Ameliorative effect of ferulic acid on thyroid dysfunction against propyl-thiouracil induced hypothyroid rats
ConclusionIn conclusion, FA treatment showed a protective effect against hypothyroidism by stimulating the thyroid hormones through the activation of thyroid peroxidase enzyme and improving thyroid function. In addition, FA diminished the increase in lipids, liver and kidney markers, oxidative stress and inflammation.Graphical Abstract (Source: Endocrine)
Source: Endocrine - April 18, 2024 Category: Endocrinology Source Type: research
One sip of water with LT-4 supplementation —a key to euthyroidism in Hashimoto’s thyroiditis
ConclusionsThe reduction of water ingestion to a maximum of two sips, which is<50 mL, combined with LT-4 supplementation helps to achieve euthyroidism in HT. In addition, it reduces the L-T4 medication dosage needed to lower TSH serum levels and decreases TPO antibodies in HT. (Source: Endocrine)
Source: Endocrine - April 18, 2024 Category: Endocrinology Source Type: research
Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction
AbstractNeuroactive steroids are a type of steroid hormones produced within the nervous system or in peripheral glands and then transported to the brain to exert their neuromodulatory effects. Neuroactive steroids have pleiotropic effects, that include promoting myelination, neuroplasticity, and brain development. They also regulate important physiological functions, such as metabolism, feeding, reproduction, and stress response. The homoeostatic processes of metabolism and reproduction are closely linked and mutually dependent. Reproductive events, such as pregnancy, bring about significant changes in metabolism, and meta...
Source: Endocrine - April 18, 2024 Category: Endocrinology Source Type: research
One sip of water with LT-4 supplementation —a key to euthyroidism in Hashimoto’s thyroiditis
ConclusionsThe reduction of water ingestion to a maximum of two sips, which is<50 mL, combined with LT-4 supplementation helps to achieve euthyroidism in HT. In addition, it reduces the L-T4 medication dosage needed to lower TSH serum levels and decreases TPO antibodies in HT. (Source: Endocrine)
Source: Endocrine - April 18, 2024 Category: Endocrinology Source Type: research
Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction
AbstractNeuroactive steroids are a type of steroid hormones produced within the nervous system or in peripheral glands and then transported to the brain to exert their neuromodulatory effects. Neuroactive steroids have pleiotropic effects, that include promoting myelination, neuroplasticity, and brain development. They also regulate important physiological functions, such as metabolism, feeding, reproduction, and stress response. The homoeostatic processes of metabolism and reproduction are closely linked and mutually dependent. Reproductive events, such as pregnancy, bring about significant changes in metabolism, and meta...
Source: Endocrine - April 18, 2024 Category: Endocrinology Source Type: research
New insights into the vitamin D/PTH axis in endocrine-driven metabolic bone diseases
ConclusionsAssessing the status of the vitamin D/PTH axis and using vitamin D and PTH as therapeutic agents is mandatory in several endocrine-related bone metabolic conditions. (Source: Endocrine)
Source: Endocrine - April 17, 2024 Category: Endocrinology Source Type: research
The health-related quality of life of patients with type 1 and type 2 diabetes mellitus: a meta-analysis
ConclusionOur results are sample-specific and cannot be generalized to all patients with DM. Therefore, more research is warranted on this topic. (Source: Endocrine)
Source: Endocrine - April 17, 2024 Category: Endocrinology Source Type: research
New insights into the vitamin D/PTH axis in endocrine-driven metabolic bone diseases
ConclusionsAssessing the status of the vitamin D/PTH axis and using vitamin D and PTH as therapeutic agents is mandatory in several endocrine-related bone metabolic conditions. (Source: Endocrine)
Source: Endocrine - April 17, 2024 Category: Endocrinology Source Type: research
The health-related quality of life of patients with type 1 and type 2 diabetes mellitus: a meta-analysis
ConclusionOur results are sample-specific and cannot be generalized to all patients with DM. Therefore, more research is warranted on this topic. (Source: Endocrine)
Source: Endocrine - April 17, 2024 Category: Endocrinology Source Type: research
Reappraising the role of thyroid scintigraphy in the era of TIRADS: A clinically-oriented viewpoint
AbstractThyroid nodules (TNs) are a common entity, with the majority being benign. Therefore, employing an accurate rule-out strategy in clinical practice is essential. In the thyroid field, the current era is significantly marked by the worldwide diffusion of ultrasound (US)-based malignancy risk stratification systems of TN, usually reported as Thyroid Imaging Reporting And Data System (TIRADS). With the advent of US (and later TIRADS), the role of thyroid scintigraphy (TS) in clinical practice has gradually diminished. The authors of the present paper believe that the role of TS should be reappraised, also considering i...
Source: Endocrine - April 16, 2024 Category: Endocrinology Source Type: research
Neuroendocrine modulation by metamizole and indomethacin: investigating the impact on neuronal markers and GnRH release
ConclusionsThe results of our study showing an increase in the expression of neuronal factors reveal that metamizole and indomethacin may have possible neuroprotective effects. Moreover, the effects on the GnRH expression appear to be different. Animal models are required to confirm these effects of NSAIDs on neurons. (Source: Endocrine)
Source: Endocrine - April 16, 2024 Category: Endocrinology Source Type: research
Hypertension and diabetes, but not leptin and adiponectin, mediate the relationship between body fat and chronic kidney disease
ConclusionOur results suggest that the relations between BMI, TBF and CKD are in part mediated by diabetes and hypertension. (Source: Endocrine)
Source: Endocrine - April 16, 2024 Category: Endocrinology Source Type: research
Reappraising the role of thyroid scintigraphy in the era of TIRADS: A clinically-oriented viewpoint
AbstractThyroid nodules (TNs) are a common entity, with the majority being benign. Therefore, employing an accurate rule-out strategy in clinical practice is essential. In the thyroid field, the current era is significantly marked by the worldwide diffusion of ultrasound (US)-based malignancy risk stratification systems of TN, usually reported as Thyroid Imaging Reporting And Data System (TIRADS). With the advent of US (and later TIRADS), the role of thyroid scintigraphy (TS) in clinical practice has gradually diminished. The authors of the present paper believe that the role of TS should be reappraised, also considering i...
Source: Endocrine - April 16, 2024 Category: Endocrinology Source Type: research
Neuroendocrine modulation by metamizole and indomethacin: investigating the impact on neuronal markers and GnRH release
ConclusionsThe results of our study showing an increase in the expression of neuronal factors reveal that metamizole and indomethacin may have possible neuroprotective effects. Moreover, the effects on the GnRH expression appear to be different. Animal models are required to confirm these effects of NSAIDs on neurons. (Source: Endocrine)
Source: Endocrine - April 16, 2024 Category: Endocrinology Source Type: research
