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Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - November 6, 2009 Category: Gastroenterology Source Type: journals

One year of Editorship: Are we there yet?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
When in mid 2008 I took over the role of Editor-in-Chief of Digestive and Liver Disease and started working to create the new editorial team, I was well aware that one year was too short a time for the new editorial policy to have an impact on the Journal. Whether a difference is indeed visible and whether it has been for the better may be debated among our readers, however I believe it is still too early to draw conclusions. The year 2009, which is coming to a close, has been for myself and for the whole editorial staff a year of study, investigation and training, in which we have focused on what we believe should be the ...
Source: Digestive and Liver Disease - October 15, 2009 Category: Gastroenterology Authors: M. Angelico Tags: Editorial Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 9, 2009 Category: Gastroenterology Source Type: journals

The putative role of the intestinal microbiota in the irritable bowel syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The irritable bowel syndrome (IBS) is a chronic abdominal symptom complex that is heterogeneous in terms of its clinical presentation and underlying pathophysiology and pathogenesis. It is now established that enteric infection can trigger the syndrome in at least a subset of patients. In addition, there is growing evidence of low grade inflammation and immune activation in the distal bowel of some IBS patients. These observations now prompt the question as to what maintains gut dysfunction in these patients. The intestinal microbiota influences a broad array of host organs that include the gut and the brain, and...
Source: Digestive and Liver Disease - September 9, 2009 Category: Gastroenterology Authors: S.M. Collins, E. Denou, E.F. Verdu, P. Bercik Tags: Mini-Symposium Part II: New Perspectives in Irritable Bowel Syndrome Source Type: journals

Infection, inflammation, and the irritable bowel syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Gastrointestinal infection is ubiquitous worldwide though the pattern of infection varies widely. Poor hygiene and lack of piped water is associated with a high incidence of childhood infection, both viral and bacterial. However in developed countries bacterial infection is commoner in young adults. Studies of bacterial infections in developed countries suggest 75% of adults fully recover, however around 25% have long lasting changes in bowel habit and a smaller number develop the irritable bowel syndrome (IBS). Whether the incidence is similar in developing countries is unknown. Post-infective IBS (PI-IBS) share...
Source: Digestive and Liver Disease - September 1, 2009 Category: Gastroenterology Authors: R. Spiller, K. Garsed Tags: Mini-Symposium Part II: New Perspectives in Irritable Bowel Syndrome Source Type: journals

New perspectives in irritable bowel syndrome: Introduction to Part 2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Symptoms of the irritable bowel syndrome (IBS) occur in the absence of underlying structural or biochemical abnormalities within or outside the gut. Although widely accepted, this definition reflects uncertainty on the actual nature of the symptoms and does not satisfy patients. Nonetheless, the future is likely to be brighter since research in the field of IBS is fast moving and cellular, molecular and microbiological mechanisms are being identified and recognised as significant players in the complex pathophysiology of IBS. These recent steps forward in the understanding of IBS pathophysiology represent a unique opportun...
Source: Digestive and Liver Disease - August 26, 2009 Category: Gastroenterology Authors: G. Barbara, V. Stanghellini Tags: Mini-Symposium Part II: New Perspectives in Irritable Bowel Syndrome Source Type: journals

Hepatocellular carcinoma: The beginning of a long journeyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The treatment of hepatocellular carcinoma (HCC) has witnessed major changes over the last 5 years. Until the early 2000s, HCC was a malignancy typically diagnosed at an advanced stage with a few therapeutic options: after the failure of a locoregional treatment there was no effective systemic therapy other than supportive care . (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 24, 2009 Category: Gastroenterology Authors: S. Cascinu Tags: Commentary Source Type: journals

