Exposure to per- and polyfluoroalkyl substances and high-throughput proteomics in Hispanic youth
CONCLUSION: PFAS was associated with broad alterations of the proteomic profiles linked to pro-inflammation and immunoregulation. The biological functions of these proteins provide insight into potential molecular mechanisms of PFAS toxicity.PMID:38537583 | DOI:10.1016/j.envint.2024.108601 (Source: Environment International)
Source: Environment International - March 27, 2024 Category: Environmental Health Authors: Jiawen Carmen Chen Jesse A Goodrich Douglas I Walker Jiawen Liao Elizabeth Costello Tanya L Alderete Damaskini Valvi Hailey Hampson Shiwen Li Brittney O Baumert Sarah Rock Dean P Jones Sandrah P Eckel Rob McConnell Frank D Gilliland Max T Aung David V Con Source Type: research

Nano- and microplastic PBK modeling in the context of human exposure and risk assessment
Environ Int. 2024 Feb 16;186:108504. doi: 10.1016/j.envint.2024.108504. Online ahead of print.ABSTRACTInsufficient data on nano- and microplastics (NMP) hinder robust evaluation of their potential health risks. Methodological disparities and the absence of established toxicity thresholds impede the comparability and practical application of research findings. The diverse attributes of NMP, such as variations in sizes, shapes, and compositions, complicate human health risk assessment. Although probability density functions (PDFs) show promise in capturing this diversity, their integration into risk assessment frameworks is ...
Source: Environment International - March 27, 2024 Category: Environmental Health Authors: Ira Wardani Nur Hazimah Mohamed Nor Stephanie L Wright Ingeborg M Kooter Albert A Koelmans Source Type: research

A scoping review of human health co-benefits of forest-based climate change mitigation in Europe
The objective of this scoping review was to examine research trends related to the interdisciplinary nexus between forests as carbon sinks and human health co-benefits. We developed a conceptual framework model, supporting the inclusion of exposure pathways, such as recreational opportunities or aesthetic experiences, in the co-benefit context. We used a scoping review methodology to identify the proportion of European research on forest-based mitigation strategies that acknowledge the interconnection between mitigation strategies and human impacts. We also aimed to assess whether synergies and trade-offs between forest-ba...
Source: Environment International - March 26, 2024 Category: Environmental Health Authors: Matilda van den Bosch Mar ía Lucía Bartolomeu Sarah Williams Corina Basnou Ian Hamilton Mark Nieuwenhuijsen Joan Pino Cathryn Tonne Source Type: research

Naked-eye sensitive detection of nanoPET by pH-responsive colorimetric method based on dual-enzyme catalysis
Environ Int. 2024 Mar 25;186:108598. doi: 10.1016/j.envint.2024.108598. Online ahead of print.ABSTRACTA pH-responsive colorimetric method based on dual-enzyme catalysis for rapid and facile detection and quantification of nanoPET at environment-dependent concentration is proposed. The nanoPET was hydrolyzed by the synergistic catalysis of cutinase and lipase to terephthalic acid which can be sensitive detected using bromocresol purple as the indicator. The color changed from purple to bright yellow as the nanoPET detection concentration increased from 0 mg/mL to 2 mg/mL which can be detected by UV-Vis. This naked-eye metho...
Source: Environment International - March 26, 2024 Category: Environmental Health Authors: Wenchao Zhan Chenxu Wang Xiyu Yang Hongtao Li Sicheng Xiong Xiaoyang Li Source Type: research

SOC bioavailability significantly correlated with the microbial activity mediated by size fractionation and soil morphology in agricultural ecosystems
This study aims to investigate the SOC division based on bioavailability differences formed by physical isolation, and to clarify the relationships of SOC bioavailability with soil elements, pore characteristics, and microbial activity. Results revealed that soil element abundances such as SOC, TN, and DOC ranked in the same order as the soil porosity as clay > silt ≥ coarse sand > fine sand in both top and sub soil. In contrast to silt and clay, which had reduced SOC bioavailability, fine sand and coarse sand had dramatically enhanced SOC bioavailability compared to the bulk soil. The bacterial and fungal communit...
Source: Environment International - March 25, 2024 Category: Environmental Health Authors: Shujie Xiao Jie Gao Qiuying Wang Zixuan Huang Guoqiang Zhuang Source Type: research

Interaction of tetracycline and copper co-intake in inducing antibiotic resistance genes and potential pathogens in mouse gut
Environ Int. 2024 Mar 21;186:108594. doi: 10.1016/j.envint.2024.108594. Online ahead of print.ABSTRACTThe widespread use of copper and tetracycline as growth promoters in the breeding industry poses a potential threat to environmental health. Nevertheless, to the best of our knowledge, the potential adverse effects of copper and tetracycline on the gut microbiota remain unknown. Herein, mice were fed different concentrations of copper and/or tetracycline for 6 weeks to simulate real life-like exposure in the breeding industry. Following the exposure, antibiotic resistance genes (ARGs), potential pathogens, and other pathog...
Source: Environment International - March 25, 2024 Category: Environmental Health Authors: Ying-Xin Xue Li-Jie Huang Hong-Yu Wang Jing-Jing Peng Ming-Kang Jin Shi-Lin Hu Hong-Bo Li Xi-Mei Xue Yong-Guan Zhu Source Type: research

SOC bioavailability significantly correlated with the microbial activity mediated by size fractionation and soil morphology in agricultural ecosystems
This study aims to investigate the SOC division based on bioavailability differences formed by physical isolation, and to clarify the relationships of SOC bioavailability with soil elements, pore characteristics, and microbial activity. Results revealed that soil element abundances such as SOC, TN, and DOC ranked in the same order as the soil porosity as clay > silt ≥ coarse sand > fine sand in both top and sub soil. In contrast to silt and clay, which had reduced SOC bioavailability, fine sand and coarse sand had dramatically enhanced SOC bioavailability compared to the bulk soil. The bacterial and fungal communit...
Source: Environment International - March 25, 2024 Category: Environmental Health Authors: Shujie Xiao Jie Gao Qiuying Wang Zixuan Huang Guoqiang Zhuang Source Type: research

Interaction of tetracycline and copper co-intake in inducing antibiotic resistance genes and potential pathogens in mouse gut
Environ Int. 2024 Mar 21;186:108594. doi: 10.1016/j.envint.2024.108594. Online ahead of print.ABSTRACTThe widespread use of copper and tetracycline as growth promoters in the breeding industry poses a potential threat to environmental health. Nevertheless, to the best of our knowledge, the potential adverse effects of copper and tetracycline on the gut microbiota remain unknown. Herein, mice were fed different concentrations of copper and/or tetracycline for 6 weeks to simulate real life-like exposure in the breeding industry. Following the exposure, antibiotic resistance genes (ARGs), potential pathogens, and other pathog...
Source: Environment International - March 25, 2024 Category: Environmental Health Authors: Ying-Xin Xue Li-Jie Huang Hong-Yu Wang Jing-Jing Peng Ming-Kang Jin Shi-Lin Hu Hong-Bo Li Xi-Mei Xue Yong-Guan Zhu Source Type: research

Bioactivity assessment of organophosphate flame retardants via a dose-dependent yeast functional genomics approach
Environ Int. 2024 Mar 23;186:108596. doi: 10.1016/j.envint.2024.108596. Online ahead of print.ABSTRACTOrganophosphate flame retardants (OPFRs) have been widely detected in multiple environment media and have many adverse effects with complex toxicity mechanisms. However, the early molecular responses to OPFRs have not been fully elucidated, thereby making it difficult to assess their risks accurately. In this work, we systematically explored the point of departure (POD) of biological pathways at genome-wide level perturbed by 14 OPFRs with three substituents (alkyl, halogen, and aryl) using a dose-dependent functional geno...
Source: Environment International - March 24, 2024 Category: Environmental Health Authors: Miao Guan Xiaoyang Wang Xinyuan Xu Tianqi Ling Jing Wu Jinjun Qian Fei Ma Xiaowei Zhang Source Type: research

Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity
Environ Int. 2024 Mar 20;186:108569. doi: 10.1016/j.envint.2024.108569. Online ahead of print.ABSTRACTEnvironmental toxicants (ETs) are associated with adverse health outcomes. Here we hypothesized that exposures to ETs are linked with obesity and insulin resistance partly through a dysbiotic gut microbiota and changes in the serum levels of secondary bile acids (BAs). Serum BAs, per- and polyfluoroalkyl substances (PFAS) and additional twenty-seven ETs were measured by mass spectrometry in 264 Danes (121 men and 143 women, aged 56.6 ± 7.3 years, BMI 29.7 ± 6.0 kg/m2) using a combination of targeted and suspect screening...
Source: Environment International - March 24, 2024 Category: Environmental Health Authors: Partho Sen Yong Fan Jennifer J Schlezinger Stanislav D Ehrlich Thomas F Webster Tuulia Hy ötyläinen Oluf Pedersen Matej Ore šič Source Type: research

