Ecotoxicology and Environmental Safety This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Effect of zeolites on the reduction of the ecotoxicity of carbamazepine in the environment
In this study, the impact of calcination of zeolites on the ecotoxicity of carbamazepine solutions in two matrices, water and synthetic sewage, was assessed. Two types of zeolites were tested: natural zeolite, in the form of a zeolite rock consisting mainly of clinoptilolite, and a synthetic zeolite type 5 A. Additionally, zeolites were calcined at a temperature of 200 °C. The kinetics of carbamazepine adsorption in aqueous solutions and in synthetic sewage matrix was determined. Higher adsorption capacity was obtained for carbamazepine aqueous solutions as well as zeolites after the calcination process. Considering type ...
Source: Ecotoxicology and Environmental Safety - April 23, 2024 Category: Environmental Health Authors: Aleksandra Bogusz Beata Tomczyk Magdalena Trzci ńska Barbara Miros ław Barbara Gworek Source Type: research

Environmental pollutants and male infertility: Effects on CatSper
Ecotoxicol Environ Saf. 2024 Apr 22;277:116341. doi: 10.1016/j.ecoenv.2024.116341. Online ahead of print.ABSTRACTInfertility is a growing health concern among many couples worldwide. Men account for half of infertility cases. CatSper, a sperm-specific Ca2+ channel, is expressed on the cell membrane of mammalian sperm. CatSper plays an important role in male fertility because it facilitates the entry of Ca2+ necessary for the rapid change in sperm motility, thereby allowing it to navigate the hurdles of the female reproductive tract and successfully locate the egg. Many pollutants present in the environment have been shown ...
Source: Ecotoxicology and Environmental Safety - April 23, 2024 Category: Environmental Health Authors: Yuxin He Binhui Wang Jian Huang Dalei Zhang Yangyang Yuan Source Type: research

Removal and reduction mechanism of Cr (VI) in Leersia hexandra Swartz constructed wetland-microbial fuel cell coupling system
Ecotoxicol Environ Saf. 2024 Apr 22;277:116373. doi: 10.1016/j.ecoenv.2024.116373. Online ahead of print.ABSTRACTCr (VI) is extremely harmful to both the environment and human health, and it can linger in the environment for a very long period. In this research, the Leersia hexandra Swartz constructed wetland-microbial fuel cell (CW-MFC) system was constructed to purify Cr (VI) wastewater. By comparing with the constructed wetland (CW) system, the system electricity generation, pollutants removal, Cr enrichment, and morphological transformation of the system were discussed. The results demonstrated that the L. hexandra CW-...
Source: Ecotoxicology and Environmental Safety - April 23, 2024 Category: Environmental Health Authors: Yucui Shi Qing Liu Guowei Wu Shasha Zhao Yongwei Li Shaohong You Guofu Huang Source Type: research

Exposure to nicotine regulates prostaglandin E2 secretion and autophagy of granulosa cells to retard follicular maturation in mammals
In this study, we notably found that nicotine was likely to specifically raise the expression of histone deacetylase 3 (HDAC3) to promote the apoptosis and autophagy of granulosa cells (GCs) and block follicular maturation. Moreover, prostaglandin E2 (PGE2) inhibited the apoptosis of GCs and facilitated follicular maturation, and nicotine appeared to inhibit PGE2 secretion by freezing the expression of cyclooxygenase 1 (COX1), which was the rate-limiting and essential enzyme for PGE2 synthesis. Epigenetically, the nicotine was observed to diminish the histone H3 lysine 9 acetylation (H3K9ac) level and compact the chromatin...
Source: Ecotoxicology and Environmental Safety - April 23, 2024 Category: Environmental Health Authors: Xiaofeng Zhou Yingting He Hongyan Quan Jinghao Yang Shuo Li Yao Jiang Jiaqi Li Xiaolong Yuan Source Type: research

The mitochondria-targeted antioxidant MitoQ ameliorates inorganic arsenic-induced DCs/Th1/Th2/Th17/Treg differentiation partially by activating PINK1-mediated mitophagy in murine liver
This study has provided new insights on the immunotoxicity of inorganic arsenic and established a foundation for exploring preventive and therapeutic strategies targeting PINK1-mediated mitophagy in acute liver injury. Consequently, the application of mitochondrial antioxidant MitoQ may offer a promising treatment for the metalloid-induced acute liver injury.PMID:38653026 | DOI:10.1016/j.ecoenv.2024.116350 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - April 23, 2024 Category: Environmental Health Authors: Hui Li Yaning Guo Wei Su Huan Zhang Xiaoxi Wei Xinyu Ma Shuwen Gong Gaoyang Qu Lin Zhang Hong Xu Fuhai Shen Shoufang Jiang Dingjie Xu Jinlong Li Source Type: research

Genome-wide DNA methylation changes in Oryzias melastigma embryos exposed to the water accommodated fraction of crude oil
Ecotoxicol Environ Saf. 2024 Apr 22;277:116325. doi: 10.1016/j.ecoenv.2024.116325. Online ahead of print.ABSTRACTThe water accommodated fraction (WAF) of crude oil exerts considerable impacts on marine fish during embryonic stage. Clarifying changes in epigenetic modifications is helpful for understanding the molecular mechanism underlying the toxicity of embryonic WAF exposure. The aim of this study was to explore genome-wide DNA methylation changes in Oryzias melastigma embryos after exposure to the nominal total petroleum hydrocarbon concentration of 500 μg/L in WAF for 7 days. Whole-genome bisulfite sequencing reveale...
Source: Ecotoxicology and Environmental Safety - April 23, 2024 Category: Environmental Health Authors: Chenshi Wang Wei Lei Lichao Du Yiran Xu Yingbin Lou Mo Peng Dongxu Gao Source Type: research

Associations of dichlorophenols, trichlorophenols, and ortho-phenylphenol with the risk and prognosis of diabetes and prediabetes: A population-based study
Ecotoxicol Environ Saf. 2024 Apr 22;277:116345. doi: 10.1016/j.ecoenv.2024.116345. Online ahead of print.ABSTRACT2,4-dichlorophenol (2,4-DCP), 2,5-DCP, 2,4,5-trichlorophenol (2,4,5-TCP), 2,4,6-TCP, and ortho-phenylphenol (OPP) are widely present in the environment. However, their associations with risk and prognosis of diabetes and prediabetes remains unclear. We investigated the associations of these five phenols with the risk of diabetes and prediabetes, and with all-cause and cardiovascular disease (CVD) mortality, in adults with diabetes or prediabetes (n=6419). Information on diabetes and prediabetes indicators, and m...
Source: Ecotoxicology and Environmental Safety - April 23, 2024 Category: Environmental Health Authors: Jiayin Ou Ronghui Xian Jiayu Li Jianhe Zhao Kaiyao Zhang Peishan Mo Jiansong Fang Yue Shen Xiaoling Hu Shuhuan Fang Wei Liu Huafeng Pan Source Type: research

Public health assessment of Kenyan ASGM communities using multi-element biomonitoring, dietary and environmental evaluation
This study aimed to characterise exposure pathways and risks among ASGM communities. Human hair, nails, urine, water, and staple food crops were collected and analysed from 144 ASGM miners and 25 people from the ASGM associated communities. Exposure to PHEs was predominantly via drinking water from mine shafts, springs and shallow-wells (for As>Pb>Cr>Al), with up to 366 µg L-1 arsenic measured in shaft waters consumed by miners. Additional exposure was via consumption of locally grown crops (for As>Ni>Pb>Cr>Cd>Hg>Al) besides inhalation of Hg vapour and dust, and direct dermal contact with Hg. Ur...
Source: Ecotoxicology and Environmental Safety - April 23, 2024 Category: Environmental Health Authors: Maureene Auma Ondayo Michael J Watts Olivier S Humphrey Odipo Osano Source Type: research

Tracing toxic path of antimony: From bioaccumulation to DNA hypomethylation in zebrafish (Danio rerio)
This study investigated the toxicokinetics, Global DNA Methylation (GDM), biomarker expression, and Integrated Biological Response (IBR) of Sb at different concentrations in zebrafish. The toxic mechanism of Sb exposure was simulated using molecular dynamics (MD). The results showed that significant differences effect existed (BCFk: liver > ovary > gut > brain) and uptake saturation phenomenon of Sb among zebrafish tissues. Over a 54-day exposure period, the liver emerged as the main target site for Sb-induced GDM, and the restoration was slower than in other tissues during the 54-day recovery period. Moreover, th...
Source: Ecotoxicology and Environmental Safety - April 23, 2024 Category: Environmental Health Authors: Jingyun Zhang Aijiang Yang Wen Cui Jian Zhang Apin Niu Xia Hu Qing Li Source Type: research

HO-1 upregulation promotes mitophagy-dependent ferroptosis in PM2.5-exposed hippocampal neurons
In this study, the role and underlying mechanism of ferroptosis in PM2.5-induced neurotoxicity were investigated in mice, primary hippocampal neurons, and HT22 cells. Our findings demonstrated that exposure to PM2.5 could induce abnormal behaviors, neuroinflammation, and neuronal loss in the hippocampus of mice. These effects may be attributed to ferroptosis induced by PM2.5 exposure in hippocampal neurons. RNA-seq analysis revealed that the upregulation of iron metabolism-related protein Heme Oxygenase 1 (HO-1) and the activation of mitophagy might play key roles in PM2.5-induced ferroptosis in HT22 cells. Subsequent in v...
Source: Ecotoxicology and Environmental Safety - April 20, 2024 Category: Environmental Health Authors: Xiaolan Li Qin Ran Xiang He Dan Peng Anying Xiong Manling Jiang Lei Zhang Junyi Wang Lingling Bai Shengbin Liu Shiyue Li Baoqing Sun Guoping Li Source Type: research

Cadmium modulates intestinal Wnt/ β-catenin signaling ensuing intestinal barrier disruption and systemic inflammation
In conclusion, this research advances the current understanding of the role of Wnt/β catenin signaling in gastrointestinal toxicity caused by diverse environmental pollutants.PMID:38640798 | DOI:10.1016/j.ecoenv.2024.116337 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - April 19, 2024 Category: Environmental Health Authors: Muskan Verma Manika Garg Aiysha Siddiq Khan Pawan Yadav Saman Saim Rahman Asghar Ali Mohan Kamthan Source Type: research

Toxic mechanism in Daphnia magna due to phthalic acid esters and CuO nanoparticles co-exposure: The insight of physiological, microbiomic and metabolomic profiles
In this study, Daphnia magna was exposed to nano-CuO and DBP or BBP at environmental relevant concentrations for 21-days to investigate these combined toxic effects. Acute EC50 values (48 h) of nano-CuO, DBP, and BBP were 12.572 mg/L, 8.978 mg/L, and 4.785 mg/L, respectively. Results showed that co-exposure with nano-CuO (500 μg/L) for 21 days significantly enhanced the toxicity of DBP (100 μg/L) and BBP (100 μg/L) to Daphnia magna by 18.37% and 18.11%, respectively. The activities of superoxide dismutase, catalase, and glutathione S-transferase were enhanced by 10.95% and 14.07%, 25.63% and 25.91%, and 39.93% and 35.01...
Source: Ecotoxicology and Environmental Safety - April 19, 2024 Category: Environmental Health Authors: Xu Jin Junlan Pan Cheng Zhang Xuesong Cao Chuanxi Wang Le Yue Xiaona Li Yinglin Liu Zhenyu Wang Source Type: research

Integrated physiological, intestinal microbiota, and metabolomic responses of adult zebrafish (Danio rerio) to subacute exposure to antimony at environmentally relevant concentrations
This study provides valuable insights into toxicity-related information concerning environmental impacts of Sb on aquatic organisms with significant implications for developing management strategies.PMID:38640800 | DOI:10.1016/j.ecoenv.2024.116326 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - April 19, 2024 Category: Environmental Health Authors: Can Liu Dongmei Huang Xiangquan Sheng Jianzhong Zhu Si Dong Song Chen Yaying Wang Ao Tang Renyan Duan Zeliang Yang Jing Bai Yu Zheng Source Type: research

Vital role of oxidative stress in tadpole liver damage caused by polystyrene nanoparticles
Ecotoxicol Environ Saf. 2024 Apr 18;277:116331. doi: 10.1016/j.ecoenv.2024.116331. Online ahead of print.ABSTRACTPolystyrene nanoparticles are emerging as contaminants in freshwater environments, posing potential risks to amphibians exposed to extended periods of water contamination. Using tadpoles as a model, this study aimed to evaluate the toxicity of PS NPs. Pyrolysis-gas chromatography-tandem mass spectrometry (Py-GCMS) analysis revealed a concentration-dependent increase in polystyrene nanoparticles (PS NPs) levels in tadpoles with escalating exposure concentrations. Following exposure to 100 nm fluorescent microsphe...
Source: Ecotoxicology and Environmental Safety - April 19, 2024 Category: Environmental Health Authors: Hao Zang Cenxi Zhao Runqiu Cai Haiyan Wu Liutao Wei Chaoyu Zhou Jie Chai Xuepeng Teng Tianlong Liu Source Type: research

miR-584-5p / Ykt6 - mediated autophagy - lysosome - exosome pathway as a critical route affecting the toxic effects of lead on HK-2 cells
This study aimed to investigate the role of miR-584-5p / Ykt6 axis in the toxic effect of lead on HK-2 cells and the related mechanism. Our data suggested that lead exposure caused significant cytotoxicity, DNA and chromosome damage to HK-2 cells. Mechanistically, lead exposure down-regulated miR-584-5p and up-regulated Ykt6 expression, consequently, autophagosomal number and autophagic flux increased, lysosomal number and activity decreased, exosomal secretion increased. Interestingly, when miR-584-5p level was enhanced with mimic, autophagosomal number and autophagic flux decreased, lysosomal number and activity increase...
Source: Ecotoxicology and Environmental Safety - April 18, 2024 Category: Environmental Health Authors: Yiren Xiong Zuqing Hu Di Ouyang Meilin Tang Jiayi He Shanshan He Renyi Liu Zhenjie Gao Ying Chen Dalin Hu Source Type: research