Diabetologia
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Lipid and inflammatory biomarkers and kidney function decline in type 2 diabetes
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Conclusions/interpretation Elevated sTNFR-2 levels may be an important and potentially modifiable risk factor for eGFR decline in type 2 diabetes, especially
in those with a BMI of ≥30 kg/m2.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1597-zAuthors
J. Lin, MRB-4, Brigham and Women’s Hospital Renal Division 75 Francis Street Boston MA 02115 USAF. B. Hu, Harvard Medical School Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital Boston MA USAC. Mantzoros, Beth Israel Deaconess Medical Center Division of Endocrinology, Department of Medicine Boston M...
Source: Diabetologia - November 18, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Dualities of interest are not restricted to financial ties to the pharmaceutical industryEmail this article to a colleague.
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Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-009-1603-5Authors
M. Nauck, Diabeteszentrum Bad Lauterberg Kirchberg 21 37431 Bad Lauterberg im Harz Germany
Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia)
Source: Diabetologia - November 18, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
The economic costs of diabetes in Iran: some concerns and recommendations. Reply to Khuwaja AK, Khowaja LA, Cosgrove P [letter]Email this article to a colleague.
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Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-009-1601-7Authors
A. Esteghamati, Tehran University of Medical Sciences Endocrinology and Metabolism Research Centre (EMRC), Vali-Asr Hospital, School of Medicine Tehran IranO. Khalilzadeh, Tehran University of Medical Sciences Endocrinology and Metabolism Research Centre (EMRC), Vali-Asr Hospital, School of Medicine Tehran IranM. Abbasi, Tehran University of Medical Sciences Endocrinology and Metabolism Research Centre (EMRC), Vali-Asr Hospital, School of Medicine Tehran Iran
Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia)
Source: Diabetologia - November 18, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
The gait and balance of patients with diabetes can be improved: a randomised controlled trialEmail this article to a colleague.
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Conclusions/interpretation Specific training can improve gait speed, balance, muscle strength and joint mobility in diabetic patients. Further studies
are needed to explore the influence of these improvements on the number of reported falls, patients’ physical activity levels
and quality of life.
Trial registration: ClinicalTrials.gov NCT00637546
Funding: This work was supported by the Swiss National Foundation (SNF): PBSKP-123446/1/
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1592-4Authors
L. Allet, Maastricht University and Caphri Research...
Source: Diabetologia - November 18, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Erratum to: Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesityEmail this article to a colleague.
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Content Type Journal ArticleCategory ErratumDOI 10.1007/s00125-009-1583-5Authors
S. Beck Jørgensen, University of Melbourne St Vincent’s Institute of Medical Research and Department of Medicine Fitzroy VIC AustraliaH. M. O’Neill, University of Melbourne St Vincent’s Institute of Medical Research and Department of Medicine Fitzroy VIC AustraliaK. Hewitt, University of Melbourne St Vincent’s Institute of Medical Research and Department of Medicine Fitzroy VIC AustraliaB. E. Kemp, University of Melbourne St Vincent’s Institute of Medical Research and Department of Medicine Fitzroy VIC AustraliaG. R. Steinberg, ...
Source: Diabetologia - November 18, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
A case of recurrent type 1 diabetes mellitus with insulitis of transplanted pancreas in simultaneous pancreas–kidney transplantation from cardiac death donorEmail this article to a colleague.
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Conclusions/interpretation The histological features of insulitis in transplanted pancreas were consistent with common type 1 diabetes mellitus, but
the clinical course of the recurrence appeared to be more rapid.
Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00125-009-1593-3Authors
M. Ishida-Oku, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences Maidashi 3-1-1, Higashi-ku Fukuoka 812-8582 JapanM. Iwase, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences Maidashi 3-1-1, Higashi-ku Fuk...
Source: Diabetologia - November 12, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Intensive glucose control and macrovascular outcomes in type 2 diabetes. Reply to Emanuele NV [letter] and Yudkin JS, Richter B [letter]Email this article to a colleague.
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Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-009-1565-7Authors
The CONTROL Group, University of Sydney The George Institute for International Health PO Box M201 Missenden Rd Sydney NSW 2050 Australia
Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia)
Source: Diabetologia - November 11, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Progression to microalbuminuria in type 1 diabetes: development and validation of a prediction ruleEmail this article to a colleague.
