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Interaction of RNA polymerase II and the small RNA machinery affects heterochromatic silencing in DrosophilaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our experiments show a genetic and biochemical interaction between RNA Pol II (largest and second largest subunits) and the small RNA silencing machinery in Drosophila. The interaction has functional aspects in terms of determining H3K9me2 and HP-1 deposition at the chromocentric heterochromatin. Thus, RNA Pol II has an important role in establishing heterochromatin structure in Drosophila. (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 16, 2009 Category: Genetics & Stem Cells Authors: Harsh KaviJames Birchler Source Type: journals

Epigenetics & Chromatin celebrates its first anniversaryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epigenetics & Chromatin published its first papers a year ago, together with an editorial in which we stated our aim to publish a high-quality journal with a broad scope. A year later we are happy to report that these aims are being achieved. Papers published so far represent a broad swath of research on chromatin-based processes and epigenetic mechanisms. We are also delighted with the quality and breadth of submissions from many of the leading laboratories in the field. (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 2, 2009 Category: Genetics & Stem Cells Authors: Steven HenikoffFrank Grosveld Source Type: journals

ERG-associated protein with SET domain (ESET)-Oct4 interaction regulates pluripotency and represses the trophectoderm lineageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Loss of ESET or Oct4 results in strikingly similar phenotypes both in ES cells with their differentiation into trophectoderm cells, and in early embryos where there is a failure of development of the pluripotent inner cell mass (ICM) of blastocysts. We propose that SUMOylated ESET-Oct4 complex is critical for both the initiation and maintenance of pluripotency through repression of differentiation, particularly of the trophectoderm lineage by epigenetic silencing of Cdx2. (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 6, 2009 Category: Genetics & Stem Cells Authors: Leng-Siew YeapKatsuhiko HayashiM Azim Surani Source Type: journals

Epigenetic inheritance of an inducibly nucleosome-depleted promoter and its associated transcriptional state in the apparent absence of transcriptional activatorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results suggest that there may be a memory or an epigenetic mark on the nucleosome-depleted PHO5 promoter that is independent of the transcription apparatus and maintains the promoter in a nucleosome-depleted state through DNA replication. (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - September 10, 2009 Category: Genetics & Stem Cells Authors: Ryosuke OhsawaMelissa AdkinsJessica Tyler Source Type: journals

A role for non-coding Tsix transcription in partitioning chromatin domains within the mouse X-inactivation centreEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data point toward a role for transcription of non-coding RNAs as a developmental strategy for the establishment of functionally distinct domains within the mammalian genome. (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - July 19, 2009 Category: Genetics & Stem Cells Authors: Pablo NavarroSophie ChantalatMario FoglioCorinne ChureauSebastien VigneauPhilippe ClercPhilip AvnerClaire Rougeulle Source Type: journals

Tissue-specific variation in DNA methylation levels along human chromosome 1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The varied patterns of methylation differences detected between tissues by our methylation profiling method reinforce the potential functional significance of regional differences in methylation levels outside of CpG islands. (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - June 8, 2009 Category: Genetics & Stem Cells Authors: Cecilia De BustosEdward RamosJanet YoungRobert TranUwe MenzelCordelia LangfordEvan EichlerLi HsuSteve HenikoffJan DumanskiBarbara Trask Source Type: journals

DNA replication and the GINS complex: localization on extended chromatin fibersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In agreement with its proposed role in the initiation of DNA replication, GINS proteins associated with chromatin near sites of ORC binding that were devoid of EdU (absence of DNA replication). The association of GINS proteins with PCNA was consistent with a role in the process of elongation. Additionally, the large size of our chromatin fibers (up to approximately 7 Mb) allowed for a more expansive analysis of the distance between active replicons than previously reported. (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - May 14, 2009 Category: Genetics & Stem Cells Authors: Stephanie M Cohen, Paul D Chastain, Marila Cordeiro-Stone and David G Kaufman Source Type: journals

The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data suggest a bimodal recruit and maintain model whereby Mll2 is required to establish certain epigenetic decisions during differentiation, which are then maintained by redundant mechanisms. We also suggest that these mechanisms relate to the epigenetic maintenance of CpG island promoters. (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 6, 2009 Category: Genetics & Stem Cells Authors: Stefan Glaser, Sandra Lubitz, Kate L Loveland, Kazu Ohbo, Lorraine Robb, Frieder Schwenk, Jost Seibler, Daniela Roellig, Andrea Kranz, Konstantinos Anastassiadis and A.Francis Stewart Source Type: journals

Multiple sequence-directed possibilities provide a pool of nucleosome position choices in different states of activity of a geneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: On a gene locus, multiple nucleosome positions are directed by a gene sequence to provide a pool of possibilities, out of which the preferred ones are selected by the chromatin remodeler and transcription factor of the gene under different states of activity of the gene. (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 16, 2009 Category: Genetics & Stem Cells Authors: Vinesh Vinayachandran, Rama-Haritha Pusarla and Purnima Bhargava Source Type: journals

Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In this study we demonstrate the validity of using pooled DNA samples to accurately assess group DNA methylation averages. Such an approach can be readily applied to the assessment of disease phenotypes reducing the time, cost and amount of DNA starting material required for large-scale epigenetic analyses. (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 10, 2009 Category: Genetics & Stem Cells Authors: Sophia J Docherty, Oliver SP Davis, Claire MA Haworth, Robert Plomin and Jonathan Mill Source Type: journals

Yeast Sgf73/Ataxin-7 serves to anchor the deubiquitination module into both SAGA and Slik(SALSA) HAT complexesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Spinocerebellar ataxia (SCA) is a physically devastating, genetically inherited disorder characterized by abnormal brain function that results in the progressive loss of the ability to coordinate movements. There are many types of SCAs as there are various gene mutations that can cause this disease. SCA types 1-3, 6-10, 12, and 17 result from a trinucleotide repeat expansion in the DNA-coding sequence. Intriguingly, recent work has demonstrated that increased trinucleotide repeat expansions result in defects in the function of the SAGA histone acetyltransferase complex. The SCA7 gene encodes a subunit of the SAGA complex. ...
Source: Epigenetics and Chromatin - February 18, 2009 Category: Genetics & Stem Cells Authors: Kenneth K. Lee, Selene K. Swanson, Laurence Florens, Michael P. Washburn and Jerry L. Workman Source Type: journals

High-resolution mapping of heterochromatin redistribution in a Drosophila position-effect variegation modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our molecular maps demonstrate that heterochromatin can invade a normally euchromatic region, yet the strength of HP1 binding and effects on gene expression are highly dependent on local context. Our data suggest that the white gene has an unusual intrinsic affinity for heterochromatin, which may cause this gene to be more sensitive to PEV than most other genes. (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 29, 2009 Category: Genetics & Stem Cells Authors: Maartje J Vogel, Ludo Pagie, Wendy Talhout, Marja Nieuwland, Ron M Kerkhoven and Bas van Steensel Source Type: journals

Single-epitope recognition imaging of native chromatinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Efficient and highly specific recognition of CenH3 in histone core particles isolated from native centromeric chromatin demonstrates that tetramers are the predominant form of centromeric nucleosomes in mature tetramers. Our findings provide proof of principle that this approach can yield insights into chromatin biology using direct and rapid detection of native nucleosomes in physiological salt concentrations. (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 17, 2008 Category: Genetics & Stem Cells Authors: Hongda Wang, Yamini Dalal, Steven Henikoff and Stuart Lindsay Source Type: journals