Source emission contributions to particulate matter and ozone, and their health impacts in Southeast Asia
Environ Int. 2024 Mar 18;186:108578. doi: 10.1016/j.envint.2024.108578. Online ahead of print.ABSTRACTSoutheast Asia has been experiencing severe air pollution due to its substantial local emissions and transboundary air pollution (TAP), causing significant health impacts. While literature focused on air pollution episodes in Southeast Asia, we have yet to fully understand the contributions of local emission sectors and TAP to air quality in the region annually. Herein we employed air quality modeling with the species tagging method to first assess the contributions of source sectors and locations to fine particulate matte...
Source: Environment International - March 24, 2024 Category: Environmental Health Authors: Yefu Gu Tingting Fang Steve Hung Lam Yim Source Type: research

Bioactivity assessment of organophosphate flame retardants via a dose-dependent yeast functional genomics approach
Environ Int. 2024 Mar 23;186:108596. doi: 10.1016/j.envint.2024.108596. Online ahead of print.ABSTRACTOrganophosphate flame retardants (OPFRs) have been widely detected in multiple environment media and have many adverse effects with complex toxicity mechanisms. However, the early molecular responses to OPFRs have not been fully elucidated, thereby making it difficult to assess their risks accurately. In this work, we systematically explored the point of departure (POD) of biological pathways at genome-wide level perturbed by 14 OPFRs with three substituents (alkyl, halogen, and aryl) using a dose-dependent functional geno...
Source: Environment International - March 24, 2024 Category: Environmental Health Authors: Miao Guan Xiaoyang Wang Xinyuan Xu Tianqi Ling Jing Wu Jinjun Qian Fei Ma Xiaowei Zhang Source Type: research

Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity
Environ Int. 2024 Mar 20;186:108569. doi: 10.1016/j.envint.2024.108569. Online ahead of print.ABSTRACTEnvironmental toxicants (ETs) are associated with adverse health outcomes. Here we hypothesized that exposures to ETs are linked with obesity and insulin resistance partly through a dysbiotic gut microbiota and changes in the serum levels of secondary bile acids (BAs). Serum BAs, per- and polyfluoroalkyl substances (PFAS) and additional twenty-seven ETs were measured by mass spectrometry in 264 Danes (121 men and 143 women, aged 56.6 ± 7.3 years, BMI 29.7 ± 6.0 kg/m2) using a combination of targeted and suspect screening...
Source: Environment International - March 24, 2024 Category: Environmental Health Authors: Partho Sen Yong Fan Jennifer J Schlezinger Stanislav D Ehrlich Thomas F Webster Tuulia Hy ötyläinen Oluf Pedersen Matej Ore šič Source Type: research

Source emission contributions to particulate matter and ozone, and their health impacts in Southeast Asia
Environ Int. 2024 Mar 18;186:108578. doi: 10.1016/j.envint.2024.108578. Online ahead of print.ABSTRACTSoutheast Asia has been experiencing severe air pollution due to its substantial local emissions and transboundary air pollution (TAP), causing significant health impacts. While literature focused on air pollution episodes in Southeast Asia, we have yet to fully understand the contributions of local emission sectors and TAP to air quality in the region annually. Herein we employed air quality modeling with the species tagging method to first assess the contributions of source sectors and locations to fine particulate matte...
Source: Environment International - March 24, 2024 Category: Environmental Health Authors: Yefu Gu Tingting Fang Steve Hung Lam Yim Source Type: research

Mixtures of per- and polyfluoroalkyl substances (PFAS) alter sperm methylation and long-term reprogramming of offspring liver and fat transcriptome
Environ Int. 2024 Mar 16;186:108577. doi: 10.1016/j.envint.2024.108577. Online ahead of print.ABSTRACTMale fertility has been declining worldwide especially in countries with high levels of endocrine disrupting chemicals (EDCs). Per- and polyfluorinated alkyl Substances (PFAS) have been classified as EDCs and have been linked to adverse male reproductive health. The mechanisms of these associations and their implications on offspring health remain unknown. The aims of the current study were to assess the effect of PFAS mixtures on the sperm methylome and transcriptional changes in offspring metabolic tissues (i.e., liver a...
Source: Environment International - March 23, 2024 Category: Environmental Health Authors: DruAnne L Maxwell Oladele A Oluwayiose Emily Houle Katherine Roth Karolina Nowak Savni Sawant Amanda L Paskavitz Wanqing Liu Katherine Gurdziel Michael C Petriello J Richard Pilsner Source Type: research