Diseases of the EsophagusThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Independent histological risk factors for lymph node metastasis of superficial esophageal squamous cell carcinoma; implication of claudin-5 immunohistochemistry for expanding the indications of endoscopic resectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endoscopic resection is curative for superficial esophageal squamous cell carcinoma (ESCC) limited to the lamina propria. Endoscopic resection is not recommended for superficial ESCC invading muscularis mucosa or submucosa, however, because of the high frequency of lymph node metastasis (LNM) in such patients. Methods to more accurately predict LNM by analysis of endoscopically resected specimens are needed. Patients with superficial ESCC who underwent surgery without prior chemoradiotherapy (n= 110) were retrospectively examined to determine whether LNM correlated with immunohistochemical parameters and conventional histo...
Source: Diseases of the Esophagus - November 10, 2009 Category: Gastroenterology Authors: T. Chiba, H. Kawachi, T. Kawano, J. Kumagai, K. Kitagaki, M. Sekine, K. Uchida, M. Kobayashi, K. Sugihara, Y. Eishi Source Type: journals

The high incidence of esophageal cancer in parts of China may result primarily from genetic rather than environmental factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined the impact of changing environments on esophageal cancer by comparing age-standardized mortality rates of immigrant group to the rates of native population (natives who live in high cancer location and have never moved) and host populations (hosts who live in low cancer location and have never moved people). All ESCC deaths taking place during 1999[ndash]2004 among the migrant, native, and host populations were identified by retrospective population-based screening. Direct age-adjusted mortality rates were calculated by using the China population of year 2000 as standard population. From 1999[ndash]2004...
Source: Diseases of the Esophagus - November 9, 2009 Category: Gastroenterology Authors: Hexi Zhang, Zhichao Chen, Jinpeng Cheng, Xiaoling Zhu, Weiren Guo, Andong Hu, Yukai Du, Yikai Zhou, Youjie Wang Source Type: journals

Inversed Y cardioplasty plus a truncal vagotomy-antrectomy and a Roux-en-Y gastrojejunostomy performed in patients with stricture of the esophagogastric junction after a failed cardiomyotomy or endoscopic procedure in patients with achalasia of the esophagusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Laparoscopic anterior cardiomyotomy in addition to anterior Dor's fundoplication is the procedure of choice for achalasia of the esophagus with approximately 95% success rate. Redo cardiomyotomy is complicated and associated with rerecurrence of dysphagia. Twelve patients with failed redo myotomy were clinically evaluated with radiology, endoscopy, and manometry in whom achalasia type III or IV was confirmed. We propose as treatment for these selected cases an inversed Y cardioplasty + truncal vagotomy, a partial distal gastrectomy and Roux-en-Y gastrojejunostomy in order to facilitate esophageal emptying and avoid the app...
Source: Diseases of the Esophagus - November 9, 2009 Category: Gastroenterology Authors: I. Braghetto, O. Korn, G. Cardemil, E. Coddou, H. Valladares, A. Henriquez Source Type: journals

Use of endoscopy in diagnosis and management of patients with dysphagia in an African settingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objectives of this study were to define the utility of esophagogastroduodenoscopy in the diagnosis and management of patients presenting with dysphagia and to determine the relative incidence of the various causes of dysphagia in Sudan. This is a prospective, cross-sectional, descriptive, hospital-based study carried out at the endoscopy unit of Soba University Hospital, Khartoum, Sudan. All patients complaining of dysphagia underwent upper gastrointestinal endoscopy with therapeutic intervention when necessary. A total of 114 patients were enrolled in the study, with a mean age of 47 years SD ± 19 and a male to femal...
Source: Diseases of the Esophagus - November 9, 2009 Category: Gastroenterology Authors: H. M. Y. Mudawi, A. O. A. Mahmoud, M. A. El Tahir, S. H. Suliman, S. Z. Ibrahim Source Type: journals

Diagnosis of eosinophilic esophagitis after fundoplication for 'refractory reflux': implications for preoperative evaluationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A small percentage of patients who carry the diagnosis of refractory gastroesophageal reflux disease (GERD) actually have eosinophilic esophagitis (EoE). The purpose of this study was to describe a series of patients who underwent fundoplication for presumed refractory GERD, but subsequently were found to have EoE. We performed a retrospective analysis of our EoE database. Patients diagnosed with EoE after Nissen were identified. Cases were defined according to recent consensus guidelines. Five patients underwent anti-reflux surgery for refractory GERD, but were subsequently diagnosed with EoE. None had esophageal biopsies...
Source: Diseases of the Esophagus - October 27, 2009 Category: Gastroenterology Authors: Evan S. Dellon, Timothy M. Farrell, Eugene M. Bozymski, Nicholas J. Shaheen Source Type: journals

Chemoradiotherapy for cancer of the esophagus: contribution of the leucovorin, 5-fluorouracil bolus, and infusion–cisplatin–radiotherapy schedule starting with two neoadjuvant chemotherapy cycles: results from a pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To assess feasibility and tolerance of a modification in the usual radiochemotherapy regimen for esophageal cancer by using a leucovorin, 5-fluorouracil bolus, and infusion[ndash]cisplatin regimen (six cycles), beginning with two cycles of chemotherapy before conventional radiotherapy (50 Gy), 33 patients, 30 were men, 62.8 ± 9.5 years, were treated for an esophageal carcinoma (29 squamous cell), 27 of these were in stage III (based on computed tomography scan). Neoadjuvant chemotherapy was well tolerated; concomitant radiochemotherapy was associated with severe adverse events mostly hematological in 23 patients. Complete...
Source: Diseases of the Esophagus - October 26, 2009 Category: Gastroenterology Authors: T. N. Tran Vuong, E. Le Prisé, E. Vauléon, E. Boucher, O. Audrain, J.-L. Raoul Source Type: journals

Options in the management of esophageal perforation: analysis over a 12-year periodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Controversies exist about the management of esophageal perforation in order to eliminate the septic focus. The aim of this study was to assess the etiology, management, and outcome of esophageal perforation over a 12-year period, in order to characterize optimal treatment options in this severe disease. Between May 1996 and May 2008, 44 patients (30 men, 14 women; median age 67 years) with esophageal perforation were treated in our department. Etiology, diagnostic procedures, time interval between clinical presentation and treatment, therapeutic management, and outcome were analyzed retro- or prospectively for each patient...
Source: Diseases of the Esophagus - October 26, 2009 Category: Gastroenterology Authors: D. Vallböhmer, A. H. Hölscher, M. Hölscher, M. Bludau, C. Gutschow, D. Stippel, E. Bollschweiler, W. Schröder Source Type: journals

Atypical esophageal vascular lesions observed in liver cirrhosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of esophageal vascular lesions resembling spider naevi in a patient with nonalcoholic cirrhosis who underwent an upper gastrointestinal (GI) endoscopy. We observed the presence of multiple white round elevations, 5[ndash]6 mm in size, with radiating thin-walled vessels, in the middle and distal esophagus. The histological examination documented the presence of multiple dilated blood vessels in the mucosal layer of the esophagus, with striking thickening of the endothelium wall. There was no evidence of esophagogastric varices, but only of a moderate congestive antral gastropathy. To our knowledge, these en...
Source: Diseases of the Esophagus - October 26, 2009 Category: Gastroenterology Authors: Fardowza A. Nur, C. Clemente, G. Serino, F. Salerno, L. Spina, M. Vecchi Source Type: journals

Toxicity and outcomes after chemoradiation for esophageal cancer in patients age 75 or olderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, elderly patients experienced substantial morbidity from chemoradiation, and long-term survival was low. Future efforts to improve treatment tolerability in the elderly are needed. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - September 25, 2009 Category: Gastroenterology Authors: R. H. Mak, H. J. Mamon, D. P. Ryan, D. T. Miyamoto, M. Ancukiewicz, W. K. Kobayashi, C. G. Willett, N. C. Choi, L. S. Blaszkowsky, T. S. Hong Source Type: journals

Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, perioperative administration of sivelestat sodium hydrate (starting at the beginning of surgery) mitigated postoperative hypoxia, partially suppressed postoperative hypercytokinemia, shortened the duration of SIRS, and stabilized postoperative circulatory status after thoracoscopic esophagectomy. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - September 24, 2009 Category: Gastroenterology Authors: Y. Kawahara, I. Ninomiya, T. Fujimura, H. Funaki, H. Nakagawara, H. Takamura, K. Oyama, H. Tajima, S. Fushida, H. Inaba, M. Kayahara Source Type: journals

A pilot study of fully covered self-expandable metal stents prior to neoadjuvant therapy for locally advanced esophageal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objectives of this study were the following: (i) to evaluate whether FCSEMS are useful in patients receiving neoadjuvant therapy; and (ii) to assess ease of removability and tissue reaction to FCSEMS. FCSEMS (ALIMAXX-E, Alveolus Inc) were deployed in consecutive patients with locally advanced esophageal cancer over a period of 14 months. All patients were referred for neoadjuvant chemoradiation therapy after stenting. Dysphagia scores were assessed at 0 month, 1 month, 3 months, and 6 months. Barium swallow and endoscopy were performed for new symptoms and follow-up. Eleven patients were treated with FCSEMS prior to ne...
Source: Diseases of the Esophagus - September 24, 2009 Category: Gastroenterology Authors: T. L. Lopes, M. A. Eloubeidi Source Type: journals

Time trends of endoscopic and pathological diagnoses related to gastroesophageal reflux disease in a Chinese population: eight years single institution experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The discrepancy between Eastern and Western countries exists regarding the time trends of Barrett's esophagus (BE)/adenocarcinoma. We aimed to elucidate this issue through a retrospective review of the endoscopic and pathological diagnoses of gastroesophageal reflux disease (GERD) over time in a Chinese population. All records were analyzed from 2000 to 2007. Records included demographic data, clinical indication for endoscopy, and endoscopic findings. The total number of endoscopic procedures increased over time. The indications for referral endoscopy secondary to GERD increased from 366 cases (4.9%) in the beginning of t...
Source: Diseases of the Esophagus - September 24, 2009 Category: Gastroenterology Authors: M.-J. Chen, Y.-C. Lee, H.-M. Chiu, M.-S. Wu, H.-P. Wang, J.-T. Lin Source Type: journals

Expression of FOXP3 in esophageal squamous cell carcinoma relating to the clinical dataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, expression of FOXP3 in ESCC tissue was evaluated in relation to the clinical data. Detection of FOXP3 mRNA was made by using quantitative real-time PCR while protein expression was assessed by immunocytochemistry (n = 112). The results were correlated to the clinical data including age, gender, carcinoma size, carcinoma differentiation, lymphatic invasion and pathological stage. A significantly higher FOXP3 expression in tumors was confirmed than in normal-appearing mucosa. The FOXP3 mRNA and protein expressions were higher in advanced stages (stage II B and III) than in early stages (stage I and stage II A)...
Source: Diseases of the Esophagus - September 24, 2009 Category: Gastroenterology Authors: L. Xue, H.-Q. Lu, J. He, X.-W. Zhao, L. Zhong, Z.-Z. Zhang, Z.-F. Xu Source Type: journals

Thoracic osteophyte: rare cause of esophageal perforationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report two cases of esophageal perforations caused by thoracic osteophytes and different management strategies leading to successful outcomes. An 80-year-old male presented with chest pain and dysphagia following a fall. On endoscopy, an esophageal perforation and foreign body was noted which was confirmed as a thoracic osteophyte on computed tomography scan. He was managed conservatively as he declined surgery. A 63-year-old male was admitted with dysphagia following a food bolus obstruction. Following esophagoscopy and dilatation, there was clinical and radiological evidence of perforation. During surgery, a thoracic ...
Source: Diseases of the Esophagus - August 28, 2009 Category: Gastroenterology Authors: S. Rathinam, T. Makarawo, R. Norton, F. J. Collins Source Type: journals

Definitive concomitant chemoradiotherapy with docetaxel and cisplatin in squamous esopheageal carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study evaluated the docetaxel-based definitive concomitant chemoradiotherapy in patients with esophageal squamous cell carcinoma to determine its clinical response and overall survival. In this unicenter trail, we enrolled 59 patients with histologically proven squamous cell carcinoma in the esophagus between March 2004 and December 2007. All patients were staged II to IV and treated with definitive concomitant chemoradiotherapy. Radiotherapy was delivered with conventional fraction, 50[ndash]64 Gy in 25[ndash]35 fractions. Patients received two cycles of a 1-day regimen containing docetaxel (60 mg/m2) and cisplatin (...
Source: Diseases of the Esophagus - August 27, 2009 Category: Gastroenterology Authors: Q.-Q. Li, M.-Z. Liu, Y.-H. Hu, H. Liu, Z.-Y. He, H.-X. Lin Source Type: journals

Multimodality treatment with intensity modulated radiation therapy for esophageal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study is to determine the feasibility and report the outcome of patients with locally advanced esophageal cancer treated with preoperative or definitive chemoradiotherapy (CRT) using intensity-modulated radiation therapy (IMRT). Between 2003 and 2007, 30 patients with non-cervical esophageal cancer received concurrent chemotherapy and IMRT at Stanford University. Eighteen patients were planned for definitive CRT and 12 were planned for preoperative CRT. All patients had computed tomography-based treatment planning and received IMRT. The median dose delivered was 50.4 Gy. Patients planned for preoperat...
Source: Diseases of the Esophagus - August 27, 2009 Category: Gastroenterology Authors: T. H. La, A. Y. Minn, Z. Su, G. A. Fisher, J. M. Ford, P. Kunz, K. A. Goodman, A. C. Koong, D. T. Chang Source Type: journals

Combined treatment of achalasia – botulinum toxin injection followed by pneumatic dilatation: long-term resultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Injection of botulinum toxin (BT) and pneumatic dilatation are available methods in nonsurgical treatment of achalasia. Authors anticipate beneficial effect of prior BT injection on the success of pneumatic dilatation and duration of its effect. There are no long-term data available to assess efficacy of combined treatment. From 1998 to 2007, 51 consecutive patients (20 men and 31 women, age 24[ndash]83) with achalasia were included and prospectively followed up. Each patient received injection of 200 IU of BT into the lower esophageal sphincter (LES) during endoscopy and 8 days later pneumatic dilatation (PD) under X-ray ...
Source: Diseases of the Esophagus - August 27, 2009 Category: Gastroenterology Authors: R. Kroupa, A. Hep, J. Dolina, V. Valek, Z. Matyasova, J. Prokesova, J. Mrazova, J. Sedmik, I. Novotny Source Type: journals

Clinical predictors of achalasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Limited access to esophageal manometry (EM) may delay identification and treatment of patients with achalasia. In order to assess predictors to fast-track patients for manometric confirmation of achalasia, we compared the clinical, radiographic, and endoscopic characteristics of achalasia patients to patients with functional dysphagia without manometric features of achalasia (controls). Patients referred for esophageal manometry to assess functional dysphagia prospectively identified over a 12-month period were asked to participate in this study. The Achalasia Symptom Questionnaire (ASQ), a structured 11-question survey (s...
Source: Diseases of the Esophagus - August 27, 2009 Category: Gastroenterology Authors: L. E. Ferri, J. Cools-Lartigue, J. Cao, L. Miller, S. Mayrand, G. M. Fried, G. Darling Source Type: journals

Effect of glutamine in patients with esophagus resectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article aims to study the effects of glutamine on systemic inflammatory response, morbidity, and mortality after esophagectomy. A prospective, randomized, double-blind, and controlled trial was used. Following sealed-envelope block randomization, the patients were divided into two groups. Members of the glutamine group (group G) received glutamine (Dipeptiven, Fresenius) as continuous infusion for 6 hours at 0.5 g/kg for 3 days prior to, and 7 days following surgery; while patients of the control group were given placebo. We examined 30 patients in group G, and 25 patients as controls. In both patient groups, the leve...
Source: Diseases of the Esophagus - August 27, 2009 Category: Gastroenterology Authors: S. Marton, S. Ghosh, A. Papp, L. Bogar, T. Koszegi, V. Juhasz, L. Cseke, P. O. Horvath Source Type: journals

Identification of some human genes oppositely regulated during esophageal squamous cell carcinoma formation and human embryonic esophagus developmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Here we directly compared gene expression profiles in human esophageal squamous cell carcinomas and in human fetal esophagus development. We used the suppression subtractive hybridization technique to subtract cDNAs prepared from tumor and normal human esophageal samples. cDNA sequencing and reverse transcription polymerase chain reaction (RT-PCR) analysis of RNAs from human tumor and the normal esophagus revealed 10 differentially transcribed genes: CSTA, CRNN, CEACAM1, MAL, EMP1, ECRG2, and SPRR downregulated, and PLAUR, SFRP4, and secreted protein that is acidic and rich in cysteine upregulated in tumor tissue as compar...
Source: Diseases of the Esophagus - August 27, 2009 Category: Gastroenterology Authors: M. V. Zinovyeva, G. S. Monastyrskaya, E. P. Kopantzev, T. V. Vinogradova, M. B. Kostina, A. V. Sass, O. B. Filyukova, N. Y. Uspenskaya, G. T. Sukhikh, E. D. Sverdlov Source Type: journals

High-dose definitive concomitant chemoradiotherapy in non-metastatic locally advanced esophageal cancer: toxicity and outcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is a retrospective analysis of high-dose definitive concomitant chemoradiotherapy in locally advanced esophageal cancer in a single institution. The aim of the study was to identify and quantify the toxicity associated with the high-dose treatment and to analyze the outcome of this treatment. Forty-six patients (41 men and 5 women, median age of 67.5 years) with disease stage IIA[ndash]III esophageal cancer were treated with high-dose definitive chemoradiotherapy. Thirty patients had squamous cell carcinomas and 16 had adenocarcinomas. The patients were treated with three courses of chemotherapy. Each chemothera...
Source: Diseases of the Esophagus - July 31, 2009 Category: Gastroenterology Authors: M. Hurmuzlu, O. R. Monge, R. Smaaland, A. Viste Source Type: journals

Esophageal manometry in 28 systemic sclerosis Brazilian patients: findings and correlationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Systemic sclerosis (SSc) is a multisystem disease of unknown etiology. Esophageal involvement affects 50[ndash]90% of patients and is characterized by abnormal motility and hypotonic lower esophageal sphincter. Data on the association of esophageal abnormalities and age, gender, SSc subset or duration, autoantibody profile, esophageal symptoms, and medication are lacking or conflicting. The aim of this study was the evaluation of these associations in Brazilian sclerodermic patients from the Rheumatology Division, Clinics Hospital, Federal University, Minas Gerais. They underwent medical records review, clinical interview,...
Source: Diseases of the Esophagus - July 30, 2009 Category: Gastroenterology Authors: D. C. Calderaro, M. A. P. de Carvalho, L. D. Moretzsohn Source Type: journals

Comparative proteomic analysis of β-catenin-mediated malignant progression of esophageal squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
[beta][ndash]catenin has emerged as a key regulator of Wnt signaling pathway, which plays an important role in the development and progression of various cancers. Its accumulation in nucleus of the esophagus squamous epithelium might be the crucial step for the carcinogenesis of esophageal squamous cell carcinoma (ESCC). To detect the proteins correlated with [beta][ndash]catenin function, we used the established cell lines of pGen-3-con (Eca109 cells transfected by control vector) and pGen-3-CTNNB1 (Eca109 cells transfected by [beta]-catenin siRNA) as cell models for further analysis. Two-dimensional gel electrophoresis t...
Source: Diseases of the Esophagus - July 30, 2009 Category: Gastroenterology Authors: H.-Z. Ren, J.-S. Wang, G.-Q. Pan, H. Lv, J.-F. Wen, G.-Q. Luo, K.-S. Wang, P.-F. Zhang Source Type: journals

Palliative radiation therapy practice for advanced esophageal carcinoma in AfricaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
While numerous surveys of pattern of practices of palliative radiotherapy (RT) in advanced esophageal cancers have been published in developed countries, there is no such survey in African countries. During and after a regional training course by the International Atomic Energy Agency (IAEA) in palliative cancer care, a questionnaire was distributed to African RT centers to gather information about infrastructure and human resources available, and the pattern of practice of palliative RT for esophageal cancers. Twenty-four of the 35 centers (60%) completed the questionnaire. Twenty out of 23 (87%) centers treat patients wi...
Source: Diseases of the Esophagus - July 30, 2009 Category: Gastroenterology Authors: V. Sharma, P. M. Gaye, S. A. Wahab, N. Ndlovu, T. Ngoma, V. Vanderpuye, A. Sowuhami, D. A. Dawotola, J. Kigula-Mugambe, B. Jeremic Source Type: journals

Reflux esophagitis and columnar-lined esophagus after cervical esophagogastrostomy (following esophagectomy)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reflux esophagitis (RE) and columnar-lined esophagus (CLE) are frequently observed after esophagectomy. The incidence of these conditions according to time and to the route of esophageal reconstruction after esophagectomy remains unknown. The aim of this study was to clarify any changes and differences of the incidence of RE and CLE in patients who underwent gastric tube reconstruction after esophagectomy. A hundred patients who underwent cervical esophagogastrostomy after resection of the thoracic esophagus were included in this study. We reviewed their endoscopic findings at 1 month, at 1 year and at 2 years after surger...
Source: Diseases of the Esophagus - July 30, 2009 Category: Gastroenterology Authors: K. Nishimura, T. Tanaka, Y. Tanaka, S. Matono, K. Murata, K. Shirouzu, H. Fujita Source Type: journals

Lgr5, an intestinal stem cell marker, is abnormally expressed in Barrett's esophagus and esophageal adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5), a recently discovered intestinal stem cell marker, is expressed in premalignant lesions including Barrett's esophagus (BE) and cancers including colon cancer, ovarian cancer, and hepatocellular carcinoma. It was also recently found to be expressed in tumor spheres prepared from colon cancer, suggesting that it will likely serve as a cancer stem cell marker. We sought to examine Lgr5 as a biomarker in BE-associated neoplasia. Using standard immunohistochemistry, we performed immunostaining on 81 esophageal specimens (53 biopsy specimens and 28 surgical rese...
Source: Diseases of the Esophagus - June 21, 2009 Category: Gastroenterology Authors: L. Becker, Q. Huang, H. Mashimo Source Type: journals

Effectiveness of voice therapy in reflux-related voice disordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gastroesophageal reflux (GER) with laryngopharyngeal reflux plays a significant role in voice disorders. A significant proportion of patients attending ear, nose, and throat clinics with voice disorders may have gastresophageal reflux disease (GERD). There is no controlled study of the effect of voice therapy on GERD. We assessed the effect of voice therapy in patients with dysphonia and GERD. Thirty-two patients with dysphonia and GERD underwent indirect laryngoscopy and voice analysis. Esophageal and laryngeal symptoms were assessed using the reflux symptom index (RSI). At endoscopy, esophagitis was graded according to L...
Source: Diseases of the Esophagus - June 21, 2009 Category: Gastroenterology Authors: K. Vashani, M. Murugesh, G. Hattiangadi, G. Gore, V. Keer, V. S. Ramesh, V. Sandur, S. J Bhatia Source Type: journals

Protective effects of glycoursodeoxycholic acid in Barrett's esophagus cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, treatment of BE cells with acidified medium and a bile acid cocktail at physiologically relevant concentrations induces DNA damage, cytotoxicity, and ROS. The cytoprotective bile acid, GUDCA, inhibits these deleterious effects by inhibiting oxidative stress. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - June 21, 2009 Category: Gastroenterology Authors: A. Goldman, A. Condon, E. Adler, M. Minnella, C. Bernstein, H. Bernstein, K. Dvorak Source Type: journals

Endoscopic classification for reflux pharyngolaryngitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The quality of life in patients who have undergone surgery for esophageal cancer is frequently disturbed by postoperative gastroesophageal reflux disease or pharyngolaryngeal reflux disease. Recently, there have been many reports on gastroesophageal reflux disease after esophagectomy, and only a few on pharyngolaryngeal reflux disease. There is not yet any convenient endoscopic classification of reflux pharyngolaryngitis. We designed a new classification for reflux pharyngolaryngitis based on endoscopic findings. Our new classification consists of the five grades from 0 to IV based on (i) the extent and severity of erythem...
Source: Diseases of the Esophagus - June 21, 2009 Category: Gastroenterology Authors: K. Nishimura, H. Fujita, T. Tanaka, Y. Tanaka, S. Matono, K. Murata, H. Umeno, K. Shirouzu Source Type: journals

Prevalence and outcome of esophagogastric anastomotic leak after esophagectomy in a UK regional cancer networkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to determine the contemporary prevalence, outcome, and survival after esophagogastric anastomotic leakage (EGAL) following esophagectomy by a regional upper gastrointestinal cancer network and to investigate etiological factors. Two hundred forty consecutive patients underwent esophagectomy over a 10-year period (median age 61 [31[ndash]79] years, 147 transthoracic and 93 transhiatal esophagectomy, 105 neoadjuvant chemotherapy, 49 chemoradiotherapy). The primary outcome measures were the development of EGAL and survival. Twenty patients developed EGAL (8.3%, 15 managed conservatively, 5 reoperatio...
Source: Diseases of the Esophagus - June 21, 2009 Category: Gastroenterology Authors: X. Escofet, A. Manjunath, C. Twine, T. J. Havard, G. W. Clark, W. G. Lewis Source Type: journals

Safety, tolerability, and efficacy of endoscopic low-pressure liquid nitrogen spray cryotherapy in the esophagusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study is to characterize safety, tolerability, and efficacy of low-pressure liquid nitrogen endoscopic spray cryotherapy ablation in a large cohort across multiple study sites. Parallel prospective treatment studies at four tertiary care academic medical centers in the U.S. assessed spray cryotherapy in patients with Barrett's esophagus with or without dysplasia, early stage esophageal cancer, and severe squamous dysplasia who underwent cryotherapy ablation of the esophagus. All patients were contacted between 1 and 10 days after treatment to assess for side effects and complications of treatment. The...
Source: Diseases of the Esophagus - June 11, 2009 Category: Gastroenterology Authors: Bruce D. Greenwald, John A. Dumot, J. David Horwhat, Charles J. Lightdale, Julian A. Abrams Source Type: journals

Medium-term outcome of fundoplication after lung transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gastroesophageal reflux disease (GERD) in lung transplant recipients has gained increasing attention as a factor in allograft failure. There are few data on the impact of fundoplication on survival or lung function, and less on its effect on symptoms or quality of life. Patients undergoing fundoplication following lung transplantation from 1999 to 2005 were included in the study. Patient satisfaction, changes in GERD symptoms, and the presence of known side effects were assessed. The effect on lung function, body mass index, and rate of progression to the bronchiolitis obliterans syndrome (BOS) were recorded. Twenty-one pa...
Source: Diseases of the Esophagus - June 9, 2009 Category: Gastroenterology Authors: P. R. Burton, B. Button, W. Brown, M. Lee, S. Roberts, S. Hassen, M. Bailey, A. Smith, G. Snell Source Type: journals

Superficial primary small cell carcinoma of the esophagus: clinicopathological and immunohistochemical analysis of 15 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study mainly retrospectively analyzed clinicopathological and immunohistochemical features of 15 cases of superficial PESCC in our hospital from 1990 to 2004, in order to find suitable diagnostic markers and applicable therapies for this disease. The records mainly included presenting symptoms, demographics, diagnostic method, histopathology, follow[ndash]up, and therapy. Immunohistochemical staining of chromogranin A (CgA), neuron-specific enolase (NSE), synaptophysin (Syn), neuronal cell adhesion molecules (CD56), thyroid transcription factor-1 (TTF-1), cytokeration 34[beta]E12 (CK34[beta]E12), cytokeratin (AE1/AE3)...
Source: Diseases of the Esophagus - June 9, 2009 Category: Gastroenterology Authors: J. Lu, L.-Y. Xue, N. Lu, S.-M. Zou, X.-Y. Liu, P. Wen Source Type: journals

Barrett's esophagus and endoscopically assessed esophagogastric junction integrity in 1000 consecutive Turkish patients undergoing endoscopy: a prospective studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Barrett's esophagus (BE) appears to be more common in Western than in Asian countries. BE is a complication of gastroesophageal reflux disease (GERD). Anatomical abnormalities of the esophagogastric junction (EGJ) are an important factor in the pathogenesis of GERD. We aimed to determine the prevalence of BE in Turkey, which is geographically located between Europe and Asia, and to investigate the frequency of BE according to the degree of anatomical disruption in the EGJ. This prospective study was performed on 1000 consecutive patients referred for endoscopy for any clinical indication. All patients underwent a structure...
Source: Diseases of the Esophagus - June 9, 2009 Category: Gastroenterology Authors: B. Ödemiş, B. Çiçek, N. İ. Zengin, M. Arhan, S. Kacar, C. Cengiz, O. Yüksel Source Type: journals

Influence of psychopathological changes on quality of life after laparoscopic fundoplication for the treatment of gastroesophageal refluxEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study is to analyze the influence of psychological changes, as assessed by the General Health Questionnaire-28 (GHQ-28), on patients undergoing surgery for gastroesophageal reflux. This is a prospective study in a series of 103 consecutive patients (62 males and 41 females with a mean age of 40 years) undergoing laparoscopic fundoplication. In addition to functional studies, patients completed the SF-36, Gastrointestinal Quality of Life Index, and GHQ-28 before surgery. Functional tests and questionnaires were repeated 6 months after surgery. Patients were also questioned about their degree of satisfa...
Source: Diseases of the Esophagus - June 9, 2009 Category: Gastroenterology Authors: Á. Díaz de Liaño, C. Yárnoz, C. Artieda, A. Artajona, L. Fernández, H. Ortiz Source Type: journals

Prospective non-randomized study of preoperative concurrent platinum plus 5-fluorouracil-based chemoradiotherapy with or without paclitaxel in esophageal cancer patients: long-term follow-upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study confirmed improved prognosis of patients after achieving negativity of nodes. Distant metastases prevailed as cause of the treatment failure. Prospectively, it is important to look for a therapeutic combination with better systemic effect. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - June 9, 2009 Category: Gastroenterology Authors: M. Zemanova, L. Petruzelka, A. Pazdro, D. Kralova, M. Smejkal, G. Pazdrova, H. Honova Source Type: journals

Trends in the management of esophageal carcinoma based on provider volume: treatment practices of 618 esophageal surgeonsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Controversy exists regarding optimal treatment practices for esophageal cancer. Esophagectomy has received focus as one of the index procedures for both hospital and surgical quality despite a relative paucity of controlled trials to define best practices. A survey was created to determine the degree of heterogeneity in the treatment of esophageal cancer among a diverse group of surgeons and to use high-volume (HV) ([ge]15 cases/year) and low-volume (LV) ( (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - June 9, 2009 Category: Gastroenterology Authors: C. K. Enestvedt, K. A. Perry, C. Kim, P. W. McConnell, B. S. Diggs, A. Vernon, R. W. O'Rourke, J. D. Luketich, J. G. Hunter, B. A. Jobe Source Type: journals

Esophagectomy for cancer: clinical concerns support centralizing operations within the larger hospitalsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Esophagectomy needs experienced surgical techniques and a well-trained perioperative care team. There are now many reports that the mortality rate after esophagectomy is higher in those hospitals with a low volume of esophagectomy and/or low surgeon's volume. The purpose of this study is to decide the respective numbers of esophagectomy operations per year to define low-volume and high-volume hospitals in Japan. If medical policy aims to further reduce mortality and morbidity associated with esophagectomy, then esophagectomy operations should be further centralized, away from low-volume hospitals, into high-volume hospital...
Source: Diseases of the Esophagus - June 9, 2009 Category: Gastroenterology Authors: H. Fujita, S. Ozawa, H. Kuwano, Y. Ueda, S. Hattori, T. Yanagawa Source Type: journals

Is esophagoscopy necessary for corrosive ingestion in adults?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the study was to determine whether early esophagoscopy is really necessary for the patients who have ingested a corrosive agent. Patients who were followed up with the diagnosis of corrosive ingestion in our clinic between the years 1998 and 2008 were studied retrospectively. The data were collected through the medical records of the patients and from interviews with them. The analyzed parameters included age, gender, the nature and the amount of the ingested agent, whether the event was accidental or suicidal, diagnostic tools, treatment and the results of the treatment, and long-term follow up. Over a 10-year ...
Source: Diseases of the Esophagus - June 9, 2009 Category: Gastroenterology Authors: Burcin Celik, Aydın Nadir, Ekber Sahin, Melih Kaptanoglu Source Type: journals

Does combined multichannel intraluminal esophageal impedance and manometry predict postoperative dysphagia after laparoscopic Nissen fundoplication?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Laparoscopic Nissen fundoplication (LNF) is an effective treatment for gastroesophageal reflux disease; however, some patients develop dysphagia postoperatively. Manometry is used to evaluate disorders of peristalsis, but has not been proven useful to identify which patients may be at risk for postoperative dysphagia. Multichannel intraluminal impedance (MII) evaluates the effective clearance of a swallowed bolus through the esophagus. We hypothesized that MII combined with manometry may detect those patients most at risk of developing dysphagia after LNF. Between March 2003 and January 2007, 74 patients who agreed to part...
Source: Diseases of the Esophagus - June 9, 2009 Category: Gastroenterology Authors: M. Montenovo, R. P. Tatum, E. Figueredo, A. Valeria Martin, H. Vu, E. Quiroga, C. A. Pellegrini, B. K. Oelschlager Source Type: journals

Assessment of response to neoadjuvant therapy in esophageal cancer: an updated systematic review of diagnostic accuracy of endoscopic ultrasonography and fluorodeoxyglucose positron emission tomographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For assessing response to neoadjuvant therapy in patients with esophageal cancer, both endoscopic ultrasonography (EUS) and fluorodeoxyglucose positron emission tomography (FDG-PET) are commonly used, and despite few controlled trials, it is not known if one imaging modality is superior to the other. Also, relative diagnostic accuracy of early (during the course of neoadjuvant therapy) and FDG-PET after completion of neoadjuvant therapy has not been reviewed. The aim of this study was to perform a systematic review of published information to compare diagnostic accuracy of EUS and FDG-PET in this setting. A search of the M...
Source: Diseases of the Esophagus - June 9, 2009 Category: Gastroenterology Authors: S. Ngamruengphong, V. K. Sharma, B. Nguyen, A. Das Source Type: journals

The prognostic importance of pathologically involved celiac node metastases in node-positive patients with carcinoma of the distal esophagus or gastroesophageal junction: a surgical series from the Mayo ClinicEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The management of esophageal cancer with involvement of celiac lymph nodes is controversial. The purpose of this retrospective study was to evaluate the clinical importance of metastases to celiac lymph nodes in patients with carcinoma of the distal esophagus or gastroesophageal junction (GEJ) who undergo surgical treatment with curative intent. We reviewed the medical records of 310 patients who underwent definitive esophagectomy at the Mayo Clinic, Rochester, Minnesota, between 1976 and 1999 for carcinoma of the distal esophagus or GEJ. The disease location was distal esophagus in 163 and GEJ in 147. Fifty-two patients (...
Source: Diseases of the Esophagus - June 9, 2009 Category: Gastroenterology Authors: David A. Schomas, J. Fernando Quevedo, James M. Donahue, Francis C. Nichols III, Yvonne Romero, Robert C. Miller Source Type: journals

The use of self-expandable metallic stents for palliative treatment of inoperable esophageal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the aim was to evaluate retrospectively the effectiveness of metallic stents deployed because of inoperable malignant esophageal stenosis and esophagotracheal fistulas. The results of 170 patients with 202 stents administered because of inoperable malignant esophageal stenosis and esophagorespiratory fistula between January 2000 and October 2008 at the Ataturk University, Department of Thoracic Surgery, were investigated. Despite epidemiological and clinical data, information regarding relief of dysphagia and quality of life were also examined. One hundred seventy patients with stents were between 28 and 91 ...
Source: Diseases of the Esophagus - May 19, 2009 Category: Gastroenterology Authors: A. Eroglu, A. Turkyilmaz, M. Subasi, N. Karaoglanoglu Source Type: journals

Contribution of germ line BRCA2 sequence alterations to risk of familial esophageal cancer in a high-risk area of IndiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The incidence of esophageal squamous cell carcinoma (ESCC) is very high in the northeast region of India. An earlier study from China and Iran suggested that mutations in BRCA2 gene may play a role in the etiology of familial ESCC. However, the frequency of BRCA2 gene germ line mutations and its contribution to risk of familial aggregation of ESCC in high-risk region of India are not known. In the current study of 317 cases of esophageal cancer, 92 (29%) cases had a family history of esophageal and/or other cancers. Of these 92 patients, 45 (49%) patients had a family history of esophageal cancer. The risk of developing es...
Source: Diseases of the Esophagus - May 15, 2009 Category: Gastroenterology Authors: M. Kaushal, I. Chattopadhyay, R. Phukan, J. Purkayastha, J. Mahanta, S. Kapur, S. Saxena Source Type: journals

Clinical manifestation of esophageal carcinosarcoma: a Taiwan experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to investigate its clinicopathologic features and endoscopic characteristics. The data of patients diagnosed to have esophageal carcinosarcoma pathologically in the past 30 years (January 1976[ndash]December 2007) were reviewed. Of 3318 cases of esophageal malignancy, 12 were diagnosed as esophageal carcinosarcoma, with an incidence of 0.36%. All of the cases were male with a mean age of 62.3 years. Of the 12 tumors, 8 were polypoid type, and 4 were ulcerative type. In the endoscopic ultrasonography examination, the tumors show heterogeneous hypoechoic lesions with irregular outer margins and internal mult...
Source: Diseases of the Esophagus - May 15, 2009 Category: Gastroenterology Authors: C.-J. Kuo, T.-N. Lin, C.-J. Lin, R.-C. Wu, H.-K. Chang, Y.-Y. Chu, J.-M. Lien, M.-Y. Su, C.-T. Chiu Source Type: journals

Frequent occurrence of esophageal cancer in young people in western KenyaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Esophageal cancer has a strikingly uneven geographical distribution, resulting in focal endemic areas in several countries. One such endemic area is in western Kenya. We conducted a retrospective review of all pathology-confirmed malignancies diagnosed at Tenwek Hospital, Bomet District, between January 1999 and September 2007. Tumor site, histology, sex, age, ethnicity, and location of residence were recorded. Cases were analyzed within and outside a traditional catchment area defined as [le]50 km from the hospital. Since 1999, the five most common cancer sites were the esophagus, stomach, prostate, colorectum, and cervix...
Source: Diseases of the Esophagus - May 15, 2009 Category: Gastroenterology Authors: R. K. Parker, S. M. Dawsey, C. C. Abnet, R. E. White Source Type: journals

Salvage esophagectomy after definitive chemoradiotherapy for synchronous double cancers of the esophagus and head-and-neckEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Head-and-neck cancer is frequently associated with esophageal cancer. Because the operative procedures for these synchronous double cancers are too invasive, definitive chemoradiotherapy tends to be applied as an initial treatment. A salvage esophagectomy for either recurrent or residual disease after definitive chemoradiotherapy in patients with such double cancer has never been reported. We reviewed 21 patients with esophageal cancer who underwent a salvage esophagectomy after definitive chemoradiotherapy. Among them, the treatment course of five patients who underwent a salvage esophagectomy for patients with synchronou...
Source: Diseases of the Esophagus - April 17, 2009 Category: Gastroenterology Authors: R. Yoshida, M. Morita, K. Ando, T. Masuda, H. Saeki, E. Oki, N. Sadanaga, T. Nakashima, Y. Kakeji, Y. Maehara Source Type: journals

Application of a modified McKeown procedure (thoracoscopic esophageal mobilization three-incision esophagectomy) in esophageal cancer surgery: Initial experience with 30 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Early efforts with minimally invasive esophagectomy (MIE) were hybrid approaches. No conclusive benefit was seen with this approach compared with the standard open procedure. Total MIE has demonstrated its advantages in single institution series. The drawbacks of total MIE include the steep learning curve and the high cost of the disposable instrumentation. We sought to determine the feasibility of modifying the surgical technique involved in the hybrid approach in an effort to decrease the cost of the surgery without compromising the outcome. From December 2007 to September 2008, the modified McKeown procedure (thoracosco...
Source: Diseases of the Esophagus - April 15, 2009 Category: Gastroenterology Authors: Jianhua Zhou, Haiquan Chen, Jiade J. Lu, Jiaqing Xiang, Yawei Zhang, Hong Hu, Xian Zhou, Xiaoyang Luo, Fu Yang, John Tam Source Type: journals

Prognostic significance of perigastric lymph nodes metastases on survival in patients with thoracic esophageal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several publications have showed that the number of metastatic lymph node (LN) should be taken into consideration in nodal category of esophageal cancer, but seldom considered extent of involved regional LNs. The aim of this study is to evaluate the significance of the extent of regional LN metastasis on survival in patients with esophageal cancer. A total of 245 thoracic esophageal cancer patients underwent transthoracic esophagectomy with standard lymphadenectomy between January 2000 and December 2006 were included in the study. Data including demographic factors, pathologic findings, LN parameters and survival outcomes ...
Source: Diseases of the Esophagus - April 15, 2009 Category: Gastroenterology Authors: Zhi-Yong Wu, Jun-Cai Yu, Li-Yan Xu, Jin-Hui Shen, Jian-Zhong Wu, Shao-Hong Wang, Jun-Hui Fu, Yang-Hang Fan, Bin-Na Yang, Zhong-Ying Shen, Qiao Huang, En-Min Li Source Type: journals

Polymorphisms of HLA-A and HLA-B genes in genetic susceptibility to esophageal carcinoma in Chaoshan Han ChineseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Esophageal carcinoma (EC) occurs at high rate in Chaoshan region of southern China. Human leukocyte antigen (HLA) polymorphism has been implicated in risk for various cancers. To investigate the impact of HLA-A and HLA-B polymorphisms on susceptibility to EC, a case[ndash]control study was conducted among 206 patients with esophageal squamous cell carcinoma and 524 controls from Chaoshan Han population. HLA-A and HLA-B polymorphisms were genotyped by polymerase chain reaction-sequence-specific primers. Genotypic association tests for dominant, recessive, and additive models, and haplotypic association were calculated using...
Source: Diseases of the Esophagus - April 15, 2009 Category: Gastroenterology Authors: Sheng-Ping Hu, Guang-Biao Zhou, Jian-An Luan, Yu-Ping Chen, Da-Wei Xiao, Yu-Ju Deng, Li-Qun Huang, Ke-Li Cai Source Type: journals