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Analysis of TPO gene in Turkish children with iodide organification defect: identification of a novel mutationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective was to determine molecular genetic analysis of the TPO gene in Turkish children with iodide organification defect (IOD). Patients with a diagnosis of primary hypothyroidism were evaluated. Subjects having a definite diagnosis of autoimmune thyroiditis, thyroid gland dysplasia and, or iodine deficiency were excluded. A total of 10 patients from nine unrelated Turkish families, with an unknown etiology of hypothyroidism, and with a presumptive diagnosis of IOD were included in the study. A perchlorate discharge test (PDT) was performed to all subjects, and sequence analysis of TPO gene was applied in patien...
Source: Endocrine - November 18, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Comparison of lymphomononuclear cell energy metabolism between healthy, impaired glucose intolerance and type 2 diabetes mellitus patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we concluded that impaired glucose metabolism could change energy metabolism. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12020-009-9281-0Authors L. Ozsari, Gülhane Military Medical Academy Department of Internal Medicine Ankara TurkeyN. Karadurmus, Gülhane Military Medical Academy Department of Internal Medicine Ankara TurkeyM. Sahin, Gülhane Military Medical Academy Department of Endocrinology and Metabolism Ankara 06010 TurkeyG. Uckaya, Gülhane Military Medical Academy Department of Endocrinology and Metabolism Ankara 06010 TurkeyA. U. Ural, Gülhane Military Medical Academy...
Source: Endocrine - November 18, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Age, body mass index, and serum level of DHEA-S can predict glucocorticoid receptor function in women with polycystic ovary syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Glucocorticoid receptor (GR) transduces the glucocorticoid (GC) signal that could lead to metabolic derangements depending on the tissue responsiveness to GC. We aimed to investigate possible causative relation of the GR functional properties in peripheral blood mononuclear cells of women with polycystic ovary syndrome (PCOS), with their clinical and biochemical characteristics. Thirty women with PCOS [mean age: 26.5 ± 5.1 years, mean body mass index (BMI) 24.5 ± 5 kg/m2], and thirty respective controls were analyzed for the number of GR sites per cell (B max), appare...
Source: Endocrine - November 18, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Discrimination of prolactinoma from hyperprolactinemic non-functioning adenomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, old age, extrasellar tumor extension with relatively low prolactin levels, visual defect, and GH deficiency were considered suggestive of non-functioning pituitary adenoma rather than prolactinoma in hyperprolactinemic pituitary macroadenoma. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12020-009-9279-7Authors Jae Won Hong, Yonsei University College of Medicine Endocrinology, Department of Internal Medicine, Institute of Endocrinology 250 Seongsanno, Seodaemun-gu Seoul 120-752 KoreaMi Kyung Lee, Pathology Ilsan Hospital Ilsan KoreaSun Ho Kim, Yonsei University College of Medicine ...
Source: Endocrine - November 13, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Interleukin 1 beta (IL-1β) promoter C [−511] T polymorphism but not C [+3953] T polymorphism is associated with polycystic ovary syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract PCOS is a complex multifactorial disorder involving a number of genetic and environmental factors. One of the genetic factors that has been associated with PCOS is Interleukin 1 beta (IL-1β), is an important inflammatory cytokine that plays a regulatory role in both the body’s immune and the inflammatory responses. All these responses appear to be are also affected in at least some women with PCOS. To investigate the possible association of polymorphisms of the IL-1β gene with the occurrence and clinical characteristics of PCOS, we evaluated two common polymorphisms of the IL-1β gene (promoter C...
Source: Endocrine - November 10, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Study on pancreatic islet adaptation and gene expression during pregnancy in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the adaptive changes of the pancreatic islet beta-cell mass during pregnancy in rats, and explored profiles of islet gene expression at various stages of pregnancy. Some differentially expressed genes were verified by RT-PCR and Real-time PCR. Our results showed that compared with the non-pregnant control group, insulin synthesis, glucose-stimulated insulin secretion, islet beta-cell proliferation, and islet size were all increased in pregnant rats. The study also demonstrated that expression of several-hundred islet genes were changed during pregnancy, especially at day 14.5. The differ...
