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[The C-peptide as a risk factor of development of type 1 diabetes in the first degree relatives of the autoimmunological diabetic patients.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The increase of fasting level of C-peptide can indicate compensatory increase of beta cell secretion. It can indirectly prove the presence of insulin resistance in this group of people. The presence of higher level of C-peptide and positive IAA titre with no clinical symptoms of type 1 diabetes, seems to be the prognostic factor to retard of clinical symptoms of diabetes. PMID: 19885806 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - November 6, 2009 Category: Endocrinology Authors: Siewko K, Szelachowska M, Popławska-Kita A, Szpak P, Nikołajuk A, Górska M Tags: Endokrynol Pol Source Type: journals

[The androgen receptor gene polymorphism and clinical picture of androgen deficiency syndrome during aging male of men's population in Wroclaw.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: 1. In the entire study group (n = 268) we found a positive correlation between the number of CAG repeats and the severity of psychological manifestations. We also found that in men with a higher number of CAG repeats (> 23 repeats) the somatic and psychological manifestations associated with signs of androgen deficiency are more common during the ageing period and that these patients score higher on the overall Heinemann scale. 2. We found no correlation between the number of CAG repeats in men divided into 4 subgroups with respect to their scores (hence the severity) on the overall Heinemann scale and its ...
Source: Endokrynologia Polska - November 6, 2009 Category: Endocrinology Authors: Trzmiel-Bira A, Filus A, Kuliczkowska-Płaksej J, Laczmański L, Mędraś M Tags: Endokrynol Pol Source Type: journals

[Growth hormone and IGF-1 as doping agents in competitive sport.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are often used by athletes as doping agents. It is estimated that up to 25% of sportsmen using anabolic-androgenic steroids also take GH. Available data do not confirm the influence of GH or IGF-1 preparations on physical performance improvement. However, there is some evidences for many adverse effects in athletes using this form of doping. Blood tests to detect growth hormone abuse are available since several years. Surprisingly, no one has been proven to use illegal doping agents influencing GH/IGF-1 axis. PMID: 19885810 [PubMed - as supplied by publis...
Source: Endokrynologia Polska - November 6, 2009 Category: Endocrinology Authors: Jóźków P, Mędraś M Tags: Endokrynol Pol Source Type: journals

[Two cases of serious hepatic injury caused by antithyroid drugs.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present two cases of severe hepatotoxicity caused by antithyroid drugs in women with Graves disease. The first medication in both cases was methimazole replaced by propylhiouracil due to intolerance. The main symptom was jaundice lasting about 2 months. As a first step in the treatment we terminated the antithyroid drug administration and introduced prednisone and ursodesoksycholic acid therapy. The termination of thyrotoxicosis by means of 131 I administration had also positive influence on the course of disease. In summary we emphasise the significance of prompt discontinuation of antithyroid drug once toxic symptoms ...
Source: Endokrynologia Polska - November 6, 2009 Category: Endocrinology Authors: Grzywa M, Orłowska-Florek R, Grzywa-Celińska A Tags: Endokrynol Pol Source Type: journals

[Chromogranin A (CgA) - characteristic of the currently available laboratory methods and conditions which can influence the results.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chromogranin A is a main, nonspecific neuroendocrine tumor marker (NET). It's estimation was applied for diagnostic purposes and for monitoring the treatment of NET. Currently few commercial assays are available allowing measurement of CgA concentration in serum or plasma. These methods have various sensitivity and specificity and differ in many analitycal parameters. Numerous factors and pathologies may influence the outcome of the CgA measurement. Therefore, a review article on this matter may be useful for clinical and laboratory practice. PMID: 19885814 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - November 6, 2009 Category: Endocrinology Authors: Glinicki P, Jeske W Tags: Endokrynol Pol Source Type: journals

[Relacja z Konferencji-Kursu: "Wpływ hormonów na układ kostny. Aspekty molekularne i kliniczne"]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
[Relacja z Konferencji-Kursu: "Wpływ hormonów na układ kostny. Aspekty molekularne i kliniczne"] Endokrynol Pol. 2009;60(5):424-425 Authors: Macke-Nauman A PMID: 19885816 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - November 6, 2009 Category: Endocrinology Authors: Macke-Nauman A Tags: Endokrynol Pol Source Type: journals