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Conclusions/interpretation We developed and validated a clinical prediction rule that uses relatively easily obtainable patient characteristics to predict
microalbuminuria in patients with type 1 diabetes. This rule can help clinicians to decide on more frequent check-ups for
patients at high risk of microalbuminuria in order to prevent long-term chronic complications.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1585-3Authors
Y. Vergouwe, University Medical Centre Utrecht Julius Center for Health Sciences and Primary Care Str 6.131 P.O. Box 85500 3508 GA Utrecht the Netherlands...
Source: Diabetologia - November 11, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Peroxisome proliferator-activated receptor α (PPARα) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolismEmail this article to a colleague.
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Conclusions/interpretation PPARα protected INS-1E beta cells from oleate-induced dysfunction, promoting both preservation of glucose metabolic pathways
and fatty acid turnover.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1590-6Authors
F. Frigerio, University of Geneva Medical Center Department of Cell Physiology and Metabolism 1 rue Michel-Servet 1211 Geneva 4 SwitzerlandT. Brun, University of Geneva Medical Center Department of Cell Physiology and Metabolism 1 rue Michel-Servet 1211 Geneva 4 SwitzerlandC. Bartley, University of Geneva Medical Center Department of Cell Physiolog...
Source: Diabetologia - November 11, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Diet-induced gene expression of isolated pancreatic islets from a polygenic mouse model of the metabolic syndromeEmail this article to a colleague.
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Conclusions/interpretation We demonstrated that LCM of pancreatic islet cells in combination with transcriptional profiling can be successfully used
to identify novel candidate genes for diabetes. Our data strongly implicate glucose-induced oxidative stress in disease progression.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1576-4Authors
T. Dreja, German Institute of Human Nutrition Potsdam-Rehbruecke Department of Pharmacology Arthur-Scheunert-Allee 114–116 14558 Nuthetal GermanyZ. Jovanovic, University of Cambridge Metabolic Research Laboratories Institute of Metabolic Scienc...
Source: Diabetologia - November 10, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Candidate loci for insulin sensitivity and disposition index from a genome-wide association analysis of Hispanic participants in the Insulin Resistance Atherosclerosis (IRAS) Family StudyEmail this article to a colleague.
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Conclusions/interpretation Several candidate loci were identified that are nominally associated with SI and/or DI in Hispanic-American participants. Replication of these findings in independent cohorts and additional focused
analysis of these loci is warranted.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1586-2Authors
N. D. Palmer, Wake Forest University School of Medicine Department of Biochemistry, Centers for Human Genomics & Diabetes Research 1 Medical Center Blvd Winston-Salem NC 27157 USAC. D. Langefeld, Wake Forest University School of Medicine Department of Public Health ...
Source: Diabetologia - November 10, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Human IL6 enhances leptin action in miceEmail this article to a colleague.
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Conclusions/interpretation Human IL6 enhanced central leptin action in mice, promoting nutrient homeostasis and preventing diet-induced obesity.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1580-8Authors
M. Sadagurski, Harvard Medical School, Karp Family Research Laboratories Howard Hughes Medical Institute, Division of Endocrinology, Children’s Hospital Boston Rm 4210, 300 Longwood Avenue Boston MA 02115 USAL. Norquay, Harvard Medical School, Karp Family Research Laboratories Howard Hughes Medical Institute, Division of Endocrinology, Children’s Hospital Boston Rm 4210, 300 Lo...
Source: Diabetologia - November 10, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Impaired wound healing in mouse models of diabetes is mediated by TNF-α dysregulation and associated with enhanced activation of forkhead box O1 (FOXO1)Email this article to a colleague.
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Conclusions/interpretation These studies indicate that TNF-α dysregulation in diabetic wounds impairs healing, which may involve enhanced fibroblast
apoptosis and decreased proliferation. In vitro, TNF-α induced gene sets through FOXO1 that regulate a number of pathways that could influence inflammation and apoptosis.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1529-yAuthors
M. F. Siqueira, Boston University School of Dental Medicine Department of Periodontology and Oral Biology Boston MA USAJ. Li, University of Medicine and Dentistry of New Jersey Department of Periodontics 11...