Source: Endocrine - November 7, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Raloxifene inhibits bone loss and improves bone strength through an Opg-independent mechanismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The osteoblast-derived paracrine factor osteoprotegerin (OPG) is considered to play a key role in inhibition of osteoclast formation and activity. Recently, raloxifene, a nonsteroidal benzothiophene, was found to exert anti-resorptive effects via modulating OPG expression in osteoblasts. To explore whether raloxifene regulates bone metabolism via an OPG-dependant pathway in vivo, we investigated the effects of raloxifene on bone loss in Opg-deficient mice. The results show that bone mineral density and bone strength are increased in mice deficient for Opg after treatment with raloxifene for 30 ...
Source: Endocrine - November 6, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Erratum to: Arachidonic acid induces acetyl-CoA carboxylase 1 expression via activation of CREB1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s12020-009-9276-xAuthors Yin Peng, Huazhong Agricultural University Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology 430070 Wuhan People’s Republic of ChinaTing Lei, Huazhong Agricultural University Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology 430070 Wuhan People’s Republic of ChinaJihong Yuan, Huazhong Agricultural University Key Laboratory of Agricultural Animal Genetics, Breed...
Source: Endocrine - November 5, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

A direct neuronal connection between the subparafascicular and ventrolateral arcuate nuclei in non-lactating female rats. Could this pathway play a role in the suckling-induced prolactin release?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The neuronal pathways, through which prolactin secretion is regulated during lactation, have still not been fully explored. Studies indicate that the suckling stimulus travels through the spinal cord, the brain stem, and then reaches the hypothalamus. The focus of this present experiment is to further explore the neuronal connections between the brain stem and the arcuate nucleus that may be involved in suckling-induced prolactin release. Ante- and retrograde tracing techniques were used. To chemically characterize the explored neurons neuropeptide immunohistochemistry was applied. Previous studies ...
Source: Endocrine - November 4, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

11β-hydroxysteroid dehydrogenase type-2 and type-1 (11β-HSD2 and 11β-HSD1) and 5β-reductase activities in the pathogenia of essential hypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Cortisol availability is modulated by several enzymes: 11β-HSD2, which transforms cortisol (F) to cortisone (E) and 11β-HSD1 which predominantly converts inactive E to active F. Additionally, the A-ring reductases (5α- and 5β-reductase) inactivate cortisol (together with 3α-HSD) to tetrahydrometabolites: 5αTHF, 5βTHF, and THE. The aim was to assess 11β-HSD2, 11β-HSD1, and 5β-reductase activity in hypertensive patients. Free urinary F, E, THF, and THE were measured by HPLC–MS/MS in 102 essential hypertensive patients and 18 normotensive controls. 11β-HSD2 enzyme activity was estimated by...
Source: Endocrine - October 31, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Adrenal incidentaloma, clinical, metabolic, follow-up aspects: single centre experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To investigate clinical characteristics, metabolic parameters and follow-up findings of subjects with incidentally discovered adrenal tumors. 376 consecutive subjects who have been evaluated since 2002 were included. Initial radiological examination was CT. Hormonal evaluation included 8.00 a.m. cortisol, DHEA-S, ACTH and in hypertensive subjects, plasma renin activity, and serum aldosterone. Urinary free cortisol (UFC), urinary normetanephrine, and metanephrine were measured. Overnight 1 mg dexamethasone suppression test was performed. Radiological evaluation was performed at 6th and 12th mont...
Source: Endocrine - October 30, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

IGF-I overexpression does not promote compensatory islet cell growth in diet-induced obesityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Although IGF-I was known to stimulate the growth of pancreatic islet cells from early in vitro experiments and in vivo reports on rodents, recent gene targeting experiments have indicated that IGF-I and its receptor do not play a major role in normal islet cell growth. In our previous reports, liver- or pancreatic-specific IGF-I deficiency caused no decrease in β-cell mass; a general and β-cell-enriched IGF-I overexpression caused no change in normal islet cell growth. On the other hand, increased metabolic demands (such as in obesity and insulin resistance) result in β-cell compensation in cell ...