[Occurrence of androgen receptor gene CAG trinucleotide sequence polymorphism in the metropolitan population of Polish men.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The average number of AR gene CAG repeats and its range in the population Polish men were larger in comparison to the west European populations and more reminded the number repeats distribution meeting among Asians. This ethnic differences might explain the biological variabilities among different populations and another risk of hormone-dependent diseases occurrence. PMID: 19753540 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - September 17, 2009 Category: Endocrinology Authors: Filus A, Mędraś M, Kuliczkowska-Płaksej J, Trzmiel-Bira A, Laczmański L, Jędrzejuk D Tags: Endokrynol Pol Source Type: journals

[The incidence of the thyroid microsomal autoantibodies in Alzheimer disease.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In sera of Alzheimer disease patients autoantibodies against thyroid microsomal antigens can be frequently detected. The most frequent are antibodies against 91 kDa. It is important to note that Alzheimer disease patients should be screen for thyroid hormones. PMID: 19753541 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - September 17, 2009 Category: Endocrinology Authors: Gut P, Kosowicz J, Florczak J, Ziemnicka K, Bączyk M, Sowiński J, Kozubski W Tags: Endokrynol Pol Source Type: journals

[Echocardiographic assessment of myocardial function in patients with type 2 diabetes.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Myocardial differences observed in the echocardiographic image of a diabetic compared to a healthy person suggest myocardial dysfunction caused by diabetes. The existing differences between the group with controlled diabetes and the group with uncontrolled diabetes indicate that development of organic complications in diabetic patients can only be slowed down with procedures to normalise carbohydrate and lipid metabolic parameters and the arterial blood pressure. PMID: 19753542 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - September 17, 2009 Category: Endocrinology Authors: Gać P, Poręba R, Zawadzki M, Roemer R, Pawlas K, Andrzejak R, Szuba A Tags: Endokrynol Pol Source Type: journals

[Cognitive aspects of women's body image and eating disorders.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The authors presents basics of theoretical knowledge connected with cognitive aspects women's body image in Poland. The authors also presents results of research connected with the same subject. Material and methods: The study involved 111 women divided into groups - adolescents and young women and women with eating disorders (anorexia and bulimia nervosa). The study methods included the Contour Drawing Rating Scale (CDRS) by Thompson and Gray. Results and conclusions: The statistical tests indicate differences in the cognitive dimension of body image (between ideal and real self) among adolescent and young...
Source: Endokrynologia Polska - September 17, 2009 Category: Endocrinology Authors: Izydorczyk B, Rybicka-Klimczyk A Tags: Endokrynol Pol Source Type: journals

[Hormonal regulation of feeding.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Obesity is an important healthcare problem. Steady increase in its prevalence is observed worldwide. The underlying cause of obesity is mainly increased calories intake. The regulation of appetite is held by the hypothalamus. Satiety signals are sent to central nervous system via vagus due to distension of the walls of digestive tract and secretion of cytokine signaling after meal digestion. Additionally leptin excreted from adipose tissue reflects the state of energy storage and affects the hypothalamus. The study presents the literature on hormonal regulation of feeding. PMID: 19753544 [PubMed - as supplied by pu...
Source: Endokrynologia Polska - September 17, 2009 Category: Endocrinology Authors: Kocełak P, Zahorska-Markiewicz B, Olszanecka-Glinianowicz M Tags: Endokrynol Pol Source Type: journals

[Obesity and the relationship between somatotrophic axis and bone tissue.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In postmenopausal obese women often is observed increase bone mineral density in relation to slim women. Dominate the view that positive influence of adipose tissue on state of skeleton in postmenopausal women can be consequence of the boost to load carrying bone, may also result from the role of adipose tissue as endocrine organ. Interaction existence between somatotrophic axis and bone tissue suggests that revealing itself changes of constituents concentration of this axis in obesity individuals may have significance in bone tissue remodeling modification after menopause. It has been demonstrated that GH and IGF-I se...
Source: Endokrynologia Polska - September 17, 2009 Category: Endocrinology Authors: Ostrowska Z, Kobielski A, Kos-Kudła B, Marek B, Kajdaniuk D Tags: Endokrynol Pol Source Type: journals

