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PhD Student Award in Regenerative MedicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Berlin-Brandenburg School for Regenerative Therapies (BSRT) offers youngtalented scientists in Berlin and Brandenburg: Best Publication Award: The award will be granted for the most outstandingpaper for progress in Regenerative Medicine accepted by a peer reviewjournal in the last two years. The award comprises 1.500 Euro. Best Presentation Award: The award will be granted for the best posterpresented at an international conference with a peer review system withinthe last two years. The award comprises 500 Euro. Info & Contact:BSRT, Charité Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin,E-Mail: awar...
Source: ESAO - Liver Support Working Group - October 18, 2008 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Source Type: blogs

Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: ESAO - Liver Support Working Group - September 1, 2008 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

The ESAO One Day on the Liver 2008 in Geneva - Thursday, Sept. 4th, 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As all the recent years the “One day on the liver” – a day dedicated to liver support systems and therapeutic strategies in the case of a failing liver - will take place during the ESAO 2008 meeting in Geneva.For the first time we organised the "Young investigators' Liver Session". We asked the heads of several groups working in the field to send one of their best students to present their latest results. This session is dedicated to PhD students and is chaired by PhD students involved in liver support research. Of course all participants of the meeting are invited to attend!The ESAO One Day on the Live...
Source: ESAO - Liver Support Working Group - August 1, 2008 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

TRM Awards 2008: Funding for up to 20 awards and research groupsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Translational Centre for Regenerative Medicine (TRM) Leipzig, funded by the German Federal Ministry of Research and Education and the Free State of Saxony, is charged with the development of new diagnostic and therapeutic technologies as well as preclinical models in regenerative medicine. For its new funding period that starts in 2009, researchers are invited to apply for awards to pursue research from bench-to-bedside. Funding is available for up to twenty awards and research groups in the four research areas of the centre: * Tissue Engineering and Materials Science (TEMAT) * Cell Therapies for Repair und Replaceme...
Source: ESAO - Liver Support Working Group - May 1, 2008 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: General Source Type: blogs

HepaWash and II. Medical Department, University Hospital rechts der Isar awarded € 425,000 grant from the Bayerische forschungsstiftung (BFS) for a € 0.9 Mio collaborative Preclinical study on Acute liver FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepa Wash GmbH (Hepa Wash), a medical device company developing an innovative liver support device announced today that it has received a € 425,000 grant from the Bayerische Forschungsstiftung (BFS) to test the safety and efficacy of its laboratory prototype in a preclinical animal model for acute liver failure in collaboration with the II. Medical Department, University Hospital Rechts der Isar. The grant will be used to develop an improved animal model for acute liver failure in pigs that resembles much more the clinical situation of acute liver failure in humans than currently available models. This new model will all...
Source: ESAO - Liver Support Working Group - April 29, 2008 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Companies Source Type: blogs

Recent reviews in the field of liver supportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recently several interesting reviews on liver support concepts have been published. Roger Wiliams, Institute of Hepatology, University College London Medical School, London, UK, reported on "Acute liver failure--practical management". John O'Grady, Institute of Liver Studies, King's College Hospital, London, UK, gave an overview on the management of acute or fulminant liver failure: "Modern management of acute liver failure". J.P. Vacanti and H.I. Pryor, 2nd, reviewed the significant clinical findings of ALF, as well as, the non-biologic liver support systems and the bioartificial liver devices that have been clinically...
Source: ESAO - Liver Support Working Group - March 6, 2008 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Papers Source Type: blogs

Arbios Receives Conditional Approval from the FDA to Initiate Pivotal Clinical Trial for SEPET™Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Arbios Systems, Inc., announced that the Company has received conditional approval from the U.S. Food and Drug Administration (FDA) of an Investigational Device Exemption to begin the pivotal clinical trial for SEPET™, Arbios’ extracorporeal artificial liver assist device for blood purification of chronically ill patients suffering from acute liver failure. Permission was granted to initiate the trial while the Company responds to the FDA’s conditions and request for additional information. In particular, FDA has requested a survival primary endpoint, which could potentially increase the total number of patients req...
Source: ESAO - Liver Support Working Group - February 23, 2008 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Companies Source Type: blogs

