Short post-injection seizure duration is associated with reduced power of ictal brain perfusion SPECT to lateralize the seizure onset zone
ConclusionsShort post-injection seizure duration is associated with a lower proportion of lateralizing cases in ictal brain perfusion SPECT. (Source: EJNMMI Research)
Source: EJNMMI Research - April 17, 2024 Category: Radiology Source Type: research
Mitochondrial complex I density is associated with IQ and cognition in cognitively healthy adults: an in vivo [18F]BCPP-EF PET study
ConclusionsTaken together, our findings support the theory that mitochondrial function may contribute to general intelligence and indicate that interindividual differences in MC-I should be a key consideration for research into mitochondrial dysfunction in conditions with cognitive impairment. (Source: EJNMMI Research)
Source: EJNMMI Research - April 17, 2024 Category: Radiology Source Type: research
Non-invasive quantification of 18F-florbetaben with total-body EXPLORER PET
ConclusionNon-invasive quantification of amyloid binding from total-body18F-florbetaben PET data is feasible using aorta IDIFs with high agreement between kinetic distribution volume parameters compared to\( {BP}_{ND} \)in amyloid-positive and amyloid-negative older individuals. (Source: EJNMMI Research)
Source: EJNMMI Research - April 16, 2024 Category: Radiology Source Type: research
Performance and application of the total-body PET/CT scanner: a literature review
ConclusionDue to its technical advantages, the total-body PET/CT system is bound to play a greater role in clinical practice in the future. (Source: EJNMMI Research)
Source: EJNMMI Research - April 12, 2024 Category: Radiology Source Type: research
In-vivo inhibition of neutral endopeptidase 1 results in higher absorbed tumor doses of [177Lu]Lu-PP-F11N in humans: the lumed phase 0b study
ConclusionsPremedication with Entresto® results in a relevant stabilization of [177Lu]Lu-PP-FF11N and consecutively increases radiation doses in tumors and organs.Trial registration clinicaltrails.gov, NCT03647657. Registered 20 August 2018. (Source: EJNMMI Research)
Source: EJNMMI Research - April 6, 2024 Category: Radiology Source Type: research
Evaluating the biodistribution for [68Ga]Ga-PSMA-11 and [18F]F-PSMA-1007 PET/CT with an inter- and intrapatient based analysis
ConclusionComparing biodistribution of [68Ga]Ga and [18F]F tracers, liver uptake on [68Ga]Ga-PSMA-11 PET is the most robust internal reference value. Liver uptake of [18F]F-PSMA-1007 was significantly higher, but so was the splenic uptake. The strong intra-individual association of hepatic accumulation between the two scans may allow using of a conversion factor for [18F]F-PSMA-1007 as a basis for RLT selection. (Source: EJNMMI Research)
Source: EJNMMI Research - April 5, 2024 Category: Radiology Source Type: research
Neuroimaging-guided diagnosis of possible FTLD-FUS pathology: a case report
ConclusionsOur case highlights that despite the lack of specific FUS biomarkers the combination of clinical features and neuroimaging biomarkers can guide choosing the most likely differential diagnosis in a complex neurological case. Imaging in particular allowed an accurate measure of the topography and severity of neurodegeneration and the exclusion of AD-related pathology. (Source: EJNMMI Research)
Source: EJNMMI Research - April 4, 2024 Category: Radiology Source Type: research
Brain 18 F-FDG PET reveals cortico-subcortical hypermetabolic dysfunction in juvenile neuropsychiatric systemic lupus erythematosus
Conclusionsj-NPSLE patients showed a robust bilateral cortico-subcortical hypermetabolic network, focused subcortically, particularly in thalamus, proportionally to psychiatric features severity. Further studies with larger, but homogeneous, cohorts are needed to determine the sensitivity and specificity of this dysfunctional pattern as a potential biomarker in diffuse inflammatory j-NPSLE with normal brain MRI. (Source: EJNMMI Research)
Source: EJNMMI Research - April 2, 2024 Category: Radiology Source Type: research
Automated extraction of the arterial input function from brain images for parametric PET studies
ConclusionsOur automated AIF framework accurately estimates the AIF from brain images. It reduces operator-dependence, and could facilitate the clinical adoption of parametric PET. (Source: EJNMMI Research)
Source: EJNMMI Research - April 1, 2024 Category: Radiology Source Type: research
Repeatability of 18F-FDG uptake in metastatic bone lesions of breast cancer patients and implications for accrual to clinical trials
ConclusionIn evaluating bone tumor response for breast cancer patients with bone-dominant metastases using18F-FDG SUVmax, the repeatability coefficients from test-retest studies show that reductions of more than 17% and increases of more than 20% are unlikely to be due to measurement variability. Serial18F-FDG imaging in clinical trials investigating bone lesions in these patients, such as the ECOG-ACRIN EA1183 trial, benefit from confidence limits that allow interpretation of response. (Source: EJNMMI Research)
Source: EJNMMI Research - March 27, 2024 Category: Radiology Source Type: research
Increased lesion detectability in patients with locally advanced breast cancer —A pilot study using dynamic whole-body [18F]FDG PET/CT
ConclusionsD-WB [18F]FDG PET/CT with MRFDG images show potential for improved lesion detectability compared to conventional SUV images in locally advanced breast cancer. Further validation in larger cohorts is needed.Clinical trial registrationThe trial is registered in clinicaltrials.gov, NCT05110443,https://www.clinicaltrials.gov/study/NCT05110443?term=NCT05110443&rank=1. (Source: EJNMMI Research)
Source: EJNMMI Research - March 25, 2024 Category: Radiology Source Type: research
Biodistribution and dosimetry of 177Lu-DOTA-IBA for therapy of bone metastases
ConclusionDosimetric results show that the ADs for critical organs and total body are within the safety limit and with high bone retention. It is a promising radiopharmaceutical alternative for the targeted treatment of bone metastases, controlling its progression, and improving the survival and quality of life of patients with advanced bone metastasis. (Source: EJNMMI Research)
Source: EJNMMI Research - March 22, 2024 Category: Radiology Source Type: research
89Zr-labeled ImmunoPET targeting the cancer stem cell antigen CD133 using fully-human antibody constructs
ConclusionsFully human CD133-targeted immunoPET probes [89Zr]-DFO-RW03IgG and [89Zr]-DFO-RW03scFv − Fc accumulate in CD133-expressing tumors to enable their delineation through PET imaging. Having identified [89Zr]-DFO-RW03scFv − Fc (CA = 2.9 ± 0.3) as the most attractive construct for CD133-expressing tumor delineation, the next step is to evaluate this probe using patient-derived tumor models to test its detection limit prior to clinical translation. (Source: EJNMMI Research)
Source: EJNMMI Research - March 18, 2024 Category: Radiology Source Type: research
Evidence of brain metabolism redistribution from neocortex to primitive brain structures in early acute COVID-19 respiratory syndrome
ConclusionsBrain metabolism is clearly affected during the acute phase of COVID-19 respiratory syndrome in neurologically asymptomatic or oligosymptomatic patients. The most frequent finding is marked hypermetabolism in evolutionary ancient structures such as lenticular nucleus and thalami. Neocortical metabolism was reduced in up to one third of patients, suggesting a redistribution of brain metabolism from the neocortex to evolutionary ancient brain structures in these patients. (Source: EJNMMI Research)
Source: EJNMMI Research - March 12, 2024 Category: Radiology Source Type: research
Evaluation of the theranostic potential of [64Cu]CuCl2 in glioblastoma spheroids
ConclusionsOverall, our results further support [64Cu]CuCl2 potential as a theranostic agent for glioblastoma, unveiling potential mechanisms that could be involved in the therapeutic response. (Source: EJNMMI Research)
Source: EJNMMI Research - March 7, 2024 Category: Radiology Source Type: research