[Management of Graves' orbitopathy. Comments on the EUGOGO consensus statement.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19753546 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - September 17, 2009 Category: Endocrinology Authors: Bednarczuk T, Bar-Andziak E, Wsp AH Tags: Endokrynol Pol Source Type: journals

[Adrenal disorders in pregnancy.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pregnancy dramatically affects the function of the adrenal glands and is associated with altered levels of adrenal hormones. Endocrine adaptation to pregnancy involves changes in the activities of the hypothalamic-pituitary-adrenal and renin-angiotensin-aldosterone axes. As a result, pregnancy may influence the course of pre-existing adrenal diseases or lead to their unmasking. Although disorders of the adrenal glands are rare during pregnancy, they may pose a serious health problem. The fact that some symptoms of adrenal disorders may be erroneously interpreted as symptoms of normal pregnancy together with overlapping...
Source: Endokrynologia Polska - September 17, 2009 Category: Endocrinology Authors: Marek B, Krysiak R, Okopień B Tags: Endokrynol Pol Source Type: journals

[informations about scientific congresses and conferences and other events.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
[INFORMATIONS ABOUT SCIENTIFIC CONGRESSES AND CONFERENCES AND OTHER EVENTS.] Endokrynol Pol. 2009;60(4):343-344 Authors: PMID: 19753548 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - September 17, 2009 Category: Endocrinology Tags: Endokrynol Pol Source Type: journals

[Responsiveness of parathyroid hormone secretion to a phosphate load in hypertensive patients with non insulin dependent diabetes mellitus.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: 1. Both NTS and CNT groups are characterized by an abnormal calcium and phosphate metabolism and exaggerated response of PTH secretion to an oral phosphate load as compared with GK controls. 2. Probably hypertension and not NIDDM seems to be the leading cause of calcium-phosphate abnormalities in hypertensive diabetic patients. PMID: 19569018 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - July 3, 2009 Category: Endocrinology Authors: Irzyniec T Tags: Endokrynol Pol Source Type: journals

[Pheochromocytoma in 8-year observation at a single endocrinological center in Wroclaw.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The diagnosis of pheochromocytma is usually made after long duration of the disease. The study confirms that clinical presentation of pheochromocytoma is variable and nonspecific, this finding makes the diagnosis very difficult. The most typical symptom is paroxysmal hypertension, which is present only in 40%, other symptoms are nonspecific. The measurement of 24-hour urinary metanephrines was the best indicator. CT was almost always successful in localizing the tumor. Patients with pheochromocytoma should be consider for other endocrine diseases especially medullary carcinoma, primary hyperparathyroidism and ...
Source: Endokrynologia Polska - July 3, 2009 Category: Endocrinology Authors: Bednarek-Tupikowska G, Bucyk B, Daroszewski J, Bidzińska-Speichert B, Bohdanowicz-Pawlak A, Szymczak J, Bednorz W, Podgórski F, Zaręba-Bogdał E, Kuliczkowska-Płaksej J, Lenarcik A, Filus A, Kałużny M, Kubicka E, Sy Tags: Endokrynol Pol Source Type: journals

[Activity of antioxidative enzymes and concentration of malondialdehyde as oxidative status markers in women with non-autoimmunological subclinical hyperthyroidism.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The increased EC-SOD plasma activity may reflect disturbances of oxidative state in subclinical hyperthyroidism. Parallel increase of MDA plasma concentration may indicate enhancement of lipid peroxidationin in patients with subclinical hyperthyroidism. PMID: 19569020 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - July 3, 2009 Category: Endocrinology Authors: Rybus-Kalinowska B, Zwirska-Korczala K, Kalinowski M, Kukla M, Birkner E, Jochem J Tags: Endokrynol Pol Source Type: journals

[Use of testosterone and anabolic androgenic steroids in sport.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anabolic androgenic steroids (AAS) and testosterone are the most frequently detected prohibited doping agents in sport. Professional competitors have been taking them since the fifties of the 20th century, they are used at present mainly by sport amateurs. Anabolic Androgenic Steroids are very often used in combination with other doping agents (erythropoietin, growth hormone, thyroxin). Apart from desirable for athletes anabolic and anticatabolic properties AAS have many side effects. In extreme cases doping with AAS can be life-threatening. PMID: 19569021 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - July 3, 2009 Category: Endocrinology Authors: Mędraś M, Jóźków P Tags: Endokrynol Pol Source Type: journals

[The role of estrogens in angiogenesis in the female reproductive system.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Under physiological conditions, angiogenesis is routinely observed in the uterus. Multiple lines of evidence suggest that estrogen directly modulates angiogenesis via effects on endothelial cells. A clear association between estrogen, estrogen receptor expression by endothelial cells and angiogenic activity has been confirmed. This minireview will discuss the recent progress in research into the role of estrogens in angiogenesis. PMID: 19569022 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - July 3, 2009 Category: Endocrinology Authors: Dobrzycka B, Kinalski M, Piechocka D, Terlikowski SJ Tags: Endokrynol Pol Source Type: journals

[Pathogenesis, evaluation and treatment of hypogonadism in men.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hypogonadism in men is defined as a complex of signs and symptoms due to testosterone deficiency or inappropriate production, which occurs in about 1-2%. Symptoms of hypogonadism depend primarily on the age of the male patients at the time of development of the hypogonadism (pre- or postpubertal). The dominant findings are: impaired puberty, decrease of virilization, infertility or decrease of spermatogenesis, impotence and gynecomastia. Classically hipogonadism is divided into primary (hypergonadotropic) and secondary (hypogonadotropic). The most common causes of primary hypogonadism is Klinefelter's syndrome, while s...
Source: Endokrynologia Polska - July 3, 2009 Category: Endocrinology Authors: Rabijewski M, Zgliczyński W Tags: Endokrynol Pol Source Type: journals

[informations about scientific congresses and conferences and other events.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
[INFORMATIONS ABOUT SCIENTIFIC CONGRESSES AND CONFERENCES AND OTHER EVENTS.] Endokrynol Pol. 2009;60(3):236-237 Authors: PMID: 19569025 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - July 3, 2009 Category: Endocrinology Tags: Endokrynol Pol Source Type: journals

Quality of life assessment in patients with Graves' disease and progressive infiltrative ophthalmopathy during combined treatment with methylprednisolone and orbital radiotherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: GO causes a considerable worsening of QoL. The stage of clinical development and activity of GO find no reflection in QoL. Effectiveness of treatment for GO cannot be evaluated on the basis of changes in QoL. PMID: 19569015 [PubMed - in process] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 30, 2009 Category: Endocrinology Authors: Kulig G, Andrysiak-Mamos E, Sowińska-Przepiera E, Kulig J, Karakiewicz B, Brodowski J, Robaczyk M, Homa K, Letkiewicz M, Syrenicz A Tags: Endokrynol Pol Source Type: journals

The inhibitory influence of adiponectin on the growth of the murine endothelial cell line HECa 10 in vitro.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The obtained data show that adiponectin inhibits endothelial cell growth and may participate in angiogenesis regulation as an endogenous antiangiogenic factor. PMID: 19569016 [PubMed - in process] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 30, 2009 Category: Endocrinology Authors: Połowinczak-Przybyłek J, Mełeń-Mucha G Tags: Endokrynol Pol Source Type: journals

Lack of relationship between 174G_C promoter polymorphism of the IL-6 gene and indices of metabolic syndrome in non-obese healthy subjects.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data show that IL-6 174G_C polymorphism is not associated with features describing metabolic syndrome in nonobese healthy subjects. PMID: 19569017 [PubMed - in process] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 30, 2009 Category: Endocrinology Authors: Tworowska-Bardzińska U, Kubicka E, Slezak R, Mielcarek M, Bednarek-Tupikowska G, Bolanowski M, Milewicz A Tags: Endokrynol Pol Source Type: journals

A jejunal stromal tumour in a patient with metastatic neuroendocrine cancer of unknown origin; a rare coexistence, diagnostic and therapeutic challenge.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 59-year-old woman presented to the Department of Gastroenterology complaining of progressing weight loss, unexplained diarrhoea, and, as revealed by abdominal ultrasound, numerous hyperechogenic foci in the liver. The immunohistochemical evaluations of the specimens from biopsy revealed well-differentiated hepatic neuroendocrine metastases. The biochemical marker levels, including serum chromogranin A (CGA) and urine 5-hydroxyindolacetic acid (5-HIAA) 24-hour excretion, were significantly elevated. Whole body somatostatin receptor scintigraphy showed tracer accumulation in the liver lesions, with no extrahepatic tumo...
Source: Endokrynologia Polska - April 30, 2009 Category: Endocrinology Authors: El-Ali Z, Iwanik K, Sowiński J, Swora E, Grzymislawski M Tags: Endokrynol Pol Source Type: journals

Identification of vertebral deformities in the Polish population by morphometric X-ray absorptiometry - results of the EPOLOS study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: 1. Using MXA, it was found that in the Polish population deformities of vertebrae are common, as was demonstrated in X-ray morphometric studies in the European Vertebral Observation Study (EVOS). 2. Densitometric morphometry, as a non-invasive technique, may become a useful tool in the diagnostics of vertebral fractures. PMID: 19396748 [PubMed - in process] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 1, 2009 Category: Endocrinology Authors: Skowrońska-Jóźwiak E, Płudowski P, Karczmarewicz E, Lorenc R, Lewiński A, Tags: Endokrynol Pol Source Type: journals

Compliance with alendronate 10 treatment in elderly women with postmenopausal osteoporosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Not all patients treated with alendronate are compliant. Osteoporosis is a chronic disease, which needs long clinical observation and constant adherence to medication. Effective communication between doctor and patient, and follow-up visits that are more frequent would greatly improve the adherence to osteoporosis treatment modalities. Compliant patients achieved increases in bone mass density with simultaneous fracture risk reduction. PMID: 19396749 [PubMed - in process] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 1, 2009 Category: Endocrinology Authors: Sewerynek E, Dabrowska K, Skowrońska-Jóźwiak E, Zygmunt A, Lewiński A Tags: Endokrynol Pol Source Type: journals

WHO fracture risk calculator (FRAX) in the assessment of obese patients with osteoporosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The WHO fracture risk calculator may be a useful tool in treated obese females with osteoporosis. The information regarding 10-year fracture risk may change the treatment strategy at least for those in whom the decision of treatment was based solely on low BMD. PMID: 19396750 [PubMed - in process] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 1, 2009 Category: Endocrinology Authors: Franek E, Wichrowska H, Gozdowski D, Puzianowska-Kuźnicka M Tags: Endokrynol Pol Source Type: journals

[Utility of laboratory tests in evaluation of fracture risk and in differential diagnostics of low bone mass in asymptomatic postmenopausal women]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: 1. Laboratory tests aren't useful to assess fracture risk. 2. In 64% of asymptomatic postmenopausal women with low BMD, the cause of this abnormality may by pathology that coexists with primary osteoporosis. 3. To assess the cause of low BMD, except basic lab tests, 25(OH)D should be tested. PMID: 19396751 [PubMed - in process] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 1, 2009 Category: Endocrinology Authors: Walicka M, Marcinowska-Suchowierska E Tags: Endokrynol Pol Source Type: journals

[Influence of weight reduction on leptin concentration and bone mineral density in patients with morbid obesity before and 6 months after bariatric surgery]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Weight loss in patients with morbid obesity after BS leads to decrease in serum leptin, increase in BMD in LS and decrease in PF. These changes are accompanied by regression of hyperparathyroidism, which is probably secondary to vitamin D deficiency. PMID: 19396752 [PubMed - in process] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 1, 2009 Category: Endocrinology Authors: Walicka M, Czerwińska E, Tałałaj M, Marcinowska-Suchowierska E Tags: Endokrynol Pol Source Type: journals

[Klotho - a new regulator of mineral homeostasis]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Research on the regulation of mineral homeostasis have been continuing for the decades, with an effect of establishing the impression that the governing mechanisms are already fairly well known and understood. Revealing of the molecular mechanism of action of the Klotho protein, forced us to revise this knowledge. It is known already that Kloto is a unique regulatory efector playing key role in reversing the imbalanced extracellular Ca(++) concentrations, by affecting the intensity of the transepithelial transport and modulation of the parathormone excretion. In cooperation with the phosphaturic hormone - Fgf23 it regu...
Source: Endokrynologia Polska - March 1, 2009 Category: Endocrinology Authors: Lukaszkiewicz J, Mikołajczak G, Lorenc R Tags: Endokrynol Pol Source Type: journals

[Senile osteoporosis]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The presented paper aims to summarize knowledge regarding senile osteoporosis. The article highlights high prevalence of the disease and the burden caused by osteoporotic fractures on the healthcare system. It describes shortly a complex ethiopathogenesis, in which vitamin D deficiency, other hormonal disturbances, protein-energy malnutrition, dysfunction of neuromuscular system and other factors may play a role. Possible diagnostics (x-rays, dual x-ray absorptiometry, 10-years fracture risk) and therapeutic methods are also presented. PMID: 19396754 [PubMed - in process] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 1, 2009 Category: Endocrinology Authors: Napiórkowska L, Franek E Tags: Endokrynol Pol Source Type: journals

[Effects of biologic antirheumatic treatments on bone metabolism in rheumatoid arthritis and ankylosing spondylitis]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews recent scientific literature regarding the effects of modern targeted therapies on bone turnover, bone mass and focal damage of joints. PMID: 19396755 [PubMed - in process] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 1, 2009 Category: Endocrinology Authors: Głuszko P Tags: Endokrynol Pol Source Type: journals

Critical points in strategies for the diagnosis and treatment of osteoporosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Current treatment decisions for osteoporosis depend on the fracture risk calculated based on the results of comprehensive diagnostic procedures [clinical risk factors (CRF), densitometry (BMD), morphometry, and bone turnover markers (BTM)]. Recently developed fracture risk assessment tool (FRAX) represents an important new achievement as a 10-year fracture risk calculation based on femoral neck densitometry and age combined with independent clinical fracture risk factors. FRAX presents several options: FRAX BMI (body mass index) is advocated as a helpful screening tool to identify the group of patients with high fractu...
Source: Endokrynologia Polska - March 1, 2009 Category: Endocrinology Authors: Lorenc RS, Misiorowski W, Karczmarewicz E Tags: Endokrynol Pol Source Type: journals

[Mechanisms of action of anticatabolic drugs used in osteoporosis therapy]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bone remodeling is essential for skeletal and the whole body health. Imbalance in skeletal turnover, so that bone resorption exceeds bone formation, may lead to reduction in bone strength and increase fractures risk. The main target of anticatabolic therapy is to normalize increased osteoclasts activity and bone turnover. Molecular mechanisms of action of this class of drugs are related with different points in cellular signaling pathways that control osteoclasts differentiation and resorbing activity. These mechanisms are briefly described in our review. PMID: 19396757 [PubMed - in process] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 1, 2009 Category: Endocrinology Authors: Kryśkiewicz E, Lorenc RS Tags: Endokrynol Pol Source Type: journals

[The role of bone metabolic markers in qualification for treatment of osteoporosis. Results of POMOST study.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Results of the study did not show the practical use of BTM in qualification for pharmacological treatment of osteoporosis. PMID: 19224502 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - February 21, 2009 Category: Endocrinology Authors: Przedlacki J, Bartoszewicz Z, Księżopolska-Orłowska K, Kondracka A, Grodzki A, Bartuszek T, Bartuszek D, Swirski A, Loth E, Musiał J, Luczak E, Teter P, Lasiewicki A, Walkiewicz A, Drozdowska-Rusinowicz I Tags: Endokrynol Pol Source Type: journals

[Relationship between toxic effects of potassium bromate and endocrine glands.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Potassium bromate (KBrO(3)) is a compound belonging to Group 2B of carcinogens (a possible human carcinogen). This agent was used as a food additive in flour treatment, as a component of cold-wave hair lotions, and is still used in barley processing. Additionally, KBrO(3) is formed as an oxyhalide by-product during water ozonation. KBrO(3) induces oxidative stress and may contribute to neoplasia in endocrine glands. It has been demonstrated that KBrO(3) triggers thyroid follicular cell tumors in rats. It has been revealed in our in vivo and in vitro studies that KBrO(3) significantly increases lipid peroxidation in rat...
Source: Endokrynologia Polska - February 21, 2009 Category: Endocrinology Authors: Stasiak M, Lewiński A, Karbownik-Lewińska M Tags: Endokrynol Pol Source Type: journals

[Inhibitory effect of carbamazepine on hypotensive action of spironolactone in primary aldosteronism.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a 68-year-old female with primary aldosteronism treated with spironolactone. The patient occasionally suffered from trigeminal neuralgia and was then prescribed with carbamazepine, which although alleviated pain worsened the control of blood pressure. To maintain blood pressure within normal limits the doses of spironolactone had to be increased. Replacement of carbamazepine with gabapentin prevented these drug-induced increases in blood pressure in our patient. This case shows for the first time the existence of a drug interaction between spironolactone and any anti-epileptic drug in primary aldoster...
Source: Endokrynologia Polska - February 21, 2009 Category: Endocrinology Authors: Krysiak R, Marek B, Okopień B Tags: Endokrynol Pol Source Type: journals

[Testosterone metabolism and doping test results.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glucuronidation is one of the most important metabolic processes which eliminates androgens from the human organism. Three enzymes (UDP-glucuronosyltransferases) are responsible for transfering the glucuronic group from glucuronic acid to androgens: UGT2B7, UGT2B15 and UGT2B17. Glucuronide products are more polar, water soluble, less toxic and easily extracted form the body. Testosterone is a common androgen abused in sport. The norm for urinary testosterone/epitestosterone ratio is below 4.0. Large testosterone excretion is associated with a deletion polymorphism of the UGT2B17 gene. This polymorphism decreases T/E ra...
Source: Endokrynologia Polska - February 21, 2009 Category: Endocrinology Authors: Laczmański L, Mędraś M Tags: Endokrynol Pol Source Type: journals

[informations about scientific congresses and conferences and other events.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
[INFORMATIONS ABOUT SCIENTIFIC CONGRESSES AND CONFERENCES AND OTHER EVENTS.] Endokrynol Pol. 2009;60(1):63-67 Authors: PMID: 19224507 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - February 21, 2009 Category: Endocrinology Tags: Endokrynol Pol Source Type: journals

Adrenal gland injury secondary to blunt traumatic mechanisms: a marker of overall injury severity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Adrenal gland injury is associated with significant morbidity and mortality. With modern imaging modalities capable of reliably detecting adrenal injury, the presence of AGI should be considered a marker of overall injury severity. The authors provide a CT-radiographic classification of adrenal injuries. PMID: 19224498 [PubMed - in process] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - January 1, 2009 Category: Endocrinology Authors: Stawicki SP, Seamon MJ, Carvalho CM, Bhoot N, Sharma R, Schrag SP, Steinberg SM Tags: Endokrynol Pol Source Type: journals

Peripheral blood concentrations of vascular endothelial growth factor and its soluble receptors (R1 and R2) in patients with adrenal cortex tumours treated by surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Peripheral blood concentrations of VEGF and its receptors cannot be clinically valuable markers that discriminate between benign and malignant adrenocortical tumours before and after adrenalectomy. PMID: 19224499 [PubMed - in process] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - January 1, 2009 Category: Endocrinology Authors: Jurczyńska J, Stepień T, Lawnicka H, Stepień H, Krupiński R, Kołomecki K, Kuzdak K, Komorowski J Tags: Endokrynol Pol Source Type: journals

Sonographic fatty liver in overweight and obese children, a cross sectional study in Isfahan.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The high rate of detected SFL in obese children in this study suggests that Iranian obese children are at risk of metabolic syndrome. Moreover, the WHO indicated Iran as one of the countries with high rate of obese children. Based on this information, we can conclude that the prevalence of metabolic syndrome and its related non-communicable diseases will be increasing future in . Therefore, it is necessary to develop some plan to control overweight problem including teaching healthy lifestyle in schools and kindergartens as well as mass media. PMID: 19224500 [PubMed - in process] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - January 1, 2009 Category: Endocrinology Authors: Adibi A, Kelishadi R, Beihaghi A, Salehi H, Talaei M Tags: Endokrynol Pol Source Type: journals

Abnormalities in glucose homeostasis in acromegaly. Does the prevalence of glucose intolerance depend on the level of activity of the disease and the duration of the symptoms?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The prevalence of diabetes mellitus among acromegalics is much higher than in the general population. The occurrence of glucose tolerance impairments does not depend on the duration of the disease. In patients with acromegaly insulin resistance and hyperinsulinemia are positively correlated with the level of activity of the disease. PMID: 19224501 [PubMed - in process] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - January 1, 2009 Category: Endocrinology Authors: Stelmachowska-Banaś M, Zdunowski P, Zgliczyński W Tags: Endokrynol Pol Source Type: journals

Mitogenic potency of insulin glargine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The goal of diabetes mellitus treatment is to maintain long-term near-normoglycaemia to prevent the onset or progression of long-term complications. In order to achieve tight glycaemic control and improve the quality of life for diabetic patients, a number of novel insulin preparations, insulin analogues, have been constructed thanks to recombinant DNA technologies and advanced protein chemistry. Because structurally modified insulins may differ from human insulin not only in metabolic but also in mitogenic potencies there were concerns raised about the possibility of increased insulin analogue proliferative action or ...
Source: Endokrynologia Polska - January 1, 2009 Category: Endocrinology Authors: Zełobowska K, Gumprecht J, Grzeszczak W Tags: Endokrynol Pol Source Type: journals

[informations about scientific congresses and conferences and other events.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
[INFORMATIONS ABOUT SCIENTIFIC CONGRESSES AND CONFERENCES AND OTHER EVENTS.] Endokrynol Pol. 2008;59(4):368-369 Authors: PMID: 18777508 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - December 1, 2008 Category: Endocrinology Tags: Endokrynol Pol Source Type: journals

[Salivary gland damage after (131)I therapy in patient with differentiated thyroid cancer. Preliminary report.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The main conclusion is that a single dose of (131)I has no significant influence on salivary gland function; a repeated high-doses therapy is connected with an essential risk of side-effect occurrence. Scintigraphy can evaluate salivary gland function with high sensitivity. Parotid glands are more radiosensitive than submandibular. (Pol J Endocrinol 2008; 59 (5): 403-410). PMID: 18979451 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - December 1, 2008 Category: Endocrinology Authors: Macioszek A, Bączyk M, Kopeć T, Sowiński J Tags: Endokrynol Pol Source Type: journals

[Under-age girl as a patient of pediatric and adolescent ginecology outpatient clinic.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The research carried out in Poland reflected that sexual initiation before 18 years of age is a common phenomenon and refers to roughly 80% of teenagers. In Poland there is no uniform standing of medical and legal environments with regard to dealing with a juvenile patient who has become sexually active and expects the advice of a gynaecologist, gynaecologic examination and often asks for prescribing contraceptives. The procedures must take into account the fact that in Poland, until 18 years of age, a juvenile functions under the parental or tutelary authority, while a consent for medical service requires beside of th...
Source: Endokrynologia Polska - December 1, 2008 Category: Endocrinology Authors: Sowińska-Przepiera E, Andrysiak-Mamos E, Syrenicz A Tags: Endokrynol Pol Source Type: journals

[Hormones and the cardiovascular system.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hormones have an influence on many tissues and organs, including the cardio-vascular system (CVS). Depending on their activity on CVS, they can be divided into 4 groups: having hypertensive or hypotensive influence and chronotropic positive or negative action. Endocrine regulation in CVS may occur in many ways. Apart from hormones usually connected with CVS regulation, other more recently, discovered ones can act on it. A few of these act directly through specific receptors in heart or vessel wall cells, whereas some act indirectly - stimulating other neuroendocrine factors. Additionally, novel mechanisms of signal tra...
Source: Endokrynologia Polska - December 1, 2008 Category: Endocrinology Authors: Lącka K, Czyżyk A Tags: Endokrynol Pol Source Type: journals