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121 records returned

Abnormal parieto-motor connectivity in Tuberous Sclerosis ComplexEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Abnormal connectivity might be involved in the pathophysiology of Tuberous Sclerosis Complex (TSC). We used twin-coil Transcranial Magnetic Stimulation protocol to investigate connectivity between posterior parietal cortex (PPC) and motor cortex (M1) in TSC patients. In comparison with healthy subjects and TSC patients treated with antiepileptic drugs, non-medicated TSC patients exhibited abnormal excitability of PPC–M1 connection. Such altered connectivity might play a role in TSC epileptic phenotype. (Source: Epilepsy Research)
Source: Epilepsy Research - November 1, 2009 Category: Neurology Authors: Luigi D’Argenzio, Giacomo Koch, Roberta Bombardieri, Francesco Mori, Romina Moavero, Diego Centonze, Paolo Curatolo Tags: Short Communications Source Type: journals

Supplementary implantation of intracranial electrodes in the evaluation for epilepsy surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The addition of supplementary electrodes to an ongoing invasive electrode investigation can be a useful means of clarifying a patient's suitability for a resective surgical procedure. While the surgical outcomes may not be as favorable as in patients in whom the investigations are simpler, a proportion of these patients do benefit from the eventual resective procedure. In cases where the supplementary electrodes lead to the conclusion that surgery is not indicated, these patients can be satisfied that the surgical option has been explored to the fullest extent possible. (Source: Epilepsy Research)
Source: Epilepsy Research - November 1, 2009 Category: Neurology Authors: Keith W. MacDougall, David A. Steven, Andrew G. Parrent, Jorge G. Burneo Tags: Short Communications Source Type: journals

Giant subcortical heterotopia involving the temporo-parieto-occipital region: A challenging cause of drug-resistant epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: The clinical, radiological, neurophysiological and neuropsychological findings of three patients with giant subcortical heterotopia are reported.All patients experienced psychomotor and behaviour improvement after surgery. Two subjects are seizure-free after complete excision of the heterotopia; the third patient significantly improved following subtotal removal (Engel's class II).Patients affected by giant subcortical heterotopias can have a favourable prognosis after the surgical removal of the malformation, even following long-lasting epilepsy. (Source: Epilepsy Research)
Source: Epilepsy Research - November 1, 2009 Category: Neurology Authors: Federica Novegno, Domenica Battaglia, Daniela Chieffo, Paolo Frassanito, Chiara Leoni, Gianpiero Tamburrini, Luca Massimi, Tommaso Tartaglione, Concezio Di Rocco, Francesco Guzzetta Tags: Short Communications Source Type: journals

Quantitative brain surface mapping of an electrophysiologic/metabolic mismatch in human neocortical epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: The spatial relationship between an intracranial EEG-defined epileptic focus and cortical hypometabolism on glucose PET has not been precisely described. In order to quantitatively evaluate the hypothesis that ictal seizure onset and/or rapid seizure propagation, detected by subdural EEG monitoring, commonly involves normometabolic cortex adjacent to hypometabolic cortical regions, we applied a novel, landmark-constrained conformal mapping approach in 14 children with refractory neocortical epilepsy. The 3D brain surface was parcellated into finite cortical elements (FCEs), and hypometabolism was defined using lob...
Source: Epilepsy Research - November 1, 2009 Category: Neurology Authors: Bálint Alkonyi, Csaba Juhász, Otto Muzik, Eishi Asano, Anita Saporta, Aashit Shah, Harry T. Chugani Tags: Research Papers Source Type: journals

Regional expression of Fos-like immunoreactivity following seizures in Noda epileptic rat (NER)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Noda epileptic rat (NER) is a genetic rat model of epilepsy that exhibit spontaneous generalized tonic–clonic (GTC) seizures with paroxysmal discharges. We analyzed the regional expression of Fos-like immunoreactivity (Fos-IR) following GTC seizures in NER to clarify the brain regions involved in the seizure generation. GTC seizures in NER elicited a marked increase in Fos expression in the piriform cortex, perirhinal–entorhinal cortex, insular cortex and other cortices including the motor cortex. In the limbic regions, Fos-IR was highest in the amygdalar nuclei (e.g., basomedial amygdaloid nucleus), followed ...
Source: Epilepsy Research - November 1, 2009 Category: Neurology Authors: Yukihiro Ohno, Saki Shimizu, Yuya Harada, Maho Morishita, Shizuka Ishihara, Kenta Kumafuji, Masashi Sasa, Tadao Serikawa Tags: Research Papers Source Type: journals

