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Histological correlation of mammographically detected breast calcifications – A need for rational protocolsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Stereotactic biopsy is the preferred method for histological diagnosis of mammographic calcification. Radiography to assess the presence of calcification in biopsies before processing confirms whether the mammographic calcification is included in the biopsy. Often, the pathologist encounters the situation when calcification is present in the specimen x-ray but not in the histological sections. This may be because the paraffin block been incompletely sectioned or that the calcium been lost during processing. Further sections (beyond three levels) are examined to try to detect calcification. Many laboratories routi...
Source: Diagnostic Histopathology - November 16, 2009 Category: Pathology Authors: Rajiv Swamy Tags: Review Source Type: journals

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(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - November 16, 2009 Category: Pathology Source Type: journals

Endometrial metaplasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Epithelial metaplasia refers to the replacement of normal epithelium at a given site by mature benign epithelium inappropriate to that site. The endometrium is not unique in that it too demonstrates a spectrum of metaplastic epithelia. Some of these cytoplasmic alterations are better termed “changes” as they are thought not to represent true metaplastic transformation of the endometrial epithelium. The terminology is rather confusing as these two terms have been used interchangeably in the literature. This process may be encountered in benign conditions but can also be seen in association with endometrial hyp...
Source: Diagnostic Histopathology - October 16, 2009 Category: Pathology Authors: Helen F. Stringfellow Tags: Mini-Symposium: Pathology of the Uterus and Fallopian Tube Source Type: journals

Molecular diagnostics of acute myeloid leukaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The laboratory diagnostic work-up of acute myeloid leukaemia (AML) has evolved from a largely morphology-based approach to algorithms that integrate clinical data as well as results obtained by immunological and molecular techniques. With the continued development of targeted therapies, the role of molecular diagnostics will continue to become increasingly important with regards to prognosis, selection of and prediction of response to treatment strategies, and monitoring of minimal residual disease. In this review, we provide an overview of currently used diagnostic algorithms for AML and discuss key laboratory i...
Source: Diagnostic Histopathology - October 13, 2009 Category: Pathology Authors: Zhuang Zuo, Pranil Chandra, Yong Hannah Wen, Hartmut Koeppen Tags: Review Source Type: journals

Postmortem investigation of sudden unexpected death in infancy: current issues and autopsy protocolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article will review the evidence for current postmortem investigation protocols, with particular emphasis on features which remain controversial or uncertain. The article will not discuss issues related to non-accidental or inflicted injury, including inflicted head injury in infancy, which remain contentious and are beyond the scope of this review. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - October 13, 2009 Category: Pathology Authors: Martin A. Weber, Neil J. Sebire Tags: Mini-Symposium: Paediatric Pathology Source Type: journals

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(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - October 13, 2009 Category: Pathology Source Type: journals

Lymph node pathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - October 12, 2009 Category: Pathology Authors: Sarah E. Coupland Tags: Self-Assessment Source Type: journals

Gynaecological cancers in genetically susceptible women: new thoughts on tubal pathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Women may be genetically susceptible to development of gynecological cancers. Major familial ovarian cancer syndromes include site-specific ovarian cancer, breast/ovarian cancer, and hereditary non-polyposis colon cancer (HNPCC). The former two syndromes are linked to BRCA1 and BRCA2 genes while DNA repair genes such as hMSH2 and hMLH1 are commonly involved in HNPCC. Carriers are also prone to endometrial carcinoma. BRCA mutation related ovarian tumours are more likely to be high grade serous whilst borderline tumours are conspicuously absent. Papillary serous carcinomas of the peritoneum and fallopian tube are a...
Source: Diagnostic Histopathology - October 12, 2009 Category: Pathology Authors: Ui-Soon Khoo, Dan-Hua Shen, Richard Wing-Cheuk Wong, Annie Nga-Yin Cheung Tags: Mini-Symposium: Pathology of the Uterus and Fallopian Tube Source Type: journals

Molecular genetics of endometrial carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the genetic changes of endometrial carcinogenesis in the light of morphologic features of the tumors and their precursors. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - October 9, 2009 Category: Pathology Authors: Lluis Catasus, Alberto Gallardo, Jaime Prat Tags: Mini-Symposium: Pathology of the Uterus and Fallopian Tube Source Type: journals

Problematic areas in the reporting of endometrial carcinomas in hysterectomy specimensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Accurate pathological reporting of endometrial carcinomas in hysterectomy specimens is critical in determining the tumour stage, which together with other clinical and pathological parameters, provides prognostic value and determines the need for adjuvant therapy. In this review, a variety of parameters which are important in accurate pathological staging of endometrial carcinomas are discussed, especially concentrating on areas which potentially result in diagnostic difficulty for pathologists. Topics discussed include assessment of the presence of and depth of myometrial invasion, tumour involvement of adenomyo...
Source: Diagnostic Histopathology - October 5, 2009 Category: Pathology Authors: W. Glenn McCluggage Tags: Mini-Symposium: Pathology of the Uterus and Fallopian Tube Source Type: journals

Three cases of histiocytic necrotizing lymphadenitis without granulocytic infiltration with some atypical features – an expanding spectrumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report three cases of Kikuchi–Fujimoto disease which posed diagnostic difficulties and highlight the use of clinicopathological correlation given the absence of any one diagnostic histological, laboratory or immunohistochemical feature. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - September 22, 2009 Category: Pathology Authors: S.M.H. Rizvi, M. Calaminici Tags: Instructive Case Source Type: journals

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(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - September 14, 2009 Category: Pathology Source Type: journals

Paediatric soft tissue tumours: from histology to molecular diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Paediatric sarcomas comprise a diverse group of relatively uncommon neoplasms, with morphological features that range from primitive round cell tumours to fasciculated spindle cell cancers. These histologies frequently overlap and cause diagnostic confusion or uncertainty, so that ancillary testing has become the standard of practice. In previous years, immunohistochemistry and electron microscopy were commonly used, but the genetic revolution has led to the discovery of unique molecular markers that can be detected using routinely fixed and embedded tissues. Detection of characteristic genetic features of paedia...
Source: Diagnostic Histopathology - September 13, 2009 Category: Pathology Authors: Zhongxin Yu, David M. Parham Tags: Mini-Symposium: Paediatric Pathology Source Type: journals

Renal tumours of childhood: an overviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The diagnosis, management and prognosis of paediatric renal tumours have significantly improved over the last 40 years. Pathologists have played a significant role in these developments through their work in multicentre national and international trials and studies, by recognizing new tumour entities, as well as favourable and unfavourable histological features of different tumours. Over the last few years, a number of new tumour entities have been recognized in the kidney due to the application of molecular techniques, but also on the basis of their characteristic clinicopathological features recognized by study...
Source: Diagnostic Histopathology - September 13, 2009 Category: Pathology Authors: Gordan M. Vujanić Tags: Mini-Symposium: Paediatric Pathology Source Type: journals

Pathology of minimal metastatic disease in sentinel lymph nodes in breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Sentinel lymph node biopsy (SLNB) is now widely used as an alternative to axillary lymph node dissection to stage the axilla in women with early-stage breast cancer. The detailed pathological work-up of sentinel nodes has presented new challenges in the field of pathology. For example, many patterns of low volume disease – isolated tumour cells (ITCs) and micrometastasis (MI) – are difficult to classify and current classification systems are only moderately reproducible. The significance of ITCs and MI in terms of predicting non-SLN involvement and overall outcome is also unclear. The optimal methodology for ...
Source: Diagnostic Histopathology - September 1, 2009 Category: Pathology Authors: Helen Ingoldsby, Grace Callagy Tags: Mini-Symposium: Breast Pathology Source Type: journals

Low grade endometrial stromal sarcoma with epithelial differentiation mimicking endometriosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the case of a 52-year-old female who presented with a pelvic tumour showing very minimal cytological atypia mimicking endometriosis, but diagnosed as low grade ESS with epithelial differentiation. We also discuss the possible role of a characteristic translocation t(7;17)(p15;q21), resulting in the fusion of the JAZF1/JJAZ1 genes, in aiding the histological diagnosis. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - August 31, 2009 Category: Pathology Authors: Rinsey Rose Kurian, Thumuluru Kavitha Madhuri, Simon Butler-Manuel, Francesca Micci, Silvana di Palma Tags: Instructive Case Source Type: journals

Breast cancer subtypes and molecular biomarkersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In the last decade, comprehensive whole genome expression profiling by microarray technology has extensively defined breast cancer into distinct molecular subtypes that differ in terms of patient outcome and response to systemic treatment. However, gene microarrays are expensive and several issues relating to data analysis, reproducibility and validation still need to be resolved before this technology is routinely adopted into the clinical setting. In this review, we discuss the role of established molecular markers currently used in the management of breast cancer. We outline recent evidence describing their us...
Source: Diagnostic Histopathology - August 31, 2009 Category: Pathology Authors: Marc P.J. McCafferty, Nuala A. Healy, Michael J. Kerin Tags: Mini-Symposium: Breast Pathology Source Type: journals

Gynaecological cytologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - August 31, 2009 Category: Pathology Authors: Tanya Levine Tags: Self-assessment Source Type: journals

The pathologist and the hipEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A practical overview is given of the gross and histopathological examination of hip specimens that are sent to the pathologist, as well descriptions of most lesions that can be found. Some pitfalls that should be avoided are pointed out. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - August 31, 2009 Category: Pathology Authors: F. Eulderink Tags: Mini-Symposium: Osteoarticular Pathology Source Type: journals

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(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - August 31, 2009 Category: Pathology Source Type: journals

Overview of recommendations of HER2 testing in breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: HER2 overexpression is present in approximately 15% of invasive breast cancers, and is an important prognostic and predictive marker. HER2 status should be determined in all newly diagnosed breast cancers, and testing involves immunohistochemistry looking for protein overexpression and/or fluorescence in-situ hybridization (FISH) to detect the presence of HER2 gene amplification. Both techniques can be performed on formalin-fixed, paraffin-embedded tissue. Each has limitations, and preanalytical factors, such as fixation, can impact the accuracy of results. FISH is more reproducible than immunohistochemistry, and...
Source: Diagnostic Histopathology - August 20, 2009 Category: Pathology Authors: Elena Provenzano, Nicola Johnson Tags: Mini-Symposium: Breast Pathology Source Type: journals

Pathology of B3 lesions of the breastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Breast needle core biopsy is a widely used technique for evaluation of mammographic and clinical breast abnormalities, screen detected and symptomatic. The majority of biopsies can be coded as B2 (benign) or B5 (malignant). However, certain lesions merit a B3 designation, signifying ‘uncertain malignant potential’. This is a heterogenous group including atypical intraduct epithelial proliferation, lobular neoplasia, radial scar, papillary lesions and columnar cell change. Their common denominator is the low but significant rate of malignancy within the lesion or adjacent tissue, necessitating excision biopsy ...
Source: Diagnostic Histopathology - August 19, 2009 Category: Pathology Authors: Brian D. Hayes, Cecily M. Quinn Tags: Mini-Symposium: Breast Pathology Source Type: journals

How to design and use a research databaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the scope of databases for common histopathology research projects, the ethical and legal considerations, design of the database structure, coding of data items, and import and export of data from databases. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - August 18, 2009 Category: Pathology Authors: Simon S. Cross, Ian R. Palmer, Timothy J. Stephenson Tags: Review Source Type: journals

Pathology of bone injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Although the response to injury in bone has some characteristics in common with that in soft tissues, bone repair differs in that it occurs in a mineralized tissue that has a high degree of cellular and molecular organization. Bone is a unique tissue in the body as it is capable of reconstituting itself following injury. Almost any pathological insult to bone can be said to cause a bone injury. This review deals with the response to bone injury that occurs secondary to physical agents, notably mechanical trauma, pressure and ionizing radiation. These agents evoke a common pathological response, but a number of sp...
Source: Diagnostic Histopathology - August 5, 2009 Category: Pathology Authors: Nick A. Athanasou Tags: Mini-Symposium: Osteoarticular Pathology Source Type: journals

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(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - July 31, 2009 Category: Pathology Source Type: journals

The surgical pathology of skeletal metastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In this review, we aim to (1) outline the nature and scale of metastatic skeletal disease; (2) describe the role of the multidisciplinary musculoskeletal medical and surgical team; and (3) discuss and illustrate the diagnostic pathology approach with emphasis on its clinical relevance. The employment of immunohistochemistry in helping to establish the occult primary site of metastatic skeletal tumours is reviewed. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - July 26, 2009 Category: Pathology Authors: D.C. Mangham, P.N.M. Tyrrell, W.P. Cool Tags: Mini-Symposium: Osteoarticular Pathology Source Type: journals

Diagnostic approach to congenital osteochondrodysplasias at autopsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Individual congenital disorders of bone and cartilage are rare but as a group they are not uncommon. The incidence of osteochondrodysplasias is 2–5 in 10 000 liveborn. Approximately 50 of the known 370 skeletal malformations are lethal. The frequency in perinatal autopsies is approximately 1–2 in 100. For a proper diagnosis X-rays (both anteroposterior and lateral), storage of DNA and, in case of an autopsy, histology of bone and cartilage are necessary. Classification of the osteochondro-dysplasias is based on a combination of radiological abnormalities and the molecular defect. The most common lethal oste...
Source: Diagnostic Histopathology - July 26, 2009 Category: Pathology Authors: Peter G.J. Nikkels Tags: Mini-Symposium: Osteoarticular Pathology Source Type: journals

Testicular tumours of adrenogenital syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Testicular ‘tumour’ of adrenogenital syndrome usually presents as bilateral testicular masses in patients with congenital adrenal hyperplasia. A thorough clinical evaluation is usually sufficient for diagnosis. In most circumstances this condition is well managed by replacement hormone therapy and infrequently requires surgical intervention with consequent histopathology evaluation. Attempt at differentiation from the morphologically similar Leydig cell tumour on biopsy tissue has potential for misdiagnosis; however, this distinction is crucial due to significantly different clinical interventions and the rel...
Source: Diagnostic Histopathology - July 15, 2009 Category: Pathology Authors: Anshuman Chaturvedi, Sangeeta Verma Tags: Instructive Case Source Type: journals

Breast diseases associated with systemic medical disordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Benign breast lesions are associated with a wide range of systemic medical conditions. These lesions can have features that are clinically and radiologically suspicious for carcinoma. However, with the exception of diabetes mellitus-associated breast disease, these lesions are rare and the general histopathologist is unlikely to encounter them regularly.This review examines the most common benign breast lesions associated with systemic medical disorders and drugs, including the typical clinical and radiological findings, pathogenesis, and macroscopic and microscopic findings. The specific features and immunohisto...
Source: Diagnostic Histopathology - July 13, 2009 Category: Pathology Authors: Ian Wilkinson, Jeremy Thomas Tags: Mini-Symposium: Pathology of Benign Breast Disease Source Type: journals

Benign sclerosing lesions of the breastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Benign sclerosing lesions of the breast comprise primarily sclerosing adenosis and radial scar/complex sclerosing lesions (RS/CSL). Other benign lesions which may become fibrosed and malignant tumours frequently associated with a schirrous reaction, may enter their differential diagnosis either radioloigcally or on pathological examination. This review focuses on the pre-operative diagnosis and operative pathology of these lesions with particular reference to their prognosis and recent trends in their management. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - July 13, 2009 Category: Pathology Authors: Joseph Loane Tags: Mini-Symposium: Pathology of Benign Breast Disease Source Type: journals

Benign microcalcification and its differential diagnosis in breast screeningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: One of the commonest abnormalities identified by breast screening is microcalcification. Of the 1.64 million women screened in England last year, 30,000 underwent further assessment allied to cytological or histological sampling; approximately 40% of these were for microcalcification. Sixty-three per cent of the women undergoing sampling had benign changes only. Benign breast microcalcification is, therefore, a significant clinical issue. Lesions that result in calcification may mimic in-situ and invasive malignancy both radiologically and pathologically. The common benign and borderline pathologies that cause ca...
Source: Diagnostic Histopathology - July 13, 2009 Category: Pathology Authors: Colin A. Purdie, Denis McLean Tags: Mini-Symposium: Pathology of Benign Breast Disease Source Type: journals

Fibroepithelial neoplasms of the breastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Fibroepithelial neoplasms include a large number of common lesions encountered in both symptomatic and breast screening practice. Nearly all are fibroadenomas and are harmless, but they can present a range of differing histologies. The area of most concern is the separation of fibroadenomas from phyllodes tumours, arguably an arbitrary exercise. What is most important to achieve is the recognition of those lesions in the fibroadenoma–phyllodes spectrum with the potential to do harm, either in the form of recurrence or metastases. These are few in number and the key features to identify, with the rare exception ...
Source: Diagnostic Histopathology - July 13, 2009 Category: Pathology Authors: Andrew M. Hanby Tags: Mini-Symposium: Pathology of Benign Breast Disease Source Type: journals

Rare benign lesions of the breastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In this review a wide-range of uncommon benign breast lesions, which can present as a breast mass, are described and discussed. The entities are loosely grouped into five sections; developmental lesions, in which all components of the normal breast are present, epithelial lesions, stromal lesions, lesions associated with luminal secretion and, finally, a group of soft tissue lesions, which although not specific to the breast can present in the breast. We have attempted to address the common diagnostic pitfalls associated with the lesions described. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - July 13, 2009 Category: Pathology Authors: Ghada H. Bashat, Iain D. Miller, Ashley D. Graham Tags: Mini-Symposium: Pathology of Benign Breast Disease Source Type: journals

Role of automation in cervical cytologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The introduction of liquid-based cytology (LBC) in UK laboratories has set a platform for automation in the cervical screening process. Currently, machines are used in sample preparation, recording of results and electronic transfer of data to various agencies. The UK government has recently set a turnaround time target by 2010 of 14 days from the sample being taken to the result being received by the woman. This target gives laboratories only 7 days to process and report cervical samples. Currently, two FDA-approved semi-automated machines are available which can expedite the microscopic analysis of the process;...
Source: Diagnostic Histopathology - July 2, 2009 Category: Pathology Authors: Mina Desai Tags: Mini-Symposium: Cervical Cytology Source Type: journals

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(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - June 30, 2009 Category: Pathology Source Type: journals

Autopsy pathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - June 21, 2009 Category: Pathology Authors: Matthew S. Lyall, C. Paul Johnson Tags: Self-assessment Source Type: journals

The polymerase chain reaction and pathology practiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Pathology practice is increasingly augmented with molecular tests for improved diagnostics and patient management. The polymerase chain reaction (PCR) is foremost amongst these techniques. This review explains the principles of PCR and the methodological factors that contribute to a successful assay. Key PCR technique variations, such as reverse transcription (RT)-PCR and quantitative real-time (q) PCR, are described and an overview is provided of how PCR products are analysed. The review includes examples of PCR usage in clinical practice for the detection of infectious and genetic diseases, for tumour diagnosti...
Source: Diagnostic Histopathology - June 21, 2009 Category: Pathology Authors: Mark F. Evans Tags: Review Source Type: journals

Detecting and interpreting glandular lesions in cervical cytologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Abnormal glandular cells can appear in cervical samples not only from the cervix but from the whole of the genital tract from the fallopian tubes to the vulva, and from extra-uterine sources including primary tumours of the peritoneal cavity and metastases from distant sites. There is also a wide variation in morphology in benign, pre-malignant and malignant entities which on occasion challenge even the most experienced microscopist. This review outlines areas of difficulty with particular reference to liquid-based cytology, and provides guidance on how to approach a sample which has been identified by the primar...
Source: Diagnostic Histopathology - June 21, 2009 Category: Pathology Authors: Christine Waddell Tags: Mini-Symposium: Cervical Cytology Source Type: journals

The future of cervical screening in the UKEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Full implementation of liquid-based cervical cytology (LBC) coupled with changes in the screening age range and frequency have resulted in an annual workload reduction equivalent to 10 average-sized cytology laboratories. This and increased productivity of LBC have resulted in a growing mismatch between laboratory capacity and workload, which is a strong driver for laboratory amalgamation and reconfiguration as recommended in the Carter reports. Other drivers for reconfiguration will come from human papillomavirus (HPV) testing for triage of low-grade abnormality and test of cure, automation and HPV vaccination. ...
Source: Diagnostic Histopathology - June 21, 2009 Category: Pathology Authors: John H.F. Smith Tags: Mini-Symposium: Cervical Cytology Source Type: journals

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(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - May 15, 2009 Category: Pathology Source Type: journals

Synchronous adenocarcinoma and marginal zone B-cell lymphoma of the colon: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a marginal zone B-cell lymphoma, which was incidentally diagnosed in a colonic resection for adenocarcinoma in a 77-year-old woman. It is important to be aware of the association, so as not to regard all lymphoid infiltrates surrounding a carcinoma as being reactive in nature. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - April 29, 2009 Category: Pathology Authors: Neil Sahasrabudhe, Nitin Khirwadkar, Richard Prescott Tags: Instructive Cases Source Type: journals

Diagnostic difficulties in lesions of the minor salivary glandsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A wide range of lesions arise from the intra-oral salivary glands, which present a diagnostic challenge to specialists and generalists alike. Of the salivary neoplasms, pleomorphic adenoma is the commonest, but its morphological diversity may bring several other entities to mind, notably polymorphous low-grade adenocarcinoma, particularly in a small incisional biopsy. Polymorphous low grade adenocarcinoma in turn shares features with adenoid cystic carcinoma. When the differential diagnosis includes these three tumours, immunohistochemistry can assist in the face of overlapping morphology. The other salivary neop...
Source: Diagnostic Histopathology - April 29, 2009 Category: Pathology Authors: Paul M. Speight, A. William Barrett Tags: Mini-Symposium: Oral and Maxillofacial Surgery Source Type: journals

Current concepts of odontogenic tumoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the most common and important odontogenic tumours and highlights key features that will assist the pathologist to identify and appropriately classify these lesions. In addition, several new concepts of classification are discussed and important new developments in our understanding of the biology of these lesions are highlighted. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - April 29, 2009 Category: Pathology Authors: Richard C.K. Jordan, Paul M. Speight Tags: Mini-Symposium: Oral and Maxillofacial Surgery Source Type: journals

Surgical pathology of oral cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Oral squamous cell carcinoma (OSCC) is a common malignancy with an increase in incidence reported in some developing countries. Although the aetiological risk factors are well documented and advances have been made in the different treatment modalities, the mortality and morbidity of OSCC have not improved significantly over the last decades. The histopathologist is an important member of the multidisciplinary team responsible for the management of OSCC patients. This review will discuss the different histological subtypes of OSCC as well as other pathological features that can influence the behaviour of OSCC and...
Source: Diagnostic Histopathology - April 29, 2009 Category: Pathology Authors: Willie F.P. van Heerden, Andre W. van Zyl Tags: Mini-Symposium: Oral and Maxillofacial Surgery Source Type: journals

Pathology of the teethEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Teeth are rarely submitted to general pathology departments, but on the rare occasions they are, the response is often confusion. This practically focused review aims to demystify the assessment of teeth, outlining the abnormalities which may be assessed without specialist equipment and others which may require specialist input. We will also provide a brief summary of some of the more common dental abnormalities and outline some forensic aspects of tooth pathology. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - April 29, 2009 Category: Pathology Authors: Keith D. Hunter, Geoff Craig Tags: Mini-Symposium: Oral and Maxillofacial Surgery Source Type: journals

Papillary and verrucous lesions of the oral mucosaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A variety of verrucous and papillary lesions affect the oral mucosa. Those which are benign and reactive, for example squamous papilloma or verruciform xanthoma, usually present little diagnostic difficulty. However, dysplastic and malignant verrucous and papillary lesions are a much greater diagnostic challenge, not helped by confusing terminology. Papillary hyperplasia is a reactive inflammatory condition, whereas verrucous hyperplasia is a potentially malignant dysplasia, and probably part of the spectrum of verrucous carcinoma. Papillary carcinomas, at least in the oral context, are essentially verrucous hype...
Source: Diagnostic Histopathology - April 29, 2009 Category: Pathology Authors: Gareth J. Thomas, A. William Barrett Tags: Mini-Symposium: Oral and Maxillofacial Surgery Source Type: journals

Proliferating trichilemmal tumourEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Cutaneous cysts represent a large proportion of the specimens submitted for histopathological examination and comprise a wide spectrum of entities. The less common keratinous cysts are of pilar or trichilemmal type and proliferating trichilemmal tumour is infrequent. Transitional changes between an ordinary trichilemmal cyst and proliferating trichilemmal (pilar) tumour are seen. These usually behave in a benign fashion according to their bland cytology and architecture, although occasional examples with frank malignancy have been reported, simulating squamous cell carcinoma. This paper reports two cases represen...
Source: Diagnostic Histopathology - April 29, 2009 Category: Pathology Authors: Yvonne Bury, Clive Bloxham Tags: Instructive Cases Source Type: journals

Spindle cell lesions of the head and neck: an overview and diagnostic approachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The diagnosis of lesions with spindle cell morphology is often difficult. For biopsies from the head and neck assessment is further complicated by the range of tissues present at this site, and the limited amount of material which may be available for study. We provide an overview of the lesions with a spindle cell morphology that may be encountered in this region and detail a histological approach to these biopsies which can aid the pathologist with classification. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - April 29, 2009 Category: Pathology Authors: Catriona E. Anderson, Awatif Al-Nafussi Tags: Review Source Type: journals

Infections in the HIV-infected childEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The HIV pandemic has given rise to a growing population of children at risk for infectious disease, particularly in the developing world where the majority of the estimated 2.5 million children living with human immunodeficiency virus (HIV) worldwide reside. This review will explore the opportunistic infections encountered in the HIV-infected child. Due to space constraints, only the commonest acquired immunodeficiency syndrome (AIDS)-defining infections, including mycobacterial, fungal, viral and parasitic diseases, will be discussed. The epidemiological, clinical and morphological features unique to the HIV-inf...
Source: Diagnostic Histopathology - April 29, 2009 Category: Pathology Authors: Yetish Sing, Dhirendra Govender Tags: Mini-Symposium: HIV/AIDS-Associated Pathology in Children Source Type: journals

Lymph node pathology in the HIV-positive childEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Lymphadenopathy in the HIV-positive child may be due to a range of non-neoplastic (non-infective and infective) and neoplastic conditions. Reactive changes and infective diseases, mostly of mycobacterial aetiology, are encountered most often. The common neoplastic conditions include non-Hodgkin lymphoma (Burkitt lymphoma and diffuse large B- cell lymphoma) and Kaposi sarcoma. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - April 29, 2009 Category: Pathology Authors: Komala Pillay Tags: Mini-Symposium: HIV/AIDS-Associated Pathology in Children Source Type: journals