Source: Diabetologia - November 9, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Regulation of wingless-type MMTV integration site family (WNT) signalling in pancreatic islets from wild-type and obese miceEmail this article to a colleague.
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Conclusions/interpretation Canonical WNT signalling is not active in adult beta cells in vivo. WNT4 provides a potential mechanism for suppression of
canonical WNT signalling in obese mice.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1578-2Authors
J. Krützfeldt, The Rockefeller University Laboratory of Metabolic Diseases New York NY USAM. Stoffel, The Rockefeller University Laboratory of Metabolic Diseases New York NY USA
Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia)
Source: Diabetologia - November 8, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Effects of exenatide on circulating glucose, insulin, glucagon, cortisol and catecholamines in healthy volunteers during exerciseEmail this article to a colleague.
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Conclusions/interpretation In non-diabetic participants given exenatide, blood glucose concentrations rise rather than fall during aerobic exercise with
an associated greater catecholamine response.
Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00125-009-1579-1Authors
E. Y. H. Khoo, Nottingham University Hospitals Department of Diabetes and Endocrinology Queens Medical Centre Campus, Derby Road Nottingham NG7 2UH UKJ. Wallis, University of Nottingham School of Biomedical Sciences Nottingham UKK. Tsintzas, University of Nottingham School of Biomedical Sciences Nottingham UKI. A. M...
Source: Diabetologia - November 7, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Differential relationship between physical activity and progression to diabetes by glucose tolerance status: the Inter99 StudyEmail this article to a colleague.
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Conclusions/interpretation Physical activity was associated with a lower progression to diabetes in the total study population and in individuals with
i-IGT, a condition primarily characterised by muscle insulin resistance. Physical activity did not predict progression to
diabetes in individuals with i-IFG, a condition primarily characterised by hepatic insulin resistance. Our results suggest
that there is a differential relationship between physical activity and progression to diabetes among those with i-IFG and
i-IGT. Therefore, clinical trials testing the effect of physical activity on progression from i-...
Source: Diabetologia - November 6, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Hyperglycaemic clamp test for diabetes risk assessment in IA-2-antibody-positive relatives of type 1 diabetic patientsEmail this article to a colleague.
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Conclusions/interpretation Clamp-derived functional variables stratify risk of diabetes in IA-2A+ FDRs and may more consistently identify progressors than OGTT-derived variables. A low first-phase C-peptide response specifically
predicts impending diabetes while a low second-phase response may reflect an earlier disease stage.
Trial registration: ClinicalTrials.gov NCT00654121
Funding: The insulin trial was financially supported by Novo Nordisk Pharma nv.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1569-3Authors
E. Vandemeulebroucke, Brussels F...
Source: Diabetologia - November 6, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
HOMA insulin sensitivity index and the risk of all-cause mortality and cardiovascular disease events in the general population: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab) studyEmail this article to a colleague.
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Conclusions/interpretation In this cohort, HOMA-%S showed no association with all-cause mortality and only a modest association with CVD events, largely
explained by its association with HDL. Fasting plasma glucose was a better predictor of CVD than HOMA-%S.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1588-0Authors
E. L. M. Barr, Baker IDI Heart and Diabetes Institute Department of Epidemiology and Clinical Diabetes 250 Kooyong Road Caulfield 3162 VIC AustraliaA. J. Cameron, Baker IDI Heart and Diabetes Institute Department of Epidemiology and Clinical Diabetes 250 Kooyong Road C...
Source: Diabetologia - November 6, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Glucagon-like peptide-1 therapy and the exocrine pancreas: innocent bystander or friendly fire?Email this article to a colleague.
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Content Type Journal ArticleCategory CommentaryDOI 10.1007/s00125-009-1591-5Authors
P. C. Butler, UCLA Larry Hillblom Islet Research Center at David Geffen School of Medicine 900 Weyburn Place #A Los Angeles CA 90024-2852 USAA. V. Matveyenko, UCLA Larry Hillblom Islet Research Center at David Geffen School of Medicine 900 Weyburn Place #A Los Angeles CA 90024-2852 USAS. Dry, UCLA Larry Hillblom Islet Research Center at David Geffen School of Medicine 900 Weyburn Place #A Los Angeles CA 90024-2852 USAA. Bhushan, UCLA Larry Hillblom Islet Research Center at David Geffen School of Medicine 900 Weyburn Place #A Los Angeles...