Concordance of survey and billing data in a study of outpatient healthcare cost and utilization among epilepsy patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: We assessed the concordance between healthcare utilization and cost measured with patient survey and billing data among 226 epilepsy patients in a large multi-specialty group practice. Does survey information on utilization combined with prices, provide a cost of care that is approximately equal to the cost of care derived from billing data, utilizing the same price structure? Do measures of cost from survey and billing data yield the same correlates of cost among epilepsy patients? If so, survey data may be utilized to estimate correlates and cost of epilepsy care in cases where complete billing information is no...
Source: Epilepsy Research - November 1, 2009 Category: Neurology Authors: David R. Lairson, Rituparna Basu, Charles E. Begley, Thomas Reynolds Tags: Research Papers Source Type: journals

Is asymmetric dimethylarginine responsible for the vascular events in patients under antiepileptic drug treatment?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion our data suggest that elevated ADMA levels may be responsible for the increased cardiovascular risk in patients with epilepsy under AED therapy. (Source: Epilepsy Research)
Source: Epilepsy Research - November 1, 2009 Category: Neurology Authors: Oğuzhan Öz, Zeki Gökçil, Semai Bek, Erdinç Çakır, Zeki Odabaşı Tags: Research Papers Source Type: journals

Hemispherectomy-associated complications from the Kids’ Inpatient DatabaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In-hospital mortality of HS is low, and blood transfusion was performed in over one third of patients. There appear to be several risk factors that can predict the likelihood of transfusion and may warrant close observation before hemispherectomy. (Source: Epilepsy Research)
Source: Epilepsy Research - November 1, 2009 Category: Neurology Authors: Mohamad Z. Koubeissi, Tanvir U. Syed, Ishtiaq Syed, James Jordan, Amer Alshekhlee, Eric H. Kossoff Tags: Research Papers Source Type: journals

Lack of laterality in the effects of right and left amygdala kindling on weight gain in female ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Amygdala kindling increases weight gain and serum leptin levels in rats, but in the present study no laterality effects were seen. (Source: Epilepsy Research)
Source: Epilepsy Research - November 1, 2009 Category: Neurology Authors: Kathryn M. Hum, Sofia Megna, W. McIntyre Burnham Tags: Research Papers Source Type: journals

Antiepileptic drugs in epilepsy and other disorders—A population-based study of prescriptionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Purpose: The aim of the study was to quantify the use of antiepileptic drugs (AEDs) in epilepsy and other indications in a nation-wide population using a prescription database.Materials and methods: Prescription data of AEDs were collected from the Norwegian Prescription Database for the period 2004–2007, including 5.1 million prescriptions from 144,653 patients, all having at least one prescribed and dispensed AED. Diagnosis-related reimbursement codes were used as indicators for clinical use.Results: Of the AEDs used, 71% was in epilepsy, 15% in psychiatry, 13% in neuropathic pain, and (Source: Epilepsy Research)
Source: Epilepsy Research - November 1, 2009 Category: Neurology Authors: Cecilie Johannessen Landmark, Pål G. Larsson, Elisif Rytter, Svein I. Johannessen Tags: Research Papers Source Type: journals

CDKL5 and ARX mutations are not responsible for early onset severe myoclonic epilepsy in infancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Background: Severe myoclonic epilepsy of infancy (SMEI) or Dravet syndrome (DS) is a distinctive epilepsy syndrome often associated with de novo mutations in the SCN1A gene. However, 25–30% patients with SMEI/DS are negative for SCN1A mutation screening, suggesting that other molecular mechanisms may account for these disorders. Given the overlapping and heterogeneous clinical features of CDKL5- and ARX-related epilepsies and SMEI/DS, we postulated that CDKL5 mutations in females and ARX mutations gene in males may be associated with early onset seizures forms of SMEI/DS.Methods: Twenty-eight patients with early...
Source: Epilepsy Research - November 1, 2009 Category: Neurology Authors: Rima Nabbout, Christel Depienne, Mathilde Chipaux, Benoit Girard, Isabelle Souville, Oriane Trouillard, Olivier Dulac, Jamel Chelly, Alexandra Afenjar, Delphine Héron, Eric Leguern, Cherif Beldjord, Thierry Bienvenu, Nadia Bahi-Buisson Tags: Research Papers Source Type: journals