Source: Endocrine - October 30, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Cholesterol induces mitochondrial dysfunction and apoptosis in mouse pancreatic beta-cell line MIN6 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, MIN6 mouse β-cell line was used to test the effect of cholesterol on pancreatic β-cell apoptosis over different doses and durations. It was found that cholesterol dose- and time-dependently induced cell death of MIN6 cells above 160 μM after 6 h treatment in vitro. Annexin-V staining revealed that cholesterol treatment significantly induced apoptosis in MIN6 cells. Cholesterol treatment resulted in the loss of the ability to retain Rhodamine 123, indicating mitochondrial damage in MIN6 cells. Cholesterol-induced cell apoptosis and mitochondrial damage were blocked by low-temperature conditi...
Source: Endocrine - October 30, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Allergic reactions to human insulin: a review of current knowledge and treatment optionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Although the incidence of insulin allergy decreased after the introduction of recombinant human insulin preparations, it is still a major problem which may be life-threatening in some cases. In this article, we attempted to review current knowledge concerning allergic reactions to human insulin and discuss the available treatment options of insulin allergy. Content Type Journal ArticleCategory ReviewDOI 10.1007/s12020-009-9256-1Authors Baris Akinci, Dokuz Eylul University Medical School Division of Endocrinology of Metabolism, Department of Internal Medicine Inciralti 35340 Izmir TurkeySerkan Yen...
Source: Endocrine - October 30, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Central leptin versus ghrelin: effects on bone marrow adiposity and gene expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study compared the central effects of ghrelin and leptin on body and bone marrow adiposity and gene expression in adipose tissue and bone marrow. Male Sprague–Dawley rats were injected intracerebroventricular (ICV) twice daily with control, 66 ng ghrelin (G66), 330 ng ghrelin (G330), or 5 μg leptin (L5) for 5 days. Food intake (FI) and body weight (BW) were measured daily. Gene expression in adipose tissue and bone marrow was assessed using RT–PCR. Leptin reduced FI (P < 0.05) and BW (P < 0.05), whereas ghrelin increased BW (P < 0.05) without affecting...
Source: Endocrine - October 30, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Molecular cloning and functional analysis of the FSH receptor gene promoter from the volcano mouse (Neotomodon alstoni alstoni)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To gain further insights on the genetic divergence and the species-specific characteristics of the follicle-stimulating hormone receptor (FSHR), we cloned 946 bp of the 5′-flanking region of the FSHR gene from the volcano mouse (Neotomodon alstoni alstoni), and compared its features with those from other mammalian species. The sequence of neotomodon FSHR (nFSHR) gene from the translation initiation site to −946 is 74, 71, 64, and 59% homologous to rat, mouse (129/J), human, and sheep, respectively. The nFSHR 5′-flanking region exhibits new interesting putative cis-regulatory elements inclu...
Source: Endocrine - October 28, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Acute cerebral hemorrhage normalized plasma renin activity in a patient with primary aldosteronismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12020-009-9272-1Authors Tetsuya Hiraiwa, Osaka Medical College First Department of Internal Medicine 2-7 Daigakumachi Takatsuki City, Osaka 569-8686 JapanRanko Ibata, Osaka Medical College First Department of Internal Medicine 2-7 Daigakumachi Takatsuki City, Osaka 569-8686 JapanKeiji Tanimoto, Osaka Medical College First Department of Internal Medicine 2-7 Daigakumachi Takatsuki City, Osaka 569-8686 JapanNaomune Yamamoto, Osaka Medical College First Department of Internal Medicine 2-7 Daigakumachi Takatsuki City, Osaka 569-8686 JapanJungo Terasaki, Osaka Med...
Source: Endocrine - October 28, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Inhibition of SOCS-3 in adipocytes of rats with diet-induced obesity increases leptin-mediated fatty acid oxidationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Rats with diet-induced obesity (DIO) usually experience hyperleptinemia. Thus, leptin produced by adipocytes does not deplete adipocyte fat, which implying a leptin resistance in adipocytes during overnutrition. Here, we induced hyperleptinemia in rats by feeding them a diet consisting of 45% fat. In epididymal adipose tissues, the mRNA and protein levels of a putative leptin resistant factor, suppressor of cytokine signaling 3 (SOCS-3), were increased. The mRNA levels of SOCS-3 in adipocytes differentiated from adipose-derived stromal cells (ADSCs) were higher in DIO rats than in rats on a 10% fat ...