New perspectives in Irritable Bowel Syndrome: Introduction to Part 1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is a great pleasure for us to introduce this series of six reviews on the Irritable Bowel Syndrome (IBS), an intriguing syndrome affecting millions of patients throughout the world and representing a major daily workload for general practitioners and specialists alike. The term mini symposium is definitely an understatement to indicate this collection of elegant, comprehensive, provocative state-of-the-art papers proposed by the major experts in the field to cover all the relevant aspects of IBS. Their efforts are certainly timely, since research has been speeding up in the recent past and it is difficult, even for thos...
Source: Digestive and Liver Disease - August 16, 2009 Category: Gastroenterology Authors: V. Stanghellini, G. Barbara Tags: Commentary Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 11, 2009 Category: Gastroenterology Source Type: journals

Current and novel therapeutic options for irritable bowel syndrome managementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Irritable bowel syndrome is a functional gastrointestinal disorder affecting up to 3–15% of the general population in western countries. It is characterised by unexplained abdominal pain, discomfort, and bloating in association with altered bowel habits. The pathophysiology of irritable bowel syndrome is multifactorial involving disturbances of the brain–gut axis. The pathophysiology provides the rationale for pharmacotherapy: abnormal gastrointestinal motor functions, visceral hypersensitivity, psychosocial factors, autonomic dysfunction, and mucosal immune activation. Understanding the mechanisms, and their...
Source: Digestive and Liver Disease - August 10, 2009 Category: Gastroenterology Authors: M. Camilleri, V. Andresen Tags: Mini-Symposium Part II: New Perspectives in Irritable Bowel Syndrome Source Type: journals

Peripheral factors in the pathophysiology of irritable bowel syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The pathophysiology of IBS is complex and still incompletely known. Both central and peripheral factors are thought to contribute to the symptoms of IBS, including psychosocial factors, abnormal GI motility and secretion, and visceral hypersensitivity. In this review the involvement of peripheral factors in the pathophysiology in IBS is reviewed. Altered GI motility is commonly found in this patient group, even though a specific motor pattern has been hard to find. Colonic transit has been found to be of relevance for the bowel habit of the patient. Abnormal gas handling within the gut is also commonly seen, and ...
Source: Digestive and Liver Disease - August 9, 2009 Category: Gastroenterology Authors: J. Gunnarsson, M. Simrén Tags: Mini-Symposium Part I: New Perspectives in Irritable Bowl Syndrome Source Type: journals

Recent insights on central processing and psychological processes in functional gastrointestinal disordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: There is increasing evidence for a key role of psychological processes and their central nervous system substrates in functional gastrointestinal disorders, although the exact nature of the relationship remains only partially understood. However, progress in this key area of psychosomatic medicine is rapidly being made. In this review article, we will give an overview of recent advances in understanding the complex mechanisms by which psychological processes and functional gastrointestinal disorder symptoms reciprocally influence each other. Various lines of evidence from different branches of biomedical and psyc...
Source: Digestive and Liver Disease - August 9, 2009 Category: Gastroenterology Authors: L. Van Oudenhove, Q. Aziz Tags: Mini-Symposium Part I: New Perspectives in Irritable Bowl Syndrome Source Type: journals

Irritable bowel syndrome: Novel views on the epidemiology and potential risk factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Symptoms consistent with the irritable bowel syndrome are remarkably frequent around the world. Irritable bowel syndrome prevalence ranges from 2.1% to 22%, depending on criteria used. Women are more frequently affected than men, but the reasons remain obscure; irritable bowel syndrome occurs in all age groups but there appears to be a modest decline in prevalence with advancing age again for unknown reasons. The incidence of irritable bowel syndrome per year has been estimated at approximately 1.5% in community subjects; annually only 0.2% of population will be diagnosed with irritable bowel syndrome. The natura...
Source: Digestive and Liver Disease - August 9, 2009 Category: Gastroenterology Authors: E. Rey, N.J. Talley Tags: Mini-Symposium Part I: New Perspectives in Irritable Bowl Syndrome Source Type: journals

Cyanoacrylate glue injection for acutely bleeding oesophageal varices: Is it ready for prime time?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gastroesophageal varices are present in approximately 50% of patients with cirrhosis and bleeding from these is the most common lethal complication of cirrhosis . Cirrhotic patients without varices can develop them at a rate of 8% per year, and the ones with small varices can develop large varices at a similar rate . Among these, variceal hemorrhage occurs at a yearly rate of 5–15%, with most important risk factors for bleeding being the size of varices, decompensated cirrhosis (Child B/C) and the endoscopic presence of red wale marks . The current guidelines by the American Association for the Study of Liver Diseases (A...
Source: Digestive and Liver Disease - July 29, 2009 Category: Gastroenterology Authors: K.R.S. Gill, M. Raimondo Tags: Commentary Source Type: journals

Androgen receptor alterations in hepatocarcinogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A constant epidemiologic characteristic of hepatocellular carcinoma (HCC) worldwide is its striking prevalence in males, with a male/female ratio averaging 2:1 to 7:1, the latter proportion being more often found in HBV-positive cases. The unbalanced relationship with gender is not limited to incidence, prognosis being better in females, both in terms of spontaneous survival or survival after resection. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 15, 2009 Category: Gastroenterology Authors: E. Villa Tags: Commentary Source Type: journals

Primary biliary cirrhosis-specific autoantibodies in patients with systemic sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We read with interest the paper by Norman et al. reporting the presence of primary biliary cirrhosis (PBC)-specific autoantibodies in 8/52 (15%) cases with systemic sclerosis (SSc). Among them, seven were positive for antibodies against disease-specific mitochondrial antigens and one for the sp100 nuclear body antigen. Anti-mitochondrial antibody (AMA) testing was performed by a commercially available ELISA (INOVA Diagnostics) using as antigen a hybrid preparation designated as MIT3 because it contains the three major mitochondrial autoepitopes, namely the E2 subunits of the pyruvate dehydrogenase complex (PDC), branched c...
Source: Digestive and Liver Disease - July 15, 2009 Category: Gastroenterology Authors: M.G. Mytilinaiou, D.P. Bogdanos Tags: Correspondence Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 10, 2009 Category: Gastroenterology Source Type: journals

Author's reply: PBC-specific autoantibodies in patients with systemic sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We thank Drs. Mytilinaiou and Bogdanos for their comments on our study . We understand and share their concern with the consequences of obtaining positive MIT3 test results for patients without apparent PBC. Of the 7 systemic sclerosis (SSc) patients with positive MIT3 results in our cohort, 3 had borderline positive values (25.6, 25.8, 26.7, pos≥25 units) and the remaining 4 had moderate (81.0, 84.1, 84.1 units) to strong reactivity (126.1 units). Examination of the moderate to strong positive MIT3 sera by IFA on HEp-2 substrates showed an AMA pattern of reactivity for the one strong MIT3 positive sera, weak AMA reactiv...
Source: Digestive and Liver Disease - July 8, 2009 Category: Gastroenterology Authors: Gary L. Norman, Zakera Shums, Piotr Milkiewicz Tags: Correspondence Source Type: journals

Impact on outcome of the route of conduit transposition after transhiatal oesophagectomy: A randomized controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The route of conduit transposition did not affect the outcome. However, an individualized approach depending upon the operative findings, radicality of the procedure, and perceived need for postoperative adjuvant therapy may be useful. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 7, 2009 Category: Gastroenterology Authors: L.S. Khiria, S. Pal, S. Peush, T.K. Chattopadhyay, M. Deval Tags: Alimentary Tract Source Type: journals

Erratum to “AISF Monothematic (Giardini Naxos, Messina, May 7–9, 2009)”Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Publisher regrets that an error occurred in the spelling of the author's name “L. Bellis” in the original abstract on Page A59. The corrected name and complete abstract appears below:SURVIVIN-IGM IMMUNO COMPLEX: A NOVEL CANDIDATE BIOMARKER OF CIRRHOSIS TO MONITOR PATIENTS PROGRESSION TOWARDS HEPATOCELLULAR CARCINOMAC. Matteuccia,b, R. Sorrentinoa,b, G.M. Ettorrec, L. Bellisd, A. Antenuccie, L. Beneducef, R. Santoroc, G. Vennareccic, J. Zuinf, P. Pierimarchia, C. Puotid, G. Rasia (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 5, 2009 Category: Gastroenterology Tags: Erratum Source Type: journals

Optical coherence tomography in children with coeliac diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Coeliac disease (CD) is a gluten-sensitive enteropathy occurring in genetically predisposed individuals and characterised by chronic inflammation of the small intestinal mucosa that gradually leads to villous atrophy. It typically results in malabsorption of most nutrients, but its clinical expression is highly variable . (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 2, 2009 Category: Gastroenterology Authors: S. Cucchiara, G. Di Nardo Tags: Commentary Source Type: journals

Leukocytapheresis in ulcerative colitis: A possible alternative to biological therapy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inflammatory bowel disease (IBD) is a chronic relapsing and remitting digestive disorder that includes both Crohn's disease and ulcerative colitis. The underlying cause of IBD remains unclear but is thought to involve an inherent defect in the innate immune system, possibly a breach in epithelial barrier function, which disrupts the delicate homeostatic balance achieved between commensal bacteria residing in the gut and immunosurveillance mechanisms of the mucosal immune system. The result is an overly aggressive adaptive immune response against the commensal flora or other antigens that involves massive recruitment of leu...
Source: Digestive and Liver Disease - June 21, 2009 Category: Gastroenterology Authors: K.O. Arseneau, F. Cominelli Tags: Commentaries Source Type: journals

Allocation priority in non-urgent liver transplantation: An overview of proposed scoring systemsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, several scoring systems have been described for organ allocation, but today, none is definitely able to overcome the limitations of the Child–Turcotte–Pugh and model for end-stage liver disease systems. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - June 7, 2009 Category: Gastroenterology Authors: S. Gitto, S. Lorenzini, M. Biselli, F. Conti, P. Andreone, M. Bernardi Tags: Review Article Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - June 7, 2009 Category: Gastroenterology Source Type: journals

Differential role of circulating endothelial progenitor cells in cirrhotic patients with or without hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Circulating endothelial progenitor cells are increased in patients with portal hypertension±hepatocellular carcinoma. The negative correlation of endothelial progenitor cells with hepatic venous pressure gradient suggests a protective role of endothelial progenitor cells in liver cirrhosis whilst vascular endothelial growth factor is associated with high hepatic venous pressure gradient. In contrast, increased endothelial progenitor cells in hepatocellular carcinoma rather reflect tumour specific endothelial progenitor cells mobilisation. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - June 5, 2009 Category: Gastroenterology Authors: W. Sieghart, S. Fellner, T. Reiberger, G. Ulbrich, A. Ferlitsch, V. Wacheck, M. Peck-Radosavljevic Tags: Liver, Pancreas and Biliary Tract Source Type: journals

The efficacy of Helicobacter pylori eradication regimen with and without vitamin C supplementationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: Vitamin C in gastric juice and in vitro has been shown to inhibit the growth of Helicobacter pylori (H. pylori).Aims: The purpose of this study was to investigate the effect of addition of vitamin C to eradication regimen on H. pylori eradication rate.Patients: This randomised controlled clinical trial was conducted on 312 patients with H. pylori infection who had referred to the Taleghani Research Center of Gastroenterology and Liver Disease.Methods: Patients were randomly divided into two groups. Group A patients (162 patients) received amoxicillin 1g and metronidazole 500mg b.i.d., bismuth 240mg b....
Source: Digestive and Liver Disease - June 2, 2009 Category: Gastroenterology Authors: H. Zojaji, R. Talaie, D. Mirsattari, M. Haghazali, M. Molaei, N. Mohsenian, F. Derakhshan, M.R. Zali Tags: Alimentary Tract Source Type: journals

Segmental colitis associated with diverticula: A rare clinical entity and a new challenge for the gastroenterologistEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background and aim: Segmental colitis associated with diverticula (SCAD) has recently drawn a particular attention in the field of rare forms of colitis because of some peculiarities suggesting both its autonomy as a clinical entity and a resemblance with the most relevant forms of inflammatory bowel diseases (IBD). Aim of this review was to report the state of art on this topic.Methods: Epidemiological, clinical, endoscopic/histological and diagnostic features are described. Moreover, from both the pathogenetic and therapeutic point of view, new relevant information is highlighted regarding the possible role of ...
Source: Digestive and Liver Disease - June 1, 2009 Category: Gastroenterology Authors: E. Ierardi, C. Hassan, A. Zullo, V. De Francesco, N. Della Valle, S. Prencipe, R. Rosania, S. Morini, C. Panella Tags: Progress Report Source Type: journals

Gamma-glutamyltransferase activity and insulin resistance in chronic hepatitis CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gamma-glutamyltransferase (GGT) is an enzyme present in cell membranes of many tissues, especially those concerned in secretory or absorptive processes. Increased serum GGT has been regarded as a biomarker of hepato-biliary disease and of alcohol consumption, but its serum activity is affected by several factors such as drugs, age, sex, and body weight . People with high serum GGT levels have higher mortality from all causes, liver disease, cancer, and diabetes, partly because of the association between GGT and other risk factors, and partly because GGT is an independent predictor of risk . Recent population-based epidemio...
Source: Digestive and Liver Disease - May 28, 2009 Category: Gastroenterology Authors: E. Gentilcore, E. Bugianesi Tags: Commentaries Source Type: journals

Kava hepatotoxicity: Regulatory data selection and causality assessmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The regulatory data regarding kava hepatotoxicity is selective and of low quality, not supportive of the regulatory proposed causality; but instead, is an explanation of the overall causality discussions of kava hepatotoxicity. We are proposing that the regulatory agency reports data in full length and reevaluates causality. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 28, 2009 Category: Gastroenterology Authors: R. Teschke, A. Wolff Tags: Liver, Pancreas and Biliary Tract Source Type: journals

Contribution of standard oesophageal manometry in sliding hiatal hernia: From the gastro-oesophageal pressure gradient to the diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Objective: We tested whether gastro-oesophageal pressure gradient is augmented in sliding hiatal hernia and the yield of oesophageal manometry in diagnosing sliding hiatal hernia.Methods: Patients with equivalent body mass index were categorised according to manometry and endoscopy in groups: (1) no sliding hiatal hernia (n=147); (2) sliding hiatal hernia solely at endoscopy (n=46); and (3) sliding hiatal hernia at manometry (n=22). The yield of manometry was assessed taking endoscopy as referential.Results: Gastro-oesophageal pressure gradient was similar between groups both at inspiration (13.3±5.7mmHg vs. 13....
Source: Digestive and Liver Disease - May 27, 2009 Category: Gastroenterology Authors: F. Fornari, L.M.P. Fucilini, C. Risson, L. Rossi, A. Gelain, S.G.S. Barros Tags: Digestive Endoscopy Source Type: journals

Gastric cancer exosomes promote tumour cell proliferation through PI3K/Akt and MAPK/ERK activationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Gastric cancer exosomes promoted tumour cell proliferation, at least in part, by activation of PI3K/Akt and mitogen-activated protein kinase/extracellular-regulated protein kinase pathways. The decreased expression of Casitas B-lineage lymphoma proteins might have contributed to the activation of Akt and extracellular-regulated protein kinase. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 27, 2009 Category: Gastroenterology Authors: J.-L. Qu, X.-J. Qu, M.-F. Zhao, Y.-E. Teng, Y. Zhang, K.-Z. Hou, Y.-H. Jiang, X.-H. Yang, Y.-P. Liu Tags: Alimentary Tract Source Type: journals

Transient elastography for the assessment of liver fibrosis in patients with chronic viral hepatitis: The missing tool?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The fibrogenic evolution of chronic viral hepatitis B and C towards cirrhosis represents a key issue in clinical Hepatology whose monitoring still relies on liver biopsy and consequent histopathological staging. In the last decade, non-invasive methodologies have been proposed to predict the presence of fibrosis in chronic liver disease. Most of these methods are based on algorithms, including biochemical parameters, which have demonstrated an acceptable diagnostic accuracy towards the two extremities of the fibrogenetic process. The introduction of transient elastography has represented a further advancement in ...
Source: Digestive and Liver Disease - May 25, 2009 Category: Gastroenterology Authors: C. Stasi, U. Arena, F. Vizzutti, A.L. Zignego, M. Monti, G. Laffi, G. Corti, M. Pinzani Tags: Review Article Source Type: journals

The controversial role of lamivudine prophylaxis in occult HBV carriers treated with chemo-immune therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatitis B reactivation in lymphoma patients who are isolated anti-HBc carriers is a severe and potentially fatal complication of chemotherapy or chemo-immune therapy. Conventional chemotherapy for lymphoma has been documented to cause hepatitis B virus (HBV) related liver disease in HBsAg negative patients with occult HBV infection, but HBV reactivation has been increasingly reported after combined Rituximab (a monoclonal antibody against CD20) and multiagent chemotherapy for B-cell lymphomas. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 24, 2009 Category: Gastroenterology Authors: M. D’Andrea, L. Nosotti, F. Pimpinelli, M.L. Dessanti, A. Paviglianiti, L. Miglioresi, A. Morrone, M.C. Petti Tags: Correspondence Source Type: journals

Cost-effectiveness of early colonoscopy surveillance after cancer resectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our study shows that the recently recommended short-interval 1-year surveillance colonoscopy following colorectal cancer resection is a clinically efficient and cost-effective strategy in terms of cancer detection and cancer-specific death prevention. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 22, 2009 Category: Gastroenterology Authors: C. Hassan, P.J. Pickhardt, A. Zullo, E. Di Giulio, A. Laghi, D.H. Kim, F. Iafrate Tags: Digestive Endoscopy Source Type: journals

An MBL2 haplotype and ABCB4 variants modulate the risk of liver disease in cystic fibrosis patients: A multicentre studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: Cystic fibrosis is the most common lethal recessive disorder among Caucasians. Over 1500 mutations have been identified in cystic fibrosis transmembrane conductance regulator disease-gene so far. A large variability of the clinical phenotype has been observed both in cystic fibrosis patients bearing the same genotype, and in affected sibpairs. Thus, genes inherited independently from cystic fibrosis transmembrane conductance regulator could modulate the clinical expression of cystic fibrosis.Methods: We analysed some putative modifier genes of liver cystic fibrosis phenotype (serpin 1, hemochromatosis...
Source: Digestive and Liver Disease - May 20, 2009 Category: Gastroenterology Authors: R. Tomaiuolo, D. Degiorgio, D.A. Coviello, A. Baccarelli, A. Elce, V. Raia, V. Motta, M. Seia, G. Castaldo, C. Colombo Tags: Liver, Pancreas and Biliary Tract Source Type: journals

Observational study of the frequency of use and perceived usefulness of ancillary manoeuvres to facilitate colonoscopy completionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data suggest that ancillary manoeuvres are used frequently but are not necessarily predictive of successful caecal intubation. Additional data from prospective, randomised studies are needed to address the overall utility and optimal application of individual manoeuvres. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 20, 2009 Category: Gastroenterology Authors: S.L. Hansel, J.A. Prechel, B. Horn, M.D. Crowell, J.K. DiBaise Tags: Digestive Endoscopy Source Type: journals

From the Alps to Sicily: A panorama of Italian lymphomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In 1992 “Le Lymphome Imaginaire” satirized the emerging fascination with gastric lymphomas . For a brief time, inspired by Isaacson's brilliant discovery of a direct connection between Helicobacter pylori and B-cell lymphomas of the mucosa-associated lymphoid tissue , monoclonality became the equivalent of Argan's imaginary symptoms. Countless MALT lymphomas were diagnosed and promptly cured by molecular cowboys who found clones in the most innocent of lymphoid follicles and shot them dead with triple therapies. Texas metaphors entered the therapeutic parlance – the only good Helicobacter is a dead one – and a sens...
Source: Digestive and Liver Disease - May 14, 2009 Category: Gastroenterology Authors: R.M. Genta Tags: Commentaries Source Type: journals

Corrigendum to “The early effect of proton pump inhibitor therapy on the accuracy of the 13C-urea breath test” [Dig. Liver Dis. 37 (2005) 28–32]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The author regrets that an error occurred in the spelling of the second author's name, W. Van Laer. The correction is made to the authors’ listing above. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 13, 2009 Category: Gastroenterology Authors: F. Mana, W. Van Laer, A. Bossuyt, D. Urbain Tags: Corrigendum Source Type: journals

Endoscopic sedation in Greece: Results from a nationwide survey for the Hellenic Foundation of gastroenterology and nutritionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The use of sedation and physiologic monitoring in Greece is now standard practice during endoscopy. Benzodiazepines, either alone or combined with an opioid, are used by the majority of endoscopists, while propofol is used in selected cases, mainly in the presence of an anaesthesiologist. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 3, 2009 Category: Gastroenterology Authors: G.A. Paspatis, M.M. Manolaraki, G. Tribonias, A. Theodoropoulou, E. Vardas, K. Konstantinidis, G. Chlouverakis, D.G. Karamanolis Tags: Digestive Endoscopy Source Type: journals

Irritable bowel syndrome in the elderly: An overlooked problem?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: In secondary care, irritable bowel syndrome (IBS) is frequently associated with non-colonic symptoms including lethargy, backache and chest pains which can result in inappropriate referral to different specialities with the condition remaining unrecognised. This could also be a problem in the elderly where comorbidity is common, especially as irritable bowel syndrome is usually associated with a younger age group.Methods: A survey of 230 consecutive patients (aged 65–94) attending an elderly care clinic examining referral patterns, irritable bowel syndrome symptoms, duration of disease, non-colonic ...
Source: Digestive and Liver Disease - May 3, 2009 Category: Gastroenterology Authors: A. Agrawal, M.H. Khan, P.J. Whorwell Tags: Alimentary Tract Source Type: journals

Treatment of chronic Hepatitis C: A smart coat over a ragged dress?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In recent years, the developments in the treatment of chronic hepatitis C afforded a dramatic increase in its efficacy. The registration of pegylated interferons (Peg-IFN) and ribavirin following large registrative trials has been followed by a number of studies aimed at optimising doses and duration. As a result, a sustained virological response (SVR) can be achieved in >50% of the patients with genotype 1 and >80% of those with genotype 2–3 . (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 3, 2009 Category: Gastroenterology Authors: G.B. Gaeta Tags: Commentaries Source Type: journals

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Format: Hardcover book. Purpose: To offer comprehensive, up-to-date coverage of the use of endoscopy in the prevention, diagnosis and management of cancer. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 3, 2009 Category: Gastroenterology Authors: G. Manes Tags: Book Review Source Type: journals

Large villous adenoma of the appendix: A case treated with sequential endoscopic-minimal surgical techniqueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Villous adenomas of the appendix are uncommon and rarely diagnosed during routine colonoscopy. Less than 60 cases of appendiceal villous adenomas are described worldwide and a reported frequency of 0.06% in appendectomy specimens. There are no specific symptoms for these neoplasms and clinical presentation is often acute appendicitis. The malignant potential of appendiceal adenomas is not well documented but has been assumed to be the same to those in other parts of the colon and rectum. Malignant in situ changes are reported in 63% cases . (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 3, 2009 Category: Gastroenterology Authors: I. Stroppa, R. Lionetti, F. Andrei, A. Cocco, A.M. Farinon, F. Pallone Tags: Correspondence Source Type: journals

Comment on: Severe hemolytic anemia and fatal hepatic failure associated with nimesulideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I read with interest the paper about a case of severe hemolytic anemia and fatal hepatic failure associated with prolonged nimesulide use , considering that apparently only one case of this association has previously published . In fact, spontaneous reports of adverse drug events are helpful warning signals of rare toxicities. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 3, 2009 Category: Gastroenterology Authors: Franco Bissoli Tags: Correspondence Source Type: journals

Confocal laser endomicroscopy diagnosis of gastric adenocarcinoma in a patient treated for gastric diffuse large-B-cell lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The association between gastric carcinoma and lymphoma is rare. Confocal laser endomicroscopy is a new diagnostic tool that allows the identification of cellular and vascular architecture during endoscopy. This is the first report of an in vivo early gastric carcinoma diagnosis by confocal laser endomicroscopy in a patient successfully treated for a primary gastric diffuse large-B-cell lymphoma. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 3, 2009 Category: Gastroenterology Authors: C. Trovato, A. Sonzogni, D. Ravizza, G. Pruneri, M. Rossi, G. de Roberto, D. Tamayo, A. Vanazzi, G. Fiori, C. Crosta Tags: Brief Clinical Observation Source Type: journals

Gallstone ileus: Endoscopic removal of a gallstone obstructing the lower ileumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An 81-year-old presented with a 5-day history of increasing abdominal pain, distension, and vomiting. Her bowels were not active for 2 days, but she was passing flatus. Laboratory examination showed a haemoglobin of 9.7g/dL (≤14g/dL), haematocrit of 29.7% (≥41%), leucocytes of 13.6/nl (≤10.0/nl), creatinine of 3.7mg/dL (≤1.1mg/dL). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 3, 2009 Category: Gastroenterology Authors: G.D. De Palma, G. Mastrobuoni, G. Benassai Tags: Image of the Month Source Type: journals

Nasobiliary drainage in acute cholestatic hepatitis with pruritusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Short-term nasobiliary drainage should be considered in patients with cholestatic acute viral hepatitis with intractable pruritus and cough for symptomatic relief. It may help in faster recovery in these patients. However, a larger randomized controlled study is warranted. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 3, 2009 Category: Gastroenterology Authors: V. Singh, A. Bhalla, N. Sharma, P.C. Dheerendra, R. Agarwal, S.K. Mahi Tags: Liver, Pancreas and Biliary Tract Source Type: journals

A modified TNM-based Japan Integrated Score combined with AFP level may serve as a better staging system for early-stage predominant hepatocellular carcinoma patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The CLIP system provided the best prognostic stratification in the present cohort of HCC patients who were mainly at late stages. However, early detection of HCCs has become more common in Taiwan in recent years, which has led to the predominance of early-stage HCC patients. Therefore, modified TNM-based JIS combined AFP may now be the most applicable system in recent years. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 3, 2009 Category: Gastroenterology Authors: Y.-H. Yen, C.-S. Changchien, J.-H. Wang, K.-M. Kee, C.-H. Hung, T.-H. Hu, C.-M. Lee, C.-Y. Lin, C.-C. Wang, T.-Y. Chen, Y.-J. Huang, S.-N. Lu Tags: Liver, Pancreas and Biliary Tract Source Type: journals

IL-10 promoter gene polymorphisms and sustained response to combination therapy in Taiwanese chronic hepatitis C patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data fail to demonstrate the influence of IL-10 promoter gene polymorphisms on the response to combination therapy in Taiwanese chronic hepatitis C patients. The impact of genetic variations in IL-10 haplotype on the response to anti-HCV treatment among different ethnic populations deserves further examination. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 3, 2009 Category: Gastroenterology Authors: J.Y. Chuang, S.S. Yang, Y.T. Lu, Y.Y. Hsieh, C.Y. Chen, S.C. Chang, C.S. Chang, H.Z. Yeh, J.H. Kao Tags: Liver, Pancreas and Biliary Tract Source Type: journals