Biological scaffolds for tissue engineeringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Professor Heike Mertsching and her team of researchers from the Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB), Germany, have succesfully seeded human liver cells to a piece of pig intestine to use as a 3D model in the early stages of drug development. To build up test systems, a dedicated, PC-controlled bioreactor was developed in which the re-seeded matrix is perfused with fresh medium via the arterial inflow and the spent medium and degradation products are transported away via the venous reflux. The reseeding of the vascularized matrix with adult stem cells and endothelial progenitor cells r...
Source: ESAO - Liver Support Working Group - November 6, 2007 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Lab_News Source Type: blogs

First World Bioprinting CongressEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: ESAO - Liver Support Working Group - September 12, 2007 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

ESAO Board of Governors - I.M. Sauer electedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
During the annual meeting of the ESAO 2007 in Krems Dr. Igor M. Sauer has been elected for the Board of Governors.
Source: ESAO - Liver Support Working Group - September 10, 2007 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

ESAO 2007 - One Day on the LiverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: ESAO - Liver Support Working Group - August 21, 2007 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

ESAO 2007 in Krems - One Day on the LiverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ESAO 2007 meeting in KremsOne Day on the Liver – Final program The ESAO One Day on the Liver 2007 (ODOL) will take place Thursday, Sept. 6th, 2007 in Room E 11: 10:00 – 11:30 (90 min) Chair: Vienken, Legalais What’s new in the world of liver support?10:00 – 10:15 Brief report from the USA (Ash) 10:15 – 10:30 Brief report from Japan (Hirasawa) Aspects concerning the (patho-)physiology of the failing liver10:30 – 10:50 Toxins in liver failure – what is relevant, what do we have to remove? (Joannidis) 10:50 – 11:10 &...
Source: ESAO - Liver Support Working Group - July 1, 2007 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

Apoptosis ChipEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Floor Wolbers from the Lab-on-a-Chip group of the MESA+ Institute for Nanotechnology developed a special microfluidic chip for monitoring the effect of medication on cancer cells. The new technique can already be applied in a clinical setting. At present, the process is monitored using an optical microscope, for high-throughput screening, electronics can be added to the chip. Using multiple chambers for cell culture, fast comparison will be possible. More information via http://www.mesaplus.utwente.nl/news/floor_wolbers.doc/ .
Source: ESAO - Liver Support Working Group - May 8, 2007 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: General Source Type: blogs

One Day ond the Liver 2007 in Krems in cooperation with the 9th International Symposium on Albumin Dialysis in Liver Disease (ISAD) in Rostock-WarnemündeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The European Society for Artificial Organs has for a long time reflected scientific aspects for the treatment of liver failure using artifical and bioartificial liver support systems. Therefore, during the ESAO Congress in Lausanne in 2000, ESAO has introduced a special meeting called "One Day on the Liver". In 2007 our Liver Working Group, managed by Dr. Igor Sauer, will organize a highly ranked “One Day on the Liver Meeting”, which will be held on September 6th and 7th (end 12.30 p.m.). Thanks to an agreement with the organizers of the International Symposium on Albumin Dialysis in Liver Disease (ISAD) w...
Source: ESAO - Liver Support Working Group - May 3, 2007 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

Perspectives in Liver TransplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: ESAO - Liver Support Working Group - May 2, 2007 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

Low-cost submicron fabrication technique for manufacturing human spare partsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
VTT Technical Research Centre of Finland, Tampere University of Technology and Nanofoot Finland Oy have developed a direct-write three-dimensional forming method of biomaterials. The methodology enables fabrication of nano and micrometer scale structures that can be used as parts of tissue engineering scaffolds. The project is funded by the BioneXt Tampere Research Programme. More information is available via the VTT webpage .
Source: ESAO - Liver Support Working Group - April 15, 2007 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: General Source Type: blogs

German Biotechnology Company Survey 2006Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Just two decades ago, biotechnology in Germany was taking its first developmental steps in the marketplace. Today, it is firmly established as a commercial branch. This is the picture emerging from the recent national biotechnology survey, taking in biotech companies of all sizes from across Germany, and carried out by biotechnologie.de on behalf of the Federal Ministry for Education and Research (BMBF). For the first time in this sector, the data complies with statistical standards as set by the Organization for Economic Cooperation and Development (OECD), allowing for a reliable and internationally comparable description...
Source: ESAO - Liver Support Working Group - February 28, 2007 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Companies Source Type: blogs

EASL Monothematic Symposium on Acute Liver FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The European Association for the Study of the Liver (EASL) invites you to join the monothematic symposium on acute liver failure, which will take place in the Copenhagen, Denmark, September 5-7, 2007. There have been many advances in our knowledge of aetiology and pathogenesis that have allowed us to improve intensive care management of these desperately sick patients of whom many still succumb to either multi-organ failure or development of severe brain oedema. Refinement for the use of liver grafting in the most severe cases has also over the last decade been improved. Furthermore many new designs of liver support ...
Source: ESAO - Liver Support Working Group - February 19, 2007 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

World Apheresis Association (WAA) 11 th Congress and 6 th World Congress of the International Society for Apheresis (ISFA)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The combined meeting of World Apheresis Association (WAA) 11 th Congress and 6 th World Congress of the International Society for Apheresis (ISFA) will take place in Pacifico Yokohama Yokohama, Japan, from March 2―4, 2007. WAA federates many national, continental and international societies for hemapheresis and transfusion science, and ISFA is a representative international society for therapeutic apheresis. They have contributed to the development of these scientific fields for many years. These two societies serve a regular meeting every two years. This is the first combined congress of the two Societies. It is really ...
Source: ESAO - Liver Support Working Group - January 31, 2007 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

4th International Symposium on Artificial Liver in Chongqing, PR ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The final programme of the 4th International Symposium on Artificial Liver taking place in Chongqing, PR China, March 9-12, 2007 is avaliable. Final Programme March 9 Registration day March 10 Morning 8:00-9:00 Opening ceremony 9:20-10:40 Presentation session 1 9:20-10:00 The correction of disturbed pathophysiology of hepatic failure by albumin dialysis (Roger Williams) 10:00-10:40 Hepatocyte Transplantation for the Treatment of Liver Disease (Stephen Strom)　 10:40-12:00 Presentation session 2 10:40-11:20 Liver Support in Europe - status quo (Igor Sauer) 11:20-12:00 MARS – evidence and controversies (Alexander Chiu) 12...
Source: ESAO - Liver Support Working Group - January 27, 2007 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

This blog has been nominated for the Medical Weblog Awards (Best Medical Technologies/Informatics Weblog)...Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The third annual Medical Weblog Awards! These awards are designed to honor the very best in the medical blogosphere, and to highlight the diverse world of medical blogs. The categories for this year's awards will be: - Best Medical Weblog - Best New Medical Weblog (established in 2006) - Best Literary Medical Weblog - Best Clinical Sciences Weblog - Best Health Policies/Ethics Weblog - Best Medical Technologies/Informatics Weblog - Best Patient's Blog (a new category this year) The Blog of the ESAO Liver Support Working Group has been nominated for the category "Best Medical Technologies/Informatics Weblog". Other nomine...
Source: ESAO - Liver Support Working Group - December 16, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: General Source Type: blogs

Google Patent Search launchesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Google launched a Search service dedicated to patents only: http://www.google.com/patents . The information comes from USPTO - therfore, only US-american patents are listed so far -, and results on Google do include links to the USPTO entries.
Source: ESAO - Liver Support Working Group - December 12, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Bioinformatics & IT Source Type: blogs

Journal of Visualized Experiments (JoVE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
is an online journal publishing visualized (video-based) biological research studies. This publication aims to solve some of the most difficult problems in the contemporary life science research: * low transparency and reproducibility of biological experiments * time-consuming learning of experimental techniques Example: Human ES cells: starting culture from frozen cells As every practicing biology researcher knows, it takes days, weeks or sometimes months and years to learn and apply new experimental techniques. It is especially difficult to reproduce newly published studies descr...
Source: ESAO - Liver Support Working Group - November 29, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: General Source Type: blogs

Arbios Systems Announces Addition of Senior PersonnelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Arbios Systems, Inc. , a company developing proprietary medical devices and cell-based therapies for the millions of patients each year who experience or are at risk for life-threatening episodes of liver failure, today announced the addition of two new senior personnel. Dr. Ulrich Baurmeister, Ph.D., has joined Arbios as Chief Technology Officer with responsibility for further development of proprietary blood separation technology for the Company, and Dr. Jan Stange, M.D., has joined as Senior Clinical Advisor, with responsibility for medical direction of the Company's clinical trials. Dr. Jacek Rozga, M.D., Ph.D., will c...
Source: ESAO - Liver Support Working Group - November 16, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Companies Source Type: blogs

Two articles on liver tissue engineering in Nature BiotechnologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two groups describe hepatic differentiation of mouse embryonic stem (ES) cells. Gouon-Evans et al. use knowledge of developmental pathways to produce immature hepatocytes that secrete albumin and store glycogen. Soto-Gutiérrez et al. show that ES cell-derived hepatocytes encapsulated in a bioartificial liver device are effective in treating mice with acute liver failure. In order to generate an alternative source of cells for BAL support, American and Japanese scientist around Ira Fox and Naoya Kobayashi differentiated mouse embryonic stem (ES) cells into hepatocytes by coculture with a combination of human liver nonpare...
Source: ESAO - Liver Support Working Group - November 6, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Papers Source Type: blogs

Small sections of human liver have been created from umbilical cord stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
, say scientists from Newcastle University, UK. The researchers say this technology could eventually be used to grow small livers that could be used for drug tests - doing away with the need for human volunteers to take risks. Earlier this year six volunteers became dangerously ill during a drug trial in the UK. The scientists warned that it will be tens of years before we are anywhere near producing whole new livers for transplants. However, within the next 15 years, tiny livers could be produced and used for treating patients. Team leaders, Dr. Nico Forraz and Prof. Colin McGuckin, have set up ConoStem, a company aimed a...
Source: ESAO - Liver Support Working Group - October 31, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Companies Source Type: blogs

World Apheresis Association (WAA) 11 th Congress and 6 th World Congress of the International Society for Apheresis (ISFA)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The combined meeting of World Apheresis Association (WAA) 11 th Congress and 6 th World Congress of the International Society for Apheresis (ISFA) will take place in Pacifico Yokohama Yokohama, Japan, from March 2―4, 2007. WAA federates many national, continental and international societies for hemapheresis and transfusion science, and ISFA is a representative international society for therapeutic apheresis. They have contributed to the development of these scientific fields for many years. These two societies serve a regular meeting every two years. This is the first combined congress of the two Societies. It is really...
Source: ESAO - Liver Support Working Group - October 22, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

Tissue Engineering Today, Not TomorrowEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion & Close If you are interested in attending this meeting please click here to find out more or to register. Registration is easy and straight forward. EuroScicon always endeavor to attract a balanced mix of presenters from both Industry and Academia, with cutting edge technology and applications in the BioSciences. A schedule for forthcoming events can be found at www.euroscicon.com .
Source: ESAO - Liver Support Working Group - October 20, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

ESAO 2007 - Krems, Austria, September 5-8, 2007Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dear colleague, dear member of the ESAO, On behalf of the European Society for Artificial Organs (ESAO), it is my great pleasure and honour to invite you to the XXXIV. ESAO-Congress in Krems/Austria. Krems is very well suited to be the host city for the ESAO Congress, as the city is located in the centre of Europe being famous for its architecture, culture and art. It has a history of more than 1000 years and is one of the capitals of wine culture. The blue water of the river Danube emphasises the beauty of this region, which was selected by the UNESCO as a »World Heritage Site« Because of this special atmosphere, Kre...
Source: ESAO - Liver Support Working Group - October 18, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

Stelic: Specific neutralizing agent for chemokine CXCL10Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stelic Institute & Co., a Tokyo-based bioventure company specializing in regenerative medicine, has announced development of a new treatment method for acute liver failure: The Company's Stem Cell Dynamism Research Team has shown that a protein called chemokine1 CXCL102 directly affects hepatic cells, regulating their replication and proliferation. Research results demonstrated for the first time that hepatic cells possess a mechanism for attempting to repair the wide-ranging hepatic cell necrosis associated with drug-induced acute liver failure, and that anti-CXCL10 antibodies strengthen this type of self-repairing functi...
Source: ESAO - Liver Support Working Group - September 5, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Companies Source Type: blogs

Upcoming MeetingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ESF-EMBO Symposium on Tissue EngineeringOctober 28–November 2, 2006. Sant Feliu de Guixols, Spain. For more information contact: Jane Dutton, ESF Research Conferences Unit. Tel: +33 (0)38876 7135; Fax: +33 (0) 38836 6987; Website: http://www.esf.org/conferences/lc06213. 44th Annual Congress of Japanese Society for Artificial OrgansOctober 31–November 2, 2006. Pacifico Yokohama, Yokohama, Japan. For more information contact: Congress President, Dr. Yasuharu Noishiki and Yokohama City University. E-mail: jsao2006@convention.co.jp; Website: http://www2.convention.co.jp/jsao2006. 5th IASTED International Conference ...
Source: ESAO - Liver Support Working Group - September 1, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

Recent relevant papers - Update August 2006Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A. Jung et al. report on Bilirubin kinetic modeling for quantification of extracorporeal liver support (Blood Purif. 2006;24(4):413-422): The kinetics of conjugated bilirubin were described by a two-compartment model (V(c), V(p)) with central elimination (K) and constant generation rate (G). The transfer of solute between compartments was modeled by intercompartmental clearance (K(pc)). The central compartment (V(c)) was assumed as a constant fraction of total volume (V(c) = 0.3*V(t)). Eight patients were studied during 35 treatments lasting 6 h each. The average K, V(t), K(pc), G, and mass of conjugated bilirubin removed ...
Source: ESAO - Liver Support Working Group - August 14, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Papers Source Type: blogs

New Microscope Sharpens Scientists' FocusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new type of optical microscope was developed and tested by Howard Hughes Medical Institute's investigators. Offering resolutions of only 2 to 25 nanometers, the new microscopy technology is essentially not limited by the wavelength of the visible light: A new light microscope so powerful that it allows scientists peering inside cells to discern the precise location of nearly each individual protein they are studying has been developed and successfully demonstrated by scientists at the Howard Hughes Medical Institute's Janelia Farm Research Campus in collaboration with researchers at the National Institutes of Health and ...
Source: ESAO - Liver Support Working Group - August 14, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Papers Source Type: blogs

43rd Meeting of the Society for Cryobiology in Hamburg, GermanyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The 43rd Meeting of the Society for Cryobiology in association with the Society for Low Temperature Biology in Hamburg, Germany, July 24-27, 2006, will cover a wide range of subjects including hypothermia, physiology of resistance to cold in plants, and applications of cryobiology in conservation/freeze-drying, surgery, cell, tissue and organ preservation. Relevant aspects of biology, molecular biology, physics, chemistry, physical chemistry, biochemistry, physiology, medicine, transfusion medicine, cryosurgery, cryomicroscopy, mechanical engineering, tissue engineering and transplantation will also be covered. More infor...
Source: ESAO - Liver Support Working Group - July 15, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

ESOT Basic Science Network: ESOT Master class Program - 2nd Basic Course in Laboratory SkillsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
After a very successful 1st Basic Course in Laboratory Skills in 2004, you will find attached the Announcement of the 2nd Basic Course in Laboratory Skills, which will take place on October 30 - November 2, 2006, in Rotterdam, The Netherlands. PhD students, both young physicians and scientists, are encouraged to submit a short letter of motivation and a brief abstract describing their laboratory experiences and PhD project, which has to be sent by e-mail to Dr. Carla C. Baan: <c.c.baan@erasmusmc.nl>. The application deadline is September 15th, 2006. GoalThe course aims to expand the knowledge of laboratory skills ...
Source: ESAO - Liver Support Working Group - July 12, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Dates & Deadlines Source Type: blogs

5th World Congress of Biomechanics 2006Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Institut of Biotechnik e.V. together with the Technical University of Munich and Munich University of Applied Sciences cordially invite you to the 5th World Congress of Biomechanics 2006.Biomechanics covers a wide field from solid to fluid mechanics, from motion sports mechanics to automobile crash tests. It includes tissue engineering and biomaterials, artificial organs and sports therapy. At the 5th World Congress the newest experimental studies will be presented. Special emphasis will be placed on state-of-the art technology and medical applications. Only new, unpublished papers will be accepted.The 5th World Congre...
Source: ESAO - Liver Support Working Group - July 2, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

ESAO 2006 in Umeå, SwedenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: ESAO - Liver Support Working Group - June 18, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

Recent relevant papers - Update May 2006Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, freshly isolated porcine hepatocytes can be preserved for 24 h at subnormothermic temperatures as low as 15 degrees C.
Source: ESAO - Liver Support Working Group - June 4, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Papers Source Type: blogs

Princeton University Art of Science CompetitionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The winners of the 2005 Art of Science Exhibition at Princeton University have now been announced. Fifty five works out of more than 200 entries that were submitted are now available online. "The Princeton University Art of Science Competition is a celebration of the aesthetics of research and the ways in which science and engineering inform art and vise versa. Now in its second year, the competition is open to all members of the Princeton University community.
Source: ESAO - Liver Support Working Group - June 1, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: General Source Type: blogs

Special issue of Therapeutic Apheresis and Dialysis: Cell-Free Artificial Liver SupportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An ideal extracorporeal liver support system has to provide the main functions of the liver: detoxification, synthesis and regulation. But do we need such an ideal in all clinical situations and can we afford it? The critical issue of the clinical syndrome in liver failure is the accumulation of toxins not cleared by the failing liver. This understanding led to the development of cell-free artificial liver support systems. This special issue of Therapeutic Apheresis and Dialysis is dedicated to cell-free artificial liver support, intended to give engineering scientists, inventors and clinical investigators an update and a...
Source: ESAO - Liver Support Working Group - May 1, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Papers Source Type: blogs

Recent relevant papers - Update April 2006Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, a significant decline in the serum level of water-soluble and protein-bound toxins was achieved with both devices. PROM produces higher blood clearances for most toxins, which results in higher delivered treatment doses compared with a matching treatment with MARS. A Modeling Study of Bilirubin Kinetics During Molecular Adsorbent Recirculating System Sessions (Artif Organs. 2006 Apr;30(4):285-300) E. Magosso et al. present a quantitative description, by means of a mathematical model, of bilirubin removal during Molecular Adsorbent Recirculating System sessions. The model includes four compartments: two for ...
Source: ESAO - Liver Support Working Group - April 20, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Papers Source Type: blogs

ESAO - Research Award 2006Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The annual ESAO-Research Award is aimed at encouraging young scientists working in the area of experimental research, medical science, biochemistry, chemistry, physical chemistry, mem- brane science and chemical engineering involved in the general field of artificial organs, with special emphasis on: New applications in artificial organs and regenerative medicine techniques Membrane applications in artificial organs New techniques in the field of blood purification. The awardees will be selected by a Committee appointed by the ESAO Board of Governors. The ESAO-ResearchAward 2006 of €2500,00 will be presented ...
Source: ESAO - Liver Support Working Group - April 4, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Dates & Deadlines Source Type: blogs

MIT Technology: Mayo Clinic is making advances toward longer-lasting liver "dialysis" using pig cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The MIT Technology Review has an article about ongoing progress at the Mayo Clinic to develop a liver support device based on clusters of porcine hepatocytes. The Mayo machine is loaded with 200 grams of freshly isolated pig hepatocytes, which is about 20% of liver mass of normal human liver. The research is being conducted by a group of associates led by Scott L. Nyberg M.D., Ph.D.. MIT Technology: Mayo Clinic is making advances toward longer-lasting liver "dialysis" using pig cells More on the SPHEROID RESERVOIR BAL via the Nyberg Lab web page (Artificial Liver and Liver Transplantation Lab)
Source: ESAO - Liver Support Working Group - April 1, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Liver Support Source Type: blogs

FDA Allows Increased Enrollment for SEPET™ Clinical TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Arbios Systems, Inc., a biomedical device and cell therapy company developing proprietary liver assist products for the treatment of liver failure, announced that the US Food and Drug Administration (FDA) has allowed the expansion of the number of clinical sites and increased the allowable number of patients in its IDE feasibility clinical trial for its SEPET™ liver assist device. Under the revised protocol, Arbios can include up to four clinical trial sites and to up to 20 liver failure patients with encephalopathy. The trial was previously limited to two sites and 15 patients. The company further announced that the Uni...
Source: ESAO - Liver Support Working Group - March 17, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Companies Source Type: blogs

Recent relevant papers - Update March 2006Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
J.F. Patzer 2nd et al. discuss "Slow continuous ultrafiltration with bound solute dialysis." (ASAIO J. 2006 Jan-Feb;52(1):47-58). Bound solute dialysis (BSD), often referred to as "albumin dialysis" (practiced clinically as the molecular adsorbents recirculating system, MARS, or single-pass albumin dialysis, SPAD) or "sorbent dialysis" (practiced clinically as the charcoal-based Biologic-DT), is based upon the thermodynamic principle that the driving force for solute mass transfer across a dialysis membrane is the difference in free solute concentration across the membrane. The clinically relevant practice of slow continuo...
Source: ESAO - Liver Support Working Group - March 14, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Papers Source Type: blogs

Quick access to medical calculationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
MDCalc is quick access to all those medical calculations that are too painful to memorize, and too useful to ignore. After wasting time hunting through Google results to find the equations I needed, I created this site as a respository. This handy site was created by a third-year medical student who got tired of having to wade through Google searches to find an easy to use, quick calculator for his medical equations using multiple resources and references, including Medcalc, Pocket Medicine, 2nd Edition, and eMedicine.
Source: ESAO - Liver Support Working Group - February 7, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Bioinformatics & IT Source Type: blogs

ESAO 2006 in Umeå, Sweden - Call for abstractsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dear ladies and gentlemen, On behalf of the European Society for Artificial Organs (ESAO), Working Group Liver Support, I would like to invite you and your colleagues to submit abstracts for this year’s ESAO meeting held in Umeå , Sweden, from June 21-24, 2006. The Congress will be combined with a meeting with the European Society For Haemapheresis (ESFH, June 20 and 21). Umeå is located close to the polar circle and at this time of the year it has exiting bright nights. The social program will focus on various outdoor and cultural activities and together with the scientific resources of the Congress speakers and part...
Source: ESAO - Liver Support Working Group - January 24, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

The Basic Science Committee (BSC) of ESOTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Basic Science Committee of ESOT has been founded in 2004 with the strong support of the ESOT Council. BSC wants to contribute to the advancement, communication, education and support of basic science activities in Transplantation. A network of European Laboratories of Excellence has been established to: - Increase communication - Encourage the application for ESOT grants - Provide travel funding to support the exchange of specific techniques - To encourage the submission of basic science abstracts to the biannual ESOT Meeting
Source: ESAO - Liver Support Working Group - January 23, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: General Source Type: blogs

World Congress on Medical Physics and Biomedical Engineering 2006 in SeoulEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dear Colleagues, I'm pleased to announce that the World Congress on Medical Physics and Biomedical Engineering 2006 (WC2006) will be held on August 27 to September 1, 2006 in Seoul, Korea. under the Congress Theme: Imaging the Future Medicine. The scientific program will include plenary lectures, sponsored symposia, regular oral and poster sessions. The Second Announcement, which includes: detailed information on registration procedure, (fees, hotel accommodation, travel information, scientific and social programs), call for papers, as well as registration forms (abstract submission and hotel accommodation) is available v...
Source: ESAO - Liver Support Working Group - January 22, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Meetings Source Type: blogs

Recent relevant papers - Update January 2006Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, HT using SHs showed hepatic repopulation similar to that using FHs. This suggests that both SHs and FHs can repopulate the liver as if they were hepatic stem cells. In addition, HT using SHs supported liver functions such as albumin correction at the same level as that using FHs. These observations strongly support the idea that SHs could be an alternative to primary FHs as a novel cell source for future HT. Two review articles concerning artificial liver support concepts were published: Laleman et al.: Review article: non-biological liver support in liver failure (Aliment Pharmacol Ther. 2006 Feb;23(3):35...
Source: ESAO - Liver Support Working Group - January 20, 2006 Category: Urologists and Nephrologists Authors: Dr. Igor M. Sauer Tags: Papers Source Type: blogs