Intracranial EEG power and metabolism in human epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: EEG power and high frequency activity in the seizure onset zone has been increasingly considered for its relationship with seizures in animal and human studies of epilepsy. We examine the relationship between quantitative EEG measures and metabolic imaging in epilepsy patients undergoing intracranial EEG (icEEG) analysis for seizure localization. Patients with mesial temporal lobe epilepsy (MTLE) and neocortical epilepsy (NE) were studied. Metabolic imaging was performed with MR spectroscopic imaging using N-acetyl aspartate (NAA) and creatine (Cr). All data were acquired from the mesial temporal lobe such that a ...
Source: Epilepsy Research - November 1, 2009 Category: Neurology Authors: J.W. Pan, H.P. Zaveri, D.D. Spencer, H.P. Hetherington, S.S. Spencer Tags: Research Papers Source Type: journals

Movement induces suppression of interictal spikes in sensorimotor neocortical epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Epileptic activities are known to be modulated by cortical excitability, which is altered with normal brain functioning such as movement. However, the relationship between the epileptic activity and movement has not been well studied. Here, we investigated movement-induced modulation of interictal spikes to reveal the relationship between epileptic activity and the movement-induced modulation of cortical activity. Two patients (three cases) with focal cortical dysplasia (FCD) of the pre- and/or post-central gyrus performed voluntary movements of their hands or mouths. During the movement, the interictal spikes of ...
Source: Epilepsy Research - November 1, 2009 Category: Neurology Authors: Takufumi Yanagisawa, Masayuki Hirata, Haruhiko Kishima, Tetsu Goto, Youichi Saitoh, Satoru Oshino, Koichi Hosomi, Amami Kato, Toshiki Yoshimine Tags: Research Papers Source Type: journals

Ischaemic stroke in adults and epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Stroke is an important cause of symptomatic epilepsy especially in the elderly. Seizures in the setting of stroke will furthermore worsen the prognosis of stroke. Studies show that the frequency of seizures in stroke ranges between 2.3% and 14%. Typically early seizures are defined as those that occur within 14 days of the stroke, and later seizures those that occur after this period. A number of risk factors have been identified like cortical involvement, size of the infarct and stroke severity. Status epilepticus can be a presenting symptom of acute stroke and can lead to increased mortality. Early seizures are ...
Source: Epilepsy Research - November 1, 2009 Category: Neurology Authors: Bindu Menon, Simon D. Shorvon Tags: Review Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Epilepsy Research)
Source: Epilepsy Research - November 1, 2009 Category: Neurology Source Type: journals

Corrigendum to “Effects of a static magnetic field on audiogenic seizures in black Swiss mice” [Epilepsy Res. 80 (2–3) (2008) 119–131]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors regret that the author listing was published incorrectly in the above article. The correct author listing is given above. (Source: Epilepsy Research)
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: Michael J. McLean, Stefan Engström, Zhang Qinkun, Christopher Spankovich, Daniel B. Polley Tags: Erratum Source Type: journals

Is epilepsy a real problem in multiple sclerosis patients?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We read with interest the paper by Martínez-Juárez and colleagues (Epub ahead) reporting a higher (6.55%) risk for epilepsy in their series of multiple sclerosis (MS) patients. In a similar study, we showed that epilepsy occurred in about 5% of a MS population from Italy (). Also in our series, partial seizures – with or without secondary generalization – were the most frequent seizure type, whereas generalized tonic-clonic seizures ab initio were much more rare. However, unlike to the study by Martínez-Juárez et al., most of our MS patients who developed epilepsy had a relapsing-remitting rather than a progressive...
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: Pasquale Striano, Salvatore Striano Tags: Letter to the Editor Source Type: journals

Na VPA-induced acute ischemic stroke in an epileptic patient with methylenetetrahydrofolate reductase gene polymorphismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: A 23-year-old man using Na-Valproic acid (VPA) was admitted to our clinic due to convulsion. The neurological examination revealed right hemiparesis. From the exitus notes, we learned that his two siblings had died from status epilepticus. Magnetic resonance imaging (MRI), MRI spectroscopy, and diffusion-weighted investigations (DWI) showed acute–subacute ischemic stroke in the left temporo-parieto-occipital region. The patient had an ischemic stroke. Heterozygote methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism was determined on genetic examination. The homocysteine (Hcy) level was 18.2mmol/l (5�...
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: Asuman Orhan Varoglu Tags: Short Communications Source Type: journals

