Diagnostic CytopathologyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Clear cell sarcoma: Cytopathologic finding of a "tigroid" backgroundEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - November 20, 2009 Category: Pathology Authors: Swathi Eluri, Syed Z. Ali Source Type: journals

Polymicrobial lung infection in postrenal transplant recipient diagnosed by fine-needle aspiration cytologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of concomitant pulmonary cryptococcosis, aspergillosis, and tuberculosis in a renal transplant recipient diagnosed on FNAC.A 50-year-old renal transplant recipient, asymptomatic for 3 year, presented with intermittent low-grade fever associated with cough, expectoration, and a newly developed cavitatory lesion in the left lung on chest X-ray. Computed tomography-guided FNAC performed on the lung lesion showed fungal profiles with septate hyphae and acute-angled branching consistent with morphology of Aspergillus. In addition, numerous yeast forms of cryptococcus and a few acid-fast mycobacterial tubercle b...
Source: Diagnostic Cytopathology - November 19, 2009 Category: Pathology Authors: Rajan Duggal, Arvind Rajwanshi, Nalini Gupta, Anupam Lal, Manphool Singhal Source Type: journals

Bursal gouty tophus: Fine-needle aspiration cytology intrabursal tophus on FNACEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - November 19, 2009 Category: Pathology Authors: Akansha Gandhi, Seema Aggarwal, Apurba Rajbongshi, Vinod Kumar Arora Source Type: journals

Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of cystadenocarcinoma causing difficulty in cytological diagnosis. A 23-year-old man presented with an asymptomatic mass in the left parotid gland that had been present for 2 years. The mass was elastic hard, measuring 30 × 35 mm in diameter. Preoperative fine-needle aspiration cytology (FNAC) showed a small number of tumor cell clusters in the cystic fluid. The cluster was arranged in a ball-like structure and was cohesive with overlapping. Tumor cells had a small vacuolated, soap-bubble appearance in the cytoplasm. The papillary-cystic variant of acinic cell carcinoma (ACC-PCV) was suggested from these ...
Source: Diagnostic Cytopathology - November 19, 2009 Category: Pathology Authors: Akihiko Kawahara, Hiroshi Harada, Hiroyuki Mihashi, Jun Akiba, Masayoshi Kage Source Type: journals

Cervical cytology in patients with postmenopausal bleedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the role of cervical cytology in the diagnosis of post or perimenopausal (PM) bleeding was explored. A total of 135 patients with PM bleeding were selected. In all these cases both conventional cervical cytology and histopathology follow up were available. The commonest causes of postmenopausal (PM) bleeding with abnormal histopathology were squamous cell carcinoma of cervix (14), endocervical polyp (13), endometrial adenocarcinomas (13) and simple hyperplasia without atypia (13). There were a total 13 cases of endometrial adenocarcinoma and cervical smears of these cases were reported as high grade squamous...
Source: Diagnostic Cytopathology - November 19, 2009 Category: Pathology Authors: Jasleen Kaur, Pranab Dey, Subhash Chandra Saha, Arvind Rajwanshi, Raje Nijhawan, Srinivasan Radhika, Nalini Gupta Source Type: journals

Fine-needle aspiration in myxofibrosarcoma: Experience of Institut CurieEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Myxofibrosarcoma (MFS) is a well-established nosologic entity different from the myxoid variant of malignant fibrous histiocytoma. In an attempt to better define the representative cytologic criteria of MFS, we undertook a review and a reanalysis of a series of 14 cytology samples in 12 patients whose tumors were diagnosed as MFS.Using FNA technique and reviewing the original diagnoses, 11 cases were diagnosed as malignant and three as benign tumors. The cytologic diagnosis of MFS was accurate in seven cases (2 primary tumors, 4 recurrences, and 1 metastasis). Four cases were classified malignant myxoid sarcoma (1 primary ...
Source: Diagnostic Cytopathology - November 7, 2009 Category: Pathology Authors: Pierre Colin, Réal Lagacé, Jean-Michel Caillaud, Xavier Sastre-Garau, Jerzy Klijanienko Source Type: journals

Cancer nucleus: Morphology and beyondEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There are many significant morphological alterations of a nucleus of cancer cell that are detectable by light microscopy on routine staining. These changes are often associated with deranged cellular functions of cancer cell. It is difficult to understand the exact relationship between nuclear morphology and alteration of nuclear structural organization in cancer. Herein, the salient visual and subvisual morphological changes of cancer nuclei and their possible etiology and significance have been reviewed. Diagn. Cytopathol. 2010. © 2009 Wiley-Liss, Inc. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - November 6, 2009 Category: Pathology Authors: Pranab Dey Source Type: journals

Fine-needle aspiration cytology in a case of metastatic spindle cell melanoma in liverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of a 62-year-old male, who was found to have multiple space occupying lesions in liver with large central necrotic areas. Fine-needle aspiration cytology yielded cellular material and was diagnostic of a metastatic malignant spindle cell melanoma. Diagn. Cytopathol. 2010. © 2009 Wiley-Liss, Inc. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - November 5, 2009 Category: Pathology Authors: Sandeep Kumar Arora, Nalini Gupta, Mandeep Kang, Arvind Rajwanshi Source Type: journals

Fine-needle aspiration cytology of extraskeletal myxoid chondrosarcoma: A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a typical case of EMC in left inguinal region of a 71-year-old man, which was first approached by fine-needle aspiration, followed by surgical excision and subsequently diagnosed by microscopic examination and immunohistochemical study. We discuss briefly the differential diagnosis. It is important to separate EMC from other myxoid soft tissue tumors. We point out that although cytologic features may be orientating to a myxoid tumor, may not be completely distinctive. Diagn. Cytopathol. 2010. © 2009 Wiley-Liss, Inc. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - November 5, 2009 Category: Pathology Authors: Juan B. Laforga, Joan M. Gasent Source Type: journals

Cytomorphological diagnosis of tendinous xanthomatosis: A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a rare case of tendinous xanthomatosis in a 23-year-old female, diagnosed on aspiration cytology. Diagn. Cytopathol. 2010. © 2009 Wiley-Liss, Inc. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - November 5, 2009 Category: Pathology Authors: Seema Aggarwal, Akansha Gandhi, Vinod Kumar Arora Source Type: journals

Women [ge]30 years of age with low grade squamous intraepithelial lesion (LSIL) have low positivity rates when cotested for high-risk human papillomavirus: Should we reconsider HPV triage for LSIL in older women?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
High-risk human papillomavirus (HR-HPV) testing for colposcopy triage of low grade squamous intraepithelial lesion (LSIL) is not recommended because of high positive rates in young women. It remains unclear whether HR-HPV testing may be useful for triage of older women. We compiled HR-HPV data for women aged [ge]30 years with LSIL for the period March 1, 2006 to February 28, 2008. Follow-up cervical biopsy information was collected for the period March 1, 2006 to August 15, 2008. We used the Hybrid Capture II test performed on residual material from liquid-based Pap tests. Of 735 women, 254 had HR-HPV testing, and of these...
Source: Diagnostic Cytopathology - November 5, 2009 Category: Pathology Authors: Michael J. Thrall, Debora A. Smith, Dina R. Mody Source Type: journals

Bilateral adrenal gland enlargement secondary to histoplasmosis mimicking adrenal metastases: Diagnosis with EUS-guided FNAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a patient with massive bilateral adrenal enlargement due to histoplasmosis that was diagnosed by EUS-FNA. Trans-duodenal and trans-gastric fine needle aspiration biopsy of both adrenal glands was performed. Rapid onsite cytopathologic evaluation (ROSE) revealed epithelioid histiocytes, singly and in clusters consistent with granulomas. Apparent intracytoplasmic inclusions suggestive of organisms were visible. A Gomori Methenamine Silver stain (GMS) revealed abundant small intracellular budding yeasts, morphologically consistent with Histoplasma; the patient was admitted for amphotericin B intravenous infusion. Hi...
Source: Diagnostic Cytopathology - November 5, 2009 Category: Pathology Authors: Mohamad A. Eloubeidi, Leticia P. Luz, David R. Crowe, Cindi Snowden, Desiree E. Morgan, Pablo J. Arnoletti Source Type: journals

Vertebral osteomyelitis with a rare etiology diagnosed by fine-needle aspiration cytologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report one such case of vertebral osteomyelitis due to Aspergillus diagnosed by FNAC in a well-controlled diabetic patient who presented with nonspecific symptoms and in whom a clinical and radiological diagnosis of Pott's spine was considered. The present case stresses the importance of early cytologic diagnosis of vertebral Aspergillus osteomyelitis, which in conjunction with appropriate timely medical and surgical treatment, offers good recovery without much sequelae or threat to life. Diagn. Cytopathol. 2010. © 2009 Wiley-Liss, Inc. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - November 5, 2009 Category: Pathology Authors: BN Nandeesh, Usha Kini, Betty Alexander Source Type: journals

Fine-needle aspiration biopsy as an initial diagnostic modality in a clinically unsuspected case of invasive maxillary fungal sinusitis: A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cases of invasive fungal lesions involving the paranasal sinuses are generally diagnosed either on histologic examination or on fungal culture. Here, we report a case of invasive fungal sinusitis diagnosed primarily by a fine-needle aspiration biopsy (FNAB).Our patient was a 36-year-old male who presented with a history of slowly progressive, painless swelling over the left cheek. The only positive clinical finding was a bony hard swelling in the left maxillary region, which was clinically interpreted as "fibrous dysplasia." A computed tomographic (CT) examination of the paranasal sinuses showed a soft tissue attenuation l...
Source: Diagnostic Cytopathology - November 5, 2009 Category: Pathology Authors: Neha Singh, Neelaiah Siddaraju, Surendra Kumar, Femela Muniraj, Satvinder Bakshi, Suryanarayanan Gopalakrishnan Source Type: journals

"Strap cells" in primary prostatic rhabdomyosarcoma in a childEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - November 5, 2009 Category: Pathology Authors: Shobha Castelino-Prabhu, Syed Z. Ali Source Type: journals

Osteoclast-rich undifferentiated carcinoma of the urinary tract: Cytologic findings and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report herein, the case of a 63-year-old man who was evaluated at The Johns Hopkins Hospital for gross hematuria of 4 months duration. Urinary cytology displayed high-grade malignant cells with scattered osteoclast-like giant cells in a background of acute inflammation and abundant red blood cells. Subsequently, a transurethral tumor resection was performed, which revealed infiltrating undifferentiated carcinoma with osteoclast-like giant cells. The rarity of this neoplasm and its resemblance to other giant cell-rich processes may pose diagnostic difficulties. A review of the important differential diagnoses is also pre...
Source: Diagnostic Cytopathology - November 5, 2009 Category: Pathology Authors: Shobha Castelino-Prabhu, Syed Z. Ali Source Type: journals

Interconnecting cytoplasmic processes on fine-needle aspiration smears of carotid body paragangliomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - November 5, 2009 Category: Pathology Authors: Andrew M. Schreiner, Karen Fried, Grace C. H. Yang Source Type: journals

Combining fine-needle aspiration biopsy (FNAB) and high-resolution melt analysis to reduce diagnostic delay in mycobacterial lymphadenitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tuberculous lymphadenitis is the most common cause of extra-pulmonary tuberculosis (TB) in developing countries. Lymphadenitis caused by non-tuberculous mycobacteria (NTM) requires consideration, particularly in immunocompromised patients and children in developed countries. Fine-Needle Aspiration Biopsy (FNAB) offers a valuable specimen collection technique, but culture confirmation, mycobacterial speciation and drug resistance testing (if indicated) is often unavailable in TB endemic areas and result in unacceptable diagnostic delay.We evaluated the diagnostic value of high-resolution DNA melting (HRM) analysis in the di...
Source: Diagnostic Cytopathology - November 5, 2009 Category: Pathology Authors: Colleen A. Wright, Kim G. P. Hoek, Ben J. Marais, Paul van Helden, Rob M. Warren Source Type: journals

Oral epithelial atypical changes in apparently healthy oral mucosa exposed to smoking, alcohol, peppers and hot meals, using the AgNOR and Papanicolaou staining techniquesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To evaluate cytological atypical changes in apparently healthy oral mucosa exposed to smoking, alcohol, hot meals, and peppers using the AgNOR and Papanicolaou methods. A total of 180 individuals were evaluated, of which 60 were smokers, 34 were alcohol users, 52 were habitual peppers and hot meal (exposed) consumers, 24 were non-exposed, and 10 were patients with Oral Squamous Cell Carcinoma (OSCC), as an internal control. Cytological materials were obtained by brushing of buccal mucosa, on the border of the tongue and on the floor of the mouth, and participants underwent the Papanicolaou test for cytological changes and ...
Source: Diagnostic Cytopathology - November 5, 2009 Category: Pathology Authors: Hussain Gadelkarim Ahmed, Syda Omer M. Ali Ebnoof, Mohmmed Omer M. Hussein, Afra Yousif A. Gbreel Source Type: journals

Spontaneous infarction of pleomorphic adenoma: Report of a case simulating malignancy on fine-needle cytology sampleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ischemic or hemorrhagic infarction has been described as an uncommon but possible complication of fine-needle cytology sampling in numerous organs, more frequently the thyroid, the salivary glands, the breast, the lymph node, and the kidney. In these situations, infarction appears to be directly related to the vascular disturbances caused by needle sampling, though fine this latter might be. One case of a spontaneous infarction of a parotid pleomorphic adenoma in a 46-year-old lady is here described in which the cytopathologic findings, which were related to ischemic infarction, preceded fine-needle cytology sampling and m...
Source: Diagnostic Cytopathology - November 5, 2009 Category: Pathology Authors: Franco Fulciniti, Nunzia Simona Losito, Gerardo Botti, Marco Manola, Franco Ionna Source Type: journals

Minocycline-induced black thyroidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - November 4, 2009 Category: Pathology Authors: Allison H. S. Hall, Sarah M. Bean Source Type: journals

The diagnostic value of endobronchial ultrasound-guided needle biopsy in lung cancer and mediastinal adenopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endobronchial ultrasonography (EBUS) has emerged as a new diagnostic tool that allows the bronchoscopist to see beyond the airway, including pulmonary and mediastinal lesion. The real time EBUS-guided transbronchial needle aspiration (TBNA) has advanced the diagnostic yield in primary lung pathology and mediastinal lymph node staging of lung carcinoma. Sixty-four patients (36 males, 28 females, ages ranging from 16 to 86 years) with peribronchial lung lesions and mediastinal and/or hilar lymph node lesions underwent EBUS-TBNA. All patients had intraoperative cytological assessment by smears on aspiration samples or touch p...
Source: Diagnostic Cytopathology - November 3, 2009 Category: Pathology Authors: Wei Sun, Kunchang Song, Michael Zervos, Harvey Pass, Joan Cangiarella, Costas Bizekis, Bernard Crawford, Beverly Y. Wang Source Type: journals

Correlation between morphology and human telomerase gene amplification in bronchial brushing cells for the diagnosis of lung cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to investigate the frequency of amplification of the human telomerase gene (TERC), as measured by fluorescence in situ hybridization (FISH), in routine liquid-based cytological preparations from bronchial brushing specimens, and to assess the associations between TERC amplification, cytological diagnosis, and cytological morphology, in order to obtain further insight into these associations. Bronchial brushings from 102 patients with lung carcinoma (52 squamous-cell carcinomas, 22 adenocarcinomas, 28 small cell lung carcinomas) and 40 patients with nonmalignant disease were used. Amplification of ...
Source: Diagnostic Cytopathology - October 30, 2009 Category: Pathology Authors: Yi-Bo Fan, Lin Ye, Tian-Yu Wang, Guang-Ping Wu Source Type: journals

Modified fine-needle aspiration technique for diagnosis of granulomatous skin lesions with special reference to leprosy and cutaneous tuberculosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Skin infections are commonly assessed by slit skin or scrape methods. Fine-needle aspiration biopsy (FNAB) is highly effective especially with blanching of skin to ensure good yield and reduced bleeding. The aim of this study was to assess usefulness of cytology, especially modified FNAB technique, in diagnosis of leprosy and cutaneous tuberculosis and to identify specific cytological characteristics for diagnosis and classification. The study was conducted on 40 patients - 25 cases of leprosy and 15 cases of cutaneous tuberculosis. Smears were prepared using modified FNAB technique, slit skin, and scrape methods (dependin...
Source: Diagnostic Cytopathology - October 28, 2009 Category: Pathology Authors: Ghazala Mehdi, Veena Maheshwari, Hena A. Ansari, Sonal Saxena, Rajeev Sharma Source Type: journals

Myoepithelial carcinoma of the parotid gland metastatic to the kidney: Case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a case of metastatic myoepithelial carcinoma of the kidney from the parotid gland diagnosed by computed tomography guided fine-needle aspiration biopsy. Immunochemical studies are important to confirm myoepithelial differentiation of the tumor cells. Knowledge of the clinical history, radiographic characterization, andmorphological correlation with the primary tumor are emphasized. Diagn. Cytopathol. 2009. © 2009 Wiley-Liss, Inc. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - October 26, 2009 Category: Pathology Authors: Zhiqin Wang, Bruce Herrington, Mary R. Schwartz, Rodolfo Laucirica Source Type: journals

Simultaneous Chlamydia trachomatis and HPV infection in pregnant womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pregnancy is associated with HPV infection and with Chlamydia trachomatis (CT) infection mostly due to the natural immunosuppression. In addition, pregnancy associated to CT infection can lead to adverse conditions to the woman and fetus, and CT is also believed to be a co-factor in human immunodeficiency virus infection and HPV-induced cervical cancer. The aim of this study was to establish the odds ratios (OR) of CT infection in to HPV-infected pregnant women and vice versa of women stratified by age ( (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - October 26, 2009 Category: Pathology Authors: Sônia Maria Miranda Pereira, Daniela Etlinger, Luciana Silva Aguiar, Stela Verzinhasse Peres, Adhemar Longatto Filho Source Type: journals

Respiratory cytology: Differential diagnosis and pitfallsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pulmonary cytology can be challenging and has its share of diagnostic pitfalls. Reactive atypia can occasionally be alarming, leading to diagnostic pitfall for a false-positive diagnosis of malignancy, even for experienced cytopathologists (Naryshkin and Young, Diagn Cytopathol 1993;9:89-97). In addition, cytologic preparations can show an absence of architectural clues, leading to diagnostic difficulties. Some conditions can cytologically as well as clinically and radiographically mimic malignancies, making these pitfalls even more frequent (Bedrossian et al., Lab Med 1983;14:86-95). A recent report stated that "no labora...
Source: Diagnostic Cytopathology - October 23, 2009 Category: Pathology Authors: Reda S. Saad, Jan F. Silverman Source Type: journals

Living with uncertainty: Equivocal Pap test results and the evolution of ASC terminologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the evolution of terminology for equivocal Pap test findings from the original Papanicolaou classification to the current the Bethesda System 2001 atypical squamous cells terminology, the implication and use of these terms, and the changing landscape of cervical neoplasia screening, which prompted these terminology changes. Emerging issues related to improving risk stratification through the introduction of additional terms and the impact of human papillomavirus testing may alter terminology of equivocal findings in the future. Diagn. Cytopathol. 2009. © 2009 Wiley-Liss, Inc. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - October 22, 2009 Category: Pathology Authors: Lydia Pleotis Howell, Maaya Wilton, John Bishop, Alaa Afify Source Type: journals

Combination of MUC5ac and WT-1 immunohistochemistry is useful in distinguishing pancreatic ductal carcinoma from ovarian serous carcinoma in effusion cytologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Malignant ascites may be the first presentation of an unsuspected cancer. Pancreas and ovary are among the organs that are usually evaluated as a source of primary. The purpose of this study is to investigate a panel of immunohistochemical stains to help differentiate pancreatic from ovarian carcinoma. We evaluated the immunohistochemical staining of eight commercially available antibodies MUC1, MUC2, MUC5ac, Wilm's tumor susceptibility gene 1 (WT1), cytokeratin 7 (CK7), CK20, CA125, and CA19.9 in 25 effusion specimens with evidence of metastatic carcinoma including 14 ovarian serous carcinomas, 9 pancreatic adenocarcinoma...
Source: Diagnostic Cytopathology - October 22, 2009 Category: Pathology Authors: Liying Han, Vaishali Pansare, Mousa Al-Abbadi, Mujtaba Husain, Jining Feng Source Type: journals

Nephroblastoma is a success of paediatric oncologic therapy. How further can we go?: Results of a cyto-histologic correlation studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephroblastoma is a success of paediatric oncologic therapy, yet, there are still some cases where favourable response to preoperative chemotherapy is not achieved. Fine needle biopsy has the role of diagnostic confirmation and, idyllically of predicting a response to preoperative chemotherapy.To advance in this aim, we retrieved a total of 14 nephroblastomas, (seven male patients and seven female with a mean age of 44.4 months), diagnosed in our department by fine needle biopsy and submitted afterward to chemotherapy and nephrectomy, in the last 10 years.Correlation between cytologic features, (morphology, cell death, and...
Source: Diagnostic Cytopathology - October 20, 2009 Category: Pathology Authors: Helena Barroca Source Type: journals

Two cases of intracranial germinoma showing a cell arrangement mimicking carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report two cases of intracranial germinoma, in which it was necessary to distinguish between intracranial germinoma and metastatic carcinoma in cytological specimens. Cytologically, not only single tumor cells or loosely connective tumor cells but also closely packed clusters of cells and pair cells were recognized. Immunocytochemically, almost all tumor cells were immunoreactive for M2A, placental alkaline phosphatase, and c-kit. Closely packed clusters were also immunoreactive for pan-cytokeratin. Therefore, Cytopathologists should be aware that tumor cell clusters, mimicking carcinoma might appear in cytological spec...
Source: Diagnostic Cytopathology - October 19, 2009 Category: Pathology Authors: Yoshiki Ohta, Takao Suzuki, Takahiko Tonoike, Shigeharu Hamatani, Nobuyuki Ohike, Akira Shiokawa, Miki Kushima, Hidekazu Ota Source Type: journals

Pulmonary crystal-storing histiocytosis diagnosed by computed tomography-guided fine-needle aspirationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the first case of pulmonary CSH diagnosed by fine-needle aspiration biopsy. A patient with a history of urothelial carcinoma developed a lung nodule, which was evaluated by fine-needle aspiration biopsy. Cytologic examination revealed macrophages with abundant cytoplasmic crystals diagnostic of CSH. Based on this cytologic interpretation, additional clinical laboratory evaluation was pursued and revealed a previously unknown monoclonal serum protein. CSH must be differentiated from other non-neoplastic and neoplastic lesions and when diagnosed, should trigger a search for an underlying lymphoproliferative disorde...
Source: Diagnostic Cytopathology - October 19, 2009 Category: Pathology Authors: William U. Todd, Joseph J. Drabick, Michael G. Benninghoff, Elizabeth E. Frauenhoffer, Dani S. Zander Source Type: journals

Cytopathologist-performed ultrasound-guided fine-needle aspiration of parathyroid lesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examines cytopathologist-performed ultrasound-guided fine-needle aspiration (UG-FNA) in diagnosis of parathyroid lesions. Between January 1, 2007 and December 31, 2008, seven patients with PHPT or other parathyroid lesions with one or more sonographically-visible thyroid masses underwent cytopathologist-performed UG-FNA with immediate cytological evaluation (ICE). One mass was palpable and nine were nonpalpable. Three parathyroid adenomas, two benign colloid nodules, one papillary carcinoma, three parathyroid cysts, and one thyroid cyst were diagnosed. The nodules in three patients with parathyroid adenomas were...
Source: Diagnostic Cytopathology - October 19, 2009 Category: Pathology Authors: David Lieu Source Type: journals

Anal pap smear for high risk womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - October 19, 2009 Category: Pathology Authors: Chhanda Bewtra Source Type: journals

Cytoplasmic vacuoles can occur as an artifact in small cell carcinoma smearsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - October 19, 2009 Category: Pathology Authors: Mousa A. Al-Abbadi, Agnes K. Hamati, Rowena Velilla, Debra Mitchell Nelson Source Type: journals

Histiocytic sarcoma with interdigitating dendritic cell differentiation: A case report with fine needle aspiration cytology and review of literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A hybrid histiocytic sarcoma-interdigitating dendritic cell sarcoma was found in a small perinephric lymph node of an asymptomatic 80-year-old man, who presented a year ago with two small foci of lung metastasis found during routine chest X-ray. Fine needle aspiration cytology demonstrated interconnecting long and thin cell processes radiating from dendrite-like neoplastic cells with oval, enlongated, reniform, and irregular nuclei with vesicular chromatin and distinct nucleoli. Histology showed spindled epitheliod and histiocytic cells with abundant, slightly eosinophilic cytoplasm with indistinct cell borders and forming...
Source: Diagnostic Cytopathology - October 19, 2009 Category: Pathology Authors: Grace C. H. Yang, Carrie E. Besanceney, Wayne Tam Source Type: journals

Significance of cell proliferation markers (Minichromosome maintenance protein 7, topoisomerase II[alpha] and Ki-67) in cavital fluid cytology: Can we differentiate reactive mesothelial cells from malignant cells?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to evaluate whether immunocytochemical expressions of proliferation markers, such as minichromosome maintenance protein 7 (MCM 7), topoisomerase II[alpha] (topo II[alpha]), and Ki-67, in reactive mesothelial cells and malignant cells obtained from cavital fluids could be useful for their differential diagnosis. Samples diagnosed as reactive mesothelial cells (14 cases) or malignant tumors (28 cases) in cavital fluids were examined. Immunocytochemical staining of MCM 7, topo II[alpha], and Ki-67 was performed with the universal immunoperoxidase polymer method. In reactive mesothelial cells, MCM 7 w...
Source: Diagnostic Cytopathology - October 9, 2009 Category: Pathology Authors: Fumikazu Kimura, Jumpei Kawamura, Jun Watanabe, Shingo Kamoshida, Kenji Kawai, Isao Okayasu, Sadahito Kuwao Source Type: journals

Anal cytology in patients with AIDSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the present study was to study the prevalence of abnormal anal cytology in patients with AIDS. Anal smears, obtained with a cytobrush, of 102 HIV-positive patients of the Emilio Ribas Institute (Sao Paulo, Brazil) were collected, and only after that, the patients were submitted to anoscopy. Thirty-two patients had LSIL and 14 others had HSIL. Squamous intra-epithelial lesions were also observed in 38% of the patients without condyloma (18/47): in 9 of the 33 patients without history of condyloma (27%) and in 9 of the 14 patients who had previously treated condyloma (64%). An invasive squamous cell carcinom...
Source: Diagnostic Cytopathology - October 7, 2009 Category: Pathology Authors: E. E. Calore, S. R. Nadal, C. R. Manzione, S. C. Horta, R. R. Santos, L. M. Nadal Source Type: journals

Cytomorphologic characteristics of fine needle core biopsy of multicystic peritoneal mesothelioma: A case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of MPM in a middle aged female that was diagnosed by fine needle core biopsy and touch preparations, allowing for appropriate clinical management. The cytomorphologic features of needle core biopsy, immunocytochemical studies and differential diagnosis are discussed. Furthermore, despite its infrequency, the current case emphasizes the importance of the inclusion of this entity in the differential diagnosis of cystic lesions of the abdomen and pelvis at the time of on-site evaluation and final diagnosis, in order to avoid misinterpretation of strips of benign mesothelial cells as inadequate for diagnosis. ...
Source: Diagnostic Cytopathology - October 6, 2009 Category: Pathology Authors: Anna M. Collins Kemp, Ritu Nayar, Denise De Frias, Xiaoqi Lin Source Type: journals

Comparison of the clinical significance of the Papanicolaou test interpretations LSIL cannot rule out HSIL and ASC-H Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite the two-tiered classification of dysplasia in The Bethesda System (TBS), rare cases fall into the category squamous intraepithelial lesion (SIL) of indeterminate grade. These Pap tests are often interpreted as "LSIL/ASC-H" or "LSIL" with a comment indicating the presence of cells with features approaching HSIL. Patients with LSIL/ASC-H have a significant risk of CIN 2 or worse (29-61.5%) on follow-up cervical biopsies, similar to the risk of CIN 2 or worse in patients with ASC-H Pap tests (24-68%). The purpose of this study was to compare patients with ASC-H and LSIL/ASC-H Pap tests. Women with LSIL/ASC-H had a sli...
Source: Diagnostic Cytopathology - October 6, 2009 Category: Pathology Authors: Megan J. Difurio, Thomas Mailhiot, Michael J. Sundborg, Karen K. Nauschuetz Source Type: journals

What's in a name? Evidence that Papanicolaou, not Babes, deserves credit for the PAP testEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of our study is to elaborate on the ongoing controversy regarding the origination of the Pap test between the supporters of George Papanicolaou and Aurel Babes. We studied the original articles published by Aurel Babes and George Papanicolaou and conducted a comparative evaluation of both methods. Babes' method is radically different from Papanicolaou's method. Differences included the sampling method, the fixation and staining technique, and the interpretation of the results regarding cases of cervical cancer. We conclude that theestablishment of the technique in clinical practice and the ideaof its applicatio...
Source: Diagnostic Cytopathology - October 6, 2009 Category: Pathology Authors: A. Diamantis, E. Magiorkinis, G. Androutsos Source Type: journals

Evidence-based evaluation of the risks of malignancy predicted by thyroid fine-needle aspiration biopsiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A National Cancer Institute (NCI) "Thyroid Fine-Needle Aspiration (FNA) State of the Science Conference" recently proposed standardized nomenclature and "risks of malignancies" associated with various diagnostic categories. We evaluated the evidence levels of the data used by NCI to predict malignancy risks and whether those estimates had clinical validity in our patient population.Eight hundred seventy-nine patients underwent thyroid FNA during 2006. FNA diagnoses were translated into NCI diagnostic categories, and 2-year follow-up retrospective information was obtained. Four percentages of malignancies were calculated fo...
Source: Diagnostic Cytopathology - October 6, 2009 Category: Pathology Authors: A. M. Marchevsky, A. E. Walts, S. Bose, R. Gupta, X. Fan, D. Frishberg, K. Scharre, J. Zhai Source Type: journals

Epithelioid angiosarcoma: A neoplasm with potential diagnostic challengesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, the patient is a 24-year-old man presenting with testicular pain, a pelvic mass, and innumerable liver nodules. Immediate interpretation of the needle core biopsies of the pelvic mass and liver lesions initially favored a poorly differentiated adenocarcinoma. Unusual positive immunohistochemical stains for CD30 and CK7 ultimately led the investigation toward a tumor of mesenchymal origin. Further, immunohistochemical evaluation demonstrated positive CD31 and Factor VIII staining and established the final diagnosis of epithelioid angiosarcoma. The tumor cells were negative for CD34, CK20, alpha-fetoprotein, ...
Source: Diagnostic Cytopathology - October 6, 2009 Category: Pathology Authors: Christine F. Lin, Denis DeFrias, Xiaoqi Lin Source Type: journals

Comparison of the sensitivity of conventional cytology and the ThinPrep Imaging System for 1,083 biopsy confirmed high-grade squamous lesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report our experience with ThinPrep Imaging since its introduction into our routine gynecological cytology service. 87,284 split sample pairs reported using the Imaging System demonstrated a decrease in unsatisfactory reports (3.65% for CS and 0.87% for TPI) and an increase in possible high grade and definite high-grade squamous reports (1.57% for CS and 1.62% for TPI).For 1,083 biopsy confirmed high-grade lesions, the correct diagnosis of high grade or possible high-grade squamous disease was made on the ThinPrep imaged slide in 61.0% (661/1,083) of cases and on the CS in 59.4% (643/1,083). This was not statistically s...
Source: Diagnostic Cytopathology - October 6, 2009 Category: Pathology Authors: J. A. Halford, T. Batty, T. Boost, J. Duhig, J. Hall, C. Lee, K. Walker Source Type: journals

HPV data can be used as a cytopatholoy laboratory quality indicatorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - September 30, 2009 Category: Pathology Authors: Liron Pantanowitz, Maryanne Hornish, Q. Jackie Cao, Robert A. Goulart Source Type: journals

Lipid-rich carcinoma of breast: A case report with fine needle aspiration cytologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - September 29, 2009 Category: Pathology Authors: Inmaculada Catalina-Fernández, Javier Sáenz-Santamaria Source Type: journals

An audit of cervical cytology smear results reported as "Dyskaryosis, difficult to grade; Colposcopy advised"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - September 29, 2009 Category: Pathology Authors: S. Conlon, M. Redmond, I. Nolan, M. Leader, E. W. Kay, A. Grace Source Type: journals

Inflammatory events as detected in cervical smears and squamous intraepithelial lesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study presents an analysis of 1,008,879 smears. Of each smear, the age of the woman and the reason for smear taking (screening or indication) was available. The cytoscores (per mille) for these codes were calculated. For the screening smears, the cytoscores were for koilocytosis (HPV) 2.6, for Trichomonas vaginalis 1.9, for dysbacteriosis 31.4, for Candida albicans 9.8, for Gardnerella vaginalis 0.7, for Actinomyces 6.9, for Chlamydia 0.8, and for non-specific inflammatory changes 66.4. For the calculation of the Odds Ratio (OR), normal smears were used as a reference. The cytoscores for Chlamydia and Gardnerella cova...
Source: Diagnostic Cytopathology - September 29, 2009 Category: Pathology Authors: Anne M. E. Roeters, Mathilde E. Boon, Maarten van Haaften, F. Vernooij, Tj. Romke Bontekoe, A. Peter M. Heintz Source Type: journals

Fine-needle aspiration of primary osseous lesions: A cost effectiveness studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fine-needle aspiration (FNA) is not widely used in the work-up of osseous lesions because of concerns regarding its high incidence of nondiagnostic specimens. Although several studies have shown that FNA is less expensive than surgical biopsy, the authors are aware of only one prior study evaluating the cost effectiveness of FNA, which includes the cost of incisional or core needle biopsies necessary to establish a diagnosis when the initial FNA was noncontributory. A computerized search of the pathology records of three medical centers was performed to obtain all FNAs of primary osseous lesions. For each FNA case, all sub...
Source: Diagnostic Cytopathology - September 29, 2009 Category: Pathology Authors: Lester J. Layfield, Leslie G. Dodd, Sharon Hirschowitz, Susie Newman Crabtree Source Type: journals

Emperipolesis in Rosai-Dorfman disease presenting as a peritonsillar massEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstracts. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - September 29, 2009 Category: Pathology Authors: Evan A. Farkash, Kurt A. Yaeger, Martha Bishop Pitman Source Type: journals