Source: Endocrine - October 27, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Variation in gene expression of presenilins-associated rhomboid-like protein and mitochondrial function in skeletal muscle of insulin-resistant ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we evaluated the mRNA levels of presenilins-associated rhomboid-like protein (PARL) and mitochondrial content and enzyme activity from skeletal muscle isolated from insulin-resistant rats. Rats fed a high-fat diet for 35 days developed moderate insulin resistance, which was determined by an increase in plasma glucose and insulin concentrations following an oral glucose tolerance test. The PARL mRNA level was lower in the insulin-resistant rats than in control animals, and is associated with low mitochondrial content and reduced mitochondrial enzyme activity in the skeletal muscle from the insulin-r...
Source: Endocrine - October 26, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Carcinoid tumor of the thymus associated with Cushing′s syndrome and dysgeusia: case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A 30-year-old man was hospitalized with edema, polyuria, and abnormalities in taste. ACTH and cortisol levels at admission were markedly elevated, even after attempted suppression with 8 mg dexamethasone. A thoracic–abdominal CT revealed an anterior mediastinal lesion and hyperplasia of both adrenal glands. After excision of the mediastinal mass, which confirmed the presence of a carcinoid thymic tumor, the patient became totally asymptomatic, with normal ACTH and cortisol levels. A carcinoid thymic tumor has a poor prognosis, especially when it is associated with Cushing’s syndrome. Most p...
Source: Endocrine - October 26, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Association of the common rs9939609 variant of FTO gene with polycystic ovary syndrome in Chinese womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusions, the rs9939609 variant in the FTO gene is associated with PCOS susceptibility in the Chinese population, probably because of its effect on BMI. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12020-009-9257-0Authors Qun Yan, Shanghai JiaoTong University School of Medicine Shanghai Key Laboratory for Endocrine Tumors, Shanghai Institute of Endocrine and Metabolic Disease, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital 197 RuiJin Er Lu 200025 Shanghai People’s Republic of ChinaJie Hong, Shanghai JiaoTong University School of Medicine Shanghai Key Laboratory...
Source: Endocrine - October 26, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Chronic MCH infusion causes a decrease in energy expenditure and body temperature, and an increase in serum IGF-1 levels in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Melanin concentrating hormone (MCH) is an orexigenic peptide secreted from the lateral hypothalamus. Various observations suggest a role for MCH in energy expenditure in transgenic mice; however, the influence of MCH on energy expenditure and body temperature in WT mice was inadequately studied. Therefore, our first goal was to characterize the influence of chronic intracerebroventrical MCH infusion on energy homeostasis in mice. Our second goal was to explore the effect of MCH on the GH–insulin like growth factor 1 (IGF-1) axis in vivo. We have recently published that MCH directly increased GH-se...
Source: Endocrine - October 26, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Increased thrombin-activatable fibrinolysis inhibitor and decreased tissue factor pathway inhibitor in patients with hyperthyroidismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we found some important differences in the hemostatic parameters between the patients with hyperthyroidism and healthy controls. Increased TAFI and decreased FV, protein C, protein S, and TFPI in these patients represent a potential hypercoagulable and hypofibrinolytic state, which might augment the risk for atherosclerotic and atherothrombotic complications. Thus, disturbances of the hemostatic system may contribute to the excess mortality due to cardiovascular disease seen in patients with hyperthyroidism. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12020-009-9271-2Authors Ci...
Source: Endocrine - October 26, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Ultrasonographic evaluation of thyroid nodules: comparison of ultrasonographic, cytological, and histopathological findingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, ultrasonographically, hypoechoic pattern, microcalcification and margin irregularity of thyroid nodules are important features in determining the malignancy risk. The nodule size alone still remains inadequate to exclude malignancy risk. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12020-009-9262-3Authors Kamile Gul, Ankara Ataturk Education and Research Hospital Department of Endocrinology and Metabolism Bilkent Ankara TurkeyReyhan Ersoy, Ankara Ataturk Education and Research Hospital Department of Endocrinology and Metabolism Bilkent Ankara TurkeyAhmet Dirikoc, Ankara Ataturk Ed...
Source: Endocrine - October 26, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

LMNA gene mutation search in Polish patients: new features of the heterozygous Arg482Gln mutation phenotypeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined whether skin fold thickness measurements may be an effective screening procedure to select individuals with T2DM for molecular testing of the LMNA gene. We also aimed to search for mutations in diabetic patients with evident clinical features of lipodystrophy. Skin fold measurements were performed in 249 not pre-selected T2DM patients. The sum of two trunk skin fold measurements divided by the sum of two peripheral was obtained. Men with a skin fold ratio above 2.5 and women above 1.5 were selected for further molecular analysis of the LMNA gene by direct sequencing. We also examined eight patients presenti...
Source: Endocrine - October 26, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Demographic, clinical, laboratory, ultrasonographic, and cytological features of patients with Hashimoto’s thyroiditis: results of a university hospital of 769 patients in TurkeyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We investigated the demographic and clinical features of patients with Hashimoto’s thyroiditis who had been diagnosed and treated in Ege University, the main referral center in the Aegean region of Turkey. Medical records of patients who had been followed in the endocrinology clinic of Ege University were retrospectively evaluated. Patients who had been diagnosed as having any thyroid disorder were determined. Patients with Hashimoto’s thyroiditis were selected among those patients. Seven hundred and sixty-nine patients fulfilled diagnostic criteria for Hashimoto’s thyroiditis (725 females, 44...
Source: Endocrine - October 24, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Autonomic activity and glycemic homeostasis are maintained by precocious and low intensity training exercises in MSG-programmed obese miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Current research employed electrical records from superior vagus and sympathetic nerve branch that supply fat retroperitoneal tissue (RS nerve) to investigate whether very moderate swim training in obese-programmed mice would change sympathetic and parasympathetic autonomic nervous system activities. Neonatal mice were treated with monosodium l-glutamate (MSG), during their first 5 days of life, to induce obesity. Mice started training on weaning, comprising free swimming 3 days/week, 15 min/day for 10 weeks. After 12 h fasting, the nerve electrical signals of the 90-day-old ...
Source: Endocrine - October 24, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Administration of human leptin differentially affects parameters of cortisol secretion in socially housed female rhesus monkeysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Chronic exposure to psychosocial stress may lead to a dysregulation of the limbic–hypothalamic–pituitary–adrenal axis that results in a number of adverse health outcomes. The fat-derived hormone leptin has been indicated as a potential key component to maintaining homeostasis by enhancing glucocorticoid negative feedback. Using an established model of nonhuman primate social stress, notably social subordination, this study examined the effects of continuous leptin administration on cortisol secretion in female rhesus monkeys. The 20 subjects were maintained in stable five-member social groups ...
Source: Endocrine - October 24, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

The plasminogen activator inhibitor-1 (PAI-1) gene −844 A/G and −675 4G/5G promoter polymorphism significantly influences plasma PAI-1 levels in women with polycystic ovary syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Mutations in the plasminogen activator inhibitor-1 (PAI-1) gene, along with increased PAI-1 levels, have been implicated in the pathogenesis of polycystic ovarian syndrome (PCOS). We investigated a possible influence of the promoter polymorphism (−844 A/G and −675 4G/5G) in the PAI-1 gene on plasma PAI-1 levels in 126 PCOS patients and 97 healthy controls. Levels of total testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), fasting plasma glucose (FPG), fasting insulin, and PAI-1 were measured, and body mass index (BMI), waist-to-hip ratio (WHR), LH/FSH ratio, and homeosta...
Source: Endocrine - October 23, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Differential expression of gonadotropin-releasing hormone (GnRH) in pancreas during rat pregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Many studies have shown that there is a relationship between gonadotropin-releasing hormone (GnRH) and glucose metabolism, but little is known about the effects of GnRH on the pancreas. Our experiment investigated the effect of GnRH on pancreatic islet cell in Sprague–Dawley (SD) rats fed with high-cholesterol diet before and during pregnancy. We found that although high-cholesterol diet led to no significant difference of GnRH mRNA levels in pancreas in nonpregnant rats, it led to a marked increase of those in pregnant rats. Furthermore, in rats fed with standard laboratory chow, no significant d...
Source: Endocrine - October 23, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Coronary angiographic studies of impaired glucose regulation and coronary artery disease in Chinese nondiabetic subjectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To investigate the prevalence and the extent of coronary artery disease (CAD) in nondiabetic Chinese patients with different categories of impaired glucose regulation (IGR): isolated impaired fasting glucose (I-IFG); isolated impaired glucose tolerance (I-IGT); and combined IFG and IGT (CGI). A total of 556 nondiabetic subjects who had undergone coronary angiography were included in this study. Subjects were classified according to the 75-g oral glucose tolerance test result: normal glucose tolerance (NGT) (n = 278), I-IFG (n = 52), I-IGT (n = 128), CGI (n = 9...
Source: Endocrine - October 23, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Erythrocyte osmotic fragility and lipid peroxidation in experimental hyperthyroidismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigated the relation between erythrocyte osmotic fragility and oxidative stress and antioxidant state in primary hyperthyroidism induced experimental rats. Twenty-four Spraque–Dawley-type female rats weighing between 160 and 200 g were divided into two, as control (n = 10) and experimental (n = 12), groups. The experimental group animals have received tap water and L-Tiroksin (0.4 mg/100 g fodder) added standard fodder for 30 days to induce hyperthyroidism. Control group animals were fed tap water and standard fodder for the same period. Blood samples were drawn...
Source: Endocrine - October 22, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

FABP4: a novel candidate gene for polycystic ovary syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The present study is the first to establish an association between FABP4 gene polymorphisms and the development of PCOS. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12020-009-9228-5Authors Jing Wang, Anhui Medical University Reproductive Medicine Center, The First Affiliated Hospital Hefei ChinaJingwen Tang, Anhui Medical University Reproductive Medicine Center, The First Affiliated Hospital Hefei ChinaBinbin Wang, Peking Union Medical College Graduate School Beijing ChinaJunjie Song, Peking Union Medical College Graduate School Beijing ChinaJingjing Liu, Anhui Medical U...
Source: Endocrine - October 21, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Arachidonic acid induces acetyl-CoA carboxylase 1 expression via activation of CREB1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the effect of high concentration of arachidonic acid (AA) on the expression of ACC1 mRNA in HepG2 hepatoma cells cultured in the absence of insulin. After 12 h of treatment, AA was found to significantly up-regulate ACC1 mRNA level as well as that of cAMP regulatory element binding protein 1 (CREB1), implying the possible interactions between ACC1 and CREB1. In support of the hypothesis, several potential CREB1 binding sites were identified within the PII promoter of ACC1. Further experiments demonstrated that transient over-expression of CREB1 in HepG2 cells activates ACC1 PII promoter and induces th...
Source: Endocrine - October 20, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Usefulness of aggressive lipid-lowering therapy with rosuvastatin in hypercholesterolemic patients with concomitant type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12020-009-9235-6Authors Yutaka Mori, Utsunomiya National Hospital Department of Internal Medicine, National Hospital Organization Kawachi Tochigi JapanGenshin Kuriyama, Utsunomiya National Hospital Department of Internal Medicine, National Hospital Organization Kawachi Tochigi JapanTakaaki Tanaka, Utsunomiya National Hospital Department of Clinical Research, National Hospital Organization Kawachi Tochigi JapanNaoko Tajima, Jikei University School of Medicine Department of Diabetes, Metabolism and Endocrinology Minato Tokyo Japan Journal EndocrineO...
Source: Endocrine - October 16, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

RET mutation Tyr791Phe: the genetic cause of different diseases derived from neural crestEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study shows various clinical characteristics of the frequently discussed Tyr791Phe mutation. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12020-009-9242-7Authors Eliska Vaclavikova, Institute of Endocrinology Department of Molecular Endocrinology Narodni 8, 116 94 Prague 1 Czech RepublicSarka Dvorakova, Institute of Endocrinology Department of Molecular Endocrinology Narodni 8, 116 94 Prague 1 Czech RepublicVlasta Sykorova, Institute of Endocrinology Department of Molecular Endocrinology Narodni 8, 116 94 Prague 1 Czech RepublicRadovan Bilek, Institute of Endocrinology Department of Proteohor...
Source: Endocrine - October 13, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Gender-specific associations between subclinical hypothyroidism and blood pressure in Chinese adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Hypothyroidism is often related with increased blood pressure, yet, gender-specific associations between subclinical hypothyroidism (SCH) and hypertension have not been previously assessed. We conducted a large-scale, cross-sectional study from six districts of Jiangsu Province to investigate the association of SCH and blood pressure in female and male adults. In the studied population, 4725 participants (3034 women and 1691 men) aged 20–60 years were included. The prevalence of hypertension was significantly higher in males as compared to females (37.34% vs. 27.39%, P < 0.05), w...