Unilateral thalamic lesions and generalized or lateralized spike wave dischargesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report four adult patients who had thalamic lesions and lateralized or generalized spike wave discharges (SWDs). The first two patients also had cortical lesions. The role of the cortex and thalamus in the generation of SWDs is discussed. The third patient had a history of idiopathic generalized epilepsy (IGE) with intractable seizures. The last patient had partial seizures and absences. The coexistence of IGE with refractory focal epilepsy and the relation with thalamic lesions are discussed. (Source: Epilepsy Research)
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: F. Irsel Tezer, Serap Saygi Tags: Short Communications Source Type: journals

Evaluation of duration of epilepsy prior to temporal lobe epilepsy surgery during the past two decadesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined whether duration of epilepsy prior to temporal lobe resection has decreased over the years as a result of increasing body of evidence in the literature showing the benefits of anterior temporal resection.We stratified the 213 patients, who had their first temporal lobe resection at our center between 1996 and 2007 into three groups in order to detect any trends in duration of epilepsy: group A (surgery between 1996 and 1999); group B (surgery between 2000 and 2003); group C (surgery between 2004 and 2007).No difference in mean duration of epilepsy was detected between the three groups (p=0.54).The mean duration...
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: Hyunmi Choi, Richard Carlino, Gary Heiman, W. Allen Hauser, Frank G. Gilliam Tags: Short Communications Source Type: journals

A potential model of pediatric posttraumatic epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Preclinical models of pediatric posttraumatic epilepsy (PTE) are lacking. We hypothesized that traumatic brain injury (TBI), induced by controlled cortical impact, in immature rats would cause electroencephalographic (EEG) epileptiform activity and behavioral seizures. TBI or sham craniotomy was performed on postnatal day 17. Using video-EEG monitoring 4–11 months post-TBI, most TBI rats (87.5%) showed EEG spiking and one had spontaneous, recurrent seizures. Controls showed neither EEG spikes nor electrographic/behavioral seizures. Late seizures were rare after TBI, but EEG spiking was common and may represent a...
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: K.D. Statler, P. Scheerlinck, W. Pouliot, M. Hamilton, H.S. White, F.E. Dudek Tags: Short Communications Source Type: journals

Astrocyte activation and memory impairment in the repetitive febrile seizures modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Frequently repetitive febrile seizures (FRFS) in immature brain could impair long-term memory without obvious pathological alteration. Although astrocyte activation has been implicated in many seizure models, it has never been examined in febrile seizure models. We investigated astrocyte activation states after FRFS in postnatal-10-day (P10) rats by western blot and immunohistochemical analysis of GFAP and S100β, two protein markers for activated astrocytes, at three time points (P25, P35, P45). The levels of GFAP and S100β increased significantly at all the time examined. Furthermore, we administered propentofy...
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: Lu Yang, Fuhai Li, Haiju Zhang, Wei Ge, Changrui Mi, Ruopeng Sun, Chunxi Liu Tags: Research Papers Source Type: journals

Neural networks underlying hyperkinetic seizures of “temporal lobe” originEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to determine the features of temporal epilepsy with hyperkinetic seizures and the functional anatomy of involved brain networks.Methods: We retrospectively identified patients investigated by depth electrodes (SEEG) in whom hyperkinetic manifestations were proved to be linked to initial temporal lobe involvement. Seizure organisation was determined according to the “Epileptogenicity Index” (EI), a new way to quantify rapid discharges at seizure onset.Results: We found 7 patients among 130 SEEG investigations that fulfilled the inclusion criteria. Most of the patients presented with hyper...
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: L. Vaugier, S. Aubert, A. McGonigal, A. Trébuchon, M. Guye, M. Gavaret, J. Regis, P. Chauvel, F. Wendling, F. Bartolomei Tags: Research Papers Source Type: journals

Long-term outcome and determinants of quality of life after temporal lobe epilepsy surgery in adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Duration of seizure freedom and AED side effects have the strongest impact on QOL in the long-term follow-up. Therefore it is important not only to register intake of AEDs but also to assess side effects of AEDs. Persistence of auras also had an impact on different facets of QOL, but was significantly correlated with intake of AEDs. Apart from factors directly related to epilepsy QOL was dependent of psychosocial factors as employment status, psychiatric complications, and driving a car underlining the necessity of postoperative rehabilitation in this group. (Source: Epilepsy Research)
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: Alaa Eldin Elsharkawy, Theodor May, Rupprecht Thorbecke, Steffi Koch-Stoecker, Antonia Villagran, Lydia Urak, Margarete Pfäfflin, Heinz Pannek, Terttu A. Pietilä, Alois Ebner Tags: Research Papers Source Type: journals

Working memory in children with epilepsy: An event-related potentials studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: Our study shows that children with benign, well-controlled epilepsy show a different cortical activation pattern during a visual working memory task. We hypothesize that they need more brain processing effort to achieve the same performance level as their age matched controls. (Source: Epilepsy Research)
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: Ivan Myatchin, Maarten Mennes, Heidi Wouters, Peter Stiers, Lieven Lagae Tags: Research Papers Source Type: journals

Prognostic factors for epileptic seizures in severe motor and intellectual disabilities syndrome (SMIDS)—A clinical and electroencephalographic studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings indicate that intractability of epilepsy may be identified early in the course of the disease, even in SMIDS, and EEG and epileptic syndrome are the very important factors for predicting the seizure prognosis. (Source: Epilepsy Research)
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: Akiko Matsumoto, Shuji Miyazaki, Chiemi Hayakawa, Taku Komori, Miho Nakamura, Atsushi Oshio Tags: Research Papers Source Type: journals

Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6Hz psychomotor seizure modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: The aim of this study was to characterize the anticonvulsant effects of levetiracetam (LEV) in combination with the various antiepileptic drugs (clonazepam [CZP], oxcarbazepine [OXC], phenobarbital [PB], tiagabine [TGB], and valproate [VPA]), in the mouse 6Hz psychomotor seizure model.Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32mA, 6Hz, 3s stimulus duration) delivered via ocular electrodes and isobolographic analysis for parallel and non-parallel dose–response effects was used to characterize the consequent anticonvulsant interactions between the various drug combination...
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: Ewa Wojda, Aleksandra Wlaz, Philip N. Patsalos, Jarogniew J. Luszczki Tags: Research Papers Source Type: journals

A decrease in EEG energy accompanies anti-epileptic drug taper during intracranial monitoringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A decrease in signal energy occurs during intracranial EEG monitoring, possibly accompanying AED taper. If the decrease is due to AED taper this would suggest that AEDs prevent seizures in ways other than reduction of cortical excitation and seizure generation may be influenced by factors other than poorly regulated cortical excitation. (Source: Epilepsy Research)
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: Hitten P. Zaveri, Steven M. Pincus, Irina I. Goncharova, Edward J. Novotny, Robert B. Duckrow, Dennis D. Spencer, Susan S. Spencer Tags: Research Papers Source Type: journals

Co-morbidities in people living with epilepsy: Hospital based case–control study from a resource-poor settingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Purpose: Evaluating co-morbidity in people living with epilepsy (PWE) is essential and its modification might improve their quality of life. We analyzed the various co-morbidities in PWE in comparison with the normal healthy controls.Method: This prospective study was conducted from July 2006 to December 2007. PWE attending neurology outpatient services (n=250) with age ranging from 16 to 60 years (29.66±11.31 years; M:F 116:134) were recruited after obtaining informed consent. Healthy matched controls (n=250; 30.35±11.05 years; M:F 114:136) were also recruited.Results: The seizure types were: generalized (62.4%...
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: C. Shyam Babu, P. Satishchandra, S. Sinha, D.K. Subbakrishna Tags: Research Papers Source Type: journals

Voxel-based morphometry evaluation of patients with photosensitive juvenile myoclonic epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrates structural abnormalities beyond the limits of the frontal lobes and provides evidence for the role of the occipital cortex in human PS, reinforcing the existence of functional-anatomic ictogenic networks in JME and the concept of ‘system epilepsies’. (Source: Epilepsy Research)
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: Katia Lin, Andrea Parolin Jackowski, Henrique Carrete, Gerardo Maria de Araújo Filho, Henrique Hattori Silva, Mirian Salvadori Bittar Guaranha, Laura Maria Figueiredo Ferreira Guilhoto, Rodrigo Affonseca Bressan, Elza Márcia Targas Yacubian Tags: Research Papers Source Type: journals

Cerebrospinal fluid and serum NT-proBNP concentrations in children with epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: Greater CSF NT-proBNP concentrations in children with epilepsy may reflect an unspecific activation of the cardio-neuro-endocrine system involving endocrinological stress–response mechanisms interictally. The relationship between epilepsy and the cardio-neuro-endocrine axis may further the understanding of seizure susceptibility in children as well as influences of epilepsy on central modulation of autonomic cardiovascular control. (Source: Epilepsy Research)
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: Markus Rauchenzauner, Edda Haberlandt, Carla Rösslhuber, Gerhard Luef, Markus Otto, Angelika Hammerer-Lercher, Andrea Griesmacher, Kevin Rostasy Tags: Research Papers Source Type: journals

Inflammation in rat pups subjected to short hyperthermic seizures enhances brain long-term excitabilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Lower PTZth obtained by using LPS in combination with HS in rat pups suggests a change in brain excitability. Our model with only 5min of HS in combination with LPS suggests that an inflammatory response could, in part, explain long-term change in brain excitability following short FS. (Source: Epilepsy Research)
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: Stéphane Auvin, Natacha Porta, Astrid Nehlig, Cécile Lecointe, Louis Vallée, Régis Bordet Tags: Research Papers Source Type: journals

Effects of γ-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice culturesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: Our findings demonstrate that in OHSCs GABA has an inhibitory effect on SLEs. Proconvulsant effects of GABA agonists on spontaneous neuronal activity and seizure like activity were never observed. Our findings exclude a possible contribution of impaired/altered GABA-ergic mechanisms based on immaturity of receptors and/or low receptor density to seizure susceptibility and pharmacoresistance in OHSCs. (Source: Epilepsy Research)
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: Abdul Wahab, Uwe Heinemann, Klaus Albus Tags: Research Papers Source Type: journals

Treatment of Rasmussen encephalitis half a century after its initial description: Promising prospects and a dilemmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Rasmussen encephalitis (RE), initially described half a century ago, is an inflammatory unihemispheric brain disorder. Its two clinical key facets are the progressive tissue and function loss and the epilepsy, often in form of epilepsia partialis continua. For both, treatment options are available. Anti-seizure effect of anti-epilepsy drugs is usually limited to secondarily generalized seizures and complex partial seizures whereas epilepsia partialis continua usually is totally refractory. Hemispherectomy in one of its modern variants offers a very high chance of seizure freedom, however at the price of irreversib...
Source: Epilepsy Research - September 30, 2009 Category: Neurology Authors: Christian G. Bien, Johannes Schramm Tags: Review Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Epilepsy Research)
Source: Epilepsy Research - September 30, 2009 Category: Neurology Source Type: journals

Erratum to “Relative influences of adjunctive topiramate and adjunctive lamotrigine on scanning and the effective field of view” [Epilepsy Res. 78 (2–3) (2008) 140–147]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The publisher regrets that the acknowledgement was published incorrectly in the above article. The correct acknowledgement is reproduced correctly below. (Source: Epilepsy Research)
Source: Epilepsy Research - August 22, 2009 Category: Neurology Authors: Kenneth C. Mills, Joseph F. Drazkowski, Anne E. Hammer, Paul T. Caldwell, Robert P. Kustra, David E. Blum Tags: Erratum Source Type: journals

Comment to: Addition of verapamil in the treatment of severe myoclonic epilepsy in infancy (Iannetti et al.)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I read with interest the paper by reporting the use of verapamil, a voltage-gated calcium channel blocker (Vg-CCB), as an add-on therapy in two severe myoclonic epilepsy in infancy (SMEI) patients. Treatment with verapamil resulted in a long-lasting, good control of different seizure types, including episodes of status epilepticus. (Source: Epilepsy Research)
Source: Epilepsy Research - August 22, 2009 Category: Neurology Authors: Pasquale Striano Tags: Letter to the Editor Source Type: journals

Levetiracetam-induced platelet dysfunctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here for the first time, an alteration of platelet function attributable to this drug. This effect has never been reported before. The responsibility of levetiracetam seems to be probable: restoration of platelet functionality was observed after withholding this treatment and this effect has been described for a structurally related molecule, piracetam. (Source: Epilepsy Research)
Source: Epilepsy Research - August 22, 2009 Category: Neurology Authors: Marie Hacquard, Sébastien Richard, Jean-Christophe Lacour, Thomas Lecompte, Hervé Vespignani Tags: Short Communications Source Type: journals

Molecular cytogenetic characterization of a translocation t(13;22)(q22.3;q11.23) in a patient with idiopathic partial epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on a balanced de novo translocation t(13;22)(q22.3;q11.23) in a patient with a form of focal idiopathic epilepsy. Since candidate genes for FPEVF (familial partial epilepsy with variable foci) have been mapped by linkage studies in the same cytogenetic band of chromosome 22 involved in the translocation, this case can be helpful to identify genes involved in this form of epilepsy.Methods: Molecular cytogenetics analyses (FISH and array-CGH) were performed.Results and conclusions: Neither DNA duplications nor deletions were detected by array-CGH, thus it can be inferred that the translocation is balanced. The brea...
Source: Epilepsy Research - August 22, 2009 Category: Neurology Authors: Angelo Valetto, Veronica Bertini, Alice Bonuccelli, Franca Veroni, Paolo Simi, Grazia Taddeucci Tags: Short Communications Source Type: journals

Etiology and site of temporal lobe epilepsy influence postictal cytokine releaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Inflammatory mechanisms are involved in the pathogenesis of epilepsy. Vice versa, immune functions are regulated by the brain. We measured postictal changes in serum levels of the immuno-modulating cytokines IL-1β, IL-6 and TNFα in patients with well-defined temporal lobe epilepsy (TLE) and determined modifying factors. Serum levels of IL-1β, IL-6 and TNFα were quantified by ELISA at baseline as well as immediately, 1h and 24h after a complex partial (CPS) or secondary generalized tonic–clonic seizure (GTCS) during video-EEG monitoring in 25 patients suffering from temporal epilepsy. IL-6 increased by 51% im...
Source: Epilepsy Research - August 22, 2009 Category: Neurology Authors: Sebastian Bauer, Sabine Cepok, Anelia Todorova-Rudolph, Mareike Nowak, Martina Köller, Rüdiger Lorenz, Wolfgang H. Oertel, Felix Rosenow, Bernhard Hemmer, Hajo M. Hamer Tags: Research Papers Source Type: journals

Periictal magnetic resonance imaging in status epilepticusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In this study, DWIs and FLAIR images were proved useful in determining the extent and severity of early neuronal damage caused by epileptic discharges in SE patients. Seizure-induced long-term injuries were also observed in the follow-up MRI. (Source: Epilepsy Research)
Source: Epilepsy Research - August 22, 2009 Category: Neurology Authors: Yen-Chu Huang, Hsu-Huei Weng, Yu-tai Tsai, Ying-Chih Huang, Ming-Chang Hsiao, Chih-Ying Wu, Ya-Hui Lin, Huan-Lin Hsu, Jiann-Der Lee Tags: Research Papers Source Type: journals

Intravenous levetiracetam terminates refractory status epilepticus in two patients with migrating partial seizures in infancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: MPSI is a newly recognized epileptic syndrome characterized by early onset of intractable partial seizures arisingly independently and sequentially from both hemispheres, migrating from one region of the brain to another and from one hemisphere to another. We report the efficacy of intravenous levetiracetam in resolving refractory status epilepticus in two infants with this new epilepsy syndrome. (Source: Epilepsy Research)
Source: Epilepsy Research - August 22, 2009 Category: Neurology Authors: Maria Roberta Cilio, Roberto Bianchi, Martina Balestri, Alfredo Onofri, Simona Giovannini, Matteo Di Capua, Federico Vigevano Tags: Research Papers Source Type: journals

Behavioral and histological assessment of the effect of intermittent feeding in the pilocarpine model of temporal lobe epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Temporal lobe epilepsy (TLE) is the most resistant type of epilepsy. Currently available drugs for epilepsy are not antiepileptogenic. A novel treatment for epilepsy would be to block or reverse the process of epileptogenesis. We used intermittent feeding (IF) regimen of the dietary restriction (DR) to study its effect on epileptogenesis and neuroprotection in the pilocarpine model of TLE in rats. The effect of IF regimen on the induction of status epilepticus (SE), the duration of latent period, and the frequency, duration, severity and the time of occurrence of Spontaneous Recurrent Seizures (SRS) were investiga...
Source: Epilepsy Research - August 22, 2009 Category: Neurology Authors: Neda Parinejad, Sepideh Keshavarzi, Mansoureh Movahedin, Mohsin Raza Tags: Research Papers Source Type: journals

The effect of carbamazepine treatment on serum leptin levelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was conducted in Izmir Tepecik Training and Research Hospital, Neurology Department. 56 epileptic patients who were on continuous carbamazepine monotherapy for at least 6 months before the study and 42 control subjects were included. Serum leptin and insulin levels were measured.Body mass index, leptin and insulin were not significantly elevated in carbamazepine group compared to control subjects (p>0.05).Our study demonstrated that carbamazepine therapy does not affect significantly body mass index, leptin and insulin. Data regarding the effect of carbamazepine on serum leptin level is limited but the results o...
Source: Epilepsy Research - August 22, 2009 Category: Neurology Authors: Irem Fatma Uludag, Ugur Kulu, Ufuk Sener, Sukran Kose, Yasar Zorlu Tags: Research Papers Source Type: journals

Non-alcoholic fatty liver disease (NAFLD), insulin resistance and lipid profile in antiepileptic drug treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In conclusion, VPA (and moderately CBZ) therapy is related to increased risk for ultrasonographic signs of fatty liver disease, emphasizing the importance of regular ultrasound measurements as well as monitoring of serum lipids and BMI during enzyme-modulating AED treatment. (Source: Epilepsy Research)
Source: Epilepsy Research - August 22, 2009 Category: Neurology Authors: G. Luef, M. Rauchenzauner, M. Waldmann, W. Sturm, A. Sandhofer, K. Seppi, E. Trinka, I. Unterberger, C.F. Ebenbichler, M. Joannidis, G. Walser, G. Bauer, F. Hoppichler, M. Lechleitner Tags: Research Papers Source Type: journals

The risk of asymptomatic hyperammonemia in children with idiopathic epilepsy treated with valproate: Relationship to blood carnitine statusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to evaluate the risk frequency of hyperammonemia and abnormal carnitine levels in children receiving VPA who were otherwise free of neurological or obvious nutritional problems.Methods: Ammonia levels were prospectively evaluated in 60 epileptic children with primary epilepsy free of neurological or nutritional problems and were treated with VPA for at least 1 year. Forty healthy children were included as controls. Ammonia levels were correlated with total carnitine (TC), free carnitine (FC), acylcarnitine (AC) and AC/FC ratio. The abnormal ammonia and carnitine levels were also re-checked after 3 months t...
Source: Epilepsy Research - August 22, 2009 Category: Neurology Authors: Sherifa A. Hamed, Mostafa M. Abdella Tags: Research Papers Source Type: journals

Single-subject voxel-based relaxometry for clinical assessment of temporal lobe epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Purpose: T2 relaxometry, quantitative assessment of T2 relaxation time in magnetic resonance (MR) data, typically uses manually drawn regions of interest (ROIs). This approach is limited by its subjectivity and its restricted scope of investigation. A recently developed approach called voxel-based relaxometry (VBR) provides an unbiased statistical analysis of the whole brain. Our objective was to assess the clinical utility of single-subject VBR for patients with temporal lobe epilepsy (TLE).Methods: Forty-five patients with TLE confirmed by history, EEG, and structural MRI and 25 control subjects were scanned at ...
Source: Epilepsy Research - August 22, 2009 Category: Neurology Authors: Robert K. Kosior, M. Louis Lauzon, Richard Frayne, Paolo Federico Tags: Research Papers Source Type: journals

Spectral analysis of EEG gamma rhythms associated with tonic seizures in Lennox–Gastaut syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The detection of gamma rhythms in the ictal EEGs of tonic seizures indicated that some tonic seizures might have generative mechanisms in common with epileptic spasms, and that these mechanisms are possibly related to desynchronization at seizure onset. (Source: Epilepsy Research)
Source: Epilepsy Research - August 22, 2009 Category: Neurology Authors: Katsuhiro Kobayashi, Takushi Inoue, Yoshiaki Watanabe, Makio Oka, Fumika Endoh, Harumi Yoshinaga, Yoko Ohtsuka Tags: Research Papers Source Type: journals

Epilepsy, psychosocial and cognitive functioningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article will provide an overview of the psychosocial and cognitive problems that people with epilepsy (PWE) experience as consequence of the condition and its treatment. Psychosocial problems will be discussed in light of how they impact on quality of life. The review will discuss the stigma, myths and stereotypes that PWE encounter and the implications of these for important psychological outcomes including; anxiety, depression, self-esteem, sense of mastery and cognitive dysfunction. The latter part of the article will focus on psychosocial factors including social isolation, interpersonal and family relationships a...
Source: Epilepsy Research - August 22, 2009 Category: Neurology Authors: Jane McCagh, John E. Fisk, Gus A. Baker Tags: Review Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Epilepsy Research)
Source: Epilepsy Research - August 22, 2009 Category: Neurology Source Type: journals