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Spatial distributions of on- and off-responses determined with the multifocal ERGEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We studied the contribution of retinal on- and off-mechanisms in the multifocal electroretinogram (mfERG) by measuring responses to sawtooth stimuli. Six healthy subjects participated in this study. Rapid-on and rapid-off sawtooth stimuli with a period of 427 ms were presented in a multifocal pattern composed of 19 hexagons. The stimuli were interleaved with a blank field of the mean luminance and chromaticity. On- and off-responses were added to extract response asymmetries. The amplitudes of on-, off-, and added-responses were determined for different eccentricities relative to a signal basel...
Source: Documenta Ophthalmologica - November 17, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Retinal function in patients treated with tamoxifenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Tamoxifen, an effective treatment of breast cancer, has been shown to cause ocular toxic effects. The purpose of this study was to determine retinal toxicity by full-field and focal electroretinograms (ERGs) in patients treated with tamoxifen. Full-field and focal ERGs were obtained from three groups: Tamoxifen—14 females (47–72 years, mean 58.3 ± 9.1) with normal fundus, treated with tamoxifen from 2 to 37 months; No Treatment—10 females (39–65 years, mean 50.1 ± 8.7) with previous breast cancer diagnosis and before tamoxifen treatment; Control—13 normal...
Source: Documenta Ophthalmologica - November 12, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Psychophysical assessment of low visual function in patients with retinal degenerative diseases (RDDs) with the Diagnosys full-field stimulus threshold (D-FST)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To determine whether the Diagnosys full-field stimulus threshold (D-FST) is a valid, sensitive and repeatable psychophysical method of measuring and following visual function in low-vision subjects. Fifty-three affected eyes of 42 subjects with severe retinal degenerative diseases (RDDs) were tested with achromatic stimuli on the D-FST. Included were subjects who were either unable to perform a static perimetric field or had non-detectable or sub-microvolt electroretinograms (ERGs). A subset of 21 eyes of 17 subjects was tested on both the D-FST and the FST2, a previous established full-field thresh...
Source: Documenta Ophthalmologica - November 3, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Understanding ischemic retinopathies: emerging concepts from oxygen-induced retinopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Ischemic retinopathies, such as retinopathy of prematurity and diabetic retinopathy are characterized by an initial microvascular degeneration, followed by an abnormal hypoxia-induced neovascularization. Oxygen-induced retinopathy (OIR) is a well-established in vivo model of ischemic retinopathies, which, although the triggering insult varies, all share a common end result of capillary loss. Understanding the mechanisms of normal retinal vascular development as well as the pathophysiological processes leading to the primary vascular loss is the key to develop treatments to prevent the sight-threaten...
Source: Documenta Ophthalmologica - October 30, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Assessment of depth perception using psychophysical thresholds and stereoscopically evoked brain activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Dynamic random-dot stereograms (dRDS) elicit brain activity generated exclusively by cortical neurons sensitive to binocular horizontal disparity. We studied 20 adults with stereovision deficiency but otherwise normal vision. Psychophysical thresholds were determined with static RDS and with the three-rod experiment. VEP was recorded from seven occipital channels. Stimuli were presented on a monitor by dRDS as stereoscopic checkerboard patterns that moved in depth with 8 depth reversals per second. Horizontal disparity ranged from 7 to 24.5 min of arc. Stimuli were displayed at the center, or i...
Source: Documenta Ophthalmologica - October 23, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Oxygen supply and consumption in the retina: implications for studies of retinopathy of prematurityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A disrupted oxygen environment in the retina of severely premature neonates is thought to be a key factor in the development of retinopathy of prematurity (ROP). This review describes our understanding of intraretinal oxygen distribution and consumption in a range of animal models, including species with naturally avascular retinas and models of induced occlusion of the retinal vasculature. The influence of graded systemic hyperoxia on retinal oxygenation is also discussed along with modulation of retinal oxygen metabolism. The differences in retinal oxygenation between developing and mature retinas...
Source: Documenta Ophthalmologica - October 15, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

ISCEV standard for clinical visual evoked potentials (2009 update)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Visual evoked potentials (VEPs) can provide important diagnostic information regarding the functional integrity of the visual system. This document updates the ISCEV standard for clinical VEP testing and supersedes the 2004 standard. The major change in this revision is that test parameters have been made more precise to achieve better consistency of results within and between test centers. The ISCEV standard VEP protocols are defined for a single recording channel with a midline occipital active electrode. These protocols are intended for assessment of prechiasmal function; additional electrode sit...
Source: Documenta Ophthalmologica - October 13, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

The anatomy of the rat eye with oxygen-induced retinopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study of 50/10 and 75 model rats, retinal flatmounts were used to study the full vasculature at postnatal day (P) 15, P19 and P30. In addition, the layers of the neural retina were measured in toluidine blue-stained cross sections. Finally, gross anatomic features of the eye, including axial length, retinal surface area, and the ratio of anterior to posterior axial-lengths were evaluated. Both clock hours of neovascularization (NV) and percent avascular retina (AR) peaked at P19 and resolved by P30. Through P19, NV was found in every 50/10 model rat, but in only 60% of 75 model rats. AR was positively related ...
Source: Documenta Ophthalmologica - October 10, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

The results of electrophysiological tests in unilateral extensive peripapillary myelinated nerve fibers: report of three casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The purpose of this study is to describe clinical and electrophysiological findings of three patients with unilateral extensive peripapillary myelinated nerve fibers. Three patients with unilateral extensive peripapillary myelinated nerve fibers were examined. A complete ophthalmologic examination including uncorrected and best spectacle corrected visual acuities (UCVA, BSCVA) on Snellen charts, dilated fundoscopy, fundus fluorescein angiography (FFA), optical coherence tomography (OCT), perimetry and electrophysiological tests was performed. ERG results of both eyes were normal in all cases. FFA sh...
Source: Documenta Ophthalmologica - October 7, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Fundus white spots and acquired night blindness due to vitamin A deficiencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To report a successfully treated case of acquired night blindness associated with fundus white spots secondary to vitamin A deficiency. An ocular examination, electrophysiologic testing, as well as visual field and OCT examinations were obtained on a 61-year-old man with vitamin A deficiency who had previously undergone gastric bypass surgery. The patient had a re-evaluation after treatment with high doses of oral vitamin A. The patient was observed to have numerous white spots in the retina of each eye. Best-corrected visual acuity was initially 20/80 in each eye, which improved to 20/40-1 OU after...
Source: Documenta Ophthalmologica - October 7, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Hereditary influences in oxygen-induced retinopathy in the ratEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Rodent models of oxygen-induced retinopathy (OIR) provide important insights into the pathogenesis of human retinopathy of prematurity. Herein, we present an overview of our work with rat OIR to date. We have identified marked and consistent variations in susceptibility to OIR amongst different inbred rat strains and provide strong evidence for a genetic determinant of susceptibility to OIR. Furthermore, we have characterised differences in retinal angiogenic factor gene expression amongst different inbred rat strains exposed to cyclic hyperoxia. A key determinant of susceptibility to OIR appears to...
Source: Documenta Ophthalmologica - September 19, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Dimethyl sulphoxide dose–response on rat retinal functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of the study is to determine whether dimethyl sulphoxide (DMSO), a common laboratory solvent, impacts retinal function. Long Evans rats (n = 17) were intravitreally injected with five different doses of DMSO representative of those reported in the literature and spanning over 3 log units of vitreal concentration (0.01–8%). Retinal function was evaluated 1 h after injection using electroretinograms, and the waveform was decomposed into outer (photoreceptor), middle (ON-bipolar cell) and inner retinal (amacrine and ganglion cell) components. DMSO induces a dose-dependent ...
Source: Documenta Ophthalmologica - September 17, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

The significance of neuronal and glial cell changes in the rat retina during oxygen-induced retinopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Retinopathy of prematurity is a devastating vascular disease of premature infants. A number of studies indicate that retinal function is affected in this disease. Using the rat model of oxygen-induced retinopathy, it is possible to explore more fully the complex relationship between neuronal, glial and vascular pathology in this condition. This review examines the structural and functional changes that occur in the rat retina following oxygen-induced retinopathy. We highlight that vascular pathology in rats is characterized by aberrant growth of blood vessels into the vitreous at the expense of bloo...
Source: Documenta Ophthalmologica - September 17, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Electrophysiological deficits in the retina of the DBA/2J mouseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The DBA/2J (D2J) is a genetic mouse model for glaucomatous neurodegeneration because the animals develop anatomical and functional retinal deficits that partially can be correlated with elevated intraocular pressure (IOP). The IOP starts to increase at an age of about 6 months as a result of morphological changes within the anterior eye segment, e.g., pigment dispersion and iris synechiae. The purpose of the present study was to investigate how ERG responses change in individuals at different ages in D2J mice and to compare these changes with normal aging effects in pigmented C57/B6 (B6) mice. ...
Source: Documenta Ophthalmologica - September 17, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Color Doppler imaging and pattern visual evoked potential in normal tension glaucoma and hypertension glaucomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To compare the differences in color Doppler imaging (CDI) and pattern visual evoked potential (P-VEP) examinations between normal tension glaucoma (NTG) and hypertension primary open angle glaucoma (HTG) patients, and investigate the relation between flow velocities measured by CDI and P-VEP examination in NTG and HTG patients. Sixty NTG patients, 66 HTG patients and 44 control subjects underwent CDI evaluation of the ophthalmic artery (OA), short posterior ciliary artery (SPCA) and central retinal arteries (CRA). The peak systolic velocities (PSV) and end-diastolic velocities (EDV) and resistive in...
Source: Documenta Ophthalmologica - September 16, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Metamorphopsia in patients with macular telangiectasia type 2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Metamorphopsia is a frequent clinical symptom in MacTel type 2 even in the absence of neovascularization. Since macular thickness was within normal limits in such eyes, extensive swelling or distortion of the neurosensory retina would not account for metamorphopsia in contrast to other macular diseases such as age-related macular degeneration or idiopathic epiretinal membranes. Content Type Journal ArticleCategory Original Research ArticleDOI 10.1007/s10633-009-9190-9Authors Peter Charbel Issa, University of Bonn Department of Ophthalmology Ernst-Abbe-Str. 2 53127 Bonn GermanyFrank G. Holz, University of ...
Source: Documenta Ophthalmologica - August 27, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

The XLVII ISCEV International Symposium Abstract IssueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Editorial NotesDOI 10.1007/s10633-009-9186-5Authors Alma Patrizia Tormene, Università di Padova Dipartimento di Neuroscienze, Clinica Oculistica Padova Italy Journal Documenta OphthalmologicaOnline ISSN 1573-2622Print ISSN 0012-4486 (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - August 21, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Transitions of multifocal electroretinography in patients with age-related macular degeneration after combination therapy with photodynamic therapy and intravitreal bevacizumabEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To evaluate by multifocal electroretinograms (mfERG) the macular function before and after combined treatment with photodynamic therapy (PDT) and intravitreal bevacizumab in eyes suffering from choroidal neovascularization (CNV) due to age-related macular degeneration (AMD). 15 eyes of 15 patients with subfoveal CNV were studied before and after the combined treatment. The post-treatment follow-up was 6 months. MfERG recordings were performed in each patient before and 1, 3, and 6 months after the treatment. The mean N1 response amplitudes tended to increase after the treatment, and ring 2...
Source: Documenta Ophthalmologica - August 14, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Light-adapted electroretinograms in optic nerve hypoplasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The purpose of the study is to characterise retinal function using light-adapted electroretinograms (ERGs) in a series of young children with ONH, congenital dysplasia of retinal ganglion cells. ERGs were recorded with chloral hydrate sedation in 27 children with ONH (18 with bilateral and 9 with unilateral ONH, age 4–35 months) and an adult reference population (n = 12). Stimuli included ISCEV standard flash, oscillatory potentials (OPs) and standard flicker as well as a light-adapted luminance–response series (photopic hill). The disc diameter to disc macula (DD:DM) ratio was mea...
Source: Documenta Ophthalmologica - August 11, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Programme: XLVII ISCEV International SymposiumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s10633-009-9185-6 Journal Documenta OphthalmologicaOnline ISSN 1573-2622Print ISSN 0012-4486 (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - July 31, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

The development of the rat model of retinopathy of prematurityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article provides historical perspective on the development and use of the rat model of ROP. Key findings generated through the use of this model are also summarized. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s10633-009-9180-yAuthors Joshua M. Barnett, Vanderbilt University School of Medicine Department of Pharmacology Nashville TN USASusan E. Yanni, Vanderbilt University School of Medicine Department of Cell and Developmental Biology Nashville TN USAJohn S. Penn, Vanderbilt University School of Medicine Department of Pharmacology Nashville TN USA Journal Documenta OphthalmologicaOnli...
Source: Documenta Ophthalmologica - July 29, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Abstracts: XLVII ISCEV International SymposiumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory AbstractsDOI 10.1007/s10633-009-9182-9 Journal Documenta OphthalmologicaOnline ISSN 1573-2622Print ISSN 0012-4486 (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - July 29, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

The effects of oxygen stresses on the development of features of severe retinopathy of prematurity: knowledge from the 50/10 OIR modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study is to determine growth factor expression and activation of signaling pathways associated with intravitreous neovascularization and peripheral avascular retina using a model of retinopathy of prematurity (ROP) relevant to today with oxygen monitoring in neonatal units. Studies using 50/10 oxygen-induced retinopathy (OIR) and 50/10 OIR+SO models were reviewed. Repeated fluctuations in oxygen increased retinal vascular endothelial growth factor (VEGF) even while peripheral avascular retina persisted and prior to the development of intravitreous neovascularization. Repeated fluctuations in oxyge...
Source: Documenta Ophthalmologica - July 29, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Author indexEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s10633-009-9184-7 Journal Documenta OphthalmologicaOnline ISSN 1573-2622Print ISSN 0012-4486 (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - July 28, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Threshold determination in sweep VEP and the effects of criterionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract In order to develop criteria for the range of data points used for regression line fitting in sweep visually evoked potential (sVEP), which would be objective, clearly specified and give good repeatability and validity, and in order to investigate the effect of luminance on sVEP measurement, visual acuity (VA) and contrast sensitivity (CS) were measured with sVEP in adults aged 17–30 years and children aged 6–8 years. Six to ten participants took part in each experiment. Five criteria (C0–C4) for fitting the regression line were implemented. Test–retest repeatability and validity a...
Source: Documenta Ophthalmologica - June 25, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Paradoxical robust visual evoked potentials in young patients with cortical blindnessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to review retrospectively cases of clinically blind children in whom robust pattern visual evoked potentials (VEPs) were recorded. VEP records from a 10-year period (1990–2000) were reviewed. We searched for charts of children who were clinically cortically blind, but in whom assessment of visual acuity, using visual evoked potentials (VEPs), was normal or close to normal. The majority (77.5%) of VEP and behavioral acuity measures were concordant (subset analysis). Of the 1,113 VEP records, 9 cases (<1% of records reviewed) had clinically compromised vision with fair to good levels...
Source: Documenta Ophthalmologica - June 23, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Dengue maculopathy: visual electrophysiology and optical coherence tomographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to evaluate the visual loss due to dengue fever using retinal and cortical electrophysiology and retinal imaging. The participants were three female patients with low visual acuity after dengue fever. They were evaluated by routine ophthalmological investigations, transient pattern electroretinogram (tPERG), transient pattern visual evoked cortical potential (tPVECP), and retinal optical coherence tomography (retinal OCT). tPERG and tPVECP amplitude (μV) and implicit time (ms) were the parameters evaluated using OCT retinal thickness (μm) and reflectivity. All patients presented low vi...
Source: Documenta Ophthalmologica - June 18, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Transient electro-oculogram impairment in unilateral acute idiopathic maculopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Unilateral acute idiopathic maculopathy (UAIM) is a rare distinct entity characterized by acute exudative maculopathy occurring in young persons. The purpose of this case study is to report transient electro-oculogram (EOG) impairment during the acute stage of UAIM. A 16-year-old healthy female with UAIM in the left eye underwent serial visual field, fluorescein angiography, indocyanine green angiography, full-field electroretinogram (ERG), and EOG. Initial visual acuity of the affected left eye was 4/200 with macular subretinal exudates. Indocyanine green angiography disclosed early phase foveal hy...
Source: Documenta Ophthalmologica - June 17, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Prospective, cross-sectional study, demonstrating efficacy of blue fixation target while recording Pattern Visual Evoked Potential in optic neuropathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the authors have used a blue fixation target as a method to ensure fixation in patients with RG color deficits and have demonstrated the ability to get good recordings in cases with otherwise flat recording. The use of alternate colored target or achromatic fixation target should be considered to ensure good central fixation so as to yield better quality recording that possibly correlates better with the functioning of the optic pathway in subjects with abnormal color vision. Content Type Journal ArticleCategory Original Research ArticleDOI 10.1007/s10633-009-9174-9Authors Ajoy Vincent, Narayana Neth...
Source: Documenta Ophthalmologica - June 10, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Evidence for a critical role of panretinal pathophysiology in experimental ROPEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract In this review, we summarize our in vivo studies of retinal pathophysiology in experimental models of retinopathy of prematurity, which were largely focused on the temporal and spatial links between retinal neovascularization (NV), vascular oxygenation, and intraretinal ion regulation. These studies were made possible through the use of magnetic resonance methods. Prior to the phenotype change from normal vessel development to NV, we found little support for a pathogenic role of focal retinal hypoxia at the border of vascular and avascular retina. However, key links were found between retinal NV and...
Source: Documenta Ophthalmologica - June 9, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Comparison of the effects of three different combinations of general anesthetics on the electroretinogram of dogsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study is to compare the effects of three different anesthetic combinations on the electroretinogram in the same animals under similar laboratory conditions. Thiopental–isoflurane (TI), medetomidine–ketamine (MK), and xylazine–ketamine (XK) were used on each of 12 healthy miniature schnauzer dogs (MS) with a period of at least 3 weeks in between subsequent anesthesia protocols, using the Dog Standard Protocol. The scotopic ERGs consisted of scotopic low stimulus strength (S) responses designated S1, S2, S3, S4, and S5, at 1, 5, 10, 15, and 20 min after dark adaptation, respectively,...
Source: Documenta Ophthalmologica - April 14, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Fundus autofluorescence in cone dystrophyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Hyper-autofluorescence in the foveola is a non-specific manifestation of photoreceptor-retinal pigment epithelium dysfunction. ERG studies are essential for accurate diagnosis. Content Type Journal ArticleCategory Case reportDOI 10.1007/s10633-009-9172-yAuthors Nan-Kai Wang, Edward S. Harkness Eye Institute Bernard and Shirlee Brown Glaucoma Laboratory 160 Fort Washington Ave, Research Annex, Room 513 New York NY 10032 USAChai Lin Chou, Edward S. Harkness Eye Institute Bernard and Shirlee Brown Glaucoma Laboratory 160 Fort Washington Ave, Research Annex, Room 513 New York NY 10032 USALuiz H. Lima, Vitreous...
Source: Documenta Ophthalmologica - April 2, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Reproducibility of the mfERG between instrumentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Different amplifiers can yield quite different mfERG P1 implicit times, even with identical band-pass settings. However, the reproducibility of mfERG Z-scores across recording instrumentation is relatively high. Comparison of data across systems and laboratories, necessary for multicenter or longitudinal investigations, is facilitated if raw data are converted into Z-scores based on normative data. Content Type Journal ArticleCategory Original Research ArticleDOI 10.1007/s10633-009-9171-zAuthors Wendy W. Harrison, University of California Berkeley School of Optometry, Vision Science Program 360 Minor Hal...
Source: Documenta Ophthalmologica - March 26, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Changes in chromatic pattern-onset VEP with full-body inversionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These results demonstrate that changes in ocular and/or systemic physiology during full-body inversion can result in increased latencies of chromatic and achromatic pattern-onset VEPs. Content Type Journal ArticleCategory Original Research ArticleDOI 10.1007/s10633-009-9170-0Authors Jennifer Highsmith, University of Nevada Department of Psychology Mail stop 296 1664 N. Virginia St Reno NV 89557 USAMichael A. Crognale, University of Nevada Department of Psychology Mail stop 296 1664 N. Virginia St Reno NV 89557 USA Journal Documenta OphthalmologicaOnline ISSN 1573-2622Print ISSN 0012-4486 (Source: D...
Source: Documenta Ophthalmologica - March 20, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

ERGs in children with pancreatic enzyme insufficient and pancreatic enzyme sufficient cystic fibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Similarity of ERGs across the PI and PS cystic fibrosis patient populations tested here suggests that the supplementation protocol applied to these populations allows similar levels of retinal function (as indicated by flash ERG parameters) in the two groups. Content Type Journal ArticleCategory Original Research ArticleDOI 10.1007/s10633-009-9168-7Authors Andrew Whatham, University of New South Wales School of Optometry and Vision Science Sydney 2052 AustraliaCatherine Suttle, University of New South Wales School of Optometry and Vision Science Sydney 2052 AustraliaCaron Blumenthal, University of Sydney ...
Source: Documenta Ophthalmologica - March 3, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

The mfERG response topography with scaled stimuli: effect of the stretch factorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we determined the quantitative influence of the SF striving for equal response densities over the entire stimulus area. VERIS 4.8 software was used to record multifocal ERGs from 11 normals with 61 hexagons and a 60° stimulus diameter. Six recordings were obtained per subject with SFs 0, 12, 23, 25, 27, and 29. For analysis, we calculated the mean hexagon area per eccentricity and the average amplitude for elements of equal eccentricity (rings 1–5 = R1–R5), normalized to R2. As expected, recordings with SF = 0 showed the steepest amplitude drop-off with eccentricity (relative am...
Source: Documenta Ophthalmologica - February 20, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Pattern electroretinographic results after photodynamic therapy alone and photodynamic therapy in combination with intravitreal bevacizumab for choroidal neovascularization in age-related macular degenerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In this small series of eyes with limited follow-up, the combined treatment of PDT with verteporfin and intravitreal bevacizumab seems to be associated with improvement in VA and pattern electroretinographic results when compared to those in the PDT group. Content Type Journal ArticleCategory Original Research ArticleDOI 10.1007/s10633-009-9167-8Authors Ayse Oner, Erciyes University Medical Faculty Department of Ophthalmology 38039 Kayseri TurkeyKoray Gumus, Erciyes University Medical Faculty Department of Ophthalmology 38039 Kayseri TurkeyHatice Arda, Erciyes University Medical Faculty Department of Opht...
Source: Documenta Ophthalmologica - February 19, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Transitions of multifocal electroretinography following combined intravitreal bevacizumab and photodynamic therapy for polypoidal choroidal vasculopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, combined intravitreal bevacizumab and PDT is associated with an increase of multifocal ERG centrally in PCV patients. Content Type Journal ArticleCategory Original Research ArticleDOI 10.1007/s10633-009-9166-9Authors Chengguo Zuo, Sun Yat-Sen University State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center 54 Xianlie Road Guangzhou 510060 ChinaFeng Wen, Sun Yat-Sen University State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center 54 Xianlie Road Guangzhou 510060 ChinaJiaqing Li, Sun Yat-Sen University State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center 54 Xianlie...
Source: Documenta Ophthalmologica - January 31, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Persistence of retinal function after selective ophthalmic artery chemotherapy infusion for retinoblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Retinal function can persist and even recover following selective ophthalmic artery chemotherapy infusion for retinoblastoma. Further work is indicated to determine optimal dosing regimens, maximal tolerated dosage, and subsequent visual function in these patients. Content Type Journal ArticleCategory Original Research ArticleDOI 10.1007/s10633-008-9164-3Authors Scott E. Brodie, Memorial Sloan-Kettering Cancer Center New York NY USAY. Pierre Gobin, New York Presbyterian Hospital, Weill-Cornell Medical Center New York NY USAIra J. Dunkel, Memorial Sloan-Kettering Cancer Center New York NY USAJonathan W. K...
Source: Documenta Ophthalmologica - January 25, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Tilted disc syndrome: an OCT and mfERG studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion OCT and mfERG can be objective tools for assessing anatomical and functional damage of the macula. Our results suggest that in tilted disc syndrome even without visual impairment the optic nerve and the macula show dysfunction not visible by other means. Content Type Journal ArticleCategory Original Research ArticleDOI 10.1007/s10633-009-9165-xAuthors Marilita M. Moschos, University of Athens Department of Ophthalmology 144, Kountouriotou Str 185 35 Piraeus, Athens GreeceAristides Triglianos, University of Athens Department of Ophthalmology 144, Kountouriotou Str 185 35 Piraeus, Athens GreeceTryfon Rotsos...
Source: Documenta Ophthalmologica - January 23, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

A simple integrated system for electrophysiologic recordings in animalsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract This technical note describes a modification to a fundus camera that permits simultaneous recording of pattern electroretinograms (pERGs) and pattern visual evoked potentials (pVEPs). The modification consists of placing an organic light-emitting diode (OLED) in the split-viewer pathway of a fundus camera, in a plane conjugate to the subject’s pupil. In this way, a focused image of the OLED can be delivered to a precisely known location on the retina. The advantage of using an OLED is that it can achieve high luminance while maintaining high contrast, and with minimal degradation over time. This s...
Source: Documenta Ophthalmologica - January 10, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Visually impaired children: “coming to better terms”Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract For a visually impaired child, the accurate establishment of the diagnosis provides information on the prognosis of his or her participation possibilities, including expectations about the need for care, and provides the basis for informed genetic counseling. To maximize the diagnostic value of electrophysiological testing, we use extensions of the standard ISCEV (International Society for Electrophysiology in Vision) protocols for both the ERG (electroretinogram) and the VEP (visual evoked potential). An overview of 3 years’ practice of the Department of Ophthalmology of Bartiméus, presente...
Source: Documenta Ophthalmologica - January 10, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

The ERG in drug development: translation from animal models to humanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s10633-008-9162-5Authors Mitchell Brigell, Novartis Institutes for Biomedical Research Cambridge MA USA Journal Documenta OphthalmologicaOnline ISSN 1573-2622Print ISSN 0012-4486 (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - January 8, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Influence of narcotics on luminance and frequency modulated visual evoked potentials in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Quantification of visual function is essential for the impact of disease models and their treatment. Recently, we introduced a chronic implant model to record visual evoked potentials (VEP) in awake Brown–Norway rats. Here, we investigated the hemispheric distribution of VEP after monocular stimulation, the chronic electrode implantation and the influence of commonly used anesthetics. Potentials were recorded by electrodes, implanted epidurally over the superior colliculus. The entire visual field of the rat was stimulated. Flicker stimuli were modulated in luminance with a modulation depth from 5...
Source: Documenta Ophthalmologica - January 5, 2009 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Rod and S-cone driven ERG signals at high retinal illuminancesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The purpose of the present study was to investigate whether L- and M-cone driven responses can be influenced by concomitant modulation in the rods or the S-cones. In addition, it was studied whether a change in the state of adaptation in L- or M-cones can have a different influence on ERG data when simultaneously the mean number of photoisomerizations in either rods or S-cones is altered. It was found that rods and/or S-cones cannot be neglected when measuring L- or M-cone driven ERGs. Content Type Journal ArticleCategory Original Research ArticleDOI 10.1007/s10633-008-9159-0Authors Jan Kremers,...
Source: Documenta Ophthalmologica - December 21, 2008 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

List of reviewersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s10633-008-9158-1 Journal Documenta OphthalmologicaOnline ISSN 1573-2622Print ISSN 0012-4486 (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - December 10, 2008 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Response properties of electrically evoked potential elicited by multi-channel penetrative optic nerve stimulation in rabbitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, three triangularly or linearly configured platinum–iridium wire electrodes were inserted into the optic nerves of rabbits for electrical stimulation. The charge-balanced current pulses with amplitudes ranging from 10 to 100 μA at 0.5 ms pulse duration were used as the electrical stimuli. The electrically evoked potentials (EEPs) were recorded with a 16-channel silver-ball electrode array in the rabbit visual cortex. Our experimental results showed that the activities of visual cortex could be effectively evoked by the optic nerve stimulation with penetrating electrodes. The threshold of curr...
Source: Documenta Ophthalmologica - December 3, 2008 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

ISCEV Standard for full-field clinical electroretinography (2008 update)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract This document, from the International Society for Clinical Electrophysiology of Vision (ISCEV), presents an updated and revised ISCEV Standard for clinical electroretinography (ERG). The parameters for flash stimulation and background adaptation have been tightened, and responses renamed to indicate the flash strength (in cd·s·m−2). The ISCEV Standard specifies five responses: (1) Dark-adapted 0.01 ERG (rod response); (2) Dark-adapted 3.0 ERG (combined rod–cone response); (3) Dark-adapted 3.0 oscillatory potentials; (4) Light-adapted 3.0 ERG (cone response); (5) Light-adapted 3.0 flicker (30&n...
Source: Documenta Ophthalmologica - November 23, 2008 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

A negative electroretinogram (ERG) in a case of probable multiple system atrophy (MSA)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a negative ERG in a case of cerebellar degeneration that differs significantly from earlier cases. The 65-year-old man had a 5-year history of ataxia, unsteady gait, orthostatic hypotension, and bladder and erectile dysfunction, with no family history of neurological or retinal disease. Visual acuity was 20/30 OD, 20/40 OS, but reportedly was never 20/20. His fundus exam showed optic nerve pallor, but otherwise was normal. Visual fields had enlarged blind spots but no central scotomas. Autofluorescence was normal. Photopic flash and 30-Hz ERG responses were normal. Rod b-waves were reduced and delayed. Stand...
Source: Documenta Ophthalmologica - November 21, 2008 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals

Testing retinal toxicity of drugs in animal models using electrophysiological and morphological techniquesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Drugs are frequently tested for retinal toxicity in animal models in order to address applied and basic research questions. When a retinal toxicity study is designed, the researcher needs to consider several factors depending on his/her research questions. Among the factors that need to be addressed before a toxicity study is conducted are: the animal species to be used, choice of experimental (functional and/or morphological) techniques, procedure of testing, period of follow-up, and modes of data analysis. This review is a summary of 20 years’ experience of studying retinal toxicity of diff...
Source: Documenta Ophthalmologica - November 9, 2008 Category: Opthalmology Tags: Documenta Ophthalmologica Source Type: journals