Source: Endocrine - October 13, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Discriminated benefits of a Mediterranean dietary pattern within a hypocaloric diet program on plasma RBP4 concentrations and other inflammatory markers in obese subjectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our findings suggest that following a hypocaloric diet accompanying a high adherence to a MDP resulted in specific reductions on proinflammatory markers, in addition to a significant improvement in some metabolic syndrome features induced by weight loss, which could be a good combined strategy to treat obesity as well as related metabolic and inflammatory disorders. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12020-009-9248-1Authors Helen Hermana Miranda Hermsdorff, Institute of Nutrition and Food Sciences, University of Navarra Department of Nutrition and Food Sciences, Physiol...
Source: Endocrine - October 9, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Association studies of interleukin-8 gene in Graves’ disease and Graves’ ophthalmopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Graves’ disease (GD) is an autoimmune disorder, and the most common extrathyroidal manifestation is Graves’ ophthalmopathy (GO), which is believed to be caused by a complex interaction between genetic and environmental factors. Many studies have reported that interleukin-8 (IL-8), a potent pro-inflammatory cytokine, is associated with many autoimmune diseases and could increase the degree of lymphocyte infiltration within the thyroid gland. The aim of the present study is to elucidate whether IL-8 is associated with the development of GD and GO. The serum concentration of IL-8 was tested in 39 p...
Source: Endocrine - October 9, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Primary thyroid paraganglioma presenting with double thyroid nodule: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, thyroid PG is an elusive tumor. We present this interesting nature thyroid PG case to highlight importance of careful evaluation of clinical and pathological findings to correctly identify paragangliomas which anatomically mimic MTCs. This report is the first case of thyroid PG presenting with multinodular goiter in the literature. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12020-009-9238-3Authors Cihangir Erem, Karadeniz Technical University Department of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine İç Hastalıkları Anabilim Dalı 61080 Trabzo...
Source: Endocrine - October 9, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Improvement of hypercortisolism by β-blocker therapy in subclinical Cushing’s syndrome associated with ACTH-independent macronodular adrenocortical hyperplasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A 61-year-old man with hypertension and diabetes was referred for the evaluation of multiple bilateral adrenal tumors. While Cushingoid features were not apparent, an elevated cortisol level in response to a low-dose dexamethasone suppression test (187.7 nmol/l), an elevated urinary cortisol level (170.9 nmol/day), and a weak response to a cosyntropin-releasing hormone (CRH) provocation test were observed. Furthermore, the serum cortisol level increased in response to a posture test or isoproterenol infusion. Accordingly, the patient was diagnosed as having ACTH-independent macronodular ad...
Source: Endocrine - October 8, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Serum heart type fatty acid binding protein levels in metabolic syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Heart type fatty acid binding protein (H-FABP) is a major cytoplasmic low-molecular weight protein and released into the circulation when the myocardium is injured. Previous studies have demonstrated that H-FABP is closely associated with acute coronary syndrome, hypertrophic and dilated cardiomyopathy, heart failure, stroke, obstructive sleep apnea syndrome, pulmonary embolism. The aim of this study was to investigate serum H-FABP value in the patients with metabolic syndrome (MetS). We measured serum H-FABP levels in 55 consecutive patients with MetS, and 73 age-matched control subjects by using a...
Source: Endocrine - October 6, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

The role of integrated 18F-FDG PET/CT in identification of ectopic ACTH secretion tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The role of 18F-Flurodeoxyglucose positron emission tomography (18F-FDG PET) scan in localization of ectopic Cushing’s syndrome (EAS) tumor is still controversial. Here, we report on the use of integrated 18F-FDG PET and computed tomography (18F-FDG PET/CT) in localization of EAS tumors in patients with ectopic Cushing’s syndrome. Five patients, three men and two women, were reported, whose endocrine investigations and negative pituitary imaging were suggestive of ectopic ACTH secretion. 18F-FDG PET/CT was performed to identify the source of ACTH secretion. Then the patients were suggested to per...
Source: Endocrine - October 6, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Stimulation of 11β-HSD1 expression by IL-1β via a C/EBP binding site in human fetal lung fibroblastsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, IL-1β induces the expression of 11β-HSD1 mRNA in the fetal lung tissue through mechanisms that involve C/EBPβ binding to the promoter. This impact of IL-1β on the expression of 11β-HSD1 in human fetal lung cells may explain the alternate mechanism for the lung maturation that appears to occur when there is a risk of premature delivery of the fetus due to the presence of infection. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12020-009-9245-4Authors Zhen Yang, Fudan University School of Life Sciences 220 Handan Road Shanghai 200433 People’s Republic of ChinaXiaoou Zhu, Fuda...
Source: Endocrine - October 6, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

A novel indicator of widespread endothelial damage and ischemia in diabetic patients: ischemia-modified albuminEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we aimed at establishing an association between IMA and hyperglycemia, blood pressure, lipid parameters, microvascular complications, hsCRP, and microalbuminuria in type 2 diabetes patients without overt macrovascular disease and acute ischemia. Fifty type 2 diabetes mellitus patients without a history of macrovascular disease or end-stage renal disease were enrolled into the study. Age-matched 30 healthy individuals were also included in the study as a control group. Plasma IMA (0.329 ± 0.046 and 0.265 ± 0.045 AbsU; P < 0.0001) and hsCRP levels (0.51 ± 0.36 ...
Source: Endocrine - September 30, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Role of adipocytokines in predicting the development of diabetes and its late complicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Diabetes is an important health problem since the incidence of diabetes is continuously increasing. Early diagnosis is important as type 2 diabetes begins long before we diagnose it, leading to a complicated course of the disease. In order to prevent delay in the diagnosis of type 2 diabetes, novel predictors and pathways for type 2 diabetes are mounting. Diabetic complications are common cause of morbidity and mortality among subjects with diabetes. In the pathogenesis of diabetic complications some factors other than chronic hyperglycemia may be involved. Adipocytokines play important roles in the...
Source: Endocrine - September 25, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Nonthyroidal illness syndrome in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Neuroendocrine changes in the hypothalamic–pituitary–thyroid axis during critical illness result in nonthyroidal illness syndrome (NTIS) characterized by abnormal thyrotropin (TSH) and thyroid hormone levels. Studies looking at the natural history of neuroendocrine changes during critical illness have revealed the presence of NTIS. NTIS has been described in a variety of patient settings. Many studies have tried to uncover the pathophysiology behind NTIS and several theories are proposed. Whether NTIS requires treatment or intervention is still controversial and the results of the treatment stud...
Source: Endocrine - September 25, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Improving insulin resistance with traditional Chinese medicine in type 2 diabetic patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Some clinical studies and animal researches have evaluated the efficacy of Traditional Chinese Medicine (TCM) and compared its effects with placebo or other antidiabetic drugs. TCM involves three particular plants, as an antidiabetic drug. Our present research planned to evaluate the efficacy of TCM on insulin sensitivity and other related metabolic factors in type 2 diabetic patients. There were 43 newly diagnosed type 2 diabetic patients enrolled in this study, who did not use any antidiabetic drugs before. They were randomly assigned into TCM and placebo groups, administrated with TCM and placebo...
Source: Endocrine - September 3, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Testosterone-induced downregulation of anti-Müllerian hormone expression in granulosa cells from small bovine folliclesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Polycystic ovary syndrome (PCOS) is characterized by the presence of hyperandrogenism and an increased follicular mass probably determined by deregulation of locally produced factors. Anti-Müllerian hormone (AMH) is a glycoprotein that inhibits follicular recruitment and determines the size of the follicular pool. To evaluate the role of androgens in the regulation of AMH expression in bovine granulosa cells from small follicles, granulosa cells from 3 to 4 mm follicles were isolated and incubated in basal culture media, or in media containing testosterone (T) at 10−5M, T 10−8M, or estradi...
Source: Endocrine - August 28, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

The association of adiposity with parathyroid hormone in healthy older adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to examine the association of percent body fat (%Fat) with serum PTH in 307 older men and women and to determine the extent to which it may be explained by vitamin D status, bone turnover, calcium metabolism, and glucose homeostasis. The data are from the baseline visit of a clinical trial of calcium and vitamin D to prevent bone loss. %Fat was measured by dual-energy X-ray absorptiometry and fasting blood and urine samples were collected. Serum PTH levels increased by about 0.4 pmol/l per 10 unit increase in percent body fat (P = 0.003). The variables that we examined, i...
Source: Endocrine - August 27, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals