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Mixed hepatoblastoma and teratoma of the liver in a 3-year-old child: a unique combination and clinical challengeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we describe the diagnosis and clinical management of a large liver tumor in a 3-year-old child that displayed the features of both, conventional hepatoblastoma and malignant teratoma. Pathological assessment on a pre-operative bioptical specimen showed an immature teratoid tumor with no area of hepatoblastic differentiation present. Histological and immunhistological examination of the resected tumor specimen additionally showed tumor areas of very different differentiation pattern intermixed with each other, namely areas of hepatoblastoma-typical and neuroblastoma-like morphology as well a areas of rhadomy...
Source: Diagnostic Pathology - November 12, 2009 Category: Pathology Authors: Alexander MollAlexander KrenauerUta BierbachHolger TillWolfgang HirschIvo LeuschnerNicole SchmitzChristian WittekindThomas Aigner Source Type: journals

Evaluation of 7q31 region improves the accuracy of EGFR FISH assay in non small cell lung cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data strengthen the usefulness of 7q31 region evaluation to discriminate EGFR amplification from chromosome 7 polysomy in controversial EGFR FISH positive cases. Since it has been reported a possible different contribution of amplification and polysomy to TKIs susceptibility in NSCLC, the clear distinction between these two genetic events may be important to identify a subset of patients more responsive to the therapy. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - November 4, 2009 Category: Pathology Authors: Laura CasorzoMara CoriglianoPaolo FerreroTiziana VenesioMauro Risio Source Type: journals

Utility of a dual immunostain cocktail comprising of p53 and CK20 to aid in the diagnosis of non-neoplastic and neoplastic bladder biopsiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion:This is the first study in the literature to use DIHC of p53+CK20 in distinction of non-neoplastic and neoplastic bladder lesions. Dual staining by p53+CK20 cocktail allows for histologic correlation and diminishes the risk of losing the area of interest in limited biopsy specimens. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - October 13, 2009 Category: Pathology Authors: Isil YildizRosemary RecavarrenHenry ArmahSheldon BastackyRajiv DhirAnil Parwani Source Type: journals

Collagenofibrotic glomerulopathy: Three case reports in BrazilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These cases are the first from South America to be reported, and they are about an idiopathic renal disease that is not related to any specific races or locations. The reports contribute to a better understanding of this disease, which although not so prevalent, should be considered as an importantly differential diagnostic of cases of proteinuria. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - September 24, 2009 Category: Pathology Authors: Renata FerreiraFabiano CustodioCamila GuimaraesRosana CorreaMarlene Reis Source Type: journals

Juvenile pleomorphic adenoma of the cheek: a case report and review of literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pleomorphic adenoma, also called benign mixed tumor, is the most common tumor of the salivary glands. About 90% of these tumors occur in the parotid gland and 10% in the minor salivary glands. The most common sites of pleomorphic adenoma of the minor salivary glands are the palates followed by lips and cheeks. Other rare sites include the throat, floor of the mouth, tongue, tonsil, pharynx, retromolar area and nasal cavity. In children, intraoral pleomorphic adenomas of the cheek are extremely rare with only three cases reported to date. Here we report a case of pleomorphic adenoma of minor salivary glands of the cheek in ...
Source: Diagnostic Pathology - September 21, 2009 Category: Pathology Authors: Taufik DalatiMahmoud Hussein Source Type: journals

cylindroma of the breast: a case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a breast cylindroma in a previously healthy 62 year old female detected through a national breast screening program. The patient had no significant family or past medical history, and specifically no history of breast or skin diseases. The tumor consisted of well circumscribed islands of epithelial cells surrounded by a dense membrane material, and focally containing hyaline globules. At low power the islands of tumour cells formed a "jig-saw" pattern, which is typical of cylindroma, but was present within normal breast parenchyma and no had direct connection with the overlying skin. Two distinct cell populations...
Source: Diagnostic Pathology - September 1, 2009 Category: Pathology Authors: Amr MahmoudDavid HillMartin O'sullivanMichael Bennett Source Type: journals

Histopathological study of lesions of the caruncle: a 15-year single center reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The most common caruncle lesions were epithelial tumors followed by chronic inflammation and melanocytic lesions. Although most of the lesions were benign, there was a great number of misdiagnose based on the clinical suspicious. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - August 30, 2009 Category: Pathology Authors: Helena SolariMarcelo VenturaMaria Eugenia OrellanaGustavo NovaisDevinder CheemaMiguel Burnier Source Type: journals

The human placenta releases substances that drive lung cancer into apoptosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Human placenta releases substances that mediate apoptosis and reduce proliferation in tumor tissue and cell culture. As even sterile-filtrated medium caused the mentioned effects we hypothesize one or more soluble mediators. The detailed way of promoting apoptosis and nature of these mediators need to be elucidated in further studies. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - August 20, 2009 Category: Pathology Authors: Sebastian MarwitzTobias ZeiserHolger SchultzDaniel KahlerMahdi AbdullahHans-Peter HauberPeter ZabelEkkehard VollmerTorsten Goldmann Source Type: journals

High and intermediate grade ductal carcinoma in-situ of the breast: a comparison of pathologic features in core biopsies and excisions and an evaluation of core biopsy features that may predict a close or positive margin in the excisionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we analyzed a group of intermediate and high-grade DCIS cases to determine how well the core biopsy predicts the maximal pathology in the associated excisions, and to determine if there are any core biopsy morphologic features that may predict a close (less than or equal to 0.2cm) or positive margin in the subsequent excision. Forty-nine consecutive paired specimens [core biopsies with a maximal diagnosis of DCIS, and their corresponding excisions, which included 20 and 29 specimens from mastectomies and breast conserving surgeries respectively] were evaluated in detail. In 5 (10%) of 49 cases, no residual c...
Source: Diagnostic Pathology - August 18, 2009 Category: Pathology Authors: Oluwole FadareNathan ClementMohiedean Ghofrani Source Type: journals

Primary ovarian leiomyoma associated with endometriotic cyst presenting with symptoms of acute appendicitis: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The origin of ovarian leiomyoma is still unresolved. In our case, the tumor probably arose from smooth muscle cells derived from myofibroblasts that originate from metaplastic ovarian stromal cells present in the rim of the endometriotic cyst. Despite its rarity, ovarian leiomyoma should be considered in the differential diagnosis of ovarian spindle cell tumors. Appropriate diagnosis may require additional immunohistochemical analysis in some cases. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - July 29, 2009 Category: Pathology Authors: Davor TomasTanja LenicekNeven TuckarZvonimir PuljizMario LedinskyBozo Kruslin Source Type: journals

PR3-ANCA in Wegener's granulomatosis prime human mononuclear cells for enhanced activation via TLRs and NOD1/2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In conclusion, PR3-ANCA prime human mononuclear cells to produce cytokines upon stimulation with various microbial components by up-regulating the TLR and NOD signaling pathway, and these mechanisms may partially participate in the inflammatory process in Wegener's granulomatosis. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - July 13, 2009 Category: Pathology Authors: Akiko UeharaTadasu SatoAtsushi IwashiroSou Yokota Source Type: journals

p16 as a diagnostic marker of cervical neoplasia: a tissue microarray study of 796 archival specimensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Immunohistochemical analysis of p16INK4a expression is a useful diagnostic tool. Expression is related to the degree of histological dysplasia, suggesting that it may have prognostic and predicative value in the management of cervical neoplasia. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - July 8, 2009 Category: Pathology Authors: Iana LesnikovaMarianne LidangStephen Hamilton-DutoidJorn Koch Source Type: journals

Sub-typing of renal cell tumours; contribution of ancillary techniquesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: To accurately subclassify renal cell carcinomas, simple ancillary techniques would possibly resolve all difficult cases. The relative incidence of sub-types of renal cell carcinoma is relatively consistent the world over. However, in India, RCCs afflict the patients two decades earlier. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - June 27, 2009 Category: Pathology Authors: Dinesh PradhanNandita KakkarAmanjit BalShrawan Kumar SinghKusum Joshi Source Type: journals

Expression of p-AKT characterizes adenoid cystic carcinomas of head and neck with a higher risk for tumor relapsesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Adenoid cystic carcinomas positive for p-AKT show a higher relapse risk. However, other parameters of glucose metabolism investigated here or proliferation (Ki67) were not predictive in this entity. Our findings demonstrate a possible background for therapeutic approaches targeting the inhibition of PI3K/AKT pathway. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - June 18, 2009 Category: Pathology Authors: Hans-Ullrich VolkerMatthias ScheichAnnette BerndtImme HaubitzAlexandra MetzgerHans-Konrad Muller-HermelinkUlrike KammererMelanie Schmidt Source Type: journals

Mobile cell-phones (M-phones) in telemicroscopy: increasing connectivity of isolated laboratoriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The use of otherwise already widely available technologies, without any need for adaptors or otherwise additional technology, could significantly increase opportunities and quality diagnostics while lowering costs and considerably increasing connectivity between most isolated laboratories and distant reference center. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - June 18, 2009 Category: Pathology Authors: Livia BellinaEduardo Missoni Source Type: journals

Synchronous primary carcinoid tumor and primary adenocarcinoma arising within mature cystic teratoma of horseshoe kidney: a unique case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This unique and first case herein presented with synchronous primary carcinoid tumor and primary adenocarcinoma arising within mature cystic teratoma of horseshoe kidney emphasizes the need for thorough sectioning and entire submission for histologic evaluation of mature cystic teratomas, in order to avoid missing multiple additional histogenetically distinct neoplasms. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - June 14, 2009 Category: Pathology Authors: Henry ArmahAnil ParwaniAleksandr Perepletchikov Source Type: journals

A case of lipomatous pleomorphic adenoma in the parotid glandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This is the sixth case of lipomatous pleomorphic adenoma in the English literature. Recognition of this rare subtype of pleomorphic adenoma is important for clinical diagnosis and management. On CT scan, it may not be detected possibly due to the extensive fatty component. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - June 4, 2009 Category: Pathology Authors: Takeshi Kondo Source Type: journals

Xp11.2 translocation renal cell carcinoma occurring during pregnancy with a novel translocation involving chromosome 19: a case report with review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The recently recognized renal cell carcinomas (RCCs) associated with Xp11.2 translocations (TFE3 transcription factor gene fusions) are rare tumors predominantly reported in children. They comprise at least one-third of pediatric RCCs and only few adult cases have been reported. Here, we present a case of Xp11.2 translocation RCC in 26-year-old pregnant female. Her routine antenatal ultrasonography accidentally found a complex cystic right renal mass. Further radiologic studies revealed unilocular cyst with multiple mural nodules at inferior pole of right kidney, which was suspicious for RCC. She underwent right radical ne...
Source: Diagnostic Pathology - May 18, 2009 Category: Pathology Authors: Henry B Armah, Anil V Parwani, Urvashi Surti and Sheldon I Bastacky Source Type: journals

Immunohistochemical localization of mdm-2, p27 Kip1 and bcl-2 in Warthin's tumor of the parotid gland.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Mdm-2 played a tumor-suppressor role that might be implicated with the benign behavior of Warthin's tumor. The mutual expression of both p27Kip1 and bcl-2 suggested a protective role of these slowly proliferating cells from apoptosis to maintain their survival and elevated bcl-2 expression offers a significant protection against p27Kip1-mediated apoptosis. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - May 16, 2009 Category: Pathology Authors: Ehab S Abd Elhamid and Marwa M Elshafei Source Type: journals

PAS staining of bronchoalveolar lavage cells for differential diagnosis of interstital lung diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bronchoalveolar lavage (BAL) is a useful diagnostic tool in interstitial lunge diseases (ILD). However, differential cell counts are often non specific and immunocytochemistry is time consuming. Staining of glyoproteins by periodic acid Schiff (PAS) reaction may help in discriminating different forms of ILD. In addition, PAS staining is easy to perform. BAL cells from patients with idiopathic pulmonary fibrosis (IPF) (n = 8), sracoidosis (n = 9), and extrinsic allergic alveolitis (EAA) (n = 2) were investigated. Cytospins from BAL cells were made and cells were stained using Hemacolor quick stain and PAS staining. Lymphocy...
Source: Diagnostic Pathology - April 23, 2009 Category: Pathology Authors: Hans P Hauber and Peter Zabel Source Type: journals

Mortality in human sepsis is associated with downregulation of Toll-like receptor 2 and CD14 expression on blood monocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pattern recognition receptors are a key component of the first line host defense against infection, recognizing specific microbial products. We hypothesize that monocyte hyporesponsiveness in human sepsis is associated with a downregulation of the pattern recognition receptors Toll-like receptor (TLR)-2 and TLR4. Protein expression of CD14, TLR2 and TLR4 on blood monocytes was examined using flow cytometry from 29 patients with sepsis and 14 healthy controls. In addition LPS stimulated TNF-alpha and IL-10 production was studied in a 24 hour whole blood assay. We found an increased expression of CD14, TLR2 and TLR4 in pati...
Source: Diagnostic Pathology - April 16, 2009 Category: Pathology Authors: Bernhard Schaaf, Karen Luitjens, Torsten Goldmann, Tobias van Bremen, Friedhelm Sayk, Christoph Dodt, Klaus Dalhoff and Daniel Droemann Source Type: journals

Primary Anaplastic Large Cell Lymphoma of the Breast Arising in Reconstruction Mammoplasty Capsule of Saline Filled Breast Implant after Radical Mastectomy for Breast Cancer: An Unusual Case PresentationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Primary ALK negative ALCL arising at the site of saline filled breast implant is rare. It is still unclear whether chemotherapy and breast implantation increases risk of secondary hematological malignancies significantly. However, it is important to be aware of these complications and need for careful pathologic examination of tissue removed for implant related complications to make the correct diagnosis for further patient management and treatment. It is important to be aware of this entity at this site as it can be easily misdiagnosed on histologic grounds and to exclude sarcomatoid carcinoma, malignant melan...
Source: Diagnostic Pathology - April 2, 2009 Category: Pathology Authors: Mona R.Y Bishara, Catharine Ross and Monalisa Sur Source Type: journals

Reproducibility determination of WHO classification of endometrial hyperplasia / well differentiated adenocarcinoma and comparison with computerized morphometric data in curettage specimens In Iran.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: It may be necessary to make some revisions in WHO classification for endometrial hyperplasia and precancerous lesions. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - March 25, 2009 Category: Pathology Authors: Narges Izadi-Mood, Maryam Yarmohammadi, Seyed Ali Ahmadi, Guity Irvanloo, Hayedeh Haeri, Ali Pasha Meysamie and Mahmood Khaniki Source Type: journals

Systematic comparison of RNA extraction techniques from frozen and fresh lung tissues: checkpoint towards gene expression studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data demonstrated that although the GTC technique has yielded a higher amount of RNA, the SGC technique was much more superior with respect to the reliable generation of an intact RNA and effectively amplified longer products in fresh as well as in frozen tissues. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - March 24, 2009 Category: Pathology Authors: Jai Prakash Muyal, Vandana Muyal, Brajesh Pratap Kaistha, Carola Seifart and Heinz Fehrenbach Source Type: journals

On the significance of Surfactant Protein-A within the human lungsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article gives an overview about the state of knowledge on SP-A focused in applications for human pulmonary disorders and points out the importance for pathology-orientated research approaches using immunohistochemistry or in situ hybridization as promising methods to further elucidate the role of this molecule in adult lung diseases. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - March 12, 2009 Category: Pathology Authors: Torsten Goldmann, Daniel Kahler, Holger Schultz, Mahdi Abdullah, Dagmar S. Lang, Florian Stellmacher and Ekkehard Vollmer Source Type: journals

Is there any potential link among caspase-8, p-p38 MAPK and bcl-2 in clear cell renal cell carcinomas? A comparative immunohistochemical analysis with clinical connotationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: For the first time the prognostic impact of caspase-8 and p-p38 was studied in a series of ccRCCs, using immunohistochemistry in formalin-fixed and paraffin-embedded tissue sections. The suggestive relationship of caspase-8 with patients' clinical outcome, as well as the role of p-p38 within different grade categories, mandates further studies in larger cohorts of RCCs. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - February 17, 2009 Category: Pathology Authors: Vassilis Samaras, Maria Tsopanomichalou, Angeliki Stamatelli, Christos Arnaoutoglou, Efstathios Samaras, Marianthi Arnaoutoglou, Hercules Poulias and Calypso Barbatis Source Type: journals

LED-FISH: Fluorescence microscopy based on light emitting diodes for the molecular analysis of Her-2/neu oncogene amplificationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Light emitting diodes (LED), which are available as small monochromatic light sources with characteristic features such as maximum illumination power combined with minimum energy consumption and extremely long lifespan have already proved as a highly potential low-cost alternative for specific diagnostic applications in clinical medicine such as tuberculosis fluorescence microscopy. Likewise, the most reliable evaluation of Her-2/neu (c-erbB2) gene amplification, which has been established in the last few years for routine diagnosis in clinical pathology as determinant towards Herceptin-based treatment of patients with bre...
Source: Diagnostic Pathology - December 16, 2008 Category: Pathology Authors: Dagmar S Lang, Tobias Zeiser, Holger Schultz, Florian Stellmacher, Ekkehard Vollmer, Peter Zabel and Torsten Goldmann Source Type: journals

Editorial: Diagnostic Pathology continues to riseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nearly three years have passed since the first issue of our journal Diagnostic Pathology had been accessible via our open access publisher BiomedCentral. About 150 scientific articles have been published since then. Therefore, we want to express our deep gratitude to all authors who submitted their articles. They took into account two constraints, namely paying a publication fee, and, in addition, knowing that our journal has not yet been included into the citation index list. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - December 16, 2008 Category: Pathology Authors: Klaus Kayser Source Type: journals

LED-FISH: Fluorescence microscopy based on light emitting diodes for the molecular analysis of Her-2/neu oncogene amplification.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Light emitting diodes (LED), which are available as small monochromatic light sources with characteristic features such as maximum illumination power combined with minimum energy consumption and extremely long lifespan have already proved as a highly potential low-cost alternative for specific diagnostic applications in clinical medicine such as tuberculosis fluorescence microscopy. Likewise, the most reliable evaluation of Her-2/neu (c-erbB2) gene amplification, which has been established in the last few years for routine diagnosis in clinical pathology as determinant towards Herceptin-based treatment of patients with bre...
Source: Diagnostic Pathology - December 16, 2008 Category: Pathology Authors: Dagmar S Lang, Tobias Zeiser, Holger Schultz, Florian Stellmacher, Ekkehard Vollmer, Peter Zabel and Torsten Goldmann Source Type: journals

Intrathyroidal parathyroid carcinoma: a case report with clinical and histological findingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The chance of an intrathyroidal localization of a parathyroid gland is about 1-3%. Among the causes of hyperparathyroidism, parathyroid carcinomas occur in less than 1% of patients. Hence, the probability of a parathyroid carcinoma to be intrathyroidal is less than 0.01% of all cases of hyperparathyroidism. Although parathyroid adenoma and carcinoma have disparate natural history, it can be difficult to differentiate between the two entities. Clinical presentation and operative findings may raise suspicion, but may not be conclusive, if there is no evidence of invasion or metastasis, and especially, if the para...
Source: Diagnostic Pathology - November 25, 2008 Category: Pathology Authors: Labiba Temmim, Fred Sinowatz, Wiam I Hussein, Osama Al-Sanea and Hady El-Khodary Source Type: journals

Flow cytometric immunophenotyping (FCI) of lymphoma: Correlation with histopathology and immunohistochemistryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: FCI is a sensitive and specific method in diagnosis and classification of NHL as well as in detection of monoclonality. False negative results could be due to the presence of heterogeneous populations of lymphocytes in special types of lymphoma. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - November 6, 2008 Category: Pathology Authors: Abeer M Al-Sayed, Mohammad H El-Borai, Abeer A Bahnassy and Shadia MS Al-Gerzawi Source Type: journals

Virtual karyotyping with SNP microarrays reduces uncertainty in the diagnosis of renal epithelial tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results show that virtual karyotypes generated by SNP arrays can be used as a practical ancillary study for the classification of renal epithelial tumors with complex or ambiguous morphology. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - November 6, 2008 Category: Pathology Authors: Jill M Hagenkord, Anil V Parwani, Maureen A Lyons-Weiler, Karla Alvarez, Robert Amato, Zoran Gatalica, Jose M Gonzalez-Berjon, Leif Peterson, Rajiv Dhir and Federico A Monzon Source Type: journals

Mucinous breast carcinoma presenting as Paget's disease of the nipple in a man: A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: To our best knowledge this is the first case reported of mucinous male breast cancer presenting as Paget disease of the nipple. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - October 24, 2008 Category: Pathology Authors: Dimitrios Peschos, Elena Tsanou, Pavlos Dallas, Konstantinos Charalabopoulos, Christos Kanaris and Anna Batistatou Source Type: journals

Development of Automated Brightfield Double In Situ Hybridization (BDISH) Application for HER2 Gene and Chromosome 17 Centromere (CEN 17) for Breast Carcinomas and An Assay Performance Comparison to Manual Dual Color HER2 Fluorescence In Situ Hybridization (FISH)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Automated BDISH applications for HER2 and CEN 17 targets were successfully developed and it might be able to replace manual two-color HER2 FISH methods. The application also has the potential to be used for other gene targets. The use of BDISH technology allows the simultaneous analyses of two DNA targets within the context of tissue morphological observation. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - October 22, 2008 Category: Pathology Authors: Hiroaki Nitta, Beatrice Hauss-Wegrzyniak, Megan Lehrkamp, Adrian E Murillo, Fabien Gaire, Michael Farrell, Eric Walk, Frederique Penault-Llorca, Masafumi Kurosumi, Manfred Dietel, Lin Wang, Margaret Loftus, James Pettay, Raymond R Tubbs and Thomas M Groga Source Type: journals

Clinicopathological features and the value of differential Cytokeratin 7 and 20 expression in resolving diagnostic dilemmas of ovarian involvement by colorectal adenocarcinoma and vice-versaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an analysis of 20 cases of ovarian involvement by metastatic colorectal adenocarcinomas and colorectal involvement by metastatic ovarian adenocarcinomas, including the value of differential expression of cytokeratins 7 & 20 by immunohistochemistry (IHC), in these cases. Nine cases (45%) were identified as colorectal adenocarcinomas metastatic to the ovary. On biopsy, all these cases showed a 'garland-like' tumor necrosis, with desmoplasia and predominantly exhibited a tubuloalveolar pattern (67% cases). On IHC, all 8 of 9 such cases, where staining for cytokeratin 20 was performed, displayed strong positivity and...
Source: Diagnostic Pathology - September 18, 2008 Category: Pathology Authors: Bharat Rekhi, Sophia George, Bhulaxmi Madur, R.f Chinoy, Rajesh Dikshit and Amita Maheshwari Source Type: journals

TKTL1 is overexpressed in a large portion of non-small cell lung cancer specimensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In several tumors the transketolase activity, controlled inter alia by enzymes of the pentose phosphate pathway which is an alternative, energy generating reaction-cascade to glycolysis, has been correlated with proliferation. The increase of thiamine-dependant transketolase enzyme reactions is induced especially through upregulated transketolase-like enzyme 1 (TKTL1)-activity; that shows TKTL1 to be a causative enzyme for tumors enhanced, anaerobic glucose degradation. We investigated TKTL1-expression in 88 human, formalin-fixed non-small cell lung cancer tissues and 24 carcinomas of the breast by immunohistochemical stai...
Source: Diagnostic Pathology - August 12, 2008 Category: Pathology Authors: Holger Schultz, Daniel Kähler, Detlev Branscheid, Ekkehard Vollmer, Peter Zabel and Torsten Goldmann Source Type: journals

Atypical adenomatous hyperplasia (adenosis) of the prostate: A case report with review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 62-year-old male presented with symptoms of urinary obstruction and elevated serum prostate-specific antigen level of 3.61 ng/mL. Prostate needle biopsies showed benign prostatic tissue with a focus of crowded glands with minimal cytological atypia, fairly well-circumscribed with infiltrative appearance of glands at the edges. This focus had both small and larger glands with similar histological features. This focus was strongly positive for alpha-methylacyl-coenzyme A-racemase (AMACR), but showed scattered patchy staining with basal cell markers (p63 and CK903/34betaE12). Hence, the final histologic diagnosis was benign...
Source: Diagnostic Pathology - August 12, 2008 Category: Pathology Authors: Henry B Armah and Anil V Parwani Source Type: journals

TKTL1 is overexpressed in a large portion of non small cell lung cancer specimensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In several tumors the transketolase activity, controlled inter alia by enzymes of the pentose phosphate pathway which is an alternative, energy generating reaction-cascade to glycolysis, has been correlated with proliferation. The increase of thiamine-dependant transketolase enzyme reactions is induced especially through upregulated transketolase-like enzyme 1 (TKTL1)-activity; that shows TKTL1 to be a causative enzyme for tumors enhanced, anaerobic glucose degradation. We investigated TKTL1-expression in 88 human, formalin-fixed non small cell lung cancer tissues and 24 carcinomas of the breast by immunohistochemical stai...
Source: Diagnostic Pathology - August 12, 2008 Category: Pathology Authors: Holger Schultz, Daniel Kahler, Detlev Branscheid, Ekkehard Vollmer, Peter Zabel and Torsten Goldmann Source Type: journals

A diagnostic dilemma in breast pathology - benign fibroadenoma with multinucleated stromal giant cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present their histories along with relevant radiological, microscopic and immunohistochemical features, followed by a discussion of this unusual pathological entity. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - August 1, 2008 Category: Pathology Authors: Helen M Heneghan, Sean T Martin, Mary Casey, Igdam Tobbia, Fadel Benani and Kevin M Barry Source Type: journals

Sodium polystyrene sulfonate (Kayexalate) aspirationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this short report we illustrate a case of extensive sodium polystyrene sulfonate (SPS) aspiration as an immediate cause of death in a terminally ill patient. SPS is a cation exchange resin utilized to decrease potassium levels in patients with renal failure. When administered rectally in conjunction with sorbitol, colonic necrosis and perforation have been documented. On the other hand, oral administration can be complicated by aspiration, especially in very ill or debilitated patients. In our current report, histological examination of a patient who aspirated SPS shows multiple polygonal to amorphous basophilic crystal...
Source: Diagnostic Pathology - June 17, 2008 Category: Pathology Authors: Luis F Gonzalez-Cuyar, Nathaniel B Cresswell and Allen P Burke Source Type: journals

Angiolymphoid hyperplasia with eosinophilia developing in a patient with history of peripheral T-cell lymphoma: evidence for multicentric T-cell lymphoproliferative processEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: ALHE with molecular evidence of monoclonality is extremely unusual, as is the association with nodal peripheral T-cell nodal lymphoma. The findings of this case support our hypothesis that ALHE might be an early form of T-cell lymphoma. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - May 29, 2008 Category: Pathology Authors: Luis F Gonzalez-Cuyar, Fabio Tavora, X FRANK Zhao, Guanghua Wang, Aaron Auerbach, Nadine Aguilera and Allen P Burke Source Type: journals

Fatal parvoviral myocarditis: A case report and review of literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The diagnosis of parvovirus should be considered in cases of fatal myocarditis, and diagnosis can be confirmed at autopsy by molecular techniques. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - April 30, 2008 Category: Pathology Authors: Fabio Tavora, Luis F Gonzalez-Cuyar, Jay S Dalal, Michael T O'Malley, Richard Zhao, Hong Q Peng and Allen P Burke Source Type: journals

Solitary colonic polypoid ganglioneuromaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This short report discusses a case of solitary colonic polypoid ganglioneuroma associated with melanosis coli in a woman with no systemic manifestations. To our knowledge this is the first ganglioneuroma reported in the literature in association with melanosis coli. The nature and significance of this event remains unclear, although this may be coincidental due to the laxative intake.Further investigation is necessary to clarify this point. The interest of this case lies moreover in the rarity of this entity and its endoscopic and histologic resemblance to sessile polyps frequent in the clinical practice. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - April 29, 2008 Category: Pathology Authors: Isabel Maria Mendez, Teresa Pereda, Francisco Javier Rodriguez, Rafael Funez and Andres Sanchez Source Type: journals

Detection of Epstein Barr Virus by Chromogenic In Situ Hybridization in cases of extra-hepatic biliary atresiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionConsidering the association of hepatitis with the Epstein-Barr virus in later life, it is likely that EBV hepatitis and its complications occur in the neonatal/perinatal period. Since EHBA is a relatively rare disease, a similar study on wedge biopsies of this number of proven cases of EHBA has not been performed to date. Current observation proposes the need for a study of larger series and employing other methods for confirming the etiologic role of EBV in EHBA cases. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - April 28, 2008 Category: Pathology Authors: Fatemeh Mahjoub, Reza Shahsiah, Farid Azmoudeh Ardalan, Guiti Iravanloo, Mehri Najafi Sani, Abdolmajid Zarei, Maryam Monajemzadeh, Fatemeh Farahmand and Setareh Mamishi Source Type: journals

Dysregulated angiogenesis in B-chronic lymphocytic leukemia: morphologic, immunohistochemical, and flow cytometric evidenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: CLL demonstrates enhanced angiogenesis, with increased MVD, upregulated VEGF and downregulated TSP-1. Upregulation of HIF-1a in all CLL cases suggests localized tissue hypoxia as an important stimulant of microvessel proliferation. The presence of VEGF receptors on CLL cells implies an autocrine effect for VEGF. Differences in MVD did not correlate with traditional genetic/immunophenotypic markers of aggressiveness. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - April 18, 2008 Category: Pathology Authors: John L Frater, Neil E Kay, Charles L Goolsby, Susan E Crawford, Gordon W Dewald and LoAnn C Peterson Source Type: journals

Image standards in Tissue-Based Diagnosis (Diagnostic Surgical Pathology)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The progress in virtual microscopy and application of artificial intelligence (AI) in tissue-based diagnosis demands fast preparation and implementation of an internationally acceptable standard. The described hierarchic order as well as analytic investigation in all potentially necessary aspects and details offers an appropriate tool to specifically determine standardized requirements. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - April 18, 2008 Category: Pathology Authors: Klaus Kayser, Jurgen Gortler, Torsten Goldmann, Ekkehard Vollmer, Peter Hufnagl and Gian Kayser Source Type: journals

Rare extracranial localization of primary intracranial neoplasmEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present three cases of common intracranial tumors, with purely extracranial extension. The three described cases demonstrate, that preoperative MRI and CT imaging is important for differential diagnosis to exclude intracranial connections of the tumors. A definitive diagnosis requires specialized immunohistochemical examinations. In all cases of intranasal or pharyngeal neoplasm the diagnosis of meningioma, craniopharyngeoma and glioma should be considered as differential diagnosis to optimize the surgical procedure. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - April 16, 2008 Category: Pathology Authors: Susan Arndt, Thorsten Wiech, Irina Mader, Antje Aschendorff and Wolfgang Maier Source Type: journals

Pleomorphic liposarcoma of the foot: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although the incidence of pleomorphic liposarcoma in the foot is very low, it is essential to perform thorough histological analysis of all soft tissue masses, regardless of their benign appearance, because only prompt radical surgery can result in a good prognosis for the patient. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - April 16, 2008 Category: Pathology Authors: Luka Brcic, Antonija Jakovcevic, Lovorka Batelja Vuletic, Dubravko Orlic and Sven Seiwerth Source Type: journals

A transient benign lymph node-based proliferation of T-cells simulating non-Hodgkin lymphoma in a patient with psoriasis treated with tumor necrosis factor alpha and CD11a antagonistsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Distinction between clinically benign lymphoid proliferations related to antipsoriasis therapy and malignant lymphoma avoids the unnecessary use of anti-lymphoma chemotherapy. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - March 26, 2008 Category: Pathology Authors: M Yadira Hurley, Mary Noel George, Craig L Leonardi and John L Frater Source Type: journals

Cardiac fibrosis in the elderly, normotensive athlete: case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The true incidence and importance of age- and exercise-associated myocardial fibrosis is an area for future research. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - March 19, 2008 Category: Pathology Authors: Shaheen E Lakhan and Lindsey Harle Source Type: journals