Source: Diabetologia - November 5, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Aliskiren prevents cardiovascular complications and pancreatic injury in a mouse model of obesity and type 2 diabetesEmail this article to a colleague.
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Conclusions/interpretation Our work provides the first evidence that direct renin inhibition with aliskiren protects against cardiovascular complications
and pancreatic injury, through the attenuation of oxidative stress. Thus, we propose that aliskiren may be a promising therapeutic
agent for type 2 diabetes.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1575-5Authors
Y. F. Dong, Kumamoto University Graduate School of Medical Sciences Department of Pharmacology and Molecular Therapeutics 1-1-1 Honjyo Kumamoto 860-8556 JapanL. Liu, Kumamoto University Graduate School of Medical Sc...
Source: Diabetologia - November 5, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammationEmail this article to a colleague.
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Abstract The recent major increase in the global incidence of type 2 diabetes suggests that most cases of this disease are caused by
changes in environment and lifestyle. All major risk factors for type 2 diabetes (overnutrition, low dietary fibre, sedentary
lifestyle, sleep deprivation and depression) have been found to induce local or systemic low-grade inflammation that is usually
transient or milder in individuals not at risk for type 2 diabetes. By contrast, inflammatory responses to lifestyle factors
are more pronounced and prolonged in individuals at risk of type 2 diabetes and appear to occur also in...
Source: Diabetologia - November 4, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Regulation of oxidative stress by glycaemic control: evidence for an independent inhibitory effect of insulin therapyEmail this article to a colleague.
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Conclusions/interpretation In type 1 and type 2 diabetes, insulin exerts an inhibitory effect on oxidative stress, a metabolic disorder that is significantly
activated by sustained hyperglycaemia and glucose variability in non-insulin-treated type 2 diabetes.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1574-6Authors
L. Monnier, University Institute of Clinical Research Laboratory of Human Nutrition and Atherogenesis 34093 Montpellier Cedex 5 FranceC. Colette, University Institute of Clinical Research Laboratory of Human Nutrition and Atherogenesis 34093 Montpellier Cedex 5 France...
Source: Diabetologia - November 4, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
List of refereesEmail this article to a colleague.
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Content Type Journal ArticleCategory List of RefereesDOI 10.1007/s00125-009-1584-4
Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia)
Source: Diabetologia - November 3, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Genetics of serum resistin: a paradigm of population-specific regulation?Email this article to a colleague.
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Content Type Journal ArticleCategory CommentaryDOI 10.1007/s00125-009-1589-zAuthors
C. Menzaghi, IRCCS ‘Casa Sollievo della Sofferenza’, Viale Padre Pio Research Unit of Diabetes and Endocrine Diseases 71013 San Giovanni Rotondo (FG) ItalyV. Trischitta, IRCCS ‘Casa Sollievo della Sofferenza’, Viale Padre Pio Research Unit of Diabetes and Endocrine Diseases 71013 San Giovanni Rotondo (FG) Italy
Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia)
Source: Diabetologia - October 31, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
A 4 year follow-up study of cognitive functioning in patients with type 2 diabetes mellitusEmail this article to a colleague.
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Conclusions/interpretation In non-demented patients with type 2 diabetes, cognitive decrements are moderate in size and cognitive decline over 4 years
is largely within the range of what can be viewed in normal ageing. Apparently, diabetes-related cognitive changes develop
slowly over a prolonged period of time.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1571-9Authors
E. van den Berg, University Medical Center Utrecht Department of Neurology (G03.228), Rudolf Magnus Institute of Neuroscience P.O. Box 85500 3508 GA Utrecht the NetherlandsY. D. Reijmer, University Medical C...
Source: Diabetologia - October 31, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreasEmail this article to a colleague.
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Conclusions/interpretation The timing of OVOL1 appearance in pancreas and its increased levels in differentiated cells suggest that OVOL1 promotes the
transition of cells from a proliferating, less-differentiated state to a quiescent more-differentiated state. We conclude
that OVOL1, a downstream target of NGN3, may play an important role in regulating the balance between proliferation and differentiation
of pancreatic cells.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1567-5Authors
A. Vetere, Harvard Medical School Section of Islet Transplantation and Cell Biology, Joslin Diab...
Source: Diabetologia - October 31, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Determinants of urinary albumin excretion within the normal range in patients with type 2 diabetes: the Randomised Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) studyEmail this article to a colleague.
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Conclusions/interpretation Although observational correlations do not prove causality, in normoalbuminuric type 2 diabetic patients the albumin excretion
rate is correlated with many factors that are potentially susceptible to intervention.
Trial registration: ClinicalTrials.gov ID no.: NCT00185159
Funding: This study was sponsored by Daichii-Sankyo.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1577-3Authors
E. Ritz, University of Heidelberg Department of Nephrology Heidelberg GermanyG. C. Viberti, KCL Guy’s Hospital London UKL. M. Ruilope, Ho...
Source: Diabetologia - October 30, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
An empirical index of insulin sensitivity from short IVGTT: validation against the minimal model and glucose clamp indices in patients with different clinical characteristicsEmail this article to a colleague.
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Conclusions/interpretation A short test can achieve a good approximation of minimal model analysis and clamp insulin sensitivity. The importance of a
method such as CSI is that it allows analysis of IVGTT datasets with samples limited to 1 h.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1547-9Authors
A. Tura, Metabolic Unit, ISIB-CNR Corso Stati Uniti, 4 35127 Padova ItalyS. Sbrignadello, Metabolic Unit, ISIB-CNR Corso Stati Uniti, 4 35127 Padova ItalyE. Succurro, University Magna Græcia of Catanzaro Department of Experimental and Clinical Medicine Catanzaro ItalyL. Groop, L...
Source: Diabetologia - October 29, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Erratum to: Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitroEmail this article to a colleague.
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Content Type Journal ArticleCategory ErratumDOI 10.1007/s00125-009-1566-6Authors
S. K. Pinnamaneni, RMIT University Cellular and Molecular Metabolism Laboratory, School of Medical Sciences Melbourne VIC AustraliaR. J. Southgate, RMIT University Cellular and Molecular Metabolism Laboratory, School of Medical Sciences Melbourne VIC AustraliaM. A. Febbraio, RMIT University Cellular and Molecular Metabolism Laboratory, School of Medical Sciences Melbourne VIC AustraliaM. J. Watt, RMIT University Cellular and Molecular Metabolism Laboratory, School of Medical Sciences Melbourne VIC Australia
Journal DiabetologiaOnlin...
Source: Diabetologia - October 29, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
The economic costs of diabetes in developing countries: some concerns and recommendationsEmail this article to a colleague.
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Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-009-1581-7Authors
A. K. Khuwaja, Aga Khan University Department of Family Medicine Karachi 74880 PakistanL. A. Khowaja, Aga Khan University Department of Community Health Sciences Karachi PakistanP. Cosgrove, The Open University in the North West Faculty of Social Sciences Sharston Manchester UK
Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia)
Source: Diabetologia - October 28, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
The endothelin receptor antagonist avosentan ameliorates nephropathy and atherosclerosis in diabetic apolipoprotein E knockout miceEmail this article to a colleague.
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Conclusions/interpretation This study demonstrates that ETA blockade with avosentan may provide an alternate therapeutic strategy for the treatment of
diabetic micro- and macrovascular complications.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1540-3Authors
A. M. D. Watson, Baker IDI Heart and Diabetes Institute PO Box 6492 St Kilda Road Central Melbourne 8008 VIC AustraliaJ. Li, Baker IDI Heart and Diabetes Institute PO Box 6492 St Kilda Road Central Melbourne 8008 VIC AustraliaC. Schumacher, Novartis Pharma Basel SwitzerlandM. de Gasparo, MG Consulting Rossemaison Switzerland...
Source: Diabetologia - October 27, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Diabetes treatment with insulin glargine and risk of malignancy: methodological pitfalls and ethical issuesEmail this article to a colleague.
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Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-009-1572-8Authors
D. Simon, INSERM U-780 94807 Villejuif Cedex France
Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia)
Source: Diabetologia - October 26, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues. Reply to Nagel JM, Mansmann U, Wegscheider K et al. [letter] and Simon D [letter]Email this article to a colleague.
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Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-009-1582-6Authors
U. Grouven, Institute for Quality and Efficiency in Health Care (IQWiG) Dillenburger Str. 27 51105 Cologne GermanyL. G. Hemkens, Institute for Quality and Efficiency in Health Care (IQWiG) Dillenburger Str. 27 51105 Cologne GermanyR. Bender, Institute for Quality and Efficiency in Health Care (IQWiG) Dillenburger Str. 27 51105 Cologne GermanyP. T. Sawicki, Institute for Quality and Efficiency in Health Care (IQWiG) Dillenburger Str. 27 51105 Cologne Germany
Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia)
Source: Diabetologia - October 23, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulationEmail this article to a colleague.
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Conclusions/interpretation Human beta cells, unlike those of young rodents, are long-lived. LB proportions in type 2 diabetes and obesity suggest that
little adaptive change occurs in the adult human beta cell population, which is largely established by age 20 years.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1562-xAuthors
M. Cnop, Université Libre de Bruxelles Laboratory of Experimental Medicine and Division of Endocrinology Brussels BelgiumS. J. Hughes, Churchill Hospital DRWF Islet Isolation Facility, Nuffield Department of Surgery Oxford UKM. Igoillo-Esteve, UniversitÃ...
Source: Diabetologia - October 23, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Mitogenic action of insulin: friend, foe or ‘frenemy’?Email this article to a colleague.
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Abstract Either endogenous or exogenous hyperinsulinaemia in the setting of insulin resistance promotes phosphorylation and activation
of farnesyltransferase, a ubiquitous enzyme that farnesylates Ras proteins. Increased availability of farnesylated Ras at
the plasma membrane enhances mitogenic responsiveness of cells to various growth factors, thus contributing to progression
of cancer and atherosclerosis. This effect is specific to insulin, but is not related to the type of insulin used. The stimulatory
effect of hyperinsulinaemia on farnesyltransferase in the presence of insulin resistance represents one ...
Source: Diabetologia - October 22, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Single pancreatic beta cells co-express multiple islet hormone genes in miceEmail this article to a colleague.
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Conclusions/interpretation This study shows co-expression of multiple hormone genes in beta cells of adult mice as well as in embryos and neonates. This
finding could: (1) represent residual expression from beta cell precursors; (2) result from alternative developmental pathways
for beta cells; or (3) denote the differentiation potential of these cells. It may be linked to functional heterogeneity.
This heterogeneity in gene expression may provide a means to characterise the functional, cellular and developmental heterogeneity
seen in beta cells.
Content Type Journal ArticleCategory ArticleDOI 10.1007...
Source: Diabetologia - October 22, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Genetic association analysis of LARS2 with type 2 diabetesEmail this article to a colleague.
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Conclusions/interpretation In this study, the largest study examining the role of sequence variants in LARS2 in type 2 diabetes susceptibility, we found no evidence to support previous data indicating a role in type 2 diabetes susceptibility.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1557-7Authors
E. Reiling, Leiden University Medical Center (LUMC) Department of Molecular Cell Biology P.O. Box 9600 2300RC Leiden the NetherlandsB. Jafar-Mohammadi, University of Oxford, Churchill Hospital Oxford Center for Diabetes, Endocrinology and Metabolism Oxford UKE. van ’t Riet, VU Unive...
Source: Diabetologia - October 22, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Cell division autoantigen 1 plays a profibrotic role by modulating downstream signalling of TGF-β in a murine diabetic model of atherosclerosisEmail this article to a colleague.
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Conclusions/interpretation CDA1 plays an important role in vascular ECM accumulation by amplifying TGF-β signalling. This is critical for the profibrotic
effect of TGF-β in the vasculature. CDA1 is therefore a potential target for attenuating vascular ECM accumulation caused
by enhanced TGF-β action, as seen in diabetic atherosclerosis.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1555-9Authors
Y. Pham, Baker IDI Heart and Diabetes Institute Diabetes and Metabolism Division 75 Commercial Rd Melbourne Victoria 3004 AustraliaY. Tu, Baker IDI Heart and Diabetes Institute Diabetes...
Source: Diabetologia - October 22, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Diabetes regulates mitochondrial biogenesis and fission in mouse neuronsEmail this article to a colleague.
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Conclusions/interpretation We propose that: (1) mitochondria undergo biogenesis in response to hyperglycaemia, but the increased biogenesis is insufficient
to accommodate the metabolic load; (2) hyperglycaemia causes an excess of mitochondrial fission, creating small, damaged mitochondria;
and (3) reduction of aberrant mitochondrial fission increases neuronal survival and indicates an important role for the fission–fusion
equilibrium in the pathogenesis of diabetic neuropathy.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1553-yAuthors
J. L. Edwards, University of Michigan Depa...
Source: Diabetologia - October 21, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Relationship between fractional pancreatic beta cell area and fasting plasma glucose concentration in monkeysEmail this article to a colleague.
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Conclusions/interpretation In adult non-human primates a decrement in fractional beta cell area of ∼50% or more leads to loss of glycaemic control.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1552-zAuthors
Y. Saisho, UCLA David Geffen School of Medicine Larry Hillblom Islet Research Center 900 Weyburn Place #A Los Angeles CA 90024-2852 USAA. E. Butler, UCLA David Geffen School of Medicine Larry Hillblom Islet Research Center 900 Weyburn Place #A Los Angeles CA 90024-2852 USAE. Manesso, UCLA David Geffen School of Medicine Larry Hillblom Islet Research Center 900 Weyburn Place #A...
Source: Diabetologia - October 21, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
The adipose tissue/central nervous system axisEmail this article to a colleague.
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Content Type Journal ArticleDOI 10.1007/BF03168181Authors
T. M. Loftus, Johns Hopkins University School of Medicine Department of Biological Chemistry Baltimore Maryland USAD. G. Maggs, Yale University School of Medicine Endocrinology Division New Haven Connecticut USAM. D. Lane, Johns Hopkins University School of Medicine Department of Biological Chemistry Baltimore Maryland USA
Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X
Journal Volume Volume 40
Journal Issue Volume 40, Supplement 3 / March, 1997 (Source: Diabetologia)
Source: Diabetologia - October 21, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Beta-cell ontogeny: growth and deathEmail this article to a colleague.
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Content Type Journal ArticleDOI 10.1007/BF03168183Authors
J. Corbett, Washington University School of Medicine Department of Pathology St. Louis Missouri USAP. Serup, Hagedorn Research Institute Gentofte DenmarkS. Bonner-Weir, Joslin Diabetes Center Boston Massachusetts USAJ. H. Nielsen, Hagedorn Research Institute Gentofte Denmark
Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X
Journal Volume Volume 40
Journal Issue Volume 40, Supplement 3 / March, 1997 (Source: Diabetologia)
Source: Diabetologia - October 21, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Surrogate beta cellsEmail this article to a colleague.
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Content Type Journal ArticleDOI 10.1007/BF03168185Authors
S. Ferber, Sheba Medical Center Institute of Endocrinology Tell-Hashomer IsraelH. Heimberg, Washington University School of Medicine Department of Cell Biology and Physiology St. Louis Missouri USAM. Brownlee, Albert Einstein College of Medicine Diabetes Research Center New York USAC. Colton, Massachusetts Institute of Technology Department of Chemical Engineering Boston Massachusetts USA
Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X
Journal Volume Volume 40
Journal Issue Volume 40, Supplement 3 / March, 1997 (Source: Diabetologia)
Source: Diabetologia - October 21, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Immunology of IDDMEmail this article to a colleague.
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Content Type Journal ArticleDOI 10.1007/BF03168187Authors
H. Noorchashm, University of Pennsylvania Hospital Philadelphia Pennsylvania USAW. Kwok, Virginia Mason Research Center Seattle Washington USAA. Rabinovitch, University of Alberta Edmonton CanadaL. C. Harrison, The Walter and Eliza Hall Institute Victoria Australia
Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X
Journal Volume Volume 40
Journal Issue Volume 40, Supplement 3 / March, 1997 (Source: Diabetologia)
Source: Diabetologia - October 21, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Epidemiology and genetics of diabetic complicationsEmail this article to a colleague.
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Content Type Journal ArticleDOI 10.1007/BF03168189Authors
R. S. Newfield, Cornell University Medical College New York New York USAM. Polak, Hôpital Robert Debré Service d’Endocrinologie et Diabétologie Pédiatriques Paris FranceR. Marchase, University of Alabama Department of Cell Biology Birmingham Alabama USAP. Czernichow, Hôpital Robert Debré Service d’Endocrinologie et Diabétologie Pédiatriques Paris France
Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X
Journal Volume Volume 40
Journal Issue Volume 40, Supplement 3 / March, 1997 (Source: Diabetologia)
Source: Diabetologia - October 21, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Cardiovascular complications of diabetesEmail this article to a colleague.
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Content Type Journal ArticleDOI 10.1007/BF03168193Authors
S. Caprio, Yale University School of Medicine New Haven Connecticut USAS. Wong, Yale University School of Medicine New Haven Connecticut USAK. G. M. M. Alberti, University of Newcastle Human Diabetes and Metabolism Research Centre Newcastle-upon-Tyne UKG. King, Joslin Diabetes Center and Harvard Medical School Boston Massachusetts USA
Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X
Journal Volume Volume 40
Journal Issue Volume 40, Supplement 3 / March, 1997 (Source: Diabetologia)
Source: Diabetologia - October 21, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Growth factors and diabetic nephropathy: Kidney structure and therapeutic interventionsEmail this article to a colleague.
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Content Type Journal ArticleDOI 10.1007/BF03168191Authors
R. W. Bilous, University of Newcastle upon Tyne Department of Medicine UKP. Fioretto, University of Padova Department of Internal Medicine ItalyP. Czernichow, Hopital Robert Debre Paris FranceK. Drummond, Montreal Children’s Hospital Montreal Quebec Canada
Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X
Journal Volume Volume 40
Journal Issue Volume 40, Supplement 3 / March, 1997 (Source: Diabetologia)
Source: Diabetologia - October 21, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Hypoglycaemia and glucose sensingEmail this article to a colleague.
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Content Type Journal ArticleDOI 10.1007/BF03168194Authors
D. Baker, University of California Department of Bioengineering San Diego California USAM. Evans, Kings College School of Medicine and Dentistry Department of Medicine London UKP. Cryer, Washington University School of Medicine St. Louis Missouri USAR. Sherwin, Yale University School of Medicine Department of Internal Medicine New Haven Connecticut USA
Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X
Journal Volume Volume 40
Journal Issue Volume 40, Supplement 3 / March, 1997 (Source: Diabetologia)
Source: Diabetologia - October 21, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
New insulins and other possible therapeutic approachesEmail this article to a colleague.
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Content Type Journal ArticleDOI 10.1007/BF03168195Authors
J. Johannesen, Steno Diabetes Center Gentofte DenmarkK. F. Petersen, Yale University School of Medicine Department of Internal Medicine New Haven Connecticut USAM. Berger, Heinrich Heine Universität Düsseldorf GermanyC. Binder, Steno Diabetes Center Gentofte Denmark
Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X
Journal Volume Volume 40
Journal Issue Volume 40, Supplement 3 / March, 1997 (Source: Diabetologia)
Source: Diabetologia - October 21, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
Pancreatic duct replication is increased with obesity and type 2 diabetes in humansEmail this article to a colleague.
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Conclusions/interpretation Pancreatic duct cell replication is increased in humans in response to both obesity and type 2 diabetes, potentially providing
a mechanism for the increased risk of pancreatitis and pancreatic cancer in those with obesity and/or type 2 diabetes.
Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1556-8Authors
A. E. Butler, UCLA David Geffen School of Medicine Larry Hillblom Islet Research Center 900 Weyburn Place #A Los Angeles CA 90024-2852 USAR. Galasso, UCLA David Geffen School of Medicine Larry Hillblom Islet Research Center 900 Weyburn Place #A Los Angele...
Source: Diabetologia - October 21, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals
