenotype (alternative activatio...
Source: Diabetes and Metabolism - June 15, 2009 Category: Endocrinology Authors: Bourlier V, Bouloumie A Tags: Diabetes Metab Source Type: journals

Safety of recreational scuba diving in type 1 diabetic patients: The Deep Monitoring programme.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19539514 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - June 15, 2009 Category: Endocrinology Authors: Bonomo M, Cairoli R, Verde G, Morelli L, Moreo A, Delle Grottaglie M, Brambilla MC, Meneghini E, Aghemo P, Corigliano G, Marroni A Tags: Diabetes Metab Source Type: journals

Effects of exposure of human islet beta-cells to normal and high glucose levels with or without gliclazide or glibenclamide.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Gliclazide and glibenclamide have different effects on the changes induced by prolonged exposure of human islet cells to high levels of glucose. PMID: 19502091 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - June 4, 2009 Category: Endocrinology Authors: Del Guerra S, D'Aleo V, Lupi R, Masini M, Bugliani M, Boggi U, Filipponi F, Marchetti P Tags: Diabetes Metab Source Type: journals

Is skeletal muscle mitochondrial dysfunction a cause or an indirect consequence of insulin resistance in humans?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The precise cause of insulin resistance and type 2 diabetes is unknown. However, there is a strong association between insulin resistance and lipid accumulation - and, in particular, lipotoxic fatty acid metabolites - in insulin-target tissues. Such accumulation is known to cause insulin resistance, particularly in skeletal muscle, by reducing insulin-stimulated glucose uptake. Reduced fat-oxidation capacity appears to cause such lipid accumulation and, over the past few years, many studies have concluded that decreased mitochondrial oxidative phosphorylation could be the initiating cause of lipid deposition and the de...
Source: Diabetes and Metabolism - May 31, 2009 Category: Endocrinology Authors: Dumas JF, Simard G, Flamment M, Ducluzeau PH, Ritz P Tags: Diabetes Metab Source Type: journals

Benefits of Ophdiat((R)), a telemedical network to screen for diabetic retinopathy: A retrospective study in five reference hospital centres.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This evaluation shows that Ophdiat((R)), combined with the availability of modern and effective devices, has improved DR screening in diabetology departments in hospitals. Additional human resources would certainly ensure more effective use of the system. PMID: 19349202 [PubMed - in process] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - May 31, 2009 Category: Endocrinology Authors: Chabouis A, Berdugo M, Meas T, Erginay A, Laloi-Michelin M, Jouis V, Guillausseau PJ, M'bemba J, Chaine G, Slama G, Cohen R, Reach G, Marre M, Chanson P, Vicaut E, Massin P Tags: Diabetes Metab Source Type: journals

Diabetic retinopathy, PAI-1 4G/5G and -844G/A polymorphisms, and changes in circulating PAI-1 levels in Tunisian type 2 diabetes patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The present study identifies changes in PAI-1 levels and genetic variations at the PAI-1 locus as risk factors for DR, but not DR severity, that may serve as useful markers of increased DR susceptibility. PMID: 19419896 [PubMed - in process] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - May 31, 2009 Category: Endocrinology Authors: Ezzidi I, Mtiraoui N, Chaieb M, Kacem M, Mahjoub T, Almawi WY Tags: Diabetes Metab Source Type: journals

A call to incorporate the prevention and treatment of geriatric disorders in the management of diabetes in the elderly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The prevalence of type 2 diabetes increases with age. However, the management of diabetes in the elderly has received surprisingly little attention. Diabetes in the elderly is associated with a high risk of geriatric syndromes including malnutrition and sarcopenia, functional impairments, falls and fractures, incontinence, depression and dementia. Tight glycaemic control for the prevention of vascular complications is often of limited value in the elderly. However, glycaemic control and non-pharmacological therapy may prevent diabetes symptoms and delay geriatric syndromes. The prevention, screening and treatment of b...
Source: Diabetes and Metabolism - May 31, 2009 Category: Endocrinology Authors: Vischer UM, Bauduceau B, Bourdel-Marchasson I, Blickle JF, Constans T, Fagot-Campagna A, Kaloustian E, Lassman-Vague V, Lecomte P, Simon D, Tessier D, Verny C, Doucet J, Tags: Diabetes Metab Source Type: journals

Evaluation of the SIisOGTT index in a healthy population with normal glucose tolerance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19457690 [PubMed - in process] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - May 31, 2009 Category: Endocrinology Authors: Antuna-Puente B, Disse E, Lavoie ME, Rabasa-Lhoret R, Laville M, Bastard JP Tags: Diabetes Metab Source Type: journals

Replication studies based on findings from a genome-wide DNA microsatellite screen in diabetic nephropathy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19481965 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - May 31, 2009 Category: Endocrinology Authors: Martin RJ, Maxwell AP, Patterson CC, McKnight AJ, Savage DA, Tags: Diabetes Metab Source Type: journals

Safety of recreational scuba diving in type 1 diabetic patients: The deep monitoring programme.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19473866 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - May 24, 2009 Category: Endocrinology Authors: Pollock NW Tags: Diabetes Metab Source Type: journals

Association between angiopoietin-like 6 (ANGPTL6) gene polymorphisms and metabolic syndrome-related phenotypes in the French MONICA Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These findings constitute the first study in humans of ANGPTL6 genetic variability. Although there was no evidence that polymorphisms in ANGPTL6 might be significantly associated with the metabolic syndrome-related phenotypes, a weak association of these polymorphisms with these parameters cannot be excluded. Further association studies are needed to arrive at any definite conclusions. PMID: 19447061 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - May 13, 2009 Category: Endocrinology Authors: Legry V, Goumidi L, Huyvaert M, Cottel D, Ferrières J, Arveiler D, Bingham A, Wagner A, Ruidavets JB, Ducimetière P, Amouyel P, Meirhaeghe A Tags: Diabetes Metab Source Type: journals

Urinary albumin excretion in latent autoimmune diabetes in adults (LADA) is more similar to type 2 than type 1 diabetes: Results of the Nord-Trøndelag Health Study 1995-1997.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In this cross-sectional study, the ACR in LADA and in T2D were similar and higher than in T1D. This similarity between LADA and T2D makes it unlikely that the autoimmune processes that operate in LADA promote albuminuria. PMID: 19423377 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - May 4, 2009 Category: Endocrinology Authors: Radtke MA, Lund Nilsen TI, Midthjell K, Grill V Tags: Diabetes Metab Source Type: journals

Left ventricular hypertrophy in hypertensive type 2 diabetic patients according to renal function.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our study confirmed that, in a population of Afro-Caribbean hypertensive type 2 diabetic patients, renal failure was associated to an increased left ventricular mass/height(2.7). The data show that the variables associated with LVH differ according to renal profile. This finding will be of value in the treatment and follow-up of these patients. PMID: 19423378 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - May 4, 2009 Category: Endocrinology Authors: Blanchet Deverly A, Kangambega P, Hue K, Donnet JP, Merault H, Foucan L Tags: Diabetes Metab Source Type: journals

Intestinal microflora and metabolic diseases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent advances in molecular sequencing technology have allowed researchers to answer major questions regarding the relationship between a vast genomic diversity-such as found in the intestinal microflora-and host physiology. Over the past few years, it has been established that, in obesity, type 1 diabetes and Crohn's disease-to cite but a few-the intestinal microflora play a pathophysiological role and can induce, transfer or prevent the outcome of such conditions. A few of the molecular vectors responsible for this regulatory role have been determined. Some are related to control of the immune, vascular, endocrine a...
Source: Diabetes and Metabolism - May 3, 2009 Category: Endocrinology Authors: Serino M, Luche E, Chabo C, Amar J, Burcelin R Tags: Diabetes Metab Source Type: journals

Mutations in the ABCC8 gene can cause autoantibody-negative insulin-dependent diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe here a rather different phenotype: two cases of adult diabetic patients-considered and treated as insulin-dependent diabetic patients since adolescence-who, in fact, turned out to be heterozygous for an ABCC8 mutation and able to successfully discontinue insulin while taking sulphonylurea treatment. PMID: 19342262 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - March 31, 2009 Category: Endocrinology Authors: Hartemann-Heurtier A, Simon A, Bellanne-Chantelot C, Reynaud R, Cavé H, Polak M, Vaxillaire M, Grimaldi A Tags: Diabetes Metab Source Type: journals

How do patients with type 2 diabetes perceive their disease? Insights from the French DIABASIS survey.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: DIABASIS provides important information for diabetes care by highlighting patients' views of the disease, such as distress at diagnosis, lack of adequate information to cope with this distress and the important supportive role played by the family. A deeper understanding of patients' perception of the disease would help optimize customized care. PMID: 19303338 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - March 18, 2009 Category: Endocrinology Authors: Mosnier-Pudar H, Hochberg G, Eschwege E, Virally ML, Halimi S, Guillausseau PJ, Peixoto O, Touboul C, Dubois C, Dejager S Tags: Diabetes Metab Source Type: journals

Impact of short-duration lifestyle intervention in collaboration with general practitioners in patients with the metabolic syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Short-term, single lifestyle modifications targeting the metabolic syndrome in collaboration with GPs was effective in decreasing most of the parameters of the syndrome. However, no factors predictive of success were identified. PMID: 19299181 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - March 17, 2009 Category: Endocrinology Authors: Bihan H, Takbou K, Cohen R, Michault A, Boitou F, Reach G, Le Clésiau H Tags: Diabetes Metab Source Type: journals

Prevalence and impact on quality of life of peripheral neuropathy with or without neuropathic pain in type 1 and type 2 diabetic patients attending hospital outpatients clinics.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: DPN and DPN-P are frequent complications of diabetes, especially in type 2, and can be identified with inexpensive and easy-to-use screening tools. Despite its profound impact on QoL, DPN-P remains undertreated. PMID: 19297223 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - March 16, 2009 Category: Endocrinology Authors: Van Acker K, Bouhassira D, De Bacquer D, Weiss S, Matthys K, Raemen H, Mathieu C, Colin IM Tags: Diabetes Metab Source Type: journals

Low levels of insulin-like growth-factor-binding protein-1 (IGFBP-1) are prospectively associated with the incidence of type 2 diabetes and impaired glucose tolerance (IGT): The Söderåkra Cardiovascular Risk Factor Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Low levels of IGFBP-1 predicted the long-term development of type 2 diabetes or IGT in a middle-aged population. The association was independent of CRP and abdominal obesity. PMID: 19297224 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - March 16, 2009 Category: Endocrinology Authors: Petersson U, Ostgren CJ, Brudin L, Brismar K, Nilsson PM Tags: Diabetes Metab Source Type: journals

Smoking habits and the risk of type 2 diabetes: A case-control study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our data confirms that smoking may be an independent risk factor for type 2 diabetes. PMID: 19269874 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - March 6, 2009 Category: Endocrinology Authors: Radzevičienė L, Ostrauskas R Tags: Diabetes Metab Source Type: journals

Glucose transporter 2 gene polymorphisms and beta-cell function in isolated human pancreatic islets.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19269875 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - March 6, 2009 Category: Endocrinology Authors: Del Guerra S, Lupi R, D'Aleo V, Filipponi F, Boggi U, Marchetti P Tags: Diabetes Metab